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Congenital arteriovenous anastomosis
SELECTED
Watkins,
A. G.:
Congenital
587
ABSTRACTS
Arteriovenous
Anastomosis.
Brit.
M. J. 11:
849,
1941. The unusual and puzzling feature of this case was the milky discharge, and no Unfortunately reference to a similar happening has been found in the literature. this cleared up so quickly that we were unable to make full observations on it, but its presence pointed to an increased flow of lymph in the limb. The close embryonic relation between lymphatic vessels and veins, which are both derived from a common capillary plexus, may have produced a lymphatic developmental disturbance with increase in the lymph channels, or the greater lymph flow may simply have been the result of an increased blood supply to the limb. No edema of the limb was present. when the patient was first seen, and we do not know whether there had been any before the discharge. The most striking clinical feature of these cases is the increased growth of the limb, affecting bones and soft parts. Paterson and Wyllie (1925) suggested that this is due to an increased vascularity at the growing ends of the tibia and femur. Experimental section of the sympathetic nerves of limbs of kittens, as described by Harris and Wright (1930), although producing a greater blood supply, did not increase their growth. When the cervical sympathetic nerve and ganglia were removed in a rabbit’s ear, some increase in growth was noted after 100 days, and those authors suggested that it may be the higher temperature of the limb that acts as a stimulus. The exact cause of the hypertrophy is still far from clear, and the presence of the lymphatic discharge in the above case must remain unexplained until a recurrence of the discharge allows later investigation, or further cases have been observed. AUTHOR. Pedley,
F. G.:
Coronary
Disease
and
Occupation.
Canad.
M.
A: J. 46:
47,
1942.
The author gives a tabular record of mortality from diseases of the coronary arteries and angina peetoris in Canada since 1931. The table shows an increase from 1,937 males and 923 females in 1931 to 4,978 males and 2,271 females in 1938. These figures represent an understatement rather than an overstatement of the actual picture. Vital statistics alone do not settle the question whether coronary disease is on the increase or not. Figures are not available which would enable one to calculate the occupational incidence of coronary disease. The author reviews the available data on the subject and presents a tabular analysis of fifteen specific occupational groups. The lowest group of agricultural and garden workers shows less than one-ninth of the rate among the highest group of physicians and surgeons, MCCULLOCH.
Keys, A., and Violante, A.: The Cardio-Circulatory Effects in Man of Synephrin Tartrate (dZ-a-hydroxy-P-methylamino-4-hydroxy-ethylbenzene hydrochloride). J. Clin.
Investigation
21:
13, 1942.
A study has been made, under controlled environmental and physiologic conditions, of the cardiocirculatory effects in man of racemic synephrin tartrate. The threshold subcutaneous dosage is about 100 mg., and the indicated therapeutic dosage for pressor action is about 400 mg. given subcutaneously. In normal man synephrin tartrate produces a marked rise in systolic blood pressure, a ‘slight rise in diastolic blood pressure, and a slight fall in pulse rate. With subcutaneous administration these effects are at a maximum in ten to thirty minutes after injection and persist in diminishing degree for more than an hour.
Watkins,
A. G.:
Congenital
587
ABSTRACTS
Arteriovenous
Anastomosis.
Brit.
M. J. 11:
849,
1941. The unusual and puzzling feature of this case was the milky discharge, and no Unfortunately reference to a similar happening has been found in the literature. this cleared up so quickly that we were unable to make full observations on it, but its presence pointed to an increased flow of lymph in the limb. The close embryonic relation between lymphatic vessels and veins, which are both derived from a common capillary plexus, may have produced a lymphatic developmental disturbance with increase in the lymph channels, or the greater lymph flow may simply have been the result of an increased blood supply to the limb. No edema of the limb was present. when the patient was first seen, and we do not know whether there had been any before the discharge. The most striking clinical feature of these cases is the increased growth of the limb, affecting bones and soft parts. Paterson and Wyllie (1925) suggested that this is due to an increased vascularity at the growing ends of the tibia and femur. Experimental section of the sympathetic nerves of limbs of kittens, as described by Harris and Wright (1930), although producing a greater blood supply, did not increase their growth. When the cervical sympathetic nerve and ganglia were removed in a rabbit’s ear, some increase in growth was noted after 100 days, and those authors suggested that it may be the higher temperature of the limb that acts as a stimulus. The exact cause of the hypertrophy is still far from clear, and the presence of the lymphatic discharge in the above case must remain unexplained until a recurrence of the discharge allows later investigation, or further cases have been observed. AUTHOR. Pedley,
F. G.:
Coronary
Disease
and
Occupation.
Canad.
M.
A: J. 46:
47,
1942.
The author gives a tabular record of mortality from diseases of the coronary arteries and angina peetoris in Canada since 1931. The table shows an increase from 1,937 males and 923 females in 1931 to 4,978 males and 2,271 females in 1938. These figures represent an understatement rather than an overstatement of the actual picture. Vital statistics alone do not settle the question whether coronary disease is on the increase or not. Figures are not available which would enable one to calculate the occupational incidence of coronary disease. The author reviews the available data on the subject and presents a tabular analysis of fifteen specific occupational groups. The lowest group of agricultural and garden workers shows less than one-ninth of the rate among the highest group of physicians and surgeons, MCCULLOCH.
Keys, A., and Violante, A.: The Cardio-Circulatory Effects in Man of Synephrin Tartrate (dZ-a-hydroxy-P-methylamino-4-hydroxy-ethylbenzene hydrochloride). J. Clin.
Investigation
21:
13, 1942.
A study has been made, under controlled environmental and physiologic conditions, of the cardiocirculatory effects in man of racemic synephrin tartrate. The threshold subcutaneous dosage is about 100 mg., and the indicated therapeutic dosage for pressor action is about 400 mg. given subcutaneously. In normal man synephrin tartrate produces a marked rise in systolic blood pressure, a ‘slight rise in diastolic blood pressure, and a slight fall in pulse rate. With subcutaneous administration these effects are at a maximum in ten to thirty minutes after injection and persist in diminishing degree for more than an hour.