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Contents index -- Volume 38
CONTENTS INDEX -- VOLUME 38 Hormone Mediated Changes in Monoamine Stores and Regulation of Enzymes of Biosynthesis and Metabolism in the Rat Adrenal Gland. Influence of Progesterone, Estradiol, ACTH and Testosterone Administration. Abid-Raza Bukhari, Ali Guessab, and Marc Louis Nicol . . 2767 . . . 1 7P-Hydroxycardenolide Glycosides. 2. Szeleczky, M. S&i, Gy. Horvdth, and K. Albrecht . . 2775 . . . . . . . . . . . . . . .
11
Evidence of a Sex Related Difference of Transcortin Level in Adult Ducks. J.Y. Daniel, F. Malaval, and I.Assenmacher . . 2786 . . . .
29
Primary Cultures of Leydig Cells from Rat, Mouse and Pig: Advantages of Porcine Cells for the Study of Gonadotropin Regulation of Leydig Cell Function. J.P. Mather, J.M. Saez, and F. Haour . 2801 . .
35
Direct Enzymeimmunoassay of Progesterone in Bovine Milk. Maurice J. Sauer, John A. Foulkes, and Alan D. Cookson . . 2802 . .
45
5a-Reduction of an Anti-Androgen TSAA-291, 168-Ethyl-17B-Hydroxy4-Estren-3-One, by Nuclear 5a-Reductase in Rat Prostates. K. Sudo, K. Yoshida, Y. Akinaga, and R. Nakayama . . 2804 . . . . .
55
Development of a Solid-Phase Chemiluminescence Immunoassay for Plasma Progesterone. F. Kohen, J.B. Kim, H.R. Lindner, and W.P. Collins . 2805 . . 73 Use of Monoclonal Antibodies to Pregnanediol-3a-Glucuronide for the Development of a Solid Phase Chemiluminescence Immunoassay. Z. Eshhar, J.B. Kim, G. Barnard, W.P. Collins, S. Gilad, H.R. Lindner, and F. Kohen . . 2806 . . . . . . . . . . . . . . . .
89
Double Antibody Enzyme Immunoassay of Cortisol in Bovine Plasma. T. Nakao, F. Tamamura, N. Tsunoda, and K. Kawata . . 2810 . . . . .
111
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739
Prostatic Cancer. I. 6-Methylene-4-Pregnen-3-Ones as Irreversible Inhibitors of Rat Prostatic A4-3-Ketosteroid Sa-Reductase. Vladimir Petrow, Yueh-sha Wang, Leon Lack, and Avery Sandberg . 2764 . .
121
Tetracyclic Triterpenes. Part VI. The Synthesis of 4,4,14aSynthons for the Preparation Trimethyl-19(10*9fl) ABEO-Steroids. Zdzislaw Paryzek and Roman Wydra . . 2782 . . . of Cucurbitacins.
141
Synthesis of 16a-Bromoacetoxy Androgens and lJP-Bromoacetylamino4-Androsten-3-One: Potential Affinity Labels of Human Placental Aromatase. Mitsuteru Numazawa and Yoshio Osawa . . 2790 . . . .
149
.
A Chemical Approach to Solving Bridging Phenomena in Steroid G.D. Nordblom, R. Webb, R.E. Counsell, Radioimmunoassays. and B.G. England . . 2811 . . . . . . . . . . . . . . . . . . . . I
161
The Changing Estrogen Content of the Nuclear Fraction of Human . 2813 . Myometrium During Labor. Hilary H. Ko and Saul L.Cohen
,
175
Quantification of Endogenous Testosterone and Dihydrotestosterone in Fetal Tissues from Male Guinea-Pig. N. Rigaudisre . . 2815 .
.
185
ViVo Regulation of Ovarian Activity by Alpha-Fetoprotein. Claude Aussel, Marc Lafaurie, Rene Masseyeff, and Claude Stora . 2818 . .
195
Distribution of 19-Iodocholesterol-1251 3-Acetate in the Dog and the Rat. J.A. Owoyale . . 2825 . . . . . . . . . . . . . . . . . .
205
Quantitative Requirements for NADPH in the Support of Aromatization by Human Placental Microsomes. Leon A. Sheean and Robert A. Meigs . 2826 . .
211
lJ-Hydroxyprogesterone Metabolism in the Monkey Fetal Adrenal: ClJ-2GLyase and 21-Hydroxylase Activities. Samuel A. Sholl. 2831 .
221
A Method for the Isolation of Lipid Droplet Fractions from Decapsulated Rat Adrenals. J.J. Mrotek, J.K. Mathew, J.C. Curtis, and K.R. Johansson . . 2843 . . . . . . . . . . . . . . . . . . . .
229
In
Steroid Structural Requirements for High Affinity Binding to Human Sex Steroid Binding Protein (SBP). G.R. Cunningham, D.J. Tindall, T.J. Lobl, J.A. Campbell, and A.R. Means . . 2793 . . . . . . . . .
243
Plasma Testosterone-Binding Proteins in the Developing Rat. Yasuyuki Suzuki and Hyogo Sinohara . . 2820 , . . . . . . . . . . .
263
Aromatization of Testosterone in Large and Small Bovine Luteal Cells. Conflicting Results Between Radioimmunoassay and Cocrystallization Data. Jocelyn Ursely, Jean-Marie Darbon, and Pierre Leymarie . . 2821 . . . . . . . . . . . . . . . . . . . . .
271
Rapid Analysis of Human Fecal Bile Acids. William T. Beher, Sofia Stradnieks, Grace J. Lin, and Jeffrey Sanfield . . 2823 . . . . .
281
Rapid Pulsatile Corticosterone Secretion in the Rat Is Not Confirmed. R.F. Vining, D.E. James, S.P. Bennett, and E.W. Kraegen . . 2827 . . . . . . . . . . . . . . . . . . . . 297 The Role of Cytochrome P-450 in the Synthesis of Polar Metabolites of Aldosterone by Microsomes of Male Rat Liver. Syed A. Latif, Martin J. McDermott, and David J. Morris . . 2829 . . . . . . . .
307
Hyperprolactinemia in Monkeys: Induction by an Estrogen-Progesterone Synergy. Robert F. Williams, Donald L. Barber, Bryan D. Cowan, Almorris Lynch, Edward L. Marut, and Gary D. Hodgen . . 2842 . , . 321 The Preparation of Bile Acid Amides and Oxazolines. Narayan K.N. Ayengar, Anil K. Singhal, Charles K. McSherry, and Erwin H. Mosbach . . 2847 . .
333
Minor and Trace Sterols from Marine Invertebrates 28. A Novel Polyhydroxylated Sterol from the Soft Coral Anthe'liaGlauca. U. Sjijstrand, L. Bohlin, L. Fisher, M. Colin, and Carl Djerassi . . 2848 . .
347
Minor and Trace Sterols from Marine Invertebrates 29, (22E)Ergosta-5,22,25-Trien-38-01 and (22E,24R)-24,26-Dimethyl-Cholesta-5, 22,25(27)-Trien-38-01, Two New Marine Sterols from the Sponge PseudaxineZZa Lunacharta. U, Sjijstrand, J.M. Kornprobst, and Carl Djerassi , . . 2849 . . . . . . , . . . . . . . . . . . . . .
355
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Stabilization of Rat Liver Lyosomes by New Anti-Inflammatory Steroids 365 Ann S. Heiman and Henry J. Lee . . 2799 . . . . . . . . in vitro. Dinoflagellate Sterols IV: Isolation and Structure of 4a,235,245Trimethylcholestanol from the Dinoflagellate Glenodiniwn HaZZii. M. Alam, T.B. Sansing, J.R. Guerra, and Alan D. Harmon . . 2807 .
375
The Major Neutral Products of the Aerobic Catabolism of Cattle Bile by Pseudomonas sp. ATCC 31752. R.J. Park . . 2834 . . . . . . . .
383
Effects of 4-Hydroxy-4-Androstene-3,17-Dione and lo-Propargylestr4-Ene-3,17-Dione on the Metabolism of Androstenedione in Human Breast Carcinoma and Breast Adipose Tissues. E. Perel, S.P. Davis, 397 D.F. Covey, and D.W. Killinger . . 2835 . . . . . . . . . . . . . The Aging Leydig Cell: VII. Cytoplasmic Estradiol Receptors. T. Lin, G.C.C. Chen, E.P. Murono, J. Oaterman, and H.R. Nankin . . 2836 . 407 Structural Requirement of Sterol Side Chain for the Silkworm Growth and Development. Yoko Isaka, Masuo Morisaki, and Nobuo Ikekawa . . 2841 . . . . . . . . . . . . . . . . . . . . . .
417
Radioimmunoassay of Estradiol-17B in Unextracted Ewe Plasma. J. Saumande . . 2850 . . . . . . . . . . . . . . . . . . . . . . .
425
The Specific Binding of Androgens and the Subsequent Distribution of Androgen-Receptor Complexes within MCF-7 Human Breast Cancer Cells. John H. MacIndoe, Gayle R. Woods, and Ferrol J. Lee . . 2851 . . . 439 Chemiluminescence Enzyme Immunoassay of Dehydroepiandrosterone and Its Sulfate Using Peroxidase as Label. Hidetoshi Arakawa, Masako Maeda, Akio Tsuji, and Akira Kambegawa . . 2856 . . . . . . . . .
453
Bile Acids. LXIV. Synthesis of 5a-Cholestane-3a,7a,25-Triol and Esters of New 5a-Bile Acids. S.V. Hiremath and William H. Elliott. 2861. 465 Persistent Enhancement of Bile Acid Synthesis in Guinea Pigs Following Stimulation of Cholesterol Catabolism in Neonatal Life. Aslam S. Hassan, L.S. Gallon, L.A. Zimmer, W.F. Balistreri, and M.T.R. Subbiah . . 2862 . . . . . . . . . . . . . . . . . . . , . 477
742
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Derivatization of Estrogen Conjugates for Analysis by Capillary Gas Chromatography. C.H.L. Shakleton . . 2814 . . . . . . . . . .
485
Role of Endogenous and Exogenous Cholesterol in Liver as the Precursor for Bile Acids in Rats. Yoshikazu Ayaki, Terumi Tsuma, Sachiko Endo, and Michio Ogura . . 2819 . . . . . . , . . . . . .
495
The Effect of Progesterone on RNA Polymerases in the Rat Uterus. R.N. Kurl and N.M. Borthwick . . 2839 . . . . . . . . . . . . . .
511
Steroid Sulfotransferase in Hamster Epididymis. M. Bouthillier, A. Chapdelaine, G. Bleau, and K.D. Roberts . . 2840 . . . . . . .
523
The Synthesis and Study of Some Potential Affinity Reagents for Estrogen Receptors. Thomas Ratajczak, Peter N. Sheppard, Robert J. Capon, and Roland HBhnel . . 2852 , . . . . . . . . . .
537
A Short Efficient Synthesis of 16-Oxygenated Estratriene 3-Sulfates. Mitsuteru Numasawa, Katsuhiko Kimura, and Masao Nagaoka . . 2860 . 557 Synthesis and Biological Activity of Isomer: Novel Plant Growth-Promoting N. Bhushan Mandava, Werner J. Meudt, David W. Spaulding . . 2864 . . . _
Brassinolide and Its 220,238Steroids. Malcolm J. Thompson, William R. Lusby, and
. . . . . . . . . . . . . . .
567
Steroid 17a-Hydroxylase Activity of Ovarian Granulosa Cells from Hypophysectomized Immature Rats Treated with Pregnant Mare's Serum Gonadotropin (PMSG). Donald C. Johnson, Chon-Hwa Tsai, and Roger C. Hoversland . . 2870 . . . . . . . , . . . . . . . . . . .
581
Isomerization of Trans-Diethylstilbestrol to Pseudo-Diethylstilbestrel. Subhash C. Airy and Joseph E. Sinsheimer . . 2877 . . . . . . . . 593
743
Synthesis and Stereochemistry of 7$- and 7a-Amino-, Acetamido-, Hemisuccinamido- and Terephthalamido Derivatives of Testosterone. Claude-Yves Cuilleron, Elisabeth Mappus, Maguelone G. Forest, and Jean Bertrand . . 2785 f . . . . . . . . . . . . . . f . . . . . .
607
Biosynthesis and Inactivation of Ecdysone during the Pupal-Adult Development of the Cabbage Butterfly, Pieris Brassicae L. Philippe Beydon, Jacques Claret, Patrick Porcheron, and Rene Lafont . . 2830 . . . . , . . . . . . . . . . . . . . . . . .
633
17~-Alkynyl-118,17-D~hydroxyandrost~e Derivatives: A New Class of Potent Glucocorticoids. G. Teutsch, G. Costerousse, R. Deraedt, J. Benzoni, M. Fortin, and D. Philibert . , 2838 . . . . . . . . .
651
Specificity Studies of Monoclonal and Rabbit Antibodies Raised against Steroid Glucuronides. P. Samarajeewa, D.A. Weerasekera, and W.F. Coulson . . 2859 . . . , . . . . . . . . . . . . . . . .
667
Antiestrogenic and Antifertility Actions of Anordrin (2a,l7a_DiethynylA-Nor-5a-Androstane-ZS,17&Diol 2,17-Diwropionate). R.R. Mehta, J.M. Jenco, and R.T. Chatterton, Jr. 2863. ., ,... . . . . . 679 Inactivation of Aromatase in &tro by 4-Hydroxv-4-Androstene-3,17Dione and 7-Acetoxy-4-Androstene-3,17-Dione and Sustained Effects in z&X?, Angela M.H. Brodie, Wesley M. Garrett, James R. Hendrickson, Chon-Hwa Tsai-Morris, Patrick A. Marcotte, and Cecil H. Robinson . . 2866 . . . . . . . . . . . . . . . . . . . .
693
A Ring Contraction of 18,20-Cycle-Steroids. Preparation of 18-Acetyl17,18-Cycle-4-Androsten-3-One and 18-Hydroxyacetyl-17,18-Cycle-4Androsten-3-One. Masateru Miyano . . 2867 . + s . . . . . . * . . 703 Generally Applicable 125Iodine-Based Radioimmunoassays for Plasma Progesterone. John E.T. Corrie, Wendy A. Ratcliffe, and Janet S. Macpherson . . 2882 . . . . . . . . . . . . . . . . . . . . . . .
709
Progesterone Synthesis, Secretion and Metabolism by Human TeratomaDerived Cell-Lines. M.J. O'Hare, E.C. Nice, R.A.J. McIlhinney, andMCapp..2886.............. . . . . . . . . . 719 Volume 38 Tables of Content, Author Index, and Subject Index . , .
738
744
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AUTHOR INDEX - VOLUME 38 Airy, S.C., 593 Akinaga, Yumiko, 55 Alam, M., 375 Albrecht, K., 11 Arakawa, Hidetoshi, 453 Assenmacher, I., 29 Aussel, Claude, 195 Ayaki, Yoshikazu, 495 Ayengar, Narayan K.N., 333 Balistreri, W.F., 477 Barber, Donald L., 321 Barnard, G., 89 Beher, William T., 281 Bennett, S., 297 Benzoni, .I., 651 Bertrand, J., 607 Beydon, Philippe, 633 Bleau, G., 523 Bohlin, L., 347 Borthwick, N.M., 511 Bouthillier, M., 523 Brodie, Angela M.H., 693 Bukhari, Abid-Raza, 1 Capon, R.J., 537 Capp, M., 719 Chapdelaine, A., 523 Chatterton, Robert T., Jr.. 679 Chen, G.C.C., 407 Claret, Jacques, 633 Cohen, Saul L., 175 Colin, M., 347 Collins, W.P., 73, 89 Cookson, Alan D., 45 Corrie, John E.T., 709 Costerousse, G., 651 Coulson, W.F., 667 Counsell, R.E., 161 Covey, D.F., 397 Cowan, Bryan D., 321 Cuilleron, Cl.Y., 607 Curtis, J.C., 229 Daniel, J.-Y., 29 Darbon, Jean Marie, 271 Davis, S.P., 397 Deraedt, R., 651 Djerassi, Carl, 347, 355 Elliott, William H., 465
Endo, Sachiko, 495 England, B.G., 161 Eshhar, Z., 89 Fisher, L,, 347 Forest, M.G., 607 Fortin, M., 651 Foulkes, John A., 45 Gallon, L.S., 477 Garrett, Wesley M,, 693 Gilad, S,, 89 Guerra, J.R., 375 Guessab, Ali, 1 Hshnel, R., 537 Haour, F., 35 Harmon, Alan D., 375 Hassan, Aslam S., 477 Heiman, Ann S., 365 Hendrickson, James R., 693 Hiremath, S.V., 465 Hodgen, Gary D., 321 Horvath, Gy., 11 Hoversland, Roger C., 581 Ikekawa, Nobuo, 417 Isaka, Yoko, 417 James, D., 297 Jenco, John M., 679 Johansson, K.R., 229 Johnson, Donald C., 581 Kambegawa, Akira, 453 Kawata, K,, 111 Killinger, D.W., 397 Kim, J.B., 73, 89 Kimura, Katsuhiko, 557 Ko, Hilary, 175 Kohen, F., 73, 89 Komprobst, J.M., 355 Kraegen, E.W., 297 Kurl, R.N., 511 Lack, Leon, 121 Lafaurie, Marc, 195 Lafont, Reng, 633 Latif, Syed A., 307 Lee, Ferrol J., 439 Lee, Henry J., 365
S Leymarie, Pierre, 271 Lin, Grace J., 281 Lin, T., 407 Lindner, H.R., 73, 89 Lusby, William R., 567 Lynch, Almorris, 321 MacIndoe, J.H., 439 MacPherson, Janet S., 709 Maeda, Masako, 453 Malaval, F., 29 Mandava, N. Bhushan, 567 Mappus, E., 607 Marcotte, Patrick A., 693 Marut, Edward L., 321 Masseyeff, Rene, 195 Mather, J.P., 35 Mathew, J.K., 229 McDermott, Martin J., 307 McIlhinney, R.A.J., 719 McSherry, Charles K., 333 Mehta, Rajeshwari R., 679 Meigs, Robert A., 211 Meudt, Werner J., 567 Miyano, Masateru, 703 Morisaki, Masuo, 417 Morris, David J., 307 Mosbach, Erwin H., 333 Mrotek, J.J., 229 Murono, E.P., 407 Nagaoka, Masao, 557 Nakao, T., 111 Nakayama, Ryo, 55 Nankin, H.R., 407 Nice, E.C., 719 Nicol, Marc Louis, 1 Nordblom, G.D., 161 Numazawa, Mitsuteru, 149, 557 Ogura, Michio, 495 O'Hare, M.J., 719 Osawa, Yoshio, 149 Osterman, J., 407 Owoyale, J.A., 205 Park, R.J., 383 Paryzek, Zdzislav, 141 Perel, E., 397 Petrow, Vladimir, 121 Philibert, D., 651 Porcheron, Patrick, 633
WEIEOXDI
Ratajczak, T., 537 Ratcliffe, Wendy A., 709 Rigaudiere, N. 185 Roberts, K.D., 523 Robinson, Cecil H., 693 Saez, J.M., 35 Samarajeewa, P., 667 Sandberg, Avery, 121 Sanfield, Jeffrey, 281 Sansing, T.B., 375 Sauer, Maurice J., 45 Saumande, J., 425 Shackleton, C.H.L., 485 Sheean, Leon A., 211 Sheppard, P.N., 537 Shall, Samuel A., 221 Singhal, Anil K., 333 Sinohara, Hyogo, 263 Sinsheimer, J.E., 593 Sjostrand, U., 347, 355 Soti, M., 11 Spaulding, David W., 567 Stora, Claude, 195 Stradnieks, Sofia, 281 Subbiah, M.T.R., 477 Sudo, Katsuichiro, 55 Suzuki, Yasuyuki, 263 Szeleczky, Z., 11 Tamamura, F., 111 Teutsch, G., 651 Thompson, Malcolm J., 567 Tsai, Chon-Hwa, 581, 693 Tsuji, Akio, 453 Tsuma(-Date), Terumi, 495 Tsunoda, N., 111 Ursely, Jocelyne, 271 Vining, R.F., 297 Wang, Yueh-Sha, 121 Webb, R., 161 Weerasekera, D.A., 667 Williams, Robert F., 321 Woods, Gayle R., 439 Wydra, Roman, 141 Yoshida, Keiji, 55 Zimmer, L.A., 477
745
SUBJECT INDEX - VOLUKF 38 17a-Acetoxy-6-dibromomethylenepregn-4-ene-3,2O-dione, 5a-reductase inhibitor, 121 17a-Acetoxy-6-dichloromethylenepregn-4-ene-3,2O-dione, as 5a-reductase inhibitor, 121 3B-Acetoxy-19-iodo-5-cholestene, in dog and rat, 205 2OB-Acetoxy-6-methylenepregn-4-en-3-one, 5a-reductase inhibitor, 121 4-Acetoxyandrostene-3,17-dione, inactivation of aromatase activity by, 693 18, Acetyl-17,18-cycle-&androsten-3-one, preparation of, 703 ACTH, influence of, on adrenal monoamines, 1 Adrenal, a method for the isolation of lipid droplet fractions from, 229 Adrenal uptake, of 38-acetoxy-19-iodo-5-cholestene- 12%, 205 Affinity labeling reagents, for estrogen receptors, 537 Affinity labels, of human placental aromatase, 149 Aging Leydig cells, receptor levels in, 407 Aldosterone metabolites, with cytochrome P-450, 307 17a-Alkynyl-llb,17-dihydroxy-androstane derivatives, a new class of potent glucocorticoids, 651 Alpha-fetoprotein, regulation of ovarian activity by, 195 7B- and 7a-Amino-17$-hydroxy-androst-4-en-3-one, synthesis and stereochemistry of, 607 Androgens, specific binding of, 439 Androst-4-ene-3,17-dione, radioimmunoassay of, 161 Anordrin, antiestrogenic and antifertility actions of, 679 Anti-androgen TSAA-291, 5u-reduction of, lbðyl-17B-hydroxy-4estren-3-one, by nuclear 5a-reductase in rat prostates, 55 Antiestrogen action, of anordrin, 679 Antifertility action, of anordrin, 679 Anti-inflammatory steroids, stabilization of rat liver lysosomes by, 365 Aromatase inhibition, 397 Aromatization, by bovine luteal cells, of testosterone, 271 Aromatization, NADPH requirement of, 211 Bile, cattle, products of catabolism of bile acids by a Pseudomonas sp., 383 Bile acid synthesis, enhancement of, in pigs, 477 Bile acids, biosynthesis of, from endogenous and exogenous cholest-5-en3f3-01, in liver, 495 Bile acids, preparation of, 333 Biosynthesis, and inactivation of ecdvsone during the pupal-adult development of the cabbage butterfly, 633 Bovine milk, progesterone novel enzymeimmunoassay of, in, 45 Brassinosteroids, synthesis and biological activity of, 567 Breast tissue, inhibitors of steroid metabolism, 397 16a-Bromoacetoxy androgens, synthesis of, 149 17!3-Bromoacetylamino-4-androsten-3-one, synthesis of, 149 Cancer cells, androgen receptor complexes in, 439 Cardenolides, 7B-hydroxy-structure elucidation of, 11 Chemiluminescence assay, of dehydroepiandrosterone, 453 Cholest-5-en-36-01, as the precursor for bile acid formation, 495
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TXtEOXXBI
747
5u-Cholestane-3a,7a,Z5-triol, synthesis of, 465 Cholesterol analog, in silkworm growth, 417 Cholesterol catabolism, in pigs, 477 Coral, Anthelia GZauca, isolation of marine sterols from, 347 Corticosterone, pulsatile secretion, 297 Cortisol, enzyme immunoassay of, 111 Cucurbitacins [1,2], synthons for the preparation of, 141 18,20-Cycle-steroid, ring contraction of, 703 Cytochrome P-450, role in metabolism of aldosterone, 307 Dehydroepiandrosterone, enzyme assay of, 453 J-Dehydroxylation inhibitors, preparation of, 333 Diethylstilbestrol, isomerization of, to pseudo-diethylstilbestrol, 593 Diethylstilbestrol-dimethylsulfoxide adjunct, isolation and characterization of, 593 Digitoxin, microbial hydroxylation of, 11 Dihydrotestosterone, quantification of, in pig, 185 3a,Ja-Dihydroxy-5a-25-homocholanic acid, methyl ester, 465 118,1J-Dihydroxy-1Ja-propynyl-l,4,6-androstatrien-3-one, a pure glucocorticoid devoid of any affinity for the aldosterone receptor, 651 (22E,24R)-24,26-Dimethyl-cholesta-5,22,25(27)-trien-3i3-o1, isol.ation of, 355 Dinoflagellate sterols, isolation of, 375 Duck, transcortin levels in, 29 Ecdysone, biosynthesis and inactivation of, during the pupal-adult development of the cabbage butterfly, 633 Enz~ei~unoassay, of cortisol, Ill Enzymeimmunoassay, of dehydroepiandrosterone, 453 Enzymeimmunoassay, of progesterone, in milk, 45 Epididymis, hamster, steroid sulfotransferase in, 523 Episodic secretion, of corticosterone, 297 (22E)-Ergosta-5,22,25-trien-3B-01, isolation of, 355 Estradiol, influence of, on adrenal monoamines, 1 17B-Estradiol, radioimmunoassay of, in unextracted nlasma, 425 Estradiol receptor levels, in testes, 407 17B-Estradiol synthesis, in bovine luteal cells, 271 Estrogen, content of myometrial nuclei, 175 Estrogen, induction by, 321 Estrogen conjugates, analysis by gas chromatography, 485 Estrogen receptors, affinity labeling reagents for, 537 lb&Ethyl-lJB-hydroxy-4-estren-3-one (TSAR-291), 5a-reduction of, by nuclear 5a-reductase in rat prostates, 55 Fecal bile acids, assay of, 281 Fetal tissue, in pig, quantification of steroids in, 185 Gas chromatography, direct analysis of estrogen conjugates, 485 GZenodiniwn haZZii sterols, isolation of, 375 Gonadotropin regulation, of Leydig cell function, 35 Growth-promoting steroids, synthesis and biological activity of, 567
7B- and 7a-Hemisuccipamido-l7B-hydroxy-androst-4-en-3-one, synthesis and stereochemistry of, 607 Hepatic steroid hydroxylation, in rat liver, 307 25-Homo-5a-bile acids, synthesis of, 465 Human cell-lines, secretion of progesterone in, 719 Human sex steroid binding protein (SBP), structural requirements for, 243 4-Hydroxy-4-androstene-3,17-dione, effect of, on breast tissue metabolism, 397 ZOB-Hydroxy-6-methylenepregn-4-en-3-one, 5a-reductase inhibitor, 121 18-Hydroxyacetyl-17,18-cyclo-4-androsten-3-one, preparation of, 703 4-Hydroxyandrostene-3,17-dione, inactivation of aromatase activity by, 693 70_Hydroxydigoxin, structure elucidation of, 11 Zl-Hydroxylase activity, in fetal adrenal, 221 17a-Hydroxylase activity, in ovarian granulosa cells, 581 17-Hydroxyprogesterone, metabolism, in fetal adrenal, 221 lz510dinated tracer assay, of progesterone, 709 Inactivation of aromatase activity, 693 Inactivation and biosynthesis, of ecdysone during the pupal-adult development of the cabbage butterfly, 633 Ketamine hydrochloride,
induction of, 321
Leydig cell, receptor levels in, 407 Leydig cells, in study of gonadotropin regulation, 35 Lipid dro let purification, from decapsulated rat adrenals, 229 Lyase, C1p-20 activity in fetal adrenal, 221 Lysosome stabilization, by new anti-inflammatory steroids in vitro, 365 Marine sterols, isolation of, 347, 355 Methyl 6-formyl-3-methoxypregna-3,5-dien-ZOa-oate, 5a-reductase inhibitor, 121 Methyl 3-methoxypregna-3,5-dien-ZOa-oate, 5a-reductase inhibitor, 121 Methyl 6-methylene-3-oxopregn-4-en-ZOa-oate, 5a-reductase inhibitor, 121 6-Methylene-3-oxopregn-4-en-3-ones, as 5a-reductase inhibitors, 121 6-Methylenepregn-4-ene-3,20-dione, 5a-reductase inhibitor, 121 Monoamines, metabolism of, in rat adrenal gland, 1 Monoclonal antibodies of pregnanediol-3a-glucuronide, for immunoassay, 89 Monoclonal antibodies, stereospecificity studies with, 667 Myometrial nuclei, nuclear fraction, estrogen content in, 175 NADPH, quantitative requirement for aromatization, 211 Neonatal life, cholesterol catabolism, 477 Ovarian activity, regulation of, 195 Ovary, granulosa cells, 17a-hydroxylase activity in, 581 2-Oxazolines, preparation of, 333 3-Oxopregn-4-ene-20a-carboxylic acid, 5a-reductase inhibitor, 121 Placental microsomes, aromatization by, 211 Plasma testosterone-binding protein, in rat, 263
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TDEOTDI
749
Porcine cell culture, in gonadotropin regulation, 35 Pregnanediol-3a-glucuronide, immunoassay of, 89 4-Pregnene-3,20-dione, secretion and metabolism of, 719 Progesterone, effect upon RNA polymerase, 511 Progesterone, I.lz5 radioimmunoassay of, 709 Progesterone, induction by, 321 Progesterone, influence of, on adrenal monoamines, 1 Progesterone, novel conjugation to enzyme, for enzymeimmunoassay, 45 Progesterone, solid phase chemiluminescence immunoassay of, 73 Prolactin, induction of, 321 IO-Propargylestr-4-ene-3,17-dione, effect of, on breast tissue metabolism, 397 Prostatic A4-3-ketosteroid 5o-reductase inhibitors, 121 Pseudo-diethylstilbestrol, stereochemistry and isomerization from trams-diethylstilbestrol, 593 Pseudomonas catabolism, of bile acids in cattle bile, 383 Pulsatile secretion, of corticosterone, 297 Quantification, of fecal bile acids, 281 Radioimmunoassay, bridging phenomena in, 161 Radioimmunoassay, of estradiol, 271, 425 Radioimmunoassay, of progesterone, 709 Rat, developing, testosterone assay in, 263 Receptors, androgen, 439 5a-Reduction, of an anti-androgen TSAA-291, lbðyl-17B-hydroxy-4estren-3-one, by nuclear 5a-reductase in rat prostates, 55 Resazurin, assay of, 281 RNA polymerase, effect of progesterone upon, 511 Serum free medium, in gonadotropin regulation, 35 Silkworm, effect of steroids on growth, 417 Sodium 3,16a-dihydroxy-l,3,5(10)-estratrien-17-on-3-y1 sulfate, synthesis of, 557 Sodium 3,17&dihydroxy-1,3,5(10) -estratrien-16-on-3-yl sulfate, synthesis of, 557 Sodium 1,3,5(10)-estratriene-3,16a,17~-trio1-3-y1 sulfate, synthesis of, 557 Solid phase, chemiluminescence immunoassay, for progesterone, 73 Sponge, PseudaxineZta Lunacharta, isolation of marine sterols, 347 Steroid glucuronide, antibodies raised against, 667 Steroid secretion, a method for the isolation of lipid droplet fractions from decapsulated rat adrenals, 229 Sterol side chain, structural requirements for silkworm growth, 417 Sterol sulfates, in hamster, 523 Sulfotransferase, in hamster, 523 Teratomas, secretion of progesterone by, 719 7B- and 7a-Terephtalamido-178-hydroxy-androst-4-en-3-one, and stereochemistry of, 607 Testosterone, aromatization of, 271 Testosterone, estrogen binding globulin (TeBG), 243 Testosterone, influence of, on adrenal monoamines, 1
synthesis
Testosterone, quantification of, in pig, 185 Tetracyclic triterpenes, synthesis of, 141 Topical anti-inflammatory activity of, 118,17-dihydroxy-17a-propynyl-1, 4,6-androstatrien-3-one, 651 Transcortin level, in ducks, 2.9 4,4,14a-Trimethyl-19(10+9B) ARE0 steroids, synthesis of, 141 4a,235,24R-Trimethylcholestanol, isolation of, 375 Uterus, rat, effect of progesterone upon RNA polymerase in, 511
11
Evidence of a Sex Related Difference of Transcortin Level in Adult Ducks. J.Y. Daniel, F. Malaval, and I.Assenmacher . . 2786 . . . .
29
Primary Cultures of Leydig Cells from Rat, Mouse and Pig: Advantages of Porcine Cells for the Study of Gonadotropin Regulation of Leydig Cell Function. J.P. Mather, J.M. Saez, and F. Haour . 2801 . .
35
Direct Enzymeimmunoassay of Progesterone in Bovine Milk. Maurice J. Sauer, John A. Foulkes, and Alan D. Cookson . . 2802 . .
45
5a-Reduction of an Anti-Androgen TSAA-291, 168-Ethyl-17B-Hydroxy4-Estren-3-One, by Nuclear 5a-Reductase in Rat Prostates. K. Sudo, K. Yoshida, Y. Akinaga, and R. Nakayama . . 2804 . . . . .
55
Development of a Solid-Phase Chemiluminescence Immunoassay for Plasma Progesterone. F. Kohen, J.B. Kim, H.R. Lindner, and W.P. Collins . 2805 . . 73 Use of Monoclonal Antibodies to Pregnanediol-3a-Glucuronide for the Development of a Solid Phase Chemiluminescence Immunoassay. Z. Eshhar, J.B. Kim, G. Barnard, W.P. Collins, S. Gilad, H.R. Lindner, and F. Kohen . . 2806 . . . . . . . . . . . . . . . .
89
Double Antibody Enzyme Immunoassay of Cortisol in Bovine Plasma. T. Nakao, F. Tamamura, N. Tsunoda, and K. Kawata . . 2810 . . . . .
111
S
WmEOXDI
739
Prostatic Cancer. I. 6-Methylene-4-Pregnen-3-Ones as Irreversible Inhibitors of Rat Prostatic A4-3-Ketosteroid Sa-Reductase. Vladimir Petrow, Yueh-sha Wang, Leon Lack, and Avery Sandberg . 2764 . .
121
Tetracyclic Triterpenes. Part VI. The Synthesis of 4,4,14aSynthons for the Preparation Trimethyl-19(10*9fl) ABEO-Steroids. Zdzislaw Paryzek and Roman Wydra . . 2782 . . . of Cucurbitacins.
141
Synthesis of 16a-Bromoacetoxy Androgens and lJP-Bromoacetylamino4-Androsten-3-One: Potential Affinity Labels of Human Placental Aromatase. Mitsuteru Numazawa and Yoshio Osawa . . 2790 . . . .
149
.
A Chemical Approach to Solving Bridging Phenomena in Steroid G.D. Nordblom, R. Webb, R.E. Counsell, Radioimmunoassays. and B.G. England . . 2811 . . . . . . . . . . . . . . . . . . . . I
161
The Changing Estrogen Content of the Nuclear Fraction of Human . 2813 . Myometrium During Labor. Hilary H. Ko and Saul L.Cohen
,
175
Quantification of Endogenous Testosterone and Dihydrotestosterone in Fetal Tissues from Male Guinea-Pig. N. Rigaudisre . . 2815 .
.
185
ViVo Regulation of Ovarian Activity by Alpha-Fetoprotein. Claude Aussel, Marc Lafaurie, Rene Masseyeff, and Claude Stora . 2818 . .
195
Distribution of 19-Iodocholesterol-1251 3-Acetate in the Dog and the Rat. J.A. Owoyale . . 2825 . . . . . . . . . . . . . . . . . .
205
Quantitative Requirements for NADPH in the Support of Aromatization by Human Placental Microsomes. Leon A. Sheean and Robert A. Meigs . 2826 . .
211
lJ-Hydroxyprogesterone Metabolism in the Monkey Fetal Adrenal: ClJ-2GLyase and 21-Hydroxylase Activities. Samuel A. Sholl. 2831 .
221
A Method for the Isolation of Lipid Droplet Fractions from Decapsulated Rat Adrenals. J.J. Mrotek, J.K. Mathew, J.C. Curtis, and K.R. Johansson . . 2843 . . . . . . . . . . . . . . . . . . . .
229
In
Steroid Structural Requirements for High Affinity Binding to Human Sex Steroid Binding Protein (SBP). G.R. Cunningham, D.J. Tindall, T.J. Lobl, J.A. Campbell, and A.R. Means . . 2793 . . . . . . . . .
243
Plasma Testosterone-Binding Proteins in the Developing Rat. Yasuyuki Suzuki and Hyogo Sinohara . . 2820 , . . . . . . . . . . .
263
Aromatization of Testosterone in Large and Small Bovine Luteal Cells. Conflicting Results Between Radioimmunoassay and Cocrystallization Data. Jocelyn Ursely, Jean-Marie Darbon, and Pierre Leymarie . . 2821 . . . . . . . . . . . . . . . . . . . . .
271
Rapid Analysis of Human Fecal Bile Acids. William T. Beher, Sofia Stradnieks, Grace J. Lin, and Jeffrey Sanfield . . 2823 . . . . .
281
Rapid Pulsatile Corticosterone Secretion in the Rat Is Not Confirmed. R.F. Vining, D.E. James, S.P. Bennett, and E.W. Kraegen . . 2827 . . . . . . . . . . . . . . . . . . . . 297 The Role of Cytochrome P-450 in the Synthesis of Polar Metabolites of Aldosterone by Microsomes of Male Rat Liver. Syed A. Latif, Martin J. McDermott, and David J. Morris . . 2829 . . . . . . . .
307
Hyperprolactinemia in Monkeys: Induction by an Estrogen-Progesterone Synergy. Robert F. Williams, Donald L. Barber, Bryan D. Cowan, Almorris Lynch, Edward L. Marut, and Gary D. Hodgen . . 2842 . , . 321 The Preparation of Bile Acid Amides and Oxazolines. Narayan K.N. Ayengar, Anil K. Singhal, Charles K. McSherry, and Erwin H. Mosbach . . 2847 . .
333
Minor and Trace Sterols from Marine Invertebrates 28. A Novel Polyhydroxylated Sterol from the Soft Coral Anthe'liaGlauca. U. Sjijstrand, L. Bohlin, L. Fisher, M. Colin, and Carl Djerassi . . 2848 . .
347
Minor and Trace Sterols from Marine Invertebrates 29, (22E)Ergosta-5,22,25-Trien-38-01 and (22E,24R)-24,26-Dimethyl-Cholesta-5, 22,25(27)-Trien-38-01, Two New Marine Sterols from the Sponge PseudaxineZZa Lunacharta. U, Sjijstrand, J.M. Kornprobst, and Carl Djerassi , . . 2849 . . . . . . , . . . . . . . . . . . . . .
355
S
-3.=DEOID6
Stabilization of Rat Liver Lyosomes by New Anti-Inflammatory Steroids 365 Ann S. Heiman and Henry J. Lee . . 2799 . . . . . . . . in vitro. Dinoflagellate Sterols IV: Isolation and Structure of 4a,235,245Trimethylcholestanol from the Dinoflagellate Glenodiniwn HaZZii. M. Alam, T.B. Sansing, J.R. Guerra, and Alan D. Harmon . . 2807 .
375
The Major Neutral Products of the Aerobic Catabolism of Cattle Bile by Pseudomonas sp. ATCC 31752. R.J. Park . . 2834 . . . . . . . .
383
Effects of 4-Hydroxy-4-Androstene-3,17-Dione and lo-Propargylestr4-Ene-3,17-Dione on the Metabolism of Androstenedione in Human Breast Carcinoma and Breast Adipose Tissues. E. Perel, S.P. Davis, 397 D.F. Covey, and D.W. Killinger . . 2835 . . . . . . . . . . . . . The Aging Leydig Cell: VII. Cytoplasmic Estradiol Receptors. T. Lin, G.C.C. Chen, E.P. Murono, J. Oaterman, and H.R. Nankin . . 2836 . 407 Structural Requirement of Sterol Side Chain for the Silkworm Growth and Development. Yoko Isaka, Masuo Morisaki, and Nobuo Ikekawa . . 2841 . . . . . . . . . . . . . . . . . . . . . .
417
Radioimmunoassay of Estradiol-17B in Unextracted Ewe Plasma. J. Saumande . . 2850 . . . . . . . . . . . . . . . . . . . . . . .
425
The Specific Binding of Androgens and the Subsequent Distribution of Androgen-Receptor Complexes within MCF-7 Human Breast Cancer Cells. John H. MacIndoe, Gayle R. Woods, and Ferrol J. Lee . . 2851 . . . 439 Chemiluminescence Enzyme Immunoassay of Dehydroepiandrosterone and Its Sulfate Using Peroxidase as Label. Hidetoshi Arakawa, Masako Maeda, Akio Tsuji, and Akira Kambegawa . . 2856 . . . . . . . . .
453
Bile Acids. LXIV. Synthesis of 5a-Cholestane-3a,7a,25-Triol and Esters of New 5a-Bile Acids. S.V. Hiremath and William H. Elliott. 2861. 465 Persistent Enhancement of Bile Acid Synthesis in Guinea Pigs Following Stimulation of Cholesterol Catabolism in Neonatal Life. Aslam S. Hassan, L.S. Gallon, L.A. Zimmer, W.F. Balistreri, and M.T.R. Subbiah . . 2862 . . . . . . . . . . . . . . . . . . . , . 477
742
SC
fPBEOfDI
Derivatization of Estrogen Conjugates for Analysis by Capillary Gas Chromatography. C.H.L. Shakleton . . 2814 . . . . . . . . . .
485
Role of Endogenous and Exogenous Cholesterol in Liver as the Precursor for Bile Acids in Rats. Yoshikazu Ayaki, Terumi Tsuma, Sachiko Endo, and Michio Ogura . . 2819 . . . . . . , . . . . . .
495
The Effect of Progesterone on RNA Polymerases in the Rat Uterus. R.N. Kurl and N.M. Borthwick . . 2839 . . . . . . . . . . . . . .
511
Steroid Sulfotransferase in Hamster Epididymis. M. Bouthillier, A. Chapdelaine, G. Bleau, and K.D. Roberts . . 2840 . . . . . . .
523
The Synthesis and Study of Some Potential Affinity Reagents for Estrogen Receptors. Thomas Ratajczak, Peter N. Sheppard, Robert J. Capon, and Roland HBhnel . . 2852 , . . . . . . . . . .
537
A Short Efficient Synthesis of 16-Oxygenated Estratriene 3-Sulfates. Mitsuteru Numasawa, Katsuhiko Kimura, and Masao Nagaoka . . 2860 . 557 Synthesis and Biological Activity of Isomer: Novel Plant Growth-Promoting N. Bhushan Mandava, Werner J. Meudt, David W. Spaulding . . 2864 . . . _
Brassinolide and Its 220,238Steroids. Malcolm J. Thompson, William R. Lusby, and
. . . . . . . . . . . . . . .
567
Steroid 17a-Hydroxylase Activity of Ovarian Granulosa Cells from Hypophysectomized Immature Rats Treated with Pregnant Mare's Serum Gonadotropin (PMSG). Donald C. Johnson, Chon-Hwa Tsai, and Roger C. Hoversland . . 2870 . . . . . . . , . . . . . . . . . . .
581
Isomerization of Trans-Diethylstilbestrol to Pseudo-Diethylstilbestrel. Subhash C. Airy and Joseph E. Sinsheimer . . 2877 . . . . . . . . 593
743
Synthesis and Stereochemistry of 7$- and 7a-Amino-, Acetamido-, Hemisuccinamido- and Terephthalamido Derivatives of Testosterone. Claude-Yves Cuilleron, Elisabeth Mappus, Maguelone G. Forest, and Jean Bertrand . . 2785 f . . . . . . . . . . . . . . f . . . . . .
607
Biosynthesis and Inactivation of Ecdysone during the Pupal-Adult Development of the Cabbage Butterfly, Pieris Brassicae L. Philippe Beydon, Jacques Claret, Patrick Porcheron, and Rene Lafont . . 2830 . . . . , . . . . . . . . . . . . . . . . . .
633
17~-Alkynyl-118,17-D~hydroxyandrost~e Derivatives: A New Class of Potent Glucocorticoids. G. Teutsch, G. Costerousse, R. Deraedt, J. Benzoni, M. Fortin, and D. Philibert . , 2838 . . . . . . . . .
651
Specificity Studies of Monoclonal and Rabbit Antibodies Raised against Steroid Glucuronides. P. Samarajeewa, D.A. Weerasekera, and W.F. Coulson . . 2859 . . . , . . . . . . . . . . . . . . . .
667
Antiestrogenic and Antifertility Actions of Anordrin (2a,l7a_DiethynylA-Nor-5a-Androstane-ZS,17&Diol 2,17-Diwropionate). R.R. Mehta, J.M. Jenco, and R.T. Chatterton, Jr. 2863. ., ,... . . . . . 679 Inactivation of Aromatase in &tro by 4-Hydroxv-4-Androstene-3,17Dione and 7-Acetoxy-4-Androstene-3,17-Dione and Sustained Effects in z&X?, Angela M.H. Brodie, Wesley M. Garrett, James R. Hendrickson, Chon-Hwa Tsai-Morris, Patrick A. Marcotte, and Cecil H. Robinson . . 2866 . . . . . . . . . . . . . . . . . . . .
693
A Ring Contraction of 18,20-Cycle-Steroids. Preparation of 18-Acetyl17,18-Cycle-4-Androsten-3-One and 18-Hydroxyacetyl-17,18-Cycle-4Androsten-3-One. Masateru Miyano . . 2867 . + s . . . . . . * . . 703 Generally Applicable 125Iodine-Based Radioimmunoassays for Plasma Progesterone. John E.T. Corrie, Wendy A. Ratcliffe, and Janet S. Macpherson . . 2882 . . . . . . . . . . . . . . . . . . . . . . .
709
Progesterone Synthesis, Secretion and Metabolism by Human TeratomaDerived Cell-Lines. M.J. O'Hare, E.C. Nice, R.A.J. McIlhinney, andMCapp..2886.............. . . . . . . . . . 719 Volume 38 Tables of Content, Author Index, and Subject Index . , .
738
744
S
THEOXDm
AUTHOR INDEX - VOLUME 38 Airy, S.C., 593 Akinaga, Yumiko, 55 Alam, M., 375 Albrecht, K., 11 Arakawa, Hidetoshi, 453 Assenmacher, I., 29 Aussel, Claude, 195 Ayaki, Yoshikazu, 495 Ayengar, Narayan K.N., 333 Balistreri, W.F., 477 Barber, Donald L., 321 Barnard, G., 89 Beher, William T., 281 Bennett, S., 297 Benzoni, .I., 651 Bertrand, J., 607 Beydon, Philippe, 633 Bleau, G., 523 Bohlin, L., 347 Borthwick, N.M., 511 Bouthillier, M., 523 Brodie, Angela M.H., 693 Bukhari, Abid-Raza, 1 Capon, R.J., 537 Capp, M., 719 Chapdelaine, A., 523 Chatterton, Robert T., Jr.. 679 Chen, G.C.C., 407 Claret, Jacques, 633 Cohen, Saul L., 175 Colin, M., 347 Collins, W.P., 73, 89 Cookson, Alan D., 45 Corrie, John E.T., 709 Costerousse, G., 651 Coulson, W.F., 667 Counsell, R.E., 161 Covey, D.F., 397 Cowan, Bryan D., 321 Cuilleron, Cl.Y., 607 Curtis, J.C., 229 Daniel, J.-Y., 29 Darbon, Jean Marie, 271 Davis, S.P., 397 Deraedt, R., 651 Djerassi, Carl, 347, 355 Elliott, William H., 465
Endo, Sachiko, 495 England, B.G., 161 Eshhar, Z., 89 Fisher, L,, 347 Forest, M.G., 607 Fortin, M., 651 Foulkes, John A., 45 Gallon, L.S., 477 Garrett, Wesley M,, 693 Gilad, S,, 89 Guerra, J.R., 375 Guessab, Ali, 1 Hshnel, R., 537 Haour, F., 35 Harmon, Alan D., 375 Hassan, Aslam S., 477 Heiman, Ann S., 365 Hendrickson, James R., 693 Hiremath, S.V., 465 Hodgen, Gary D., 321 Horvath, Gy., 11 Hoversland, Roger C., 581 Ikekawa, Nobuo, 417 Isaka, Yoko, 417 James, D., 297 Jenco, John M., 679 Johansson, K.R., 229 Johnson, Donald C., 581 Kambegawa, Akira, 453 Kawata, K,, 111 Killinger, D.W., 397 Kim, J.B., 73, 89 Kimura, Katsuhiko, 557 Ko, Hilary, 175 Kohen, F., 73, 89 Komprobst, J.M., 355 Kraegen, E.W., 297 Kurl, R.N., 511 Lack, Leon, 121 Lafaurie, Marc, 195 Lafont, Reng, 633 Latif, Syed A., 307 Lee, Ferrol J., 439 Lee, Henry J., 365
S Leymarie, Pierre, 271 Lin, Grace J., 281 Lin, T., 407 Lindner, H.R., 73, 89 Lusby, William R., 567 Lynch, Almorris, 321 MacIndoe, J.H., 439 MacPherson, Janet S., 709 Maeda, Masako, 453 Malaval, F., 29 Mandava, N. Bhushan, 567 Mappus, E., 607 Marcotte, Patrick A., 693 Marut, Edward L., 321 Masseyeff, Rene, 195 Mather, J.P., 35 Mathew, J.K., 229 McDermott, Martin J., 307 McIlhinney, R.A.J., 719 McSherry, Charles K., 333 Mehta, Rajeshwari R., 679 Meigs, Robert A., 211 Meudt, Werner J., 567 Miyano, Masateru, 703 Morisaki, Masuo, 417 Morris, David J., 307 Mosbach, Erwin H., 333 Mrotek, J.J., 229 Murono, E.P., 407 Nagaoka, Masao, 557 Nakao, T., 111 Nakayama, Ryo, 55 Nankin, H.R., 407 Nice, E.C., 719 Nicol, Marc Louis, 1 Nordblom, G.D., 161 Numazawa, Mitsuteru, 149, 557 Ogura, Michio, 495 O'Hare, M.J., 719 Osawa, Yoshio, 149 Osterman, J., 407 Owoyale, J.A., 205 Park, R.J., 383 Paryzek, Zdzislav, 141 Perel, E., 397 Petrow, Vladimir, 121 Philibert, D., 651 Porcheron, Patrick, 633
WEIEOXDI
Ratajczak, T., 537 Ratcliffe, Wendy A., 709 Rigaudiere, N. 185 Roberts, K.D., 523 Robinson, Cecil H., 693 Saez, J.M., 35 Samarajeewa, P., 667 Sandberg, Avery, 121 Sanfield, Jeffrey, 281 Sansing, T.B., 375 Sauer, Maurice J., 45 Saumande, J., 425 Shackleton, C.H.L., 485 Sheean, Leon A., 211 Sheppard, P.N., 537 Shall, Samuel A., 221 Singhal, Anil K., 333 Sinohara, Hyogo, 263 Sinsheimer, J.E., 593 Sjostrand, U., 347, 355 Soti, M., 11 Spaulding, David W., 567 Stora, Claude, 195 Stradnieks, Sofia, 281 Subbiah, M.T.R., 477 Sudo, Katsuichiro, 55 Suzuki, Yasuyuki, 263 Szeleczky, Z., 11 Tamamura, F., 111 Teutsch, G., 651 Thompson, Malcolm J., 567 Tsai, Chon-Hwa, 581, 693 Tsuji, Akio, 453 Tsuma(-Date), Terumi, 495 Tsunoda, N., 111 Ursely, Jocelyne, 271 Vining, R.F., 297 Wang, Yueh-Sha, 121 Webb, R., 161 Weerasekera, D.A., 667 Williams, Robert F., 321 Woods, Gayle R., 439 Wydra, Roman, 141 Yoshida, Keiji, 55 Zimmer, L.A., 477
745
SUBJECT INDEX - VOLUKF 38 17a-Acetoxy-6-dibromomethylenepregn-4-ene-3,2O-dione, 5a-reductase inhibitor, 121 17a-Acetoxy-6-dichloromethylenepregn-4-ene-3,2O-dione, as 5a-reductase inhibitor, 121 3B-Acetoxy-19-iodo-5-cholestene, in dog and rat, 205 2OB-Acetoxy-6-methylenepregn-4-en-3-one, 5a-reductase inhibitor, 121 4-Acetoxyandrostene-3,17-dione, inactivation of aromatase activity by, 693 18, Acetyl-17,18-cycle-&androsten-3-one, preparation of, 703 ACTH, influence of, on adrenal monoamines, 1 Adrenal, a method for the isolation of lipid droplet fractions from, 229 Adrenal uptake, of 38-acetoxy-19-iodo-5-cholestene- 12%, 205 Affinity labeling reagents, for estrogen receptors, 537 Affinity labels, of human placental aromatase, 149 Aging Leydig cells, receptor levels in, 407 Aldosterone metabolites, with cytochrome P-450, 307 17a-Alkynyl-llb,17-dihydroxy-androstane derivatives, a new class of potent glucocorticoids, 651 Alpha-fetoprotein, regulation of ovarian activity by, 195 7B- and 7a-Amino-17$-hydroxy-androst-4-en-3-one, synthesis and stereochemistry of, 607 Androgens, specific binding of, 439 Androst-4-ene-3,17-dione, radioimmunoassay of, 161 Anordrin, antiestrogenic and antifertility actions of, 679 Anti-androgen TSAA-291, 5u-reduction of, lbðyl-17B-hydroxy-4estren-3-one, by nuclear 5a-reductase in rat prostates, 55 Antiestrogen action, of anordrin, 679 Antifertility action, of anordrin, 679 Anti-inflammatory steroids, stabilization of rat liver lysosomes by, 365 Aromatase inhibition, 397 Aromatization, by bovine luteal cells, of testosterone, 271 Aromatization, NADPH requirement of, 211 Bile, cattle, products of catabolism of bile acids by a Pseudomonas sp., 383 Bile acid synthesis, enhancement of, in pigs, 477 Bile acids, biosynthesis of, from endogenous and exogenous cholest-5-en3f3-01, in liver, 495 Bile acids, preparation of, 333 Biosynthesis, and inactivation of ecdvsone during the pupal-adult development of the cabbage butterfly, 633 Bovine milk, progesterone novel enzymeimmunoassay of, in, 45 Brassinosteroids, synthesis and biological activity of, 567 Breast tissue, inhibitors of steroid metabolism, 397 16a-Bromoacetoxy androgens, synthesis of, 149 17!3-Bromoacetylamino-4-androsten-3-one, synthesis of, 149 Cancer cells, androgen receptor complexes in, 439 Cardenolides, 7B-hydroxy-structure elucidation of, 11 Chemiluminescence assay, of dehydroepiandrosterone, 453 Cholest-5-en-36-01, as the precursor for bile acid formation, 495
S
TXtEOXXBI
747
5u-Cholestane-3a,7a,Z5-triol, synthesis of, 465 Cholesterol analog, in silkworm growth, 417 Cholesterol catabolism, in pigs, 477 Coral, Anthelia GZauca, isolation of marine sterols from, 347 Corticosterone, pulsatile secretion, 297 Cortisol, enzyme immunoassay of, 111 Cucurbitacins [1,2], synthons for the preparation of, 141 18,20-Cycle-steroid, ring contraction of, 703 Cytochrome P-450, role in metabolism of aldosterone, 307 Dehydroepiandrosterone, enzyme assay of, 453 J-Dehydroxylation inhibitors, preparation of, 333 Diethylstilbestrol, isomerization of, to pseudo-diethylstilbestrol, 593 Diethylstilbestrol-dimethylsulfoxide adjunct, isolation and characterization of, 593 Digitoxin, microbial hydroxylation of, 11 Dihydrotestosterone, quantification of, in pig, 185 3a,Ja-Dihydroxy-5a-25-homocholanic acid, methyl ester, 465 118,1J-Dihydroxy-1Ja-propynyl-l,4,6-androstatrien-3-one, a pure glucocorticoid devoid of any affinity for the aldosterone receptor, 651 (22E,24R)-24,26-Dimethyl-cholesta-5,22,25(27)-trien-3i3-o1, isol.ation of, 355 Dinoflagellate sterols, isolation of, 375 Duck, transcortin levels in, 29 Ecdysone, biosynthesis and inactivation of, during the pupal-adult development of the cabbage butterfly, 633 Enz~ei~unoassay, of cortisol, Ill Enzymeimmunoassay, of dehydroepiandrosterone, 453 Enzymeimmunoassay, of progesterone, in milk, 45 Epididymis, hamster, steroid sulfotransferase in, 523 Episodic secretion, of corticosterone, 297 (22E)-Ergosta-5,22,25-trien-3B-01, isolation of, 355 Estradiol, influence of, on adrenal monoamines, 1 17B-Estradiol, radioimmunoassay of, in unextracted nlasma, 425 Estradiol receptor levels, in testes, 407 17B-Estradiol synthesis, in bovine luteal cells, 271 Estrogen, content of myometrial nuclei, 175 Estrogen, induction by, 321 Estrogen conjugates, analysis by gas chromatography, 485 Estrogen receptors, affinity labeling reagents for, 537 lb&Ethyl-lJB-hydroxy-4-estren-3-one (TSAR-291), 5a-reduction of, by nuclear 5a-reductase in rat prostates, 55 Fecal bile acids, assay of, 281 Fetal tissue, in pig, quantification of steroids in, 185 Gas chromatography, direct analysis of estrogen conjugates, 485 GZenodiniwn haZZii sterols, isolation of, 375 Gonadotropin regulation, of Leydig cell function, 35 Growth-promoting steroids, synthesis and biological activity of, 567
7B- and 7a-Hemisuccipamido-l7B-hydroxy-androst-4-en-3-one, synthesis and stereochemistry of, 607 Hepatic steroid hydroxylation, in rat liver, 307 25-Homo-5a-bile acids, synthesis of, 465 Human cell-lines, secretion of progesterone in, 719 Human sex steroid binding protein (SBP), structural requirements for, 243 4-Hydroxy-4-androstene-3,17-dione, effect of, on breast tissue metabolism, 397 ZOB-Hydroxy-6-methylenepregn-4-en-3-one, 5a-reductase inhibitor, 121 18-Hydroxyacetyl-17,18-cyclo-4-androsten-3-one, preparation of, 703 4-Hydroxyandrostene-3,17-dione, inactivation of aromatase activity by, 693 70_Hydroxydigoxin, structure elucidation of, 11 Zl-Hydroxylase activity, in fetal adrenal, 221 17a-Hydroxylase activity, in ovarian granulosa cells, 581 17-Hydroxyprogesterone, metabolism, in fetal adrenal, 221 lz510dinated tracer assay, of progesterone, 709 Inactivation of aromatase activity, 693 Inactivation and biosynthesis, of ecdysone during the pupal-adult development of the cabbage butterfly, 633 Ketamine hydrochloride,
induction of, 321
Leydig cell, receptor levels in, 407 Leydig cells, in study of gonadotropin regulation, 35 Lipid dro let purification, from decapsulated rat adrenals, 229 Lyase, C1p-20 activity in fetal adrenal, 221 Lysosome stabilization, by new anti-inflammatory steroids in vitro, 365 Marine sterols, isolation of, 347, 355 Methyl 6-formyl-3-methoxypregna-3,5-dien-ZOa-oate, 5a-reductase inhibitor, 121 Methyl 3-methoxypregna-3,5-dien-ZOa-oate, 5a-reductase inhibitor, 121 Methyl 6-methylene-3-oxopregn-4-en-ZOa-oate, 5a-reductase inhibitor, 121 6-Methylene-3-oxopregn-4-en-3-ones, as 5a-reductase inhibitors, 121 6-Methylenepregn-4-ene-3,20-dione, 5a-reductase inhibitor, 121 Monoamines, metabolism of, in rat adrenal gland, 1 Monoclonal antibodies of pregnanediol-3a-glucuronide, for immunoassay, 89 Monoclonal antibodies, stereospecificity studies with, 667 Myometrial nuclei, nuclear fraction, estrogen content in, 175 NADPH, quantitative requirement for aromatization, 211 Neonatal life, cholesterol catabolism, 477 Ovarian activity, regulation of, 195 Ovary, granulosa cells, 17a-hydroxylase activity in, 581 2-Oxazolines, preparation of, 333 3-Oxopregn-4-ene-20a-carboxylic acid, 5a-reductase inhibitor, 121 Placental microsomes, aromatization by, 211 Plasma testosterone-binding protein, in rat, 263
S
TDEOTDI
749
Porcine cell culture, in gonadotropin regulation, 35 Pregnanediol-3a-glucuronide, immunoassay of, 89 4-Pregnene-3,20-dione, secretion and metabolism of, 719 Progesterone, effect upon RNA polymerase, 511 Progesterone, I.lz5 radioimmunoassay of, 709 Progesterone, induction by, 321 Progesterone, influence of, on adrenal monoamines, 1 Progesterone, novel conjugation to enzyme, for enzymeimmunoassay, 45 Progesterone, solid phase chemiluminescence immunoassay of, 73 Prolactin, induction of, 321 IO-Propargylestr-4-ene-3,17-dione, effect of, on breast tissue metabolism, 397 Prostatic A4-3-ketosteroid 5o-reductase inhibitors, 121 Pseudo-diethylstilbestrol, stereochemistry and isomerization from trams-diethylstilbestrol, 593 Pseudomonas catabolism, of bile acids in cattle bile, 383 Pulsatile secretion, of corticosterone, 297 Quantification, of fecal bile acids, 281 Radioimmunoassay, bridging phenomena in, 161 Radioimmunoassay, of estradiol, 271, 425 Radioimmunoassay, of progesterone, 709 Rat, developing, testosterone assay in, 263 Receptors, androgen, 439 5a-Reduction, of an anti-androgen TSAA-291, lbðyl-17B-hydroxy-4estren-3-one, by nuclear 5a-reductase in rat prostates, 55 Resazurin, assay of, 281 RNA polymerase, effect of progesterone upon, 511 Serum free medium, in gonadotropin regulation, 35 Silkworm, effect of steroids on growth, 417 Sodium 3,16a-dihydroxy-l,3,5(10)-estratrien-17-on-3-y1 sulfate, synthesis of, 557 Sodium 3,17&dihydroxy-1,3,5(10) -estratrien-16-on-3-yl sulfate, synthesis of, 557 Sodium 1,3,5(10)-estratriene-3,16a,17~-trio1-3-y1 sulfate, synthesis of, 557 Solid phase, chemiluminescence immunoassay, for progesterone, 73 Sponge, PseudaxineZta Lunacharta, isolation of marine sterols, 347 Steroid glucuronide, antibodies raised against, 667 Steroid secretion, a method for the isolation of lipid droplet fractions from decapsulated rat adrenals, 229 Sterol side chain, structural requirements for silkworm growth, 417 Sterol sulfates, in hamster, 523 Sulfotransferase, in hamster, 523 Teratomas, secretion of progesterone by, 719 7B- and 7a-Terephtalamido-178-hydroxy-androst-4-en-3-one, and stereochemistry of, 607 Testosterone, aromatization of, 271 Testosterone, estrogen binding globulin (TeBG), 243 Testosterone, influence of, on adrenal monoamines, 1
synthesis
Testosterone, quantification of, in pig, 185 Tetracyclic triterpenes, synthesis of, 141 Topical anti-inflammatory activity of, 118,17-dihydroxy-17a-propynyl-1, 4,6-androstatrien-3-one, 651 Transcortin level, in ducks, 2.9 4,4,14a-Trimethyl-19(10+9B) ARE0 steroids, synthesis of, 141 4a,235,24R-Trimethylcholestanol, isolation of, 375 Uterus, rat, effect of progesterone upon RNA polymerase in, 511