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Contents volume 189 (1987)
Mutation Research, 189 (1987) 417-419
417
Elsevier
Contents Volume 189 (1987) Special Issue
Genotoxicity Produced in Cultured Mammalian Cell Assays by Treatment Conditions
edited by David J. Brusick Editorial Introduction by F.H. Sobels (The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
vii
Research Papers Implications of treatment-condition-induced genotoxicity for chemical screening and data interpretation (MTR 04389) by D.J. Brusick (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . In vitro testing as a step in the evaluation of in vivo genotoxicity (MTR 04388) by F.H. Sobels (The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Base-substitution and frameshift mutagenesis by sodium chloride and potassium chloride in Saccharomyces cerevisiae (MTR 04445) by K.R. Parker and R.C. Von Borstel (Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and D N A strand breaks, and the relation to toxicity (MTR 04390) by S.M. Galloway, D.A. Deasy, C.L. Bean, A.R. Kraynak, M.J. Armstrong and M.O. Bradley (U.S.A.) . . . . . . . . . Mutagenicity of rat-liver $9 to L5178Y mouse lymphoma cells (MTR 04422) by B.C. Myhr and J.K. Mayo (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK ÷! cells (MTR 04423) by M.A. Cifone, B. Myhr, A. Eiche and G. Bolcsfoldi (U.S.A. and Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Extrapolation from in vitro tests to human risk: Experience with sodium fluoride clastogenicity (MTR 04392) by D. Scott and S.A. Roberts (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . N-Chloropiperidine and calcium hypochlorite: Possible examples of toxicity-dependent clastogenicity in vitro (MTR 04412) by J. Ashby, R. Mohammed and R.D. Callander (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and D N A double-strand breaks (MTR 04394) by M.O. Bradley, V.I. Taylor, M.J. Armstrong and S.M. Galloway (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[end of special issue]
0165-1218/87/$3.50 © 1987 Elsevier Science Publishers B.V. (Biomedical Division)
11
15 27
39 47
59
69
418
Special Issue
Guidelines for Minimal Criteria of Acceptability for Selected Short-Term Assays for Genotoxicity
edited by Robert W. Naismith Introduction (MTR 01212) by R.W. Naismith (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guide for the Salmonella typhimurium/mammalian microsome tests for bacterial mutagenicity (MTR 01175) by L.D. Claxton, J. Allen, A. Auletta, K. Mortelmans, E. Nestmann and E. Zeiger (U.S.A., Canada) . . . . . . . . . . . A guide for performing germ cell mutagenesis assays using Drosophila melanogaster (MTR 01174) by J.M. Mason, C.S. Aaron, W.R. Lee, P.D. Smith, A. Thakar, R. Valencia, R.C. Woodruff, F.E. Wiirgler and S. Zimmering (U.S.A. and Switzerland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes (MTR 01176) by J.T. MacGregor, J.A. Heddle, M. Hite, B.H. Margolin, C. Ramel, M.F. Salamone, R.R. Tice and D. Wild (U.S.A., Canada, Sweden and West Germany) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A protocol and guide for the in vitro rat hepatocyte DNA-repair assay (MTR 01170) by B.E. Butterworth, J. Ashby, E. Bermudez, D. Casciano, J. Mirsalis, G. Probst and G. Williams (U.S.A. and Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A protocol and guide for the in vivo rat hepatocyte DNA-repair assay (MTR 01169) by B.E. Butterworth, J. Ashby, E. Bermudez, D. Casciano, J. Mirsalis, G. Probst and G. Williams (U.S.A. and Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay (MTR 01171) by A.P. Li, J.H. Carver, W.N. Choy, A.W. Hsie, R.S. Gupta, K.S. Loveday, J.P. O'Neill, J.C. Riddle, L.F. Stankowski Jr. and L.L. Yang (U.S.A. and Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guide for performing the mouse lymphoma assay for mammalian cell mutagenicity (MTR 01172) by D. Clive (Chairman), W. Caspary, P.E. Kirby, R. Krehl, M. Moore, J. Mayo and T.J. Oberly (U.S.A.) . . . . . . . . Mammalian in vivo cytogenetic assays Analysis of chromosome aberrations in bone marrow cells (MTR 01173) by R.J. Preston, B.J. Dean, S. Galloway, H. Holden, A.F. McFee and M. Shelby (U.S.A.) . . . . . . . . . . . . . . . . . . . A guide for mutagenicity testing using the dominant lethal assay (MTR 01168) by S. Green, K.S. Lavappa, M. Manandhar, C.-j. Sheu, E. Whorton and J.A. Springer (U.S.A.) . . . . . . . . . . . . . . . The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents (MTR 01227) by R.J. Preston, J.R. San Sebastian and A.F. McFee (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
81 83
93
103
113
123
135 143
157 167 175
[end of special issue] Series "Current Issues in Mutagenesis and Carcinogenesis" Nos. 6, 7, 8, 9, 10 (MTR 01238) . . . . . . . . . . . . . . . . . . . . .
185
Research Papers Mutagenicity of aryl propylene and butylene oxides with Salmonella (MTR 01215) by L.B. Rosman, V. Gaddamidi and J.E. Sinsheimer (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity in Salmonella of hazardous wastes and urine from rats fed these wastes (MTR 01211) by D.M. DeMarini, J.P. Inmon, J.E. Simmons, E. Berman, T.C. Pasley, S.H. Warren and R.W. Williams (U.S.A.) . . Mutagenicity of products formed by ozonation of naphthoresorcinol in aqueous solutions (MTR 01201) by Y. Sayato, K. Nakamuro and H. Ueno (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenic activity of 27 dyes and related chemicals in the Salmonella/microsome and mouse lymphoma TK +/- assays (MTR 01221) by T.P. Cameron, T.J. Hughes, P.E. Kirby, V.A. Fung and V.C. Dunkel (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest (MTR 01210) by P. Olivier and D. Marzin (France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Benomyl-induced mitotic disturbances in Hordeum vulgate (MTR 01208) by H. Nicoloff and A. Kappas (Bulgaria and Greece) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity of dimecron studied in 3 mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster (MTR 01213) by N.K. Tripathy, B. Majhi, L. Dey, K. Patnaik and C.C. Das (India) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
189 205 217
223 263 271
277
419 Methapyrilene is a genotoxic carcinogen: Studies on methapyrilene and pyrilamine in the L 5 1 7 8 Y / T K + / - mouse lymphoma assay ( M T R 01218) by N.T. Turner, J.L. Woolley Jr., J.C. Hozier, J.R. Sawyer and D. Clive (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . Genotoxicity of analgesic compounds assessed by an in vitro micronucleus assay ( M T R 01214) by T.L. Dunn, R.A. Gardiner, G.J. Seymour and M.F. Lavin (Australia) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity of instant coffee and its interaction with dimethylnitrosamine in the micronucleus test ( M T R 01222) by M. Shimizu and E. Yano (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells ( M T R 01203) by Y.F. Sasaki, H. Imanishi, T. Ohta and Y. Shirasu (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The effects of benzodiazepines upon the fidelity of mitotic cell division in cultured Chinese hamster cells ( M T R 01223) by A. Lafi, E.M. Parry and J.M. Parry (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . In vivo and in vitro cytogenetic damage induced by sodium nitrite ( M T R 01219) by D. Luca, V. Luca, F. Cotor and L. Raileanu (Roumania) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Factors that affect the sensitivity of the in vivo-in vitro hepatocyte D N A repair assay in the male rat ( M T R 01225) by C.M. Hamilton and J.C. Mirsalis (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on h u m a n lymphocytes in vitro ( M T R 01220) by P. Vernole, D. Caporossi, B. Tedeschi, B. Porfirio, G. Melino, E. Bonmassar and B. Nicoletti (Italy) . . . . . . . . . Cytogenetic study of a group of workers exposed to thinner ( M T R 01217) by V. Souza and M. Puig (Mexico and Spain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Studies on the potent bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: aqueous stability, X A D recovery and analytical determination in drinking water and in chlorinated humic acid solutions ( M T R 01231) by J.R. Meier, R.B. Knohl, W.E. Coleman, H.P. Ringhand, J.W. Munch, W.H. Kaylor, R.P. Streicher and F.C. Kopfler (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of tumor promoter TPA on spontaneous and mitomycin C induced mitotic recombination in Drosophila melanogaster ( M T R 01228) by H. Tsuda and N. Takeda (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cytogenetic analysis in plant breeders ( M T R 01226) by F.N. Dulout, M.C. Pastori, M.G. Cid, E. Matos, H.N. Von Guradze, C.R. Maderna, D. Loria, L. Sainz, N. Albiano and N. Sobel (Argentina) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Genotoxic effects of glycidyltrimethylammonium chloride ( M T R 01232) by C. Vleminckx, J. Arany, B. Hendrickx and W. Moens (Belgium) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chromosome aberrations in workers at a tannery in Iraq ( M T R 01235) by H.A. H a m a m y , Z.S. Al-Hakkak and A.F. Hussain (Iraq) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chromosome aberrations, micronuclei and sister-chromatid exchanges in blood lymphocytes after occupational exposure to low levels of styrene ( M T R 08660) by J. M~iki-Paakkanen (Finland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The genotoxic effect of 13-propiolactone on m a m m a l i a n oocytes ( M T R 01224) by J. Santal6, A.M. Estop and J. Egozcue (Spain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Contents, Vol. 189 (1987) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
285 299 307
313 319 333 341 349 357
363
375
381 387 395
399 407 417
417
Elsevier
Contents Volume 189 (1987) Special Issue
Genotoxicity Produced in Cultured Mammalian Cell Assays by Treatment Conditions
edited by David J. Brusick Editorial Introduction by F.H. Sobels (The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
vii
Research Papers Implications of treatment-condition-induced genotoxicity for chemical screening and data interpretation (MTR 04389) by D.J. Brusick (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . In vitro testing as a step in the evaluation of in vivo genotoxicity (MTR 04388) by F.H. Sobels (The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Base-substitution and frameshift mutagenesis by sodium chloride and potassium chloride in Saccharomyces cerevisiae (MTR 04445) by K.R. Parker and R.C. Von Borstel (Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and D N A strand breaks, and the relation to toxicity (MTR 04390) by S.M. Galloway, D.A. Deasy, C.L. Bean, A.R. Kraynak, M.J. Armstrong and M.O. Bradley (U.S.A.) . . . . . . . . . Mutagenicity of rat-liver $9 to L5178Y mouse lymphoma cells (MTR 04422) by B.C. Myhr and J.K. Mayo (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of pH shifts on the mutant frequency at the thymidine kinase locus in mouse lymphoma L5178Y TK ÷! cells (MTR 04423) by M.A. Cifone, B. Myhr, A. Eiche and G. Bolcsfoldi (U.S.A. and Sweden) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Extrapolation from in vitro tests to human risk: Experience with sodium fluoride clastogenicity (MTR 04392) by D. Scott and S.A. Roberts (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . N-Chloropiperidine and calcium hypochlorite: Possible examples of toxicity-dependent clastogenicity in vitro (MTR 04412) by J. Ashby, R. Mohammed and R.D. Callander (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations, and D N A double-strand breaks (MTR 04394) by M.O. Bradley, V.I. Taylor, M.J. Armstrong and S.M. Galloway (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[end of special issue]
0165-1218/87/$3.50 © 1987 Elsevier Science Publishers B.V. (Biomedical Division)
11
15 27
39 47
59
69
418
Special Issue
Guidelines for Minimal Criteria of Acceptability for Selected Short-Term Assays for Genotoxicity
edited by Robert W. Naismith Introduction (MTR 01212) by R.W. Naismith (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guide for the Salmonella typhimurium/mammalian microsome tests for bacterial mutagenicity (MTR 01175) by L.D. Claxton, J. Allen, A. Auletta, K. Mortelmans, E. Nestmann and E. Zeiger (U.S.A., Canada) . . . . . . . . . . . A guide for performing germ cell mutagenesis assays using Drosophila melanogaster (MTR 01174) by J.M. Mason, C.S. Aaron, W.R. Lee, P.D. Smith, A. Thakar, R. Valencia, R.C. Woodruff, F.E. Wiirgler and S. Zimmering (U.S.A. and Switzerland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes (MTR 01176) by J.T. MacGregor, J.A. Heddle, M. Hite, B.H. Margolin, C. Ramel, M.F. Salamone, R.R. Tice and D. Wild (U.S.A., Canada, Sweden and West Germany) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A protocol and guide for the in vitro rat hepatocyte DNA-repair assay (MTR 01170) by B.E. Butterworth, J. Ashby, E. Bermudez, D. Casciano, J. Mirsalis, G. Probst and G. Williams (U.S.A. and Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A protocol and guide for the in vivo rat hepatocyte DNA-repair assay (MTR 01169) by B.E. Butterworth, J. Ashby, E. Bermudez, D. Casciano, J. Mirsalis, G. Probst and G. Williams (U.S.A. and Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A guide for the performance of the Chinese hamster ovary cell/hypoxanthine-guanine phosphoribosyl transferase gene mutation assay (MTR 01171) by A.P. Li, J.H. Carver, W.N. Choy, A.W. Hsie, R.S. Gupta, K.S. Loveday, J.P. O'Neill, J.C. Riddle, L.F. Stankowski Jr. and L.L. Yang (U.S.A. and Canada) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Guide for performing the mouse lymphoma assay for mammalian cell mutagenicity (MTR 01172) by D. Clive (Chairman), W. Caspary, P.E. Kirby, R. Krehl, M. Moore, J. Mayo and T.J. Oberly (U.S.A.) . . . . . . . . Mammalian in vivo cytogenetic assays Analysis of chromosome aberrations in bone marrow cells (MTR 01173) by R.J. Preston, B.J. Dean, S. Galloway, H. Holden, A.F. McFee and M. Shelby (U.S.A.) . . . . . . . . . . . . . . . . . . . A guide for mutagenicity testing using the dominant lethal assay (MTR 01168) by S. Green, K.S. Lavappa, M. Manandhar, C.-j. Sheu, E. Whorton and J.A. Springer (U.S.A.) . . . . . . . . . . . . . . . The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents (MTR 01227) by R.J. Preston, J.R. San Sebastian and A.F. McFee (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
81 83
93
103
113
123
135 143
157 167 175
[end of special issue] Series "Current Issues in Mutagenesis and Carcinogenesis" Nos. 6, 7, 8, 9, 10 (MTR 01238) . . . . . . . . . . . . . . . . . . . . .
185
Research Papers Mutagenicity of aryl propylene and butylene oxides with Salmonella (MTR 01215) by L.B. Rosman, V. Gaddamidi and J.E. Sinsheimer (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity in Salmonella of hazardous wastes and urine from rats fed these wastes (MTR 01211) by D.M. DeMarini, J.P. Inmon, J.E. Simmons, E. Berman, T.C. Pasley, S.H. Warren and R.W. Williams (U.S.A.) . . Mutagenicity of products formed by ozonation of naphthoresorcinol in aqueous solutions (MTR 01201) by Y. Sayato, K. Nakamuro and H. Ueno (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenic activity of 27 dyes and related chemicals in the Salmonella/microsome and mouse lymphoma TK +/- assays (MTR 01221) by T.P. Cameron, T.J. Hughes, P.E. Kirby, V.A. Fung and V.C. Dunkel (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . Study of the genotoxic potential of 48 inorganic derivatives with the SOS chromotest (MTR 01210) by P. Olivier and D. Marzin (France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Benomyl-induced mitotic disturbances in Hordeum vulgate (MTR 01208) by H. Nicoloff and A. Kappas (Bulgaria and Greece) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity of dimecron studied in 3 mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster (MTR 01213) by N.K. Tripathy, B. Majhi, L. Dey, K. Patnaik and C.C. Das (India) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
189 205 217
223 263 271
277
419 Methapyrilene is a genotoxic carcinogen: Studies on methapyrilene and pyrilamine in the L 5 1 7 8 Y / T K + / - mouse lymphoma assay ( M T R 01218) by N.T. Turner, J.L. Woolley Jr., J.C. Hozier, J.R. Sawyer and D. Clive (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . Genotoxicity of analgesic compounds assessed by an in vitro micronucleus assay ( M T R 01214) by T.L. Dunn, R.A. Gardiner, G.J. Seymour and M.F. Lavin (Australia) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mutagenicity of instant coffee and its interaction with dimethylnitrosamine in the micronucleus test ( M T R 01222) by M. Shimizu and E. Yano (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells ( M T R 01203) by Y.F. Sasaki, H. Imanishi, T. Ohta and Y. Shirasu (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The effects of benzodiazepines upon the fidelity of mitotic cell division in cultured Chinese hamster cells ( M T R 01223) by A. Lafi, E.M. Parry and J.M. Parry (Great Britain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . In vivo and in vitro cytogenetic damage induced by sodium nitrite ( M T R 01219) by D. Luca, V. Luca, F. Cotor and L. Raileanu (Roumania) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Factors that affect the sensitivity of the in vivo-in vitro hepatocyte D N A repair assay in the male rat ( M T R 01225) by C.M. Hamilton and J.C. Mirsalis (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cytogenetic effects of 1-p-(3-methyltriazeno)benzoic acid potassium salt on h u m a n lymphocytes in vitro ( M T R 01220) by P. Vernole, D. Caporossi, B. Tedeschi, B. Porfirio, G. Melino, E. Bonmassar and B. Nicoletti (Italy) . . . . . . . . . Cytogenetic study of a group of workers exposed to thinner ( M T R 01217) by V. Souza and M. Puig (Mexico and Spain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Studies on the potent bacterial mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: aqueous stability, X A D recovery and analytical determination in drinking water and in chlorinated humic acid solutions ( M T R 01231) by J.R. Meier, R.B. Knohl, W.E. Coleman, H.P. Ringhand, J.W. Munch, W.H. Kaylor, R.P. Streicher and F.C. Kopfler (U.S.A.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effect of tumor promoter TPA on spontaneous and mitomycin C induced mitotic recombination in Drosophila melanogaster ( M T R 01228) by H. Tsuda and N. Takeda (Japan) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cytogenetic analysis in plant breeders ( M T R 01226) by F.N. Dulout, M.C. Pastori, M.G. Cid, E. Matos, H.N. Von Guradze, C.R. Maderna, D. Loria, L. Sainz, N. Albiano and N. Sobel (Argentina) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Genotoxic effects of glycidyltrimethylammonium chloride ( M T R 01232) by C. Vleminckx, J. Arany, B. Hendrickx and W. Moens (Belgium) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chromosome aberrations in workers at a tannery in Iraq ( M T R 01235) by H.A. H a m a m y , Z.S. Al-Hakkak and A.F. Hussain (Iraq) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Chromosome aberrations, micronuclei and sister-chromatid exchanges in blood lymphocytes after occupational exposure to low levels of styrene ( M T R 08660) by J. M~iki-Paakkanen (Finland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The genotoxic effect of 13-propiolactone on m a m m a l i a n oocytes ( M T R 01224) by J. Santal6, A.M. Estop and J. Egozcue (Spain) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Contents, Vol. 189 (1987) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
285 299 307
313 319 333 341 349 357
363
375
381 387 395
399 407 417