Contents Volume 239 (1990) Reviews Studies on mammalian mutants defective in rejoining double-strand breaks in DNA P.A. Jeggo (Great Britain) Mutagenicity, carcinogenicity and teratogenicity of cobalt metal and cobalt compounds A. IAonard and R. Lauwerys (Belgium) The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program K.H. Mavournin, D.H. Blakey, M.C. Cimino, M.F. Salamone and J.A. Heddle (U.S.A., Canada)
1
17
29
ICPEMC -- International Commission for Protection Against Environmental Mutagens and Carcinogens Editorial Introduction to Working Paper No. 1/2 D.J. Brusick
81
ICPEMC Working Paper 1 / 2 A multi-factor ranking scheme for comparing the carcinogenic activity of chemicals S. Nesnow (U.S.A.)
83
Reviews Consideration of both genotoxic and nongenotoxic mechanisms in predicting carcinogenic potential B.E. Butterworth (U.S.A.) Review of the genotoxicity and carcinogenicity of 4,4'-methylene-dianiline and 4,4'-methylene-bis-2-chloroaniline C.A. McQueen and G.M. Williams (U.S.A.)
117 133
Special Issue
Report of ICPEMC Subcommittee 7 / 1 The Possible Involvement of Somatic Mutations in the Development of Atherosclerotic Plaques by B.A. Bridges et al.
Preamble B.A. Bridges (Great Britain)
v
Report of ICPEMC Subcommittee 7/1 Conclusions and recommendations
143
ICPEMC Working Paper 7 / 1 / 1 Mutational events in the etiology of arteriosclerotic plaques A. Penn (U.S.A.)
149
ICPEMC Working Paper 7 / 1 / 2 Shared risk factors for cancer and atherosclerosis - a review of the epidemiological evidence E.S. Hansen (Denmark)
163
ICPEMC Working Paper 7 / 1 / 3 Animal studies suggesting involvement of mutagen/carcinogen exposure in atherosclerosis K. Wakabayashi (Japan)