Contents volume 57 (1986)

Chem.-Biol. Interactions, 57 (1986)365--367 Elsewer Scmntlfm Publishers Ireland Ltd

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CHEMICO-BIOLOGICAL INTERACTIONS CONTENTS VOLUME 57 (1986) Review Article Sex differences in drug conjugation and their consequences for drug toxicity. Sulfation, glucuronidation and glutathione conjugation by G.J. Mulder (Leiden, The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . .

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Reduction of the metallochromic indicators murexide and tetramethylmurexide to their free radical metabolites by cytoplasmic enzymes and reducing agents by S.N.J. Moreno and R. Docampo (Research Triangle Park, NC) . . . . . . . . . . 17 Species differences in the toxicity of p-chloro-o-toluidine to rats and mice. Covalent binding to hepatic macromolecules and hepatic non-~arenchymal cell DNA and an investigation of effects upon the incorporation of [ H ]thymidine into capillary endothelial cells by P. Bentley, F. Bieri, W. Muecke, F. Waechter and W. St~ubli (Basle, Switzerland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Efficient breakage of DNA apurmic sites by the indoleamine related 9-aminoellipticine by C. Malvy, P. Pr~vost, C. Gansser, C. Viel and C. Paoletti (Villejuif and Ch~tenayMalabry, France) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Degenerative changes, DNA synthesis and mitotic activity in rat liver following single exposure to diethylnitrosamine by R. Daoust and R. Morals (Montreal, Canada) . . . . . . . . . . . . . . . . . . . . 55 Preferential binding of adriamycin and nogalamycin to DNase-I hypersensitive sites of Sarcoma-180 chromatin by C.K Panda, K. Choudhury and R.K. Neogy (Calcutta, India) . . . . . . . . . . . 65 Irreversible binding with biological macromolecules and effects in bacterial mutagenicity tests of the radical cation of promethazine and photoactivated promethazine, comparison with chlorpromazine by N.J. De Mol, A.B.C Becht, J. Koenen and G. Lodder (Leiden, The Netherlands) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Stabilities of 7-alkylguanosines and deoxyguanosines formed by phosphoramide mustard and nitrogen mustard by S. Kallama and K. Hemminki (Helsinki, Finland) . . . . . . . . . . . . . . . . . . . 85 Chemical structure and mutagenic activity of aminoimidazoquinolines and aminonaphthimidazoles related to 2-amino-3-methylimidazo[4,5-f]quinoline by G. Kaiser, D. Harnasch, M.-T. King and D. Wild (Freiburg, F.R.G.) . . . . . . . 97 Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines -- studies of the kinetics of removal of O'-methylguanine and 3-methyladenine by P.D. Lawley, G. Harris, E. Phillips, W. Irving, C.B. Cola~o, P.M. Lydyard and" I.M. Roitt (London, U.K.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 Rapid Communication The effects of c/s-dichlorodiammine platinum on alkaline density gradient centrifugation of poly(dA) • poly(dT) by M.R. Fesen and H.C. Harder (Tulsa, OK) . . . . . . . . . . . . . . . . . . . . . . . .

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366 Formation of iminoxyl and nitroxide free radicals from nistrosonaphthols: an electron spin resonance study by V. Fischer and R.P. Mason (Research Triangle Park, NC) . . . . . . . . . . . . . . Unique properties of NADPH- and NADH-dependent metabolism of p-nitroanisole catalyzed by cytoehrome P-450 isozyme 2 in pulmonary and hepatic microsomal preparations from rabbits by J.E. Croft, W.G. Harrelson, Z. Parandoosh and R.M. Philpot (Research Triangle Park, NC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Potential antiradiation drugs containing no nitrogen, and related compounds by G T. Bowman, J.J. Clement, D.E. Davidson, Jr., V. Eswar~krishnan, L. Field, J.M. Hoch, H.A. Musallam, R.O. Pick, R. Ravichandran and P.K. Srivastava (Nashville, TN, Cambridge, MA and Washington, DC) . . . . . . . . . . . . . . . . . . . Substituted polychlorinated dibenzofuran receptor binding affinities and aryl hydrocarbon hydroxylase induction potencies -- a QSAR analysis by M.A. Denomme, K. Homonko, T. Fujita, T. Sawyer and S. Safe (Ontario, Canada, Kyoto, Japan and College Station, TX) . . . . . . . . . . . . . . . . . . . . . . . Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells by. G. Capranico, N. Babudri, G. Casciarri, L. Dolzani, R.A. Gambetta, E. Longoni, B. Pare, C. Soranzo and F. Zunino (Milan, Italy) . . . . . . . . . . . . . . . . Microbial metabolism of pyrene by C.E. Cermgha, D.W. Kelly, J.P. Freeman and D.W. Miller (Jefferson, AR) . . . The formation of 6,7-dihydro-7-hydroxy-l-hydroxymethyl-SH-pyrrolizine, a metabolite of pyrrolizidine alRaloids by B. Kedzierskl and D.R. Buhler (Corvallis, OR) . . . . . . . . . . . . . . . . . . . . . Bioalkylation of dibenz [a,h ]anthracene in rat liver cytosol by J.W. Flesher, S.R. Myers, C.H. Bergo and J.W. Blake (Lexington, KY) . . . . . . Functional modification of rat liver ribosomes by the vitro action of N-methyl-N'nitro-N-nitrosoguanidine by R.K. Bhattacharya and R.S. Bagewadikar (Bombay, India) . . . . . . . . . . . . . Announcements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The influence of prolonged di(2-ethylhexyl)phthalate treatment on the dohchol and dolichyl-P content of rat hver by C. Edlund, A -E. Ganning and G. Dallner (Stockholm, Sweden) . . . . . . . . . . The inactivation of ~-l-proteinase inhibitor by gas-phase cigarette smoke: protection by anhoxldants and reducing species by W.A Pryor, M.M. Dooley and D.F. Church (Baton Rouge, LA) . . . . . . . . . Effects of hematoporphyrm-denvative on mouse erythroleukemia cells in the absence of light irradiation by R. Supmo, G Della Torre, R Ramponi and G. Bottlroli (Milan and Pavia, Italy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Modification of calf thymus DNA by methyl methanesulfonate. Quantitative determination of 7-methyldeoxyguanosine by mass spectrometry by C.-J. Chang, D.J. Ashworth, I. Isern-Flecha, X.-Y. Jiang and R.G. Cooks (West Lafayette, IN) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid peroxidation in microsomal systems m vitro by P W Albro, J.T. Corbett and J.L. Schroeder (Research Triangle Park, NC) . . Mechanism of unbalanced growth-induced cell damage. I. A probable role for hydrolytic enzymes synthesis by J. Malec, W.M. Przybyszewski, M. Grabarczyk, E. Sltarska and B. Czartoryska (Warsaw, Poland) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . QSAR for upper-respiratory tract irritation by D.W. Roberts (Wirral, U.K.) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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367 The degradation of 5-iododeoxyuridine and 5-bromodeoxyuridine by serum from d i f f e r e n t sources a n d its c o n s e q u e n c e s for tile use o f t h e c o m p o u n d s for incorporation into DNA b y R. Saffhill a n d W.J. H u m e ( M a n c h e s t e r , U.K ) . . . . . . . . . . . . . . . . . . . . . S u b j e c t I n d e x V o l u m e 57 ( 1 9 8 6 ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . A u t h o r I n d e x V o l u m e 57 ( 1 9 8 6 ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V o l u m e C o n t e n t s V o l u m e 57 ( 1 9 8 6 ) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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