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Continous regional changes in eeg power during cold pressure pain
SLIDE SESSION Pain Assessment - Experimental PREDICTIONOFINf:sIDUAL DIFFERENCESIN v PAIN RFSPCXUSIVEN!$SS and LonnieZeltzer, Dept.of Pediatrics:Dept.of AndrewC.N. Chen Anesthesiology, UCLA Schoolof Medicine,Los Angeles,CA 90024,U.S.A.
s481
931 Slide Fri
2:00
AIM OF INVESTIGATION: Recently,we reported(PAIN37, 1989)a consisten ACC Hall A observation of behavioral dichotomyof humanpain responsiveness in each of 6 studiestotaling205 subjects. The PT (paintolerant)subjectscoul1 endure1.C icewaterfor the entire5 min. of the test/whilethe PS (painsensitive)subjects toleratedthe noxioustest for only 62 sec. The focusof this studywas to examinefactors of such individual differences will that may contributeto this dichotomy. Investigation providesoms cluesto an essentialunderstanding of humanpain. m This reportexaminedthe discriminant power (i.e.the abilityto correctlyclassify the menkership) of the variablesassessedin a studyof 42 youngrhealthymale subjects: 7 dem-psychological variables(age, traitanxiety,fear,stateanxiety,perceptualabsorban, 3 ANS measures(systolic/diastolic bloodpressurer ce/ augmenting-reducing, self regulation) heartrate)and CNS measuresof corticalpowerspectrumdensities(5 bandsover 8 loci)all recordedat the restingbaselinestagefor discriminating the PS fromPT subjects. RESULTS:The resultsindicatethat,for the demo-psychological variables, specificity was 69.2%,sensitivity 68.9%and correctclassification of 69.0%. For ANS measures,specificity was 84.6%,sensitivity 79.3%and correctclassification of 82.0%. For CNS measures,both specificity and sensitivity were 100% to achievea correctclassification at 100% accuracy. Further,it was foundthat two of the CNS variablesdined couldcontribute to 83.3%of specificity and 79.3%of sensitivity with a correctclassification rate of 81.3%. Thesetwo significant corticalparameterswere the Beta-2powerdensityat the temporallocusof right hemisphereand the Beta-lpowerdensityat the frontallocusof left hemisphere. CC@KX,USION: The CNS measuresare unexpectedly quitepowerfulin the predictionof the indiThe combination of T2 Beta-2and F3 Beta-1 vidualdifferences in humanpain responsiveness. vigilence, anxiety,or some other high frequencycorticalpowermay signifya "preparatory" type of self-efficacy as corrponents of appraisaland readinessfor the noxioustest. The accuracyof theseCNS measuresin differentiating PS from PT subjectssuggestsdifferences in corticalpreparedness for a painfulevent.
CGNTINOUS REGIONAL CHANGES IN EEG POWER DURING COLD PRESSURE PAIN.
/
K. Gotliebsen’ and L. Arendt-Nielsen Dept. of Medical Infonnatics, UnivmitypfAalborg, Aalbor Denmark. P Bjening , University of A ~&IS, Aarhus, Denmark. AIM OF INVESTIGATION; TO study the changes in Electroencephalography (EEG) during experimen~~y induced cold pressor pain. METHOUS: EEG signals from F,, G, C,, C, and P, were recorded. An Visual Analog Scala was used to measure the ain intensity. The left ban.a was immersed into a vessel containing icewater (0.5 “C). The EEG was measured for 5 minuts before, 5 mmuts during and 5 Iliinuts after the icewater immxsion. 42 ri hthanded volunteers participated. Pow? of the 6, 8, a apd l3 EEG band, was computed and averaged f or the 3 periods, and compared statlstxally. The than es m EEG power were furthermore monitored continously by &viding the EEG signals into 8 sec. epochs. T! e Study was approved by the local ethical committee. * In average there was a significant increase in 6 activity during pain stimulation, (100 - 170 % 1) at q. C, and. C and ? significant decrease in a activity (10 - 20 %, p<=O.Ol) af F,, C,, C,, =The mcrease m d TVwas consistent throughout the entire 5 minuts of pain stimulation but also the ?i.i.t minute after thriz was withdrawn. The a activity showed a large decrease in the ‘fmt mmute_of_pain +stirqulation,and the first minute after withdrawal. The pam mtensi (mdicated by the Visual Analog Scala), increased the first minute during pain stimulation and remained staT le for the remaining 4 minuts of icewater immersion.
CONCLUSION; The characteristic EEG changes during cold pressure pain can be used as a quantitative model to compare the effect of various anesthetics.
s481
931 Slide Fri
2:00
AIM OF INVESTIGATION: Recently,we reported(PAIN37, 1989)a consisten ACC Hall A observation of behavioral dichotomyof humanpain responsiveness in each of 6 studiestotaling205 subjects. The PT (paintolerant)subjectscoul1 endure1.C icewaterfor the entire5 min. of the test/whilethe PS (painsensitive)subjects toleratedthe noxioustest for only 62 sec. The focusof this studywas to examinefactors of such individual differences will that may contributeto this dichotomy. Investigation providesoms cluesto an essentialunderstanding of humanpain. m This reportexaminedthe discriminant power (i.e.the abilityto correctlyclassify the menkership) of the variablesassessedin a studyof 42 youngrhealthymale subjects: 7 dem-psychological variables(age, traitanxiety,fear,stateanxiety,perceptualabsorban, 3 ANS measures(systolic/diastolic bloodpressurer ce/ augmenting-reducing, self regulation) heartrate)and CNS measuresof corticalpowerspectrumdensities(5 bandsover 8 loci)all recordedat the restingbaselinestagefor discriminating the PS fromPT subjects. RESULTS:The resultsindicatethat,for the demo-psychological variables, specificity was 69.2%,sensitivity 68.9%and correctclassification of 69.0%. For ANS measures,specificity was 84.6%,sensitivity 79.3%and correctclassification of 82.0%. For CNS measures,both specificity and sensitivity were 100% to achievea correctclassification at 100% accuracy. Further,it was foundthat two of the CNS variablesdined couldcontribute to 83.3%of specificity and 79.3%of sensitivity with a correctclassification rate of 81.3%. Thesetwo significant corticalparameterswere the Beta-2powerdensityat the temporallocusof right hemisphereand the Beta-lpowerdensityat the frontallocusof left hemisphere. CC@KX,USION: The CNS measuresare unexpectedly quitepowerfulin the predictionof the indiThe combination of T2 Beta-2and F3 Beta-1 vidualdifferences in humanpain responsiveness. vigilence, anxiety,or some other high frequencycorticalpowermay signifya "preparatory" type of self-efficacy as corrponents of appraisaland readinessfor the noxioustest. The accuracyof theseCNS measuresin differentiating PS from PT subjectssuggestsdifferences in corticalpreparedness for a painfulevent.
CGNTINOUS REGIONAL CHANGES IN EEG POWER DURING COLD PRESSURE PAIN.
/
K. Gotliebsen’ and L. Arendt-Nielsen Dept. of Medical Infonnatics, UnivmitypfAalborg, Aalbor Denmark. P Bjening , University of A ~&IS, Aarhus, Denmark. AIM OF INVESTIGATION; TO study the changes in Electroencephalography (EEG) during experimen~~y induced cold pressor pain. METHOUS: EEG signals from F,, G, C,, C, and P, were recorded. An Visual Analog Scala was used to measure the ain intensity. The left ban.a was immersed into a vessel containing icewater (0.5 “C). The EEG was measured for 5 minuts before, 5 mmuts during and 5 Iliinuts after the icewater immxsion. 42 ri hthanded volunteers participated. Pow? of the 6, 8, a apd l3 EEG band, was computed and averaged f or the 3 periods, and compared statlstxally. The than es m EEG power were furthermore monitored continously by &viding the EEG signals into 8 sec. epochs. T! e Study was approved by the local ethical committee. * In average there was a significant increase in 6 activity during pain stimulation, (100 - 170 % 1) at q. C, and. C and ? significant decrease in a activity (10 - 20 %, p<=O.Ol) af F,, C,, C,, =The mcrease m d TVwas consistent throughout the entire 5 minuts of pain stimulation but also the ?i.i.t minute after thriz was withdrawn. The a activity showed a large decrease in the ‘fmt mmute_of_pain +stirqulation,and the first minute after withdrawal. The pam mtensi (mdicated by the Visual Analog Scala), increased the first minute during pain stimulation and remained staT le for the remaining 4 minuts of icewater immersion.
CONCLUSION; The characteristic EEG changes during cold pressure pain can be used as a quantitative model to compare the effect of various anesthetics.