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CONTINUOUS POSITIVE AIRWAY PRESSURE THERAPY IMPROVES ENDOTHELIAL FUNCTION AND NEUTROPHIL-LYMPHOCYTE RATIO IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME
A2126 JACC March 17, 2015 Volume 65, Issue 10S
Vascular Medicine Continuous Positive Airway Pressure Therapy Improves Endothelial Function and Neutrophil-Lymphocyte Ratio in Patients with Obstructive Sleep Apnea Syndrome Poster Contributions Poster Hall B1 Sunday, March 15, 2015, 3:45 p.m.-4:30 p.m. Session Title: Links Between Systemic and Vascular Diseases Abstract Category: 45. Vascular Medicine: Non Coronary Arterial Disease Presentation Number: 1225-345 Authors: Jun-ichi Oyama, Daisuke Nagatomo, Goro Yoshioka, Ayumu Yamasaki, HIroshi Komoda, Koichi Node, Saga University, Saga, Japan
Background: The obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and reoxygenation during sleep in associated with elevated oxidative stress and promote cardiac and cerebral atherosclerosis and metabolic diseases including dyslipidemia and diabetes mellitus. Therefore, OSA is demonstrated by vascular dysfunction and chronic inflammation. Recently, increased neutrophil to lymphocyte ratio (NLR) is recognized as novel inflammatory biomarker for systemic inflammation. In this study, we evaluated whether NLR reflects the severity of OSA and continuous positive airway pressure (CPAP) treatment affects the endothelial function and NLR in patients with OSA. Methods: We enrolled 95 patients with suspected OSA and 29 patients have received nasal CPAP therapy for three months. We evaluated the number of endothelial progenitor cells (EPC) by flow-cytometry and NLR, the levels of nitric oxide (NOx) and asymmetric dimethylarginine (ADMA) which is endogenous inhibitor of nitric oxide synthase by blood sampling, endothelia function by flow-mediated dilation (FMD) before and after CPAP treatment.
Results: The levels of AHI demonstrated an inverse relationship with the FMD and a positive relationship with the NLR. Moreover, NLR is an independent risk factor suggests for the presence of severe OSA. CPAP therapy increased the levels of EPCs and NOx and decreased the level of ADMA. CPAP treatment also improved the FMD and decreased the NLR.
Conclusion: NLR and endothelial dysfunction significantly correlate with the severity of OSA. The FMD responses improved and the NLR decreased significantly after treatment with CPAP therapy which was accompanied by the biochemical improvements.
Vascular Medicine Continuous Positive Airway Pressure Therapy Improves Endothelial Function and Neutrophil-Lymphocyte Ratio in Patients with Obstructive Sleep Apnea Syndrome Poster Contributions Poster Hall B1 Sunday, March 15, 2015, 3:45 p.m.-4:30 p.m. Session Title: Links Between Systemic and Vascular Diseases Abstract Category: 45. Vascular Medicine: Non Coronary Arterial Disease Presentation Number: 1225-345 Authors: Jun-ichi Oyama, Daisuke Nagatomo, Goro Yoshioka, Ayumu Yamasaki, HIroshi Komoda, Koichi Node, Saga University, Saga, Japan
Background: The obstructive sleep apnea (OSA) is characterized by intermittent hypoxia and reoxygenation during sleep in associated with elevated oxidative stress and promote cardiac and cerebral atherosclerosis and metabolic diseases including dyslipidemia and diabetes mellitus. Therefore, OSA is demonstrated by vascular dysfunction and chronic inflammation. Recently, increased neutrophil to lymphocyte ratio (NLR) is recognized as novel inflammatory biomarker for systemic inflammation. In this study, we evaluated whether NLR reflects the severity of OSA and continuous positive airway pressure (CPAP) treatment affects the endothelial function and NLR in patients with OSA. Methods: We enrolled 95 patients with suspected OSA and 29 patients have received nasal CPAP therapy for three months. We evaluated the number of endothelial progenitor cells (EPC) by flow-cytometry and NLR, the levels of nitric oxide (NOx) and asymmetric dimethylarginine (ADMA) which is endogenous inhibitor of nitric oxide synthase by blood sampling, endothelia function by flow-mediated dilation (FMD) before and after CPAP treatment.
Results: The levels of AHI demonstrated an inverse relationship with the FMD and a positive relationship with the NLR. Moreover, NLR is an independent risk factor suggests for the presence of severe OSA. CPAP therapy increased the levels of EPCs and NOx and decreased the level of ADMA. CPAP treatment also improved the FMD and decreased the NLR.
Conclusion: NLR and endothelial dysfunction significantly correlate with the severity of OSA. The FMD responses improved and the NLR decreased significantly after treatment with CPAP therapy which was accompanied by the biochemical improvements.