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Contraceptive efficacy of tamoxifen in female hamsters
CONTRACEPTION
ERRATUM N. Majumdar, Contraception
JK Datta. Contraceptive efficacy of tamoxifen 1990;41:93-103. Initial was incorrect for the first
CONTRACEPTIVE
EFFICACY N.
OF TAMOXIFEN
Majumdar
and
IN
in female author.
FEMALE
hamsters.
HAMSTERS
J. K. Datta*
Department of Reproductive Biomedicine National Institute of Health and Family Welfare New Delhi-110067, India
Abstract administration of tamoxifen (trans-l(4-BSystemic 2-diphenyl-but-l-ene), an dimethylaminoethoxyphenyl) -1, at a dose level of 2 mg/kg body weight on days antiestrogen, pregnancy during (p-c.) intercepts 1, 2 and 3 post-coitum 70-80% of hamsters. peri-implantation period in the the levels of alterations in circulating Significant estradiol and progesterone were accompanied by the abolition of peak activities of various uterine lysosomal enzymes in The present study, therefore, suggests the treated animals. that estrogen plays a crucial role during the process of and tamoxifen displays an in hamsters, ovum-implantation interceptive role in this species. Introduction Normal implantation of the fertilized ovum can occur in progesterone is ovariectomized hamsters if supplemented However, it is still exogenously (1,2). controversial whether implantation of the ovum in this species can occur in an estrogen free/deficient milieu. Moreover, the role of implantation the estrogen-surge prior to remains to be investigated (3). Although it has been reported that the estrogen pre-implantation embryos produce necessary for embryonic differentiation and implantation (4,5), yet the amount appears to be inadequate (6). Systemic post-coital administration of antiestrogens in hamsters has been found to be ineffective (7), which may be either due to an inappropriate dose or dose-schedule of the drug. The present study was designed to explore the mechanism of action preventing antiestrogen in the process of implantation in hamsters. *To whom
correspondence
Submitted for publication Accepted for publication
APRIL
1990 VOL. 41 NO. 4
should
be addressed.
September 1, 1989 September 28, 1989
451
ERRATUM N. Majumdar, Contraception
JK Datta. Contraceptive efficacy of tamoxifen 1990;41:93-103. Initial was incorrect for the first
CONTRACEPTIVE
EFFICACY N.
OF TAMOXIFEN
Majumdar
and
IN
in female author.
FEMALE
hamsters.
HAMSTERS
J. K. Datta*
Department of Reproductive Biomedicine National Institute of Health and Family Welfare New Delhi-110067, India
Abstract administration of tamoxifen (trans-l(4-BSystemic 2-diphenyl-but-l-ene), an dimethylaminoethoxyphenyl) -1, at a dose level of 2 mg/kg body weight on days antiestrogen, pregnancy during (p-c.) intercepts 1, 2 and 3 post-coitum 70-80% of hamsters. peri-implantation period in the the levels of alterations in circulating Significant estradiol and progesterone were accompanied by the abolition of peak activities of various uterine lysosomal enzymes in The present study, therefore, suggests the treated animals. that estrogen plays a crucial role during the process of and tamoxifen displays an in hamsters, ovum-implantation interceptive role in this species. Introduction Normal implantation of the fertilized ovum can occur in progesterone is ovariectomized hamsters if supplemented However, it is still exogenously (1,2). controversial whether implantation of the ovum in this species can occur in an estrogen free/deficient milieu. Moreover, the role of implantation the estrogen-surge prior to remains to be investigated (3). Although it has been reported that the estrogen pre-implantation embryos produce necessary for embryonic differentiation and implantation (4,5), yet the amount appears to be inadequate (6). Systemic post-coital administration of antiestrogens in hamsters has been found to be ineffective (7), which may be either due to an inappropriate dose or dose-schedule of the drug. The present study was designed to explore the mechanism of action preventing antiestrogen in the process of implantation in hamsters. *To whom
correspondence
Submitted for publication Accepted for publication
APRIL
1990 VOL. 41 NO. 4
should
be addressed.
September 1, 1989 September 28, 1989
451