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Contrast Ecography for Classification of Kidney Cystic Injury With Bosniak Criteria Adapted to CEUS
S4
Ultrasound in Medicine and Biology
Methods: 25 patients with 30 HCCs within 3cm were included. CECT and CEUS were performed in all patients after RFA treatment in the following 2-7 days later. Total 39 assessments of therapeutic response were performed. Absence of contrast enhancement and presence of ablative margin in the treated HCCs were statistically analyzed. CECT was used as gold standard in analyzing the accuracy of CEUS. Main Results: Follow-up CECT detected residual lesions in 2 of 39 assessments and incomplete ablative margins in 18 of 39 assessments. CEUS detected residual lesions in 2 of 39 assessments and incomplete ablative margins in 18 of 39 assessments. CEUS predicted the CECT results 90% (sensitivity 90%, specificity 89%, positive predictive value 90%, negative predictive value 89%). Importance of the Conclusions: Contrast-enhanced ultrasonography with perflubutane microbubbles has high diagnostic accuracy compared with CECT in assessment of RFA treatment response. PA.03.005 How Often Does Liver Fibrosis Stage Predicted by Transient Elastography (TE) Differ From the One Diagnosed by Liver Biopsy in Chronic Hepatitis C Patients? I. Sporea, R. Sirli, S. Bota, A. Popescu, I. Dan, A. Deleanu, M. Ardelean, N. Cornu Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, Timis¸ara, Romania Brief Description of the Purpose of the Study: Aim: to evaluate how often does liver fibrosis stage predicted by Transient Elastography (TE), using cut-off values proposed by meta-analysis, differ from the one diagnosed by liver biopsy (LB) in chronic hepatitis C patients. Methods: 473 patients with chronic hepatitis C were evaluated by means of TE and LB (interpreted according to METAVIR score). Reliable measurements were defined as: median value of 10 liver stiffness (LS) measurements with a success rate $ 60% and an interquartile range interval ,30%, values expressed in kPa. We used the LS cut-offs (kPa) proposed in the most recently published meta-analysis (Tsochatzis, J Hepatol 2011): F1-6, F2-7.2, F3-9.6 and F4-14.5. Main Results: Reliable LS measurements were obtained in 453 patients (95.7%). The classification of liver fibrosis in LB was: F0-1.1%, F110.4%, F2-49.6%, F3-30.7% and F4-8.2%. We obtained the following differences between fibrosis obtained in LB and that predicted by using the cut-off values proposed by meta-analysis: perfect concordance-131 patients (28.9%), 1 grade of fibrosis-175 patients (38.6%), 2 grades-130 patients (28.7%) and 3 grades-17 patients (3.8%). Importance of the Conclusions: In two thirds of patients a perfect concordance or at most one grade of fibrosis was observed between the fibrosis predicted by means of TE cut-off values proposed by meta-analysis and that obtained in LB. PA.03.007 The Role of Contrast Enhanced Ultrasound (CEUS) for the Assessment of Percutaneous Treatment for Hepatocellular Carcinoma M. Danila, I. Sporea, R. Sirli, A. Popescu, M. Sendroiu, A. Martie, S. Bota University of Medicine and Pharmacy, Timisoara, Romania Brief Description of the Purpose of the Study: The AIM of this study was to establish the role of CEUS for the assessment of percutaneous treatment for HCC. Methods: We evaluated 48 patients with hepatocellular carcinoma treated by PEIT or RFA. A total of 73 HCC’s nodules were treated. For each nodule we evaluated by CEUS the treatment efficacy 24 hours (in some) and 1 month (in all) after therapy. We defined as incomplete therapy the presence of arterial enhancement in the nodule and as complete therapy if no arterial enhancement was present in the treated
Volume 39, Number 5S, 2013 HCC. If complete therapy was considered, we performed another imaging method (CT or MRI) to validate our findings. For inconclusive cases we also performed another imaging method. Main Results: We performed 220 CEUS for the assessment of percutaneous treatment for HCC. The CEUS examination was conclusive in 200 cases (90.9%). In cases of incomplete treatment, we performed another session of percutaneous treatment during the CEUS examination. The result of CEUS for the assessment of percutaneous treatment correlated with the second imaging method (CT or MRI) in 87.5% of the cases. Importance of the Conclusions: CEUS is a good method for the assessment of percutaneous treatment for HCC and also for targeted therapy of the residual tumor TL.03.003 Intravenous Contrast Ecography for Focal Lesions Diagnostic in the Context of Non-Cirrhotic Liver: Cost-Benefit Analysis F. C. Moreira, T. Ripolles, M. J. Martinez Hospital Universitario Dr. Peset, Valencia, Comunidad Valenciana, Espa~na Brief Description of the Purpose of the Study: To assess the costeffectiveness of intravenous contrast enhanced ultrasonography (CEUS) in the diagnosis of focal lesions in the context of non-cirrhotic liver, taking into account the subsequent need to supplement with other methods, computed tomography (CT) or magnetic resonance (MRI). Methods: CEUS examinations were retrospectively studied between May and November 2012. This included 55 patients with focal liver lesions (28 women, range 30-86 years). Main Results: We studied 33 hemangiomas, 5 (15%) showed questionable behavior and required another method (2CT, 3MRI). There were 5 focal nodular hyperplasia, only 1 (20%) required further study (MRI). We detected 12 seudolesiones (focal steatosis), only 1 (8%) was supplemented with CT. There were 8 patients with metastatic lesions, 2 (25%) underwent CT to diagnosis. Two indeterminate lesions were observed, both were recommeded for further analysis with a MRI. 89% of CEUS was performed the same day as the baseline ultrasound, only 6 were undertaken on another day (range: 4-138, average: 58 days). In 81% of cases, CEUS showed typical behavior avoiding another diagnostic method for confirmation. This meant a saving of 49 additional tests. Importance of the Conclusions: CEUS is a fast, cheap, without radiation, that helps avoid other more expensive diagnostic tests and shortening the time to diagnosis.
TL.03.010 Contrast Ecography for Classification of Kidney Cystic Injury With Bosniak Criteria Adapted to CEUS F. C. Moreira, T. Ripolles, M. J. Martinez, D. U. Navarro, L. N. Vilar Hospital Dr. Peset, Valencia, Camunidad Valenciana, Espa~na Brief Description of the Purpose of the Study: To evaluate the role of ultrasound with contrast (CEUS) in the classification of renal cystic masses with the Bosniak criteria adapted to CEUS. Methods: We retrospectively analyzed the ultrasonography findings of 35 patients with CEUS, media: 57 years (age range: 24-85) from 2009 to 2012 who had complex cystic renal masses. The results were compared with pathology or with other techniques such as computed tomography (CT), magnetic resonance (MRI), or ultrasound monitoring. Main Results: In CEUS masses were classified as Bosniak category II in 17, III in 6 and type IV in 12. 18 were underwent CT / MRI, coinciding the Bosniak in 12 cases (66%). 2 patients classified Bosniak III were operated with benign findings (hemorrhagic cyst, chronic pyelonephritis). Of 12 patients classified as Bosniak IV, 10 were operated, with findings of malignancy in 8 (4 clear cell carcinomas / 4 papillary
Abstracts
S5
carcinomas). One Bosniak IV was benign renal myxoma. All malignant lesions that were operated, had classification CEUS Bosniak IV (sensitivity 100%). CT or MRI classified 2 malignant lesions as benign. Importance of the Conclusions: CEUS is a fast method, without radiation, which has good sensitivity for screening for malignant cystic lesions, when we apply the Bosniak classification criteria adapted to CEUS.
Main Results: Compared with control group, Untw-R decreased significantly (p , 0.001) and T-PUV,UHT increased significantly (p , 0.001). For Ptw, PTV, PUV there is no significant difference in between CHD group and Control group. Compared with Single Culprit Vessel Group, Untw-R, PUV decreased significantly (p , 0.05) and T-PUV, UHT increased significantly (p , 0.05) in Multi Culprit Vessel Group. Importance of the Conclusions: The untwisting motion in CHD patients were significantly reduced and delayed, even more significant in Multi Culprit Vessel patients.
4 - Echocardiography
PA.04.003
PA.04.001
Evaluation of Flow Structure Within Left Ventricle in Patients With Chronic Heart Failure by Vector Flow Mapping L. D. Hao, Y. Liu, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China
Assessment of the Left Ventricular Untwisting in Patients With Acute Myocardial Infarction in Different Location by 2D Speckle Tracking Imaging H. N. Song, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: Left ventricular untwisting movement is considered as an important part of LV diastolic function. The location of myocardial infarction (MI) and number of MI segments may have different impact on left ventricular untwisting movement. Methods: Forty-one patient with AMI (AMI Group) were divided into two groups according to the MI location and 31 age matched subjects (Control group). Locate the position and number of segments of MI according to the bull’s eyes map of systolic strain (LPSS) values acquired by AFI. Access peak twist velocity (PTV) ,untwisting rate in IVRT (Untw-R), peak untwisting velocity (PUV),time to peak untwisting velocity (TPUV)and half time of untwisting (UHT) with STI. Main Results: Compared with control group, LVEF, global LPSS, PUV and Untw-R of AMI group decreased significantly (p , 0.001), T-PUV (p , 0.001) and UHT (p 5 0.028) increased significantly. The number of MI segments correlated with Untw-R (r5-0.420, p 5 0.006) significantly. Untw-R in Anterior wall-Anteroseptum group were lower than Inferior wall-Posterior wall group (p 5 0.022). Importance of the Conclusions: LV untwisting motion of AMI patients can be observed by 2D-STI. Untw-R is a sensitive parameter to evaluate the untwisting motion of AMI patients. The untwisting motion of AMI patients decreased significantly, even worse in Anterior wall-Anteroseptum AMI patients. PA.04.002 Assessment of Impact of Involved Coronary Artery Quantity on Left Ventricular Untwisting in Patients With CHD by 2DSTI L. D. Hao, H. N. Song, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: Diastolic function in patients with Coronary Heart Disease (CHD) may decrease. To assess LV Diastolic function in CHD patients with different involved coronary artery quantity by measuring the untwisting motion can provide basis for diagnosis for CHD. Methods: 75 patients suspected for CHD were divided in two groups according to the result of selective coronary angiography (SCA): CHD group (45 patients) and Control group (30 patients). According to the number of narrowed coronary, the CHD group was divided into Single Culprit Vessel Group (27 patients) and Multi Culprit Vessel Group (18 patients). 2DSTI indicies included, twist at aortic valve closure (AVCtw), twist at mitral valve open (MVOtw), untwisting rate in IVRT (Untw-R), peak untwisting velocity (PUV), time to peak untwisting velocity (TPUV) and half time of untwisting (UHT).
Brief Description of the Purpose of the Study: Vector flow mapping (VFM) is an application in which blood information in the heart chamber boundary can be quantitatively-analyzed based on information by color Doppler. To evaluate blood flow structure and quantify the variation of the flow within left ventricle, assess the impact of chronic heart failure(CHF) by VFM. Methods: 97 patients with chronic heart failure and 104 controls were involved. The flow vector images on the section plane of the flow within the left ventricle were acquired by VFM. Time-flow (T-F) curve and all other peak systolic and diastolic flow curve include normal velocity profile, parallel velocity profile,vector profile were analyzed by DSARS1 program. Main Results: Ventricular ejection peak S, rapid ventricular filling peak E and atrial systole peak A were relatively lower at basal and middle segments in CHF group than normal control group (p , 0.05). Normal velocity profile, parallel velocity profile, vector profile at peak S and E were lower at basal and middle segments in CHF group than normal control group (p , 0.05). Importance of the Conclusions: VFM technology could provide quantitative and intuitive information to demonstrate the flow structure of the ventricle and evaluate the cardiac function in patients with CHF. PA.04.005 Three-Dimensional Speckle Tracking Echocardiography for the Preliminary Research on the Coronary Heart Disease R. Q. Guo, J. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: 3-DSTE overcome the inherent limitations of 2-D STE and tissuel Doppler, in this studies, we performed a comparision study between strain data obtained by 2-D STE and 3D STE to detect CHD from 57 patients underwent coronary angiography. Methods: A total of 57 consecutive patients underwent three-dimensional echocardiography, According to the results of coronary angiography, divided into CHD group (30s) and control group (27s) , Normal reference values of area strain were determined in 27 healthy subjects. Main Results: 3D strain in CHD lower than the control group significantly (p , 0. 01). The ROC shows that: 3D global strain AUC is 0.89 (p , 0.01), the curve Area 95% confidence interval is 0.82-0.95, greater than 0.50. The gloabl 3D strain , 23.88 as detection of coronary heart disease cut-off Point, the sensitivity is 90%, specificity is 70%, the accuracy for 86 %, Youden index is 0. 60. The 2D global strain in ROC, the AUC is 0.75 (p , 0. 01), the 95% confidence interval is 0. 67 0.83, greater than 0.50. The global 2D strain , 28.4 as cut-off point,The sensitivity is 73%, specificity is 63%, the accuracy is 71%, Youden index 0.37.
Ultrasound in Medicine and Biology
Methods: 25 patients with 30 HCCs within 3cm were included. CECT and CEUS were performed in all patients after RFA treatment in the following 2-7 days later. Total 39 assessments of therapeutic response were performed. Absence of contrast enhancement and presence of ablative margin in the treated HCCs were statistically analyzed. CECT was used as gold standard in analyzing the accuracy of CEUS. Main Results: Follow-up CECT detected residual lesions in 2 of 39 assessments and incomplete ablative margins in 18 of 39 assessments. CEUS detected residual lesions in 2 of 39 assessments and incomplete ablative margins in 18 of 39 assessments. CEUS predicted the CECT results 90% (sensitivity 90%, specificity 89%, positive predictive value 90%, negative predictive value 89%). Importance of the Conclusions: Contrast-enhanced ultrasonography with perflubutane microbubbles has high diagnostic accuracy compared with CECT in assessment of RFA treatment response. PA.03.005 How Often Does Liver Fibrosis Stage Predicted by Transient Elastography (TE) Differ From the One Diagnosed by Liver Biopsy in Chronic Hepatitis C Patients? I. Sporea, R. Sirli, S. Bota, A. Popescu, I. Dan, A. Deleanu, M. Ardelean, N. Cornu Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, Timis¸ara, Romania Brief Description of the Purpose of the Study: Aim: to evaluate how often does liver fibrosis stage predicted by Transient Elastography (TE), using cut-off values proposed by meta-analysis, differ from the one diagnosed by liver biopsy (LB) in chronic hepatitis C patients. Methods: 473 patients with chronic hepatitis C were evaluated by means of TE and LB (interpreted according to METAVIR score). Reliable measurements were defined as: median value of 10 liver stiffness (LS) measurements with a success rate $ 60% and an interquartile range interval ,30%, values expressed in kPa. We used the LS cut-offs (kPa) proposed in the most recently published meta-analysis (Tsochatzis, J Hepatol 2011): F1-6, F2-7.2, F3-9.6 and F4-14.5. Main Results: Reliable LS measurements were obtained in 453 patients (95.7%). The classification of liver fibrosis in LB was: F0-1.1%, F110.4%, F2-49.6%, F3-30.7% and F4-8.2%. We obtained the following differences between fibrosis obtained in LB and that predicted by using the cut-off values proposed by meta-analysis: perfect concordance-131 patients (28.9%), 1 grade of fibrosis-175 patients (38.6%), 2 grades-130 patients (28.7%) and 3 grades-17 patients (3.8%). Importance of the Conclusions: In two thirds of patients a perfect concordance or at most one grade of fibrosis was observed between the fibrosis predicted by means of TE cut-off values proposed by meta-analysis and that obtained in LB. PA.03.007 The Role of Contrast Enhanced Ultrasound (CEUS) for the Assessment of Percutaneous Treatment for Hepatocellular Carcinoma M. Danila, I. Sporea, R. Sirli, A. Popescu, M. Sendroiu, A. Martie, S. Bota University of Medicine and Pharmacy, Timisoara, Romania Brief Description of the Purpose of the Study: The AIM of this study was to establish the role of CEUS for the assessment of percutaneous treatment for HCC. Methods: We evaluated 48 patients with hepatocellular carcinoma treated by PEIT or RFA. A total of 73 HCC’s nodules were treated. For each nodule we evaluated by CEUS the treatment efficacy 24 hours (in some) and 1 month (in all) after therapy. We defined as incomplete therapy the presence of arterial enhancement in the nodule and as complete therapy if no arterial enhancement was present in the treated
Volume 39, Number 5S, 2013 HCC. If complete therapy was considered, we performed another imaging method (CT or MRI) to validate our findings. For inconclusive cases we also performed another imaging method. Main Results: We performed 220 CEUS for the assessment of percutaneous treatment for HCC. The CEUS examination was conclusive in 200 cases (90.9%). In cases of incomplete treatment, we performed another session of percutaneous treatment during the CEUS examination. The result of CEUS for the assessment of percutaneous treatment correlated with the second imaging method (CT or MRI) in 87.5% of the cases. Importance of the Conclusions: CEUS is a good method for the assessment of percutaneous treatment for HCC and also for targeted therapy of the residual tumor TL.03.003 Intravenous Contrast Ecography for Focal Lesions Diagnostic in the Context of Non-Cirrhotic Liver: Cost-Benefit Analysis F. C. Moreira, T. Ripolles, M. J. Martinez Hospital Universitario Dr. Peset, Valencia, Comunidad Valenciana, Espa~na Brief Description of the Purpose of the Study: To assess the costeffectiveness of intravenous contrast enhanced ultrasonography (CEUS) in the diagnosis of focal lesions in the context of non-cirrhotic liver, taking into account the subsequent need to supplement with other methods, computed tomography (CT) or magnetic resonance (MRI). Methods: CEUS examinations were retrospectively studied between May and November 2012. This included 55 patients with focal liver lesions (28 women, range 30-86 years). Main Results: We studied 33 hemangiomas, 5 (15%) showed questionable behavior and required another method (2CT, 3MRI). There were 5 focal nodular hyperplasia, only 1 (20%) required further study (MRI). We detected 12 seudolesiones (focal steatosis), only 1 (8%) was supplemented with CT. There were 8 patients with metastatic lesions, 2 (25%) underwent CT to diagnosis. Two indeterminate lesions were observed, both were recommeded for further analysis with a MRI. 89% of CEUS was performed the same day as the baseline ultrasound, only 6 were undertaken on another day (range: 4-138, average: 58 days). In 81% of cases, CEUS showed typical behavior avoiding another diagnostic method for confirmation. This meant a saving of 49 additional tests. Importance of the Conclusions: CEUS is a fast, cheap, without radiation, that helps avoid other more expensive diagnostic tests and shortening the time to diagnosis.
TL.03.010 Contrast Ecography for Classification of Kidney Cystic Injury With Bosniak Criteria Adapted to CEUS F. C. Moreira, T. Ripolles, M. J. Martinez, D. U. Navarro, L. N. Vilar Hospital Dr. Peset, Valencia, Camunidad Valenciana, Espa~na Brief Description of the Purpose of the Study: To evaluate the role of ultrasound with contrast (CEUS) in the classification of renal cystic masses with the Bosniak criteria adapted to CEUS. Methods: We retrospectively analyzed the ultrasonography findings of 35 patients with CEUS, media: 57 years (age range: 24-85) from 2009 to 2012 who had complex cystic renal masses. The results were compared with pathology or with other techniques such as computed tomography (CT), magnetic resonance (MRI), or ultrasound monitoring. Main Results: In CEUS masses were classified as Bosniak category II in 17, III in 6 and type IV in 12. 18 were underwent CT / MRI, coinciding the Bosniak in 12 cases (66%). 2 patients classified Bosniak III were operated with benign findings (hemorrhagic cyst, chronic pyelonephritis). Of 12 patients classified as Bosniak IV, 10 were operated, with findings of malignancy in 8 (4 clear cell carcinomas / 4 papillary
Abstracts
S5
carcinomas). One Bosniak IV was benign renal myxoma. All malignant lesions that were operated, had classification CEUS Bosniak IV (sensitivity 100%). CT or MRI classified 2 malignant lesions as benign. Importance of the Conclusions: CEUS is a fast method, without radiation, which has good sensitivity for screening for malignant cystic lesions, when we apply the Bosniak classification criteria adapted to CEUS.
Main Results: Compared with control group, Untw-R decreased significantly (p , 0.001) and T-PUV,UHT increased significantly (p , 0.001). For Ptw, PTV, PUV there is no significant difference in between CHD group and Control group. Compared with Single Culprit Vessel Group, Untw-R, PUV decreased significantly (p , 0.05) and T-PUV, UHT increased significantly (p , 0.05) in Multi Culprit Vessel Group. Importance of the Conclusions: The untwisting motion in CHD patients were significantly reduced and delayed, even more significant in Multi Culprit Vessel patients.
4 - Echocardiography
PA.04.003
PA.04.001
Evaluation of Flow Structure Within Left Ventricle in Patients With Chronic Heart Failure by Vector Flow Mapping L. D. Hao, Y. Liu, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China
Assessment of the Left Ventricular Untwisting in Patients With Acute Myocardial Infarction in Different Location by 2D Speckle Tracking Imaging H. N. Song, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: Left ventricular untwisting movement is considered as an important part of LV diastolic function. The location of myocardial infarction (MI) and number of MI segments may have different impact on left ventricular untwisting movement. Methods: Forty-one patient with AMI (AMI Group) were divided into two groups according to the MI location and 31 age matched subjects (Control group). Locate the position and number of segments of MI according to the bull’s eyes map of systolic strain (LPSS) values acquired by AFI. Access peak twist velocity (PTV) ,untwisting rate in IVRT (Untw-R), peak untwisting velocity (PUV),time to peak untwisting velocity (TPUV)and half time of untwisting (UHT) with STI. Main Results: Compared with control group, LVEF, global LPSS, PUV and Untw-R of AMI group decreased significantly (p , 0.001), T-PUV (p , 0.001) and UHT (p 5 0.028) increased significantly. The number of MI segments correlated with Untw-R (r5-0.420, p 5 0.006) significantly. Untw-R in Anterior wall-Anteroseptum group were lower than Inferior wall-Posterior wall group (p 5 0.022). Importance of the Conclusions: LV untwisting motion of AMI patients can be observed by 2D-STI. Untw-R is a sensitive parameter to evaluate the untwisting motion of AMI patients. The untwisting motion of AMI patients decreased significantly, even worse in Anterior wall-Anteroseptum AMI patients. PA.04.002 Assessment of Impact of Involved Coronary Artery Quantity on Left Ventricular Untwisting in Patients With CHD by 2DSTI L. D. Hao, H. N. Song, R. Q. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: Diastolic function in patients with Coronary Heart Disease (CHD) may decrease. To assess LV Diastolic function in CHD patients with different involved coronary artery quantity by measuring the untwisting motion can provide basis for diagnosis for CHD. Methods: 75 patients suspected for CHD were divided in two groups according to the result of selective coronary angiography (SCA): CHD group (45 patients) and Control group (30 patients). According to the number of narrowed coronary, the CHD group was divided into Single Culprit Vessel Group (27 patients) and Multi Culprit Vessel Group (18 patients). 2DSTI indicies included, twist at aortic valve closure (AVCtw), twist at mitral valve open (MVOtw), untwisting rate in IVRT (Untw-R), peak untwisting velocity (PUV), time to peak untwisting velocity (TPUV) and half time of untwisting (UHT).
Brief Description of the Purpose of the Study: Vector flow mapping (VFM) is an application in which blood information in the heart chamber boundary can be quantitatively-analyzed based on information by color Doppler. To evaluate blood flow structure and quantify the variation of the flow within left ventricle, assess the impact of chronic heart failure(CHF) by VFM. Methods: 97 patients with chronic heart failure and 104 controls were involved. The flow vector images on the section plane of the flow within the left ventricle were acquired by VFM. Time-flow (T-F) curve and all other peak systolic and diastolic flow curve include normal velocity profile, parallel velocity profile,vector profile were analyzed by DSARS1 program. Main Results: Ventricular ejection peak S, rapid ventricular filling peak E and atrial systole peak A were relatively lower at basal and middle segments in CHF group than normal control group (p , 0.05). Normal velocity profile, parallel velocity profile, vector profile at peak S and E were lower at basal and middle segments in CHF group than normal control group (p , 0.05). Importance of the Conclusions: VFM technology could provide quantitative and intuitive information to demonstrate the flow structure of the ventricle and evaluate the cardiac function in patients with CHF. PA.04.005 Three-Dimensional Speckle Tracking Echocardiography for the Preliminary Research on the Coronary Heart Disease R. Q. Guo, J. Guo Renmin Hospital of Wuhan University, Wuhan City, Hubei Province, China Brief Description of the Purpose of the Study: 3-DSTE overcome the inherent limitations of 2-D STE and tissuel Doppler, in this studies, we performed a comparision study between strain data obtained by 2-D STE and 3D STE to detect CHD from 57 patients underwent coronary angiography. Methods: A total of 57 consecutive patients underwent three-dimensional echocardiography, According to the results of coronary angiography, divided into CHD group (30s) and control group (27s) , Normal reference values of area strain were determined in 27 healthy subjects. Main Results: 3D strain in CHD lower than the control group significantly (p , 0. 01). The ROC shows that: 3D global strain AUC is 0.89 (p , 0.01), the curve Area 95% confidence interval is 0.82-0.95, greater than 0.50. The gloabl 3D strain , 23.88 as detection of coronary heart disease cut-off Point, the sensitivity is 90%, specificity is 70%, the accuracy for 86 %, Youden index is 0. 60. The 2D global strain in ROC, the AUC is 0.75 (p , 0. 01), the 95% confidence interval is 0. 67 0.83, greater than 0.50. The global 2D strain , 28.4 as cut-off point,The sensitivity is 73%, specificity is 63%, the accuracy is 71%, Youden index 0.37.