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Contribution of Estrogen to the Morphology of "Secretory" Endometrium?
up of couples after hamster egg penetration testing. Fertil Steril 1993;60:1040-5. 3. Aitken RJ, Irvine DS, Wu FC. Prospective analysis of spermoocyte fusion and reactive oxygen species generation as criteria for the diagnosis of infertility. Am J Obstet Gynecol 1991; 164:542-51. 4. Aitken RJ, Thatcher S, Glasier AF, Clarkson JS, Wu FCW, Baird DT. Relative ability of modified versions ofthe hamster oocyte penetration test, incorporating hyperosmotic medium or the ionophore A23187, to predict IVF outcome. Hum Reprod 1987;2:227-31. 5. Van Duin M, Polman JEM, De Breet ITM, van Ginneken K, Bunschoten H, Grootenhuis A, et al. Production, purification and biological activity of recombinant human zona pellucida protein, ZP3. BioI Reprod 1994; 5:607 -17.
Contribution of Estrogen to the Morphology of "Secretory" Endometrium?
To the Editor: We read with interest the article published by Younis et al. (1) and were happy to observe that these authors confirmed our previous work (2) indicating that luteal E2 is not indispensable for the triggering by P of normal secretory changes in the endometrium. We regret, however, that the authors omitted to quote our own publication (2) entitled "Effects of Luteal Estradiol on the Secretory Transformation of Human Endometrium and Plasma Gonadotropins" published more than 1 year before the first submission of their paper in the Journal of Clinical Endocrinology and Metabolism, a far from obscure journal for reproductive endocrinologists. Beyond the mere courtesy of quoting investigators who previously conducted a nearly identical study, it is important for the readers of Fertility and Sterility to know that results on luteal E2 (1) that were to some extent unexpected very likely reflect a true physiological phenomenon as the study published today already represent the confirmation of prior work. Years after, we are still puzzled by the luteal E2 results. The confirmation that luteal E2 is not indispensable for the proper secretory transformation of the endometrium (1,2), while it is a necessary cofactor of the gonadotropin-lowering properties of P (2) underscores the differences between tissue-specific mechanisms of action of P.
Dominique de Ziegler, M.D. Rene Frydman, M.D. Department of Obstetrics and Gynecology Hopital A. Beclere Clamart, France Vol. 63, No.5, May 1995
Philippe Bouchard, M.D. Department of Endocrinology Hopital St. Antoine Paris, France October 3, 1994 REFERENCES 1. Younis JS, Ezra Y, Sherman Y, Simon A, Schenker JG, Laufer N. The effect of estradiol depletion during the luteal phase on endometrial development. Fertil Steril 1994; 62:103-7. 2. de Ziegler D, Bergeron C, Cornel C, Medalie A, Massai MR, Milgrom E, et al. Effects of luteal estradiol on the secretory transformation of human endometrium and plasma gonadotropins. J Clin Endocr Metab 1992;74:322-31.
Reply of the Author: We thank Dr. de Ziegler and his colleagues for their interest in our study published in the Journal (1). I would like to regretfully confirm that our group was not aware of the manuscript published by de Ziegler et al. (2), dealing with the effect of luteal E2 on the endometrium. In fact, being a prospective randomized study, our results substantiate the finding that E2 secretion by the corpus luteum, in the human, does not appear to be obligatory for the development of a normal secretory endometrium. Moreover, the corroboration of light microscopy findings to transmission electron microscopy results in our study, further supports the appraisal that luteal E2 does not seem to affect adversely the morphological developmental capacity of the endometrium. However, it is of utmost importance to notice that the actual receptivity of the endometrium, after luteal E2 depletion, is not yet settled. The crucibility of luteal E2 for embryo implantation and early pregnancy maintenance needs to be evaluated further.
Johnny S. Younis, M.D. Department of Obstetrics and Gynecology Poriya Hospital Tiberias, Israel November 18, 1994 REFERENCES 1. Younis JS, Ezrea Y, Sherman Y, Simon A, Schenker JG, Laufer N. The effect of estradiol depletion during the luteal phase on endometrial development. Fertil Steril 1994; 62:103-7. 2. de Ziegler D, Bergeron C, Cornel C, Medalie A, Massai MR, Milgrom E, et al. Effects of luteal estradiol on the secretory transformation on human endometrium and plasma gonadotropins. J Clin Endocrinol Metab 1992; 74:322-31.
Letters-to-the-editor
1135
Contribution of Estrogen to the Morphology of "Secretory" Endometrium?
To the Editor: We read with interest the article published by Younis et al. (1) and were happy to observe that these authors confirmed our previous work (2) indicating that luteal E2 is not indispensable for the triggering by P of normal secretory changes in the endometrium. We regret, however, that the authors omitted to quote our own publication (2) entitled "Effects of Luteal Estradiol on the Secretory Transformation of Human Endometrium and Plasma Gonadotropins" published more than 1 year before the first submission of their paper in the Journal of Clinical Endocrinology and Metabolism, a far from obscure journal for reproductive endocrinologists. Beyond the mere courtesy of quoting investigators who previously conducted a nearly identical study, it is important for the readers of Fertility and Sterility to know that results on luteal E2 (1) that were to some extent unexpected very likely reflect a true physiological phenomenon as the study published today already represent the confirmation of prior work. Years after, we are still puzzled by the luteal E2 results. The confirmation that luteal E2 is not indispensable for the proper secretory transformation of the endometrium (1,2), while it is a necessary cofactor of the gonadotropin-lowering properties of P (2) underscores the differences between tissue-specific mechanisms of action of P.
Dominique de Ziegler, M.D. Rene Frydman, M.D. Department of Obstetrics and Gynecology Hopital A. Beclere Clamart, France Vol. 63, No.5, May 1995
Philippe Bouchard, M.D. Department of Endocrinology Hopital St. Antoine Paris, France October 3, 1994 REFERENCES 1. Younis JS, Ezra Y, Sherman Y, Simon A, Schenker JG, Laufer N. The effect of estradiol depletion during the luteal phase on endometrial development. Fertil Steril 1994; 62:103-7. 2. de Ziegler D, Bergeron C, Cornel C, Medalie A, Massai MR, Milgrom E, et al. Effects of luteal estradiol on the secretory transformation of human endometrium and plasma gonadotropins. J Clin Endocr Metab 1992;74:322-31.
Reply of the Author: We thank Dr. de Ziegler and his colleagues for their interest in our study published in the Journal (1). I would like to regretfully confirm that our group was not aware of the manuscript published by de Ziegler et al. (2), dealing with the effect of luteal E2 on the endometrium. In fact, being a prospective randomized study, our results substantiate the finding that E2 secretion by the corpus luteum, in the human, does not appear to be obligatory for the development of a normal secretory endometrium. Moreover, the corroboration of light microscopy findings to transmission electron microscopy results in our study, further supports the appraisal that luteal E2 does not seem to affect adversely the morphological developmental capacity of the endometrium. However, it is of utmost importance to notice that the actual receptivity of the endometrium, after luteal E2 depletion, is not yet settled. The crucibility of luteal E2 for embryo implantation and early pregnancy maintenance needs to be evaluated further.
Johnny S. Younis, M.D. Department of Obstetrics and Gynecology Poriya Hospital Tiberias, Israel November 18, 1994 REFERENCES 1. Younis JS, Ezrea Y, Sherman Y, Simon A, Schenker JG, Laufer N. The effect of estradiol depletion during the luteal phase on endometrial development. Fertil Steril 1994; 62:103-7. 2. de Ziegler D, Bergeron C, Cornel C, Medalie A, Massai MR, Milgrom E, et al. Effects of luteal estradiol on the secretory transformation on human endometrium and plasma gonadotropins. J Clin Endocrinol Metab 1992; 74:322-31.
Letters-to-the-editor
1135