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Control of Cancer of the Uterus
THE
VAGINAL
SMEAR
:
‘ (PRECANCER”
CELL
STUDIES
1219
Experimental therapy to precancer cases has been attempted. A group of cases is presently under observation. One of those is described in whom precancer cells disappeared following prolonged administration of massive doses of an estrogenic-riboflavin combination. Diagrammatic representation of the localization of cancer cells, precancer cell types, and normal cells in early microscopic cancers is attempted. The cytological method is visualized as opening up a valuable new field of approach for diagnosis and for behavior studies of lesions believed to represent the formative stage of cancer. Tile author wishes to \V. Burton Ayre for assistance precancer type; to Dr. J. 8. Department of Gynecology operated in making possible preeiation is due also to Miss nical Staff who have cooperated This work was assisted Blood Pressure Research, New
express sincere appreciation to Dr. Robert Chambers and Dr. in the interpretation and evaluation of cells classified as of Henry and Dr. W. A. G. Bauld and other Staff Members of the and Obstetrics of the Royal Victoria Hospital, who have eothe careful follow-up on cases diagnosed as precancer. BpEvelyn Dakin, Director of Technicians, and to the entire Techin the preparation of this work. by a grant from the Public Health Foundation for Cancer ant1 York.
References 1. Papanicolaou, G. N.: Proceedings of the Third Race Betterment Conference, 538, 1928. 2. Papanicolaou, G. N.: Diagnosis of Cancer by Vaginal Smears, New York, 1943, The Commonwealth Fund. Sure.. Gvnec. & Obst. 77: 449. 1943. 3. Meias. J. V.. et al: 4. Jon&( C. A.; NeustaedteF,‘T.,” and Mackenzie, L. L.: AM. J-. OBST. & GYNEC. 49: 159, 1945. 5. Graham, R. M., Sturgi.s, S. H., and McGraw, J.: AM. J. OBST. & GYNEC. 55: 303, 1948. 6. Foote, F. W., and Li, K.: AI& J. OBST. & GYNEC. 56: 335, 1948. 7. Seibels, R. E.: AM. J. OBST. & GYNEC. 54: 343,1947. J. A. M. A. 10&‘1145, 1937. 8. Novak, E.: 9. Te Linde, R. W., and Gal+, G.: AM. J. OBST. & GYNEC. 48: 774, 1944. 10. Taylor, H. C., Jr., and Guyer, H. B.: AM. J. OBST. & GYNEC. 52: 451, 1946. 11. Schiller, W.: Personal Communication to the Author. 12. Ayre, J. E.: AM. J. OBST. & GYNEC. 53: 609, 1947. 13. Traut, H. F.: Rocky Mountain M. J. 44: 376, 1947. 14. Ayre, J. E.: J. A. M. A. 138: 11, 1918.
Macfarlane, Catherine, Sturgis, Margaret C., and Fetterman, of the Uterus, J. A. M. -4. 138: 941, Nov. 97, 1945.
Faith
S.:
Control
of Cancer
The authors report their findings on 732 volunteers who have been examined more or less regularly over a period of 10 years. Eight cancers of the pelvic crgans were discovered in the group of 732 volunteers over this ten-year period. The authors continue to stress the importance of periodic pelvic examination, especially on women past 30 years of WILLIAM BERMAN. age who have had one child.
VAGINAL
SMEAR
:
‘ (PRECANCER”
CELL
STUDIES
1219
Experimental therapy to precancer cases has been attempted. A group of cases is presently under observation. One of those is described in whom precancer cells disappeared following prolonged administration of massive doses of an estrogenic-riboflavin combination. Diagrammatic representation of the localization of cancer cells, precancer cell types, and normal cells in early microscopic cancers is attempted. The cytological method is visualized as opening up a valuable new field of approach for diagnosis and for behavior studies of lesions believed to represent the formative stage of cancer. Tile author wishes to \V. Burton Ayre for assistance precancer type; to Dr. J. 8. Department of Gynecology operated in making possible preeiation is due also to Miss nical Staff who have cooperated This work was assisted Blood Pressure Research, New
express sincere appreciation to Dr. Robert Chambers and Dr. in the interpretation and evaluation of cells classified as of Henry and Dr. W. A. G. Bauld and other Staff Members of the and Obstetrics of the Royal Victoria Hospital, who have eothe careful follow-up on cases diagnosed as precancer. BpEvelyn Dakin, Director of Technicians, and to the entire Techin the preparation of this work. by a grant from the Public Health Foundation for Cancer ant1 York.
References 1. Papanicolaou, G. N.: Proceedings of the Third Race Betterment Conference, 538, 1928. 2. Papanicolaou, G. N.: Diagnosis of Cancer by Vaginal Smears, New York, 1943, The Commonwealth Fund. Sure.. Gvnec. & Obst. 77: 449. 1943. 3. Meias. J. V.. et al: 4. Jon&( C. A.; NeustaedteF,‘T.,” and Mackenzie, L. L.: AM. J-. OBST. & GYNEC. 49: 159, 1945. 5. Graham, R. M., Sturgi.s, S. H., and McGraw, J.: AM. J. OBST. & GYNEC. 55: 303, 1948. 6. Foote, F. W., and Li, K.: AI& J. OBST. & GYNEC. 56: 335, 1948. 7. Seibels, R. E.: AM. J. OBST. & GYNEC. 54: 343,1947. J. A. M. A. 10&‘1145, 1937. 8. Novak, E.: 9. Te Linde, R. W., and Gal+, G.: AM. J. OBST. & GYNEC. 48: 774, 1944. 10. Taylor, H. C., Jr., and Guyer, H. B.: AM. J. OBST. & GYNEC. 52: 451, 1946. 11. Schiller, W.: Personal Communication to the Author. 12. Ayre, J. E.: AM. J. OBST. & GYNEC. 53: 609, 1947. 13. Traut, H. F.: Rocky Mountain M. J. 44: 376, 1947. 14. Ayre, J. E.: J. A. M. A. 138: 11, 1918.
Macfarlane, Catherine, Sturgis, Margaret C., and Fetterman, of the Uterus, J. A. M. -4. 138: 941, Nov. 97, 1945.
Faith
S.:
Control
of Cancer
The authors report their findings on 732 volunteers who have been examined more or less regularly over a period of 10 years. Eight cancers of the pelvic crgans were discovered in the group of 732 volunteers over this ten-year period. The authors continue to stress the importance of periodic pelvic examination, especially on women past 30 years of WILLIAM BERMAN. age who have had one child.