- Email: [email protected]
Controlled cyclic drug release based on chemomechanical gels
Abstracts / Journal of Controlled Release 213 (2015) e8–e152
a breast cancer cell line. In conclusion, this glutathione responsive hydrogel could be an efficient delivery system for various cargos such as gene materials. Keywords: dextran, miR-145, hydrogel, disulfide bonds Acknowledgments We express our sincere thanks to the Iran Stem Cell Technology Institute for the facilities provided. Authors are thankful to the financial support from Nanotechnology Research Centre of Tehran University of Medical Sciences. References [1] M. Sachdeva, Y.Y. Mo, miR-145-mediated suppression of cell growth, invasion and metastasis, Am. J. Transl. Res. 2 (2010) 170–180. [2] G. Shahnaz, G. Perera, D. Sakloetsakun, D. Rahmat, A. BernkopSchnürch, Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate, J. Control. Release 144 (2010) 32–38.
to their intelligent, controllable and especially biomimetic behavior. In this study, we proposed a general model coupling the large deformation, chemical reaction and mass diffusion to describe the complicated behaviors of chemomechanical gels [2]. Furthermore, the simulation of the drug release from these gels under an external cyclic force demonstrated that the amplitude and period of the external force significantly affect the released drug quantity of each squeeze. These investigations are supposed to further understand and develop the application of chemomechanical gels in drug delivery. Keywords: chemomechanics, functional gels, chemical reaction, controllability analysis References [1] K.Y. Lee, M.C. Peters, K.W. Anderson, D.J. Mooney, Controlled growth factor release from synthetic extracellular matrices, Nature 408 (2000) 998–1000. [2] P.F. Wang, S.B. Liu, J.X. Zhou, F. Xu, T.J. Lu, Kinetic modelling and bifurcation analysis of chemomechanically miniaturized gels under mechanical load, Euro. Phys. J. E 36 (2013) 1–9.
doi:10.1016/j.jconrel.2015.05.051
doi:10.1016/j.jconrel.2015.05.052
Controlled cyclic drug release based on chemomechanical gels
Coordination micelles containing silver nanoparticles and the antibacterial activity thereof
Peng-Fei Wanga,b, Lin Wanga, Baoqiang Lic, Tian-Jian Lua, Feng Xua,d,* a Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, 28 Xianning West Rd., Xi'an 710049, China b Qian Xuesen Laboratory of Space Technology, China Academy of Space Technology, 102 Youyi Rd., Beijing 100094, China c Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150001, China d MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ⁎Corresponding author. E-mail address: [email protected] (F. Xu). With advances in biomaterials, various novel artificial gels with capability to respond to stimuli (e.g., temperature, light, force, pH) have emerged with great potential applications in drug delivery [1]. Among them, chemomechanical gels, exhibiting bioinspired energy transformation between volume deformation and chemical reaction, are expected to be a better vehicle for the drug delivery system due
Fig. 1. Schematic of the drug release using a chemomechanical gel involving a chemical reaction BD ⇆ D + B. (a) During the chemical reaction, the fixed components BD produce a number of “drug” species D in the gel. (b) While the gel is squeezed by an external force, D leaves the gel together with solvent.
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Gang Huang, Guoquan Tong, Jie Liu, Changyun Quan, Qing Jiang, Chao Zhang* School of Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510006, China ⁎Corresponding author. E-mail address: [email protected] (C. Zhang). Silver nanoparticles (AgNPs) exhibit excellent antibacterial activity to gram-negative and gram positive bacteria such as Staphylococcus aureus (S. aureus) [1] and Escherichia coli (E. coli) [2]. However, the antimicrobial activity of AgNPs is highly susceptible to oxidation and aggregation because of the small size effect [3]. Micelles have been widely used as nano-carriers in drug delivery, and the core–shell structure of micelles could be harnessed to protect AgNPs from oxidation and aggregation as well as to achieve sustained release [3]. In this work, Ag+ ions were first encapsulated in micelles via coordinative interaction between Ag+ and a block copolymer, methoxypoly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile). In situ reduction of the Ag+ ions resulted in the formation of evenly distributed AgNPs with mean diameter of 4 nm in the spherical micelles (mean diameter ~40 nm) (Fig. 1a). The coordination bonds between AgNPs and the block copolymer were verified by FT-IR. Excellent antibacterial activity of AgNPs-loaded micelles was observed at a micelle concentration of 37.5 g/mL after 24 h of incubation with gram-negative E. coli in suspension (Fig. 1b). This coordination micelle could be used as a promising antibacterial agent.
Fig. 1. (a) TEM image of AgNPs-loaded micelles. (b) Antibacterial activity of AgNPsloaded micelles.
a breast cancer cell line. In conclusion, this glutathione responsive hydrogel could be an efficient delivery system for various cargos such as gene materials. Keywords: dextran, miR-145, hydrogel, disulfide bonds Acknowledgments We express our sincere thanks to the Iran Stem Cell Technology Institute for the facilities provided. Authors are thankful to the financial support from Nanotechnology Research Centre of Tehran University of Medical Sciences. References [1] M. Sachdeva, Y.Y. Mo, miR-145-mediated suppression of cell growth, invasion and metastasis, Am. J. Transl. Res. 2 (2010) 170–180. [2] G. Shahnaz, G. Perera, D. Sakloetsakun, D. Rahmat, A. BernkopSchnürch, Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate, J. Control. Release 144 (2010) 32–38.
to their intelligent, controllable and especially biomimetic behavior. In this study, we proposed a general model coupling the large deformation, chemical reaction and mass diffusion to describe the complicated behaviors of chemomechanical gels [2]. Furthermore, the simulation of the drug release from these gels under an external cyclic force demonstrated that the amplitude and period of the external force significantly affect the released drug quantity of each squeeze. These investigations are supposed to further understand and develop the application of chemomechanical gels in drug delivery. Keywords: chemomechanics, functional gels, chemical reaction, controllability analysis References [1] K.Y. Lee, M.C. Peters, K.W. Anderson, D.J. Mooney, Controlled growth factor release from synthetic extracellular matrices, Nature 408 (2000) 998–1000. [2] P.F. Wang, S.B. Liu, J.X. Zhou, F. Xu, T.J. Lu, Kinetic modelling and bifurcation analysis of chemomechanically miniaturized gels under mechanical load, Euro. Phys. J. E 36 (2013) 1–9.
doi:10.1016/j.jconrel.2015.05.051
doi:10.1016/j.jconrel.2015.05.052
Controlled cyclic drug release based on chemomechanical gels
Coordination micelles containing silver nanoparticles and the antibacterial activity thereof
Peng-Fei Wanga,b, Lin Wanga, Baoqiang Lic, Tian-Jian Lua, Feng Xua,d,* a Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, 28 Xianning West Rd., Xi'an 710049, China b Qian Xuesen Laboratory of Space Technology, China Academy of Space Technology, 102 Youyi Rd., Beijing 100094, China c Institute for Advanced Ceramics, Harbin Institute of Technology, Harbin 150001, China d MOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ⁎Corresponding author. E-mail address: [email protected] (F. Xu). With advances in biomaterials, various novel artificial gels with capability to respond to stimuli (e.g., temperature, light, force, pH) have emerged with great potential applications in drug delivery [1]. Among them, chemomechanical gels, exhibiting bioinspired energy transformation between volume deformation and chemical reaction, are expected to be a better vehicle for the drug delivery system due
Fig. 1. Schematic of the drug release using a chemomechanical gel involving a chemical reaction BD ⇆ D + B. (a) During the chemical reaction, the fixed components BD produce a number of “drug” species D in the gel. (b) While the gel is squeezed by an external force, D leaves the gel together with solvent.
e33
Gang Huang, Guoquan Tong, Jie Liu, Changyun Quan, Qing Jiang, Chao Zhang* School of Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510006, China ⁎Corresponding author. E-mail address: [email protected] (C. Zhang). Silver nanoparticles (AgNPs) exhibit excellent antibacterial activity to gram-negative and gram positive bacteria such as Staphylococcus aureus (S. aureus) [1] and Escherichia coli (E. coli) [2]. However, the antimicrobial activity of AgNPs is highly susceptible to oxidation and aggregation because of the small size effect [3]. Micelles have been widely used as nano-carriers in drug delivery, and the core–shell structure of micelles could be harnessed to protect AgNPs from oxidation and aggregation as well as to achieve sustained release [3]. In this work, Ag+ ions were first encapsulated in micelles via coordinative interaction between Ag+ and a block copolymer, methoxypoly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile). In situ reduction of the Ag+ ions resulted in the formation of evenly distributed AgNPs with mean diameter of 4 nm in the spherical micelles (mean diameter ~40 nm) (Fig. 1a). The coordination bonds between AgNPs and the block copolymer were verified by FT-IR. Excellent antibacterial activity of AgNPs-loaded micelles was observed at a micelle concentration of 37.5 g/mL after 24 h of incubation with gram-negative E. coli in suspension (Fig. 1b). This coordination micelle could be used as a promising antibacterial agent.
Fig. 1. (a) TEM image of AgNPs-loaded micelles. (b) Antibacterial activity of AgNPsloaded micelles.