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Controls of stability and sterility in parenteral nutrition mixtures containing fat emulsions
P15 CONTROLS OF STABILITY AND STERILITY IN PARENTERAL NUTRITION MIXTURES CONTAINING FAT EMULSIONS D. Garcia, M. Anaya, M. C&a, 5. Mejia. Dept.of Pharmacy, Ramon y Cajal Hospital, Madrid, Spanien Recent incorporation of fat emulsions to parenteral nutrition mixtures for adult therapy presented a new dimension for our research interests: the investigation of stability of the solutions, pH changes in pre-mixed solutions, changes in size of micelae and formation of big fat particles. Relationship of this formation with amount of electrolites added, problems related to unsuspected precipitation of one or more components of the solution, and incidence of solution contamination. A critical analysis of 2000 parenteral nutrition mixtures containing lipids allows us to design a standard solution with lipids in its composition which minimizes the above mentioned problems.
P16 AMINO
ACIDS
IN
CONTINUOUS
MIXING
SYSTEM
FOR
TOTAL
PARENTERAL
NUTRITION 0.1. Alant, J. Weltner. First Surg. Dept.of the Semmelweis Med.Univ. Budapest, Hungary The aim of our study was to elaborate a method, by which the infusion of adequate volumina and different components of the parenteral nutrition provides the possibly best circumstances for the utilisation of amino acids i.e. for the protein anabolism. Our method is based on two principles, the first is that all patients need an individual therapy. The second, that amino acids must be infused in non-fasting patients. To achieve this we used an infusion system as shown on the side. The first infusion will pull instead of air the next infusion, the seond the third etc. This results in a mixing of the solutions. We used MC insulin or tolbutamide to complete or support the endogenous insulin secretion. At 29 patients /including septic patients/ we measured the concentration of the components of the solutions in the i.v.line, the blood and urin sugar level, the IRI level and the total protein level of the serum. The tolbutamide was enough to support the insulin secretion in the non diabetic patients /as were all patients in this study/. No glycosuria occured if infusion rate did not exceed 40 drops/min. This method provided the patients a sufficient energy intake and simultaneously a continuous lonq-term amino acid intake, and as a result of the latter, a physiological blood protein level. 1. Fat inf. 40% cabohydr. 3. Albumin + Insulin 4. Amino Acids/Amino-Mel 5. Further inf.
2.
Opt.
114
P16 AMINO
ACIDS
IN
CONTINUOUS
MIXING
SYSTEM
FOR
TOTAL
PARENTERAL
NUTRITION 0.1. Alant, J. Weltner. First Surg. Dept.of the Semmelweis Med.Univ. Budapest, Hungary The aim of our study was to elaborate a method, by which the infusion of adequate volumina and different components of the parenteral nutrition provides the possibly best circumstances for the utilisation of amino acids i.e. for the protein anabolism. Our method is based on two principles, the first is that all patients need an individual therapy. The second, that amino acids must be infused in non-fasting patients. To achieve this we used an infusion system as shown on the side. The first infusion will pull instead of air the next infusion, the seond the third etc. This results in a mixing of the solutions. We used MC insulin or tolbutamide to complete or support the endogenous insulin secretion. At 29 patients /including septic patients/ we measured the concentration of the components of the solutions in the i.v.line, the blood and urin sugar level, the IRI level and the total protein level of the serum. The tolbutamide was enough to support the insulin secretion in the non diabetic patients /as were all patients in this study/. No glycosuria occured if infusion rate did not exceed 40 drops/min. This method provided the patients a sufficient energy intake and simultaneously a continuous lonq-term amino acid intake, and as a result of the latter, a physiological blood protein level. 1. Fat inf. 40% cabohydr. 3. Albumin + Insulin 4. Amino Acids/Amino-Mel 5. Further inf.
2.
Opt.
114