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Coronary risk factors (CRF) in acute myocardial infarction (AMI) of elderly with and without hypertension
POSTERS: Cerebrovascular Disease/Stroke
AJH 1999;12:197A-I99A
G001
G002
GENETIC ANALYSIS OF THE ENDOTHELIALDEPENDENT IMPAIRED VASORELAXATION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT: A CANDIDATE GENE APPROACH. S. Rubattu, R. Giliberti, R. Russo, U. Oanten ~, D. Ganten ~, F. Cosentino, M. Volpe*. Istituto Neurologico Mediterraneo Neuromed, Pozzilli (Is) and Department o f Experimental Medicine and Pathology, Univ. La Sapienza, Rome, Italy; "MDC, Berlin, Germany. An endothelial-dependent vascular dysfunction has been previously shown to associate and co-segregate with stroke in the stroke-prone spontaneously hypertensive rat (SI-IRsp), as compared to the stroke-resistant SHR (SHRsr). This abnormality is blood pressure-independent and it may accelerate the development o f cerebrovaseular disease. In the attempt to elucidate the genetic basis o f this endothelial dysfunction, an extensive genome screen has been started on an SHRsp/SHRsr F2intercross (n=137, 64 males and 73 females). As a first approach, all suitable candidate genes, for which a polymorphic marker was available, were tested. The maximal vasorelaxation to acetylcholine vemus the maximal vaSOconstriction to norepinephrine (delta ratio) was chosen as the quantitative phenotype. This parameter showed a wide range o f variation among the F2 animals, from 0 to I through all the intermediate values. The following candidate genes were screened in our F2 population: Renin, Angiotensinogen, ACE, Ang I1 A T I b receptor, ANP, BNP, ANP GC-A receptor, Kallikrein, eNOS. Polymorphic markers located inside the areas containing the Ang It A T I a receptor and the Endothelin genes were also included. An analysis o f variance was performed for each genotype after adjustment for gender. As a result, none o f the genes so far tested co-segregated with the vascular dysfunction o f the stroke-prone strain.
CORONARY RISK FACTORS (CRF) IN ACUTE MYOCARDIAL INFARCTION (AMI) OF ELDERLY WITH AND WITHOUT HYPERTENSION G. Bartoncmi, F. BcrtaneIli and A. Leone *, Division o f Medicine City Hospital Pontremoli (MS), Italy.
K e y Words:
Stroke, endothelial candidate genes,
dysfunction,
genetics,
Among elderly patiants(pts) with CRF, hypertension and diabetes mellitus were usually associated with a poor prognosis. Smoking, elevated cholesterol, and family history appemed to have much less significance. The aim o f this study was to assess the role o f blood pressure in 144(8%)AMlpts out o f I782 subjects admitted. 84(58.3%) were males, and 60(41.7%)females aged from 70 to 91 years(mean:77+~5.7).100 pts(69%) had CRF, whereas 44(31%)similar pts without CRF were used as a control group. Statistical aualysis was perfonned(ANOVA). Death affected 20 CRFpts(20%) vs 2 contlx~,l pts(4.5%)-P
K e y Words:
G003
G004
Prevalence of ~ and o(her Uidd and non411dd dsk factors In stroke. Olov~ R . ~ G,Del CO¢1O C,Panigada O,Oluntoll F,Saba P. Oept. o~ M e d ~ , H ~ of P,mda (PT), ~,y. 102 consecub've pdlents wnh stroke ~ on CT iman)who were amm=aalde ~=~dvors,all~ • 12 hrs fa~ng pedod of Initial i ~ w e r e evaluated wtm r e q ~ to pUm~a uric ackl.to~ d~=l~bxol,bl~lyce,'k~mJ~.C •rid LP(al.On admission blood pmm~e,ECO and cBo0ds ultrasound imaging In standacd poklts were ahlo u•mmed In ord~' to evldute the of r n e d l a ~ ~ (untl~ 1J~ mm~r plaqoes (~J~ove l.emmI.The ~ vatm d m Invem~ded w~th mspeet to thor hy~t~ry of dl~x~e&,hypmton~on m~d Imoklng h~d~.The i~Uon~ ~mple vms dlvidod In two groups accordingto piuma LP(al levels unlll (gnx~ tl o¢ 9taMer than 30 rng/dl (Group 2).Lp(a) concentration high~ thaet 30 ~ are gene~lly co~ddemd an undepend~t risk factor b r ~ evenls.The results ol~dned In the two groul~ (table) w e ~ ~ amlyzed by ANOVA m d U ~ m ~ q 0 m m d u p m m m ~ vthe X2 m M h o ~ ! O 1Lp(a] < M mg/dl 0 2 Lplal > 30 m~dl 44 ( 4 e q ~ n ~ e i A~e ly~s| N*1.S 71qLI 8mo;dng habit ~2'p' i,m'/,t mabet~ o 0(w4 s i'tm,t
EFFECTOF BLOODpRESSUREIN ACUTESTROKEON MORTALITYAND FUNCTIONALSTATUSAT 30 DAYS.~ R. pegales,A. Lesido, J.M. F~z, E. S~chez, C. Lmm8o,A. Punts. H~ital N*Sra. del pal~tuo Sooot~o,
Hyp,am,~
ECG4m:twnla C.I.: .Norm .< 1.6 mm
i 'he(=~/4 17 (W'~, I 16 (U'/,) ~ (4e'/,) 'US
p,,:o,,os P
n 07~I ~o (w/. I
P
~ (am,/,) N (me/~ 12e:HNI 211~44 TrU~09~:=td~ 2,41f~ 222~1M F~7 42~11 U r k Ack~ Lo*s.7 P
2 paum~ ~
wa= m h l ~
A l b a ~ Spain.
To dmon'bethe effector"bloodprmmre(Bp)on mmcalityand fumdioeahtattmat 30 da~ 0¢an acutoItrt~keweadeelad91 ¢xmseet,qiveImtinntsattmdedat finecmaagmcy room0ER)betwemJune 1997- June 1998withImagute=utlieo~ku than 24 hou~ frominstaurmkm.BPw= recmdedat the ERwitha memnyqftyBmmmometermd forate fatt 24 hotwswithm authomati¢mdllometricdevioe( S ~ 90207)md by cammlrmdinp m w~l rid. Fmetia~ status wu ammsedwith the Modified Rm~mIndex(RY,J). Memnabe was 71,5 (SD 9,9). 53 male md 38 female. 75,6% of Urok~ were bdmemicmd 24,4%h e m 0 ~ RKIat the ER w=~ 0-1 : 8 ca~s; 2-3 : 22; 4-5 : 61. At 30 day.RKIwalO-1:22 cam; 2-3 : 22 ;4-5:27. II patimUdindinthe firat 7 days attd 20 at day 30. S~tolicbleedpttmm~(SBP)md duutollcbloodptemure (DBP)at ~ ERwere 155,4mmH8 (95%CI 150,5to 160,4)and 87,6mmHg(95% CI 84,5to 9O,8)nepectivdy. SBP and DBP in the tint 24 hour=wiflatmb.,t=ocy bloodpremm~monitonlng(ABPM)wa'e 144,8mmHa (95%CI 140,5to 149)md 80,7 mmHg(95% CI 77,7to 83,7). SBP RndDBP in the fiftt 24 hours by camml teadmp st wKdwere 142,3mmHg(95%Cl 139,5to 145,2)and 79,6mmHg(95% C177,7to 81,4). SRp(154,2ninths; 95%C1 145,9to 162,5)and DEIP(87 mmHg;95%CI 80,4to 93,7) by ABPMwere in averag=12,1 ~ (95% C] 2 to 22,1) md 8,2 mmHg (95% CI l,l to 15.2) ~ ixqmetivelyin patim~ who died (p< 0,05). No ~aift
e¢¢umae= ef c i r c a l~qum.hmhm~
comrunry arn~:l cw•txld dlaaoan•e N VmH u m o N ugovulod I~goud ~ ~ckl lev~=.Our data _-,_~,,~,~___ thanJn sls~e p a ~ r 4 s , w h m Lp(a) concenln~lon is J ~ l e J o u respoNl~e f~r I K h m d c hemt and cemlmd dh~mu,mey ~ the n~In rld( facS~; on the o~her hand when L4~)
levekt am " m a m d ~ . ~
may be ~
the mNot ~tO~t
Key Words:
~ ~ ,
ui~d pmm.= moaitod~ ~ ~z~l a=~L
.trok~
AJH 1999;12:197A-I99A
G001
G002
GENETIC ANALYSIS OF THE ENDOTHELIALDEPENDENT IMPAIRED VASORELAXATION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT: A CANDIDATE GENE APPROACH. S. Rubattu, R. Giliberti, R. Russo, U. Oanten ~, D. Ganten ~, F. Cosentino, M. Volpe*. Istituto Neurologico Mediterraneo Neuromed, Pozzilli (Is) and Department o f Experimental Medicine and Pathology, Univ. La Sapienza, Rome, Italy; "MDC, Berlin, Germany. An endothelial-dependent vascular dysfunction has been previously shown to associate and co-segregate with stroke in the stroke-prone spontaneously hypertensive rat (SI-IRsp), as compared to the stroke-resistant SHR (SHRsr). This abnormality is blood pressure-independent and it may accelerate the development o f cerebrovaseular disease. In the attempt to elucidate the genetic basis o f this endothelial dysfunction, an extensive genome screen has been started on an SHRsp/SHRsr F2intercross (n=137, 64 males and 73 females). As a first approach, all suitable candidate genes, for which a polymorphic marker was available, were tested. The maximal vasorelaxation to acetylcholine vemus the maximal vaSOconstriction to norepinephrine (delta ratio) was chosen as the quantitative phenotype. This parameter showed a wide range o f variation among the F2 animals, from 0 to I through all the intermediate values. The following candidate genes were screened in our F2 population: Renin, Angiotensinogen, ACE, Ang I1 A T I b receptor, ANP, BNP, ANP GC-A receptor, Kallikrein, eNOS. Polymorphic markers located inside the areas containing the Ang It A T I a receptor and the Endothelin genes were also included. An analysis o f variance was performed for each genotype after adjustment for gender. As a result, none o f the genes so far tested co-segregated with the vascular dysfunction o f the stroke-prone strain.
CORONARY RISK FACTORS (CRF) IN ACUTE MYOCARDIAL INFARCTION (AMI) OF ELDERLY WITH AND WITHOUT HYPERTENSION G. Bartoncmi, F. BcrtaneIli and A. Leone *, Division o f Medicine City Hospital Pontremoli (MS), Italy.
K e y Words:
Stroke, endothelial candidate genes,
dysfunction,
genetics,
Among elderly patiants(pts) with CRF, hypertension and diabetes mellitus were usually associated with a poor prognosis. Smoking, elevated cholesterol, and family history appemed to have much less significance. The aim o f this study was to assess the role o f blood pressure in 144(8%)AMlpts out o f I782 subjects admitted. 84(58.3%) were males, and 60(41.7%)females aged from 70 to 91 years(mean:77+~5.7).100 pts(69%) had CRF, whereas 44(31%)similar pts without CRF were used as a control group. Statistical aualysis was perfonned(ANOVA). Death affected 20 CRFpts(20%) vs 2 contlx~,l pts(4.5%)-P
K e y Words:
G003
G004
Prevalence of ~ and o(her Uidd and non411dd dsk factors In stroke. Olov~ R . ~ G,Del CO¢1O C,Panigada O,Oluntoll F,Saba P. Oept. o~ M e d ~ , H ~ of P,mda (PT), ~,y. 102 consecub've pdlents wnh stroke ~ on CT iman)who were amm=aalde ~=~dvors,all~ • 12 hrs fa~ng pedod of Initial i ~ w e r e evaluated wtm r e q ~ to pUm~a uric ackl.to~ d~=l~bxol,bl~lyce,'k~mJ~.C •rid LP(al.On admission blood pmm~e,ECO and cBo0ds ultrasound imaging In standacd poklts were ahlo u•mmed In ord~' to evldute the of r n e d l a ~ ~ (untl~ 1J~ mm~r plaqoes (~J~ove l.emmI.The ~ vatm d m Invem~ded w~th mspeet to thor hy~t~ry of dl~x~e&,hypmton~on m~d Imoklng h~d~.The i~Uon~ ~mple vms dlvidod In two groups accordingto piuma LP(al levels unlll (gnx~ tl o¢ 9taMer than 30 rng/dl (Group 2).Lp(a) concentration high~ thaet 30 ~ are gene~lly co~ddemd an undepend~t risk factor b r ~ evenls.The results ol~dned In the two groul~ (table) w e ~ ~ amlyzed by ANOVA m d U ~ m ~ q 0 m m d u p m m m ~ vthe X2 m M h o ~ ! O 1Lp(a] < M mg/dl 0 2 Lplal > 30 m~dl 44 ( 4 e q ~ n ~ e i A~e ly~s| N*1.S 71qLI 8mo;dng habit ~2'p' i,m'/,t mabet~ o 0(w4 s i'tm,t
EFFECTOF BLOODpRESSUREIN ACUTESTROKEON MORTALITYAND FUNCTIONALSTATUSAT 30 DAYS.~ R. pegales,A. Lesido, J.M. F~z, E. S~chez, C. Lmm8o,A. Punts. H~ital N*Sra. del pal~tuo Sooot~o,
Hyp,am,~
ECG4m:twnla C.I.: .Norm .< 1.6 mm
i 'he(=~/4 17 (W'~, I 16 (U'/,) ~ (4e'/,) 'US
p,,:o,,os P
n 07~I ~o (w/. I
P
~ (am,/,) N (me/~ 12e:HNI 211~44 TrU~09~:=td~ 2,41f~ 222~1M F~7 42~11 U r k Ack~ Lo*s.7 P
2 paum~ ~
wa= m h l ~
A l b a ~ Spain.
To dmon'bethe effector"bloodprmmre(Bp)on mmcalityand fumdioeahtattmat 30 da~ 0¢an acutoItrt~keweadeelad91 ¢xmseet,qiveImtinntsattmdedat finecmaagmcy room0ER)betwemJune 1997- June 1998withImagute=utlieo~ku than 24 hou~ frominstaurmkm.BPw= recmdedat the ERwitha memnyqftyBmmmometermd forate fatt 24 hotwswithm authomati¢mdllometricdevioe( S ~ 90207)md by cammlrmdinp m w~l rid. Fmetia~ status wu ammsedwith the Modified Rm~mIndex(RY,J). Memnabe was 71,5 (SD 9,9). 53 male md 38 female. 75,6% of Urok~ were bdmemicmd 24,4%h e m 0 ~ RKIat the ER w=~ 0-1 : 8 ca~s; 2-3 : 22; 4-5 : 61. At 30 day.RKIwalO-1:22 cam; 2-3 : 22 ;4-5:27. II patimUdindinthe firat 7 days attd 20 at day 30. S~tolicbleedpttmm~(SBP)md duutollcbloodptemure (DBP)at ~ ERwere 155,4mmH8 (95%CI 150,5to 160,4)and 87,6mmHg(95% CI 84,5to 9O,8)nepectivdy. SBP and DBP in the tint 24 hour=wiflatmb.,t=ocy bloodpremm~monitonlng(ABPM)wa'e 144,8mmHa (95%CI 140,5to 149)md 80,7 mmHg(95% CI 77,7to 83,7). SBP RndDBP in the fiftt 24 hours by camml teadmp st wKdwere 142,3mmHg(95%Cl 139,5to 145,2)and 79,6mmHg(95% C177,7to 81,4). SRp(154,2ninths; 95%C1 145,9to 162,5)and DEIP(87 mmHg;95%CI 80,4to 93,7) by ABPMwere in averag=12,1 ~ (95% C] 2 to 22,1) md 8,2 mmHg (95% CI l,l to 15.2) ~ ixqmetivelyin patim~ who died (p< 0,05). No ~aift
e¢¢umae= ef c i r c a l~qum.hmhm~
comrunry arn~:l cw•txld dlaaoan•e N VmH u m o N ugovulod I~goud ~ ~ckl lev~=.Our data _-,_~,,~,~___ thanJn sls~e p a ~ r 4 s , w h m Lp(a) concenln~lon is J ~ l e J o u respoNl~e f~r I K h m d c hemt and cemlmd dh~mu,mey ~ the n~In rld( facS~; on the o~her hand when L4~)
levekt am " m a m d ~ . ~
may be ~
the mNot ~tO~t
Key Words:
~ ~ ,
ui~d pmm.= moaitod~ ~ ~z~l a=~L
.trok~