- Email: [email protected]
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer
136
Abstracts /Lung
Cancer 11 (1994)
Endobronchial metastasis Heitmiller RF, Marmco WJ, H~batt RI-I, Marsh BR. O&r 624, JO/VU Hopkins Hospital, 600 N. Wolf Street, Baltimore, MD 21205. J Thorac Cardiovasc Surg 1993;106:537-42. Endobmochial metastasm from ooopulmooary oeoplasms are rare. Sioce 1971, we have treated 23 patients with endobroochial metastases, the findings for which form the basis of this article. Many types of primary tumors are capable of eodobmochial metastases, although breast, colon, and renal carcinomas predominate. The mean time fmm thediagnosisoftheprimarycarcinomatothediagnosisofeodobmochial metastases was 59.9 months. Bmochoscopic results were diagnostic in all cases. Although the mean time for the appearance of endobmochial metastasea is almost 5 yeara, ooexaminatioo the majority ofpatients will have symptomatic extrabmochial metastatic disease, the quality of their survival will oReo be poor, and their survival time will be limited (12.5 months). Surgicalresectionshouldbeconfined topatientswithlocalixed disease.
Pharmacokinetics of cisplatin instilled into the pleural cavity following panpleuropneumonectomy in patients with malignant pleurisy due to lung amcer Yasumoto K, Shimokawa T, Nagashima A, Himse N, Nakahashi H. Department of Chest Surgery. Kita&shu Medical Center, Barhaku 2I-l, Kokura-kita-ku, Kitakywhu. Fukuoka&I2. J SurgOncol1993;54:6770. The pharmacokinetics of cisplatin instilled into the pleural cavity in patients with malignant pleurisy due to lung cancer were studied. Higher concentrations of total and free platinum in pleural effusion have been maintained for longer than 72 hours in patients who were subjected to panpleumpoeumooectomy than in those who received simple drainage. Early rapid drop of total platinum within 6 hours was significant in the drainage group. Total platinum level in the serum of the panpleumpneumonectomy gmup gradually increased during l-72 hours, however, that of the drainage gmup was highest at 1 hour after instillatiooanddecli graduallywith time. Fmeplatinuminthes was also present at lowerconcentratioosin the panpleumpneumonectomy gmup than in the drainage group. These facts may be ascribed to the absorptive activity of parietal pleura which is present in the drainage group but absent in the panpleumpoeumooectomy group. In summary, removal of the pa&al pleura by panpleumpoeumooectomy could cause cisplatin to be oot only more active but also leas toxic in patients with malignant pleurisy due to lung cancer.
Bone marrow haemosiderin iron and serum iron status markers in small cell carcinoma of the lung Milman N, Mellemgaard A, Hansen SH, Dombemowsky P. Department of Pulmonary Medicine, Gentoje Hospital, DK-2900 Hellerup. Int J Oncol 1993;3:29-32. Bone marrow haemosiderin iron grade and serum (S-) imo status markers (haemoglobin (Hb), S-iron, S-transfer&, transferrin saturation, S-fenitin) were measured in 3 1 patients with newly discovered small cell cancer of the lung (SCCL), and compared to the values in 53 healthy control subjects. Among SCCL patients, 2 had grade 0 (absent), 5 grade (1+)(trace),8gradel+(oormal),and16grade2+(increased)marmw haemosiderin imo. Median S- ferritin values in the respective groups were 38 g/l, 243 g/l, 384 g/l and 433 g/l. There was oo correlation betweeo Hb, S-iron, S-transferrin or transferrin saturation and marrow iron grade. S-ferritio displayed a correlation with marrow iron grade (r(s) = 0.40, p <0.05) but them was marked overlap between the groups. Amoogthecootmls, ShadgradeO, 11 grade(l+), and37grade 1+ marrow imo. Median S-fenitin values in the respective groups were 14 g/l, 26 g/l and 57 g/l. Hb, S-iron, S- transferrin, transferrin
123-150
saturation and S-ferritin were all significantly correlated to marrow imo grade; S-ferritin, r(s) = 0.64, p
Monoclonal antibody KP16D3 as a prognostic marker in stage I lung adenocarcinoma Suehim T, Ishida T, Sugio K, Sugimachi K, Sueishi K. Department of Surgery II, Faculty of Medicine, Kyushu University 60,3-l-l Maidashi. HigaFhi-ku, Fukwka 812. J Surg Oncol 1993;54:51-6. MoooclonalantibodyKP16D3recognizesa60~pmteinessociated with mu&-noopmducing papillary adenocarcinoma, especially that originating from nonciliated bmnchiolar epithelial cells of the lung. We immunohistochemically examined 56 primary lung adeoocarcinomas using the monoclonal antibody KP16D3. Of them tumors, 31 (55%) were positive for KP16D3 immunoreactivity. The disease-free survival rates showed no statistical differences behueen KPl6Dfpositive and KP16D3-negative patients. However, in stage I and TI di-, the dimas&reesurvivalratcsofKP16D3-positivepatimtswerestatistically lower than those of KP16D3- negative patients (P C 0.05). These findings suggest that KP16D3 may be useful as a prognostic marker for patients with stage I primary lung adenocarcinoma. Conversely, use of thismarkerandsubtypingoflungadenocarcinomasreflectthepmgnosis of the disease.
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer GabazzaEC, Taguchi 0, Yamakami T, Ma&i&i M, Ibata H, Suxuki S. Me University School of Medicine, 514 Eiobashi, Mie Prefecture, Tsu-city. Cancer 1993;72:2134-40. Background. Coagulopathies often are associated with malignant tumors. The pathogen&s of them complications in cancer is not clear. Host inflammatory (]monocyte/macmphage) cell-mediated triggering ofclottingactivationhasbeensuggeated. Methouk. Theobjectiveofthis study was to evaluate the role of neutmphilderived elastase in the activation of blood coagulation and fibrinolysis in lung cancer. The study population was 42 consecutive patients with lung cancer (34 men and 8 women). Thirtmo patients had small cell lung cancer (SCLC), 13 had squamouscell lung cancer, and 16 had adenocarcinoma. Hemostatic timctioo was assessed by measuring D-dimer (DD), thrombinantithrombin III complex (TAT), plasminur-antiplasmin complex (PAP), fibrin degradation product (FDP), fibrinogen, prothmmbin time (PT) and activated partial thmmboplastin time (APIT). Elastasea,protease inhibitor (EPI) complex was measured as a marker of oeutmphiI activation. Redts. Significant elevation of the elastase plasma levels and coagulation-tibrinolysis parameters was found in patieotswith cancer compared with cootml subjects. Among all patients, the plasma concentration of EPI was significantly correlated with APTT, DD, TAT, PAP, and fibrinogen. Although in patients with ooosmall cell lung cancer (non-SCLC), DD, TAT, PAP, APTI’, and fibrinogen were significantly correlated with EPI, such a correlation was not found in patients with SCLC. Patients with non-SCLC had stronger correlation of EPI with TAT, PAP, and PT than did patients with advanced stages of disease. Conclusion. The activation of coagulation-fibrinolysis system in lung cancer may be triggered, at least in part, by an increased release of oeutmphil elastase. This mechanism is stage related and seems to operate predominantly in ooo-SCLC.
Abstracts /Lung
Cancer 11 (1994)
Endobronchial metastasis Heitmiller RF, Marmco WJ, H~batt RI-I, Marsh BR. O&r 624, JO/VU Hopkins Hospital, 600 N. Wolf Street, Baltimore, MD 21205. J Thorac Cardiovasc Surg 1993;106:537-42. Endobmochial metastasm from ooopulmooary oeoplasms are rare. Sioce 1971, we have treated 23 patients with endobroochial metastases, the findings for which form the basis of this article. Many types of primary tumors are capable of eodobmochial metastases, although breast, colon, and renal carcinomas predominate. The mean time fmm thediagnosisoftheprimarycarcinomatothediagnosisofeodobmochial metastases was 59.9 months. Bmochoscopic results were diagnostic in all cases. Although the mean time for the appearance of endobmochial metastasea is almost 5 yeara, ooexaminatioo the majority ofpatients will have symptomatic extrabmochial metastatic disease, the quality of their survival will oReo be poor, and their survival time will be limited (12.5 months). Surgicalresectionshouldbeconfined topatientswithlocalixed disease.
Pharmacokinetics of cisplatin instilled into the pleural cavity following panpleuropneumonectomy in patients with malignant pleurisy due to lung amcer Yasumoto K, Shimokawa T, Nagashima A, Himse N, Nakahashi H. Department of Chest Surgery. Kita&shu Medical Center, Barhaku 2I-l, Kokura-kita-ku, Kitakywhu. Fukuoka&I2. J SurgOncol1993;54:6770. The pharmacokinetics of cisplatin instilled into the pleural cavity in patients with malignant pleurisy due to lung cancer were studied. Higher concentrations of total and free platinum in pleural effusion have been maintained for longer than 72 hours in patients who were subjected to panpleumpoeumooectomy than in those who received simple drainage. Early rapid drop of total platinum within 6 hours was significant in the drainage group. Total platinum level in the serum of the panpleumpneumonectomy gmup gradually increased during l-72 hours, however, that of the drainage gmup was highest at 1 hour after instillatiooanddecli graduallywith time. Fmeplatinuminthes was also present at lowerconcentratioosin the panpleumpneumonectomy gmup than in the drainage group. These facts may be ascribed to the absorptive activity of parietal pleura which is present in the drainage group but absent in the panpleumpoeumooectomy group. In summary, removal of the pa&al pleura by panpleumpoeumooectomy could cause cisplatin to be oot only more active but also leas toxic in patients with malignant pleurisy due to lung cancer.
Bone marrow haemosiderin iron and serum iron status markers in small cell carcinoma of the lung Milman N, Mellemgaard A, Hansen SH, Dombemowsky P. Department of Pulmonary Medicine, Gentoje Hospital, DK-2900 Hellerup. Int J Oncol 1993;3:29-32. Bone marrow haemosiderin iron grade and serum (S-) imo status markers (haemoglobin (Hb), S-iron, S-transfer&, transferrin saturation, S-fenitin) were measured in 3 1 patients with newly discovered small cell cancer of the lung (SCCL), and compared to the values in 53 healthy control subjects. Among SCCL patients, 2 had grade 0 (absent), 5 grade (1+)(trace),8gradel+(oormal),and16grade2+(increased)marmw haemosiderin imo. Median S- ferritin values in the respective groups were 38 g/l, 243 g/l, 384 g/l and 433 g/l. There was oo correlation betweeo Hb, S-iron, S-transferrin or transferrin saturation and marrow iron grade. S-ferritio displayed a correlation with marrow iron grade (r(s) = 0.40, p <0.05) but them was marked overlap between the groups. Amoogthecootmls, ShadgradeO, 11 grade(l+), and37grade 1+ marrow imo. Median S-fenitin values in the respective groups were 14 g/l, 26 g/l and 57 g/l. Hb, S-iron, S- transferrin, transferrin
123-150
saturation and S-ferritin were all significantly correlated to marrow imo grade; S-ferritin, r(s) = 0.64, p
Monoclonal antibody KP16D3 as a prognostic marker in stage I lung adenocarcinoma Suehim T, Ishida T, Sugio K, Sugimachi K, Sueishi K. Department of Surgery II, Faculty of Medicine, Kyushu University 60,3-l-l Maidashi. HigaFhi-ku, Fukwka 812. J Surg Oncol 1993;54:51-6. MoooclonalantibodyKP16D3recognizesa60~pmteinessociated with mu&-noopmducing papillary adenocarcinoma, especially that originating from nonciliated bmnchiolar epithelial cells of the lung. We immunohistochemically examined 56 primary lung adeoocarcinomas using the monoclonal antibody KP16D3. Of them tumors, 31 (55%) were positive for KP16D3 immunoreactivity. The disease-free survival rates showed no statistical differences behueen KPl6Dfpositive and KP16D3-negative patients. However, in stage I and TI di-, the dimas&reesurvivalratcsofKP16D3-positivepatimtswerestatistically lower than those of KP16D3- negative patients (P C 0.05). These findings suggest that KP16D3 may be useful as a prognostic marker for patients with stage I primary lung adenocarcinoma. Conversely, use of thismarkerandsubtypingoflungadenocarcinomasreflectthepmgnosis of the disease.
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer GabazzaEC, Taguchi 0, Yamakami T, Ma&i&i M, Ibata H, Suxuki S. Me University School of Medicine, 514 Eiobashi, Mie Prefecture, Tsu-city. Cancer 1993;72:2134-40. Background. Coagulopathies often are associated with malignant tumors. The pathogen&s of them complications in cancer is not clear. Host inflammatory (]monocyte/macmphage) cell-mediated triggering ofclottingactivationhasbeensuggeated. Methouk. Theobjectiveofthis study was to evaluate the role of neutmphilderived elastase in the activation of blood coagulation and fibrinolysis in lung cancer. The study population was 42 consecutive patients with lung cancer (34 men and 8 women). Thirtmo patients had small cell lung cancer (SCLC), 13 had squamouscell lung cancer, and 16 had adenocarcinoma. Hemostatic timctioo was assessed by measuring D-dimer (DD), thrombinantithrombin III complex (TAT), plasminur-antiplasmin complex (PAP), fibrin degradation product (FDP), fibrinogen, prothmmbin time (PT) and activated partial thmmboplastin time (APIT). Elastasea,protease inhibitor (EPI) complex was measured as a marker of oeutmphiI activation. Redts. Significant elevation of the elastase plasma levels and coagulation-tibrinolysis parameters was found in patieotswith cancer compared with cootml subjects. Among all patients, the plasma concentration of EPI was significantly correlated with APTT, DD, TAT, PAP, and fibrinogen. Although in patients with ooosmall cell lung cancer (non-SCLC), DD, TAT, PAP, APTI’, and fibrinogen were significantly correlated with EPI, such a correlation was not found in patients with SCLC. Patients with non-SCLC had stronger correlation of EPI with TAT, PAP, and PT than did patients with advanced stages of disease. Conclusion. The activation of coagulation-fibrinolysis system in lung cancer may be triggered, at least in part, by an increased release of oeutmphil elastase. This mechanism is stage related and seems to operate predominantly in ooo-SCLC.