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Correlation of Laboratory Data for Renal Function in Newly Diagnosed Multiple Myeloma
Annals of Oncology 25 (Supplement 5): v75–v109, 2014 doi:10.1093/annonc/mdu436.37
Poster Session (Poster presentations categorized by each organ) P1
19
3
Kazuhito Suzuki1, Shingo Yano1, Takaki Shimada1, Shinobu Takahara1, Kinuyo Kasama1,2, Tomohito Machishima1, Yumiko Inui1, Masaharu Kawashima1, Noriko Usui1,2, Keisuke Aiba1 1 Department of Clinical Oncology/ Hematology, The Jikei University School of Medicine 2 Department of Transfusion Medicine, The Jikei University School of Medicine
abstracts
Background: Renal insufficiency is one of symptoms for diagnosis of newly diagnosed active multiple myeloma. Serum creatinine (Cr) level or estimated glomerular filtration rate (eGFR) has been used in CRAB criteria. However, Cr is affected by several factors, such as gender, age, and muscle mass. eGFR, clearance of creatinine by timed urine
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_5/v83/2240470 by guest on 24 October 2019
CORRELATION OF LABORATORY DATA FOR RENAL FUNCTION IN NEWLY DIAGNOSED MULTIPLE MYELOMA
collection (24hr-CCr), and clearance of creatinine by Cockcroft and Gault model (CCr by Cockcroft-Gault) might show accurate renal function. Methods: We retrospectively analyzed 84 patients newly diagnosed with multiple myeloma in our institute. We evaluated the correlation among Cr, eGFR, 24hr CCr, CCr by Cockcroft Gault, and several factors by Pearsons product moment correlation method. Comparison between renal function of male and female was analyzed by t-test. eGFR was evaluated by the criteria of Modification of Diet in Renal Disease (MDRD). Results: Median age of the patients was 65 years old. The number of male and female patients was 45 and 39, respectively. The median levels of Cr, eGFR, 24hr-CCr, and CCr by Cockcroft Gault were 0.9 mg/dL (range, 0.4-8.9), 55 mL/min (range, 5-107), 84 mL/min (range, 12-107), and 64.2 mL/min (range, 5.6-115.3), respectively. The average level of Cr and eGFR in male was higher than female, significantly ( p = .005, and .002). The average level of 24hr-CCr and CCr by Cockcroft-Gault were similar in male and female ( p = .755, and .862). There was strong correlation between eGFR and CCr by Cockcroft and Gault (r = .863) and 24hr-CCr and CCr by Cockcroft and Gault (r = .745). There was moderate correlation between eGFR and 24hr-CCr (r. = 671), Cr and CCr by Cockcroft and Gault (r = -.621), Cr and eGFR (r = -.603), and Cr and 24hr-CCr (r = -.505). Conclusions: The average level of Cr and eGFR differed by gender. CCr by Cockcroft-Gault was strongly correlated with eGFR and 24hr-CCr. eGFR and CCr by Cockcroft-Gault might be reasonable in myeloma patients.
© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].
Poster Session (Poster presentations categorized by each organ) P1
19
3
Kazuhito Suzuki1, Shingo Yano1, Takaki Shimada1, Shinobu Takahara1, Kinuyo Kasama1,2, Tomohito Machishima1, Yumiko Inui1, Masaharu Kawashima1, Noriko Usui1,2, Keisuke Aiba1 1 Department of Clinical Oncology/ Hematology, The Jikei University School of Medicine 2 Department of Transfusion Medicine, The Jikei University School of Medicine
abstracts
Background: Renal insufficiency is one of symptoms for diagnosis of newly diagnosed active multiple myeloma. Serum creatinine (Cr) level or estimated glomerular filtration rate (eGFR) has been used in CRAB criteria. However, Cr is affected by several factors, such as gender, age, and muscle mass. eGFR, clearance of creatinine by timed urine
Downloaded from https://academic.oup.com/annonc/article-abstract/25/suppl_5/v83/2240470 by guest on 24 October 2019
CORRELATION OF LABORATORY DATA FOR RENAL FUNCTION IN NEWLY DIAGNOSED MULTIPLE MYELOMA
collection (24hr-CCr), and clearance of creatinine by Cockcroft and Gault model (CCr by Cockcroft-Gault) might show accurate renal function. Methods: We retrospectively analyzed 84 patients newly diagnosed with multiple myeloma in our institute. We evaluated the correlation among Cr, eGFR, 24hr CCr, CCr by Cockcroft Gault, and several factors by Pearsons product moment correlation method. Comparison between renal function of male and female was analyzed by t-test. eGFR was evaluated by the criteria of Modification of Diet in Renal Disease (MDRD). Results: Median age of the patients was 65 years old. The number of male and female patients was 45 and 39, respectively. The median levels of Cr, eGFR, 24hr-CCr, and CCr by Cockcroft Gault were 0.9 mg/dL (range, 0.4-8.9), 55 mL/min (range, 5-107), 84 mL/min (range, 12-107), and 64.2 mL/min (range, 5.6-115.3), respectively. The average level of Cr and eGFR in male was higher than female, significantly ( p = .005, and .002). The average level of 24hr-CCr and CCr by Cockcroft-Gault were similar in male and female ( p = .755, and .862). There was strong correlation between eGFR and CCr by Cockcroft and Gault (r = .863) and 24hr-CCr and CCr by Cockcroft and Gault (r = .745). There was moderate correlation between eGFR and 24hr-CCr (r. = 671), Cr and CCr by Cockcroft and Gault (r = -.621), Cr and eGFR (r = -.603), and Cr and 24hr-CCr (r = -.505). Conclusions: The average level of Cr and eGFR differed by gender. CCr by Cockcroft-Gault was strongly correlated with eGFR and 24hr-CCr. eGFR and CCr by Cockcroft-Gault might be reasonable in myeloma patients.
© The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: [email protected].