Corrigendum to “Structure–activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors” [Bioorg. Med. Chem. Lett. 13 (2003) 4085]

Bioorganic & Medicinal Chemistry Letters 14 (2004) 1817

Corrigendum

Corrigendum to ‘‘Structure–activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors’’ [Bioorg. Med. Chem. Lett. 13 (2003) 4085]§ Hidekazu Masaki,a,* Yusuke Mizuno,a Akira Tatui,b Akira Murakami,b Yuuki Koide,a Shoji Satoha and Atsuo Takahashia a

Drug Research Department, Tokyo Research Laboratories, TOA EIYO Ltd., 2-293-3 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama 330-0834, Japan b Drug Research Department, Fukushima Research Laboratories, TOA EIYO Ltd., 1 Tanaka, Yuno, Iizaka-cho, Fukushima-shi, Fukushima 960-0280, Japan

The authors regret that the general structure in Table 1 was not shown in the above article. The full table appears below. Table 1. Effect of substitution on the benzo[b]thiophene ring and N-phenyl ring

Compd 1 8 9 10 11 12 13 14 15 16 17 18 19 7 a b

X

R1

R2

R3

IC50 (nM)a Human chymase

Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Cl Me H F

H H H H H NO2 OMe CO2Me SO2Me H SO2Me SO2Me SO2Me SO2Me

SO2(CH2)2CH3 S(CH2)2CH3 CN NO2 CO2Me CO2Me CO2Me CO2Me CO2Me CO2Me CO2Me CO2Me CO2Me CO2Me

H H H H H H H H H CO2Me Me H H H

10,600 NIb NI NI 1647 880 663 NI 203 4208 594 325 305 56

Values are means of three experiments. No inhibition at 10 mM.

§

DOI of original article: 10.1016/j.bmcl.2003.08.040 * Corresponding author. Tel.: +81-48-647-7971; fax: +81-48-648-0078; e-mail: [email protected]

0960-894X/$ - see front matter # 2003 Elsevier Ltd. All rights reserved. doi:10.1016/j.bmcl.2004.01.046