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V O L U M E 1 2 1 , N O. 1 JANUARY 2008

ISSN 0091-6749

www.jacionline.org

T HE J OURNAL

OF

Allergy Clinical Immunology AND

OFFICIAL JOURNAL OF

CLINICAL REVIEWS Targeting TNF-α: A novel therapeutic approach for asthma

EDITORIALS The Journal: Adapting to change, positioning ourselves for the future

MECHANISMS OF ALLERGIC DISEASE B cell–directed therapies for autoimmune disease and correlates of disease response and relapse

Involvement of eosinophils in the onset of asthma