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Cranio-facial characteristics of pycnodysostosis: case report
OOOO Volume 114, Number 4 Rho GTPases regulate various biological processes, such as tumorigenesis. This study aimed to evaluate the distribution of Rho GTPases in oral squamous cell carcinoma (OSCC). Immunohistochemistry by avidin-biotin-peroxidase was performed for RhoA, Cdc42 and Rac1, also intensity of stain quantified in 81 cases of OSCC (classified according to World Health Organization: well differentiated, moderately differentiated and poorly differentiated). The expression pattern of RhoA varied in direct proportion to tumor differentiation (p ⬍0.0001), suggesting their involvement in the regulation of differentiation. The less differentiated the lesion and the greater the potential for proliferation increased expression of Cdc42 (p ⬍0.0001), suggesting their involvement in regulation of cell proliferation. Cells expressed Rac1 at the migratory front, indicating its involvement in the regulation of cell migration. The expression of RhoA, Cdc42 and Rac1 suggests that Rho GTPases may participate in signal transduction pathways regulating biological processes involved in the pathogenesis of OSCC.
HODGKIN’S LYMPHOMA DIAGNOSED IN A YOUNG PATIENT UNDERGOING ROUTINE DENTAL CARE Sena-Filho M1, Fonseca FP1, Correa MB2, Mariano FV3, Jorge J4, Vargas PA4, Santos-Silva AR4 - 1FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA / DOUTORANDO, 2HOSPITAL DOS FORNECEDORES DE CANA DE PIRACICABA - CIRURGIÃO DE CABEÇA E PESCOÇO, 3FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA, 4FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA / PROFESSOR ASSOCIADO The purpose of this presentation is to report the case of a 17-year-old female patient who was undergoing routine dental care in our Dental School when two fixed and hard on palpation neck swellings, ranging from 3 to 5 cm in diameter, affecting the left cervical region were noticed by an undergraduate student. The patient was referred to our Oral Medicine Clinic where further examination included ultrasonography, which revealed a deep conglomerate of enlarged lymph nodes, and a fine needle aspiration cytology (FNAC), which suggested the diagnosis of lymphoma. An incisional biopsy was performed, confirming the diagnosis of Hodgkin’s Lymphoma (further immunohistochemical studies demonstrated positivity for LCA, CD20, MUM1, CD30 and Ki-67). The patient was referred for medical treatment and is currently alive and free of the disease. The current case highlights the importance of systematic head and neck examinations during routine dental treatment.
CRANIO-FACIAL CHARACTERISTICS OF PYCNODYSOSTOSIS: CASE REPORT Vilela MCN1, Carvalhaes CLL2, Kitamura KT2, Gallottini MHC2, Rezende NPM2 - 1FACULDADE DE ODONTOLOGIA DA UNIVERSIDADE DE SÃO PAULO, 2FACULDADE DE ODONTOLOGIA DA UNIVERSIDADE SÃO PAULO Pycnodysostosis was described in 1962 by Maroteaux and Lamy. It is a rare skeletal disease caused by a genetic autosomal recessive inheritance, with no predilection for sex, and related to consanguineous families in 30% of cases. It is characterized by
ORAL ABSTRACTS Abstracts e95 short stature, osteosclerosis with multiple fractures, mandibular hypoplasia, obtuse mandibular angle, delayed closure of cranial sutures, abnormal tooth formation, dysplasia of clavicles and aplasia of terminal phalanges. Case report: Patient RPN, male, 12 years old, with pycnodysostosis, attended the Special Care Dentistry Center complaining of difficulties in chewing. On extraoral physical examination we observed short stature, aplasia of the terminal phalanges, macrocephaly with prominent frontal bossing and brachycephaly. On intra oral examination, we observed: anterior and posterior cross bite and mouth opening limitation. CT imaging with 3D reconstruction showed hypoplasia of the maxilla and mandible with obtuse mandibular angle and crowed tooth. The treatment plan included a rapid maxillary expansion for correction of posterior crossbite and a face mask for the correction of the anterior cross bite.
ASSESSMENT OF RISK FACTORS FOR THE OCCURRENCE OF ORAL LESIONS IN HIV-POSITIVE ADULTS FROM PORTO ALEGRE, BRAZIL Petruzzi MNMR1, Salum FG2, Cherubini K2, Figueiredo MAZ2 - 1PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL (PUCRS) - POSTGRADUATE PROGRAM IN DENTISTRY, 2 PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL (PUCRS) - ORAL MEDICINE UNIT, SÃO LUCAS HOSPITAL Objective: To assess the risk factors for oral manifestations occurrence in HIV-positive adults. Study design: A retrospective and descriptive-analytical survey was conducted in 534 medical/dental records. Sociodemographical, clinical and laboratory data were collected from 6 month before and after the onset of oral lesions. Definitive diagnosed pathologies were included and classified according to the criteria of ECC on Oral Problems Related to HIV infection. Cross-tabulations, Chi-squared tests and logistic regression models were conveniently applied. Results: A higher risk for oral candidiasis was associated to the female gender (OR⫽0.66; CI⫽0.45-0.96; p⫽0.031), alcohol use (OR⫽2.38; CI⫽1.22-4.67; p⫽0.011) and CD4⫹⬍350cells/ mm3 (OR⫽3.82; CI⫽2.16-6.77; p⬍0.001). Hairy leukoplakia was associated to CD4⫹⬍350cells/mm3 (OR⫽8.48; CI⫽1.1065.54; p⫽0.040), viral load⬎5000copies/mm3 (OR⫽8.02; CI⫽2.04-31.52; p⫽0.003) and smoking (OR⫽2.85; CI⫽1.385.88; p⫽0.005). Conclusion: Oral lesions strongly associated to HIV tended to occur in patients with low CD4⫹counts and detectable viral loads, females, smokers and alcohol users, independently of the use of antiretroviral therapy.
RECURRENT ADENOID CYSTIC CARCINOMA OF MAXILLARY SINUS Carvalho MV1, Fonseca FP1, Correa MB1, Silva ARS1, Vargas PA1, Almeida OP1, Lopes MA1 - 1PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS - ORAL DIAGNOSIS Adenoid cystic carcinoma (ACC) is an unusual tumor of maxillary sinus. A 56-year-old woman was referred with 4-month history of a non-ulcerated and painful nodule on the palate impairing fit of the upper complete denture. Computed tomography showed a mass in the maxillary sinus. An incisional biopsy was performed and histopathological diagnosis was adenocarcinoma. The patient was referred to head and neck surgeon who performed a surgical resection followed by radiotherapy. The
HODGKIN’S LYMPHOMA DIAGNOSED IN A YOUNG PATIENT UNDERGOING ROUTINE DENTAL CARE Sena-Filho M1, Fonseca FP1, Correa MB2, Mariano FV3, Jorge J4, Vargas PA4, Santos-Silva AR4 - 1FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA / DOUTORANDO, 2HOSPITAL DOS FORNECEDORES DE CANA DE PIRACICABA - CIRURGIÃO DE CABEÇA E PESCOÇO, 3FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA, 4FACULDADE DE ODONTOLOGIA DE PIRACICABA / UNIVERSIDADE ESTADUAL DE CAMPINAS - ESTOMATOPATOLOGIA / PROFESSOR ASSOCIADO The purpose of this presentation is to report the case of a 17-year-old female patient who was undergoing routine dental care in our Dental School when two fixed and hard on palpation neck swellings, ranging from 3 to 5 cm in diameter, affecting the left cervical region were noticed by an undergraduate student. The patient was referred to our Oral Medicine Clinic where further examination included ultrasonography, which revealed a deep conglomerate of enlarged lymph nodes, and a fine needle aspiration cytology (FNAC), which suggested the diagnosis of lymphoma. An incisional biopsy was performed, confirming the diagnosis of Hodgkin’s Lymphoma (further immunohistochemical studies demonstrated positivity for LCA, CD20, MUM1, CD30 and Ki-67). The patient was referred for medical treatment and is currently alive and free of the disease. The current case highlights the importance of systematic head and neck examinations during routine dental treatment.
CRANIO-FACIAL CHARACTERISTICS OF PYCNODYSOSTOSIS: CASE REPORT Vilela MCN1, Carvalhaes CLL2, Kitamura KT2, Gallottini MHC2, Rezende NPM2 - 1FACULDADE DE ODONTOLOGIA DA UNIVERSIDADE DE SÃO PAULO, 2FACULDADE DE ODONTOLOGIA DA UNIVERSIDADE SÃO PAULO Pycnodysostosis was described in 1962 by Maroteaux and Lamy. It is a rare skeletal disease caused by a genetic autosomal recessive inheritance, with no predilection for sex, and related to consanguineous families in 30% of cases. It is characterized by
ORAL ABSTRACTS Abstracts e95 short stature, osteosclerosis with multiple fractures, mandibular hypoplasia, obtuse mandibular angle, delayed closure of cranial sutures, abnormal tooth formation, dysplasia of clavicles and aplasia of terminal phalanges. Case report: Patient RPN, male, 12 years old, with pycnodysostosis, attended the Special Care Dentistry Center complaining of difficulties in chewing. On extraoral physical examination we observed short stature, aplasia of the terminal phalanges, macrocephaly with prominent frontal bossing and brachycephaly. On intra oral examination, we observed: anterior and posterior cross bite and mouth opening limitation. CT imaging with 3D reconstruction showed hypoplasia of the maxilla and mandible with obtuse mandibular angle and crowed tooth. The treatment plan included a rapid maxillary expansion for correction of posterior crossbite and a face mask for the correction of the anterior cross bite.
ASSESSMENT OF RISK FACTORS FOR THE OCCURRENCE OF ORAL LESIONS IN HIV-POSITIVE ADULTS FROM PORTO ALEGRE, BRAZIL Petruzzi MNMR1, Salum FG2, Cherubini K2, Figueiredo MAZ2 - 1PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL (PUCRS) - POSTGRADUATE PROGRAM IN DENTISTRY, 2 PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL (PUCRS) - ORAL MEDICINE UNIT, SÃO LUCAS HOSPITAL Objective: To assess the risk factors for oral manifestations occurrence in HIV-positive adults. Study design: A retrospective and descriptive-analytical survey was conducted in 534 medical/dental records. Sociodemographical, clinical and laboratory data were collected from 6 month before and after the onset of oral lesions. Definitive diagnosed pathologies were included and classified according to the criteria of ECC on Oral Problems Related to HIV infection. Cross-tabulations, Chi-squared tests and logistic regression models were conveniently applied. Results: A higher risk for oral candidiasis was associated to the female gender (OR⫽0.66; CI⫽0.45-0.96; p⫽0.031), alcohol use (OR⫽2.38; CI⫽1.22-4.67; p⫽0.011) and CD4⫹⬍350cells/ mm3 (OR⫽3.82; CI⫽2.16-6.77; p⬍0.001). Hairy leukoplakia was associated to CD4⫹⬍350cells/mm3 (OR⫽8.48; CI⫽1.1065.54; p⫽0.040), viral load⬎5000copies/mm3 (OR⫽8.02; CI⫽2.04-31.52; p⫽0.003) and smoking (OR⫽2.85; CI⫽1.385.88; p⫽0.005). Conclusion: Oral lesions strongly associated to HIV tended to occur in patients with low CD4⫹counts and detectable viral loads, females, smokers and alcohol users, independently of the use of antiretroviral therapy.
RECURRENT ADENOID CYSTIC CARCINOMA OF MAXILLARY SINUS Carvalho MV1, Fonseca FP1, Correa MB1, Silva ARS1, Vargas PA1, Almeida OP1, Lopes MA1 - 1PIRACICABA DENTAL SCHOOL, UNIVERSITY OF CAMPINAS - ORAL DIAGNOSIS Adenoid cystic carcinoma (ACC) is an unusual tumor of maxillary sinus. A 56-year-old woman was referred with 4-month history of a non-ulcerated and painful nodule on the palate impairing fit of the upper complete denture. Computed tomography showed a mass in the maxillary sinus. An incisional biopsy was performed and histopathological diagnosis was adenocarcinoma. The patient was referred to head and neck surgeon who performed a surgical resection followed by radiotherapy. The