1001 mixed with many other oxidation products of glucose, Thannhauser and Jenke some of which are toxic. treated cases of severe diabetes with the commercial product, and found that it cleared up the urine from sugar and acetone bodies, but its use could not be continued because of gastro-intestinal complications. Pure glucosone, made by Fischer’s method, does not appear to give rise to any bad effects beyond those immediately produced from an overdose, but this method of preparation is costly and complicated. Only small quantities of the pure substance have been hitherto available, and for that reason the experiments recorded by Dr. Hynd have been carried out on mice. Rats and rabbits, however, show the same effects on administration of an overdose, and the symptoms are remarkably similar to those which follow an overdose of insulin. Hitherto there have been many attempts to find a substitute for insulin, but few have been directed to ascertaining what form of carbohydrate other than glycogen results from the action of insulin upon glucose. If it can be established that glucosone is an important intermediate its importance is obvious. T
am.
c4ir-
yours
THE
CREAM IN INFANT FEEDING. To the Editor of THE LANCET.
SIR,—Dr. R. C. Jewesbury, in the concluding paragraph of his letter, asks for information on the point " whether fat is needed rather for its vitamin ’, content than for its food value," and adds, until’, we are better informed surely we must believe that it "
Imperial Cancer Research Fund, Queen-square, W.C., May 2nd, 1927.
BROMSULPHALEIN. To the Editor
of THE LANCET.
SIR,—Dr. Varrier-Jones has misunderstood the purpose of my letter. My meaning would, perhaps, have been clearer if my remarks had been entitled The Penalisation of the Notified." I do not know anything about the gentleman who was refused a post in a sanatorium because he had been treated for tuberculosis, further than was to be gleaned from M.O’s" letter in your issue of March 19th, but I gathered that he had been advised to be treated for this affection and had made a good recovery. It does not always follow that when a patient in the early and curable stage of the disease is advised to be treated in a sanatorium that this advice is taken ; the patient concerned preferring to take the risk of getting better as best he may, and if this should happen, having avoided notification, or at least publicity, will suffer no disabilities, but will be regarded as an ordinary citizen. To illustrate what I mean, I may say that some years ago my advice was asked as to what had better be done with a young police-constable who was suffering from haemoptysis ; who, by the way, had also tubercle I replied that he should be bacilli in his sputum. sent to the sanatorium at once as no one was justified in risking this man’s life because he might lose his job if he admitted that he was suffering from tuberculosis, but I pointed out that in my opinion there was no reason why he should not be reinstated if he made a good recovery ; this course was followed and after an uneventful recovery taking five months, he was taken back into the force, having lost his tubercle bacilli, and has been doing duty ever since. My letter was in no way concerned with the wellknown fact that many cases of chronic disease can be kept alive and working for many years if their surroundings are favourable ; indeed, there are thousands of chronic cases of tuberculosis carrying on their ordinary avocations, suffering from tuberculosis often in complete ignorance as to the nature of the disease from which they are suffering. A sanatorium should not, however, be concerned with these cases, but should spend its time in preventing the formation of persons chronically ill, but in order that this may happen it is necessary that the public should be well assured that no penalties shall follow when they elect to make a proper effort towards recovery instead of hiding the nature of their illness lest a worse fate befall them. It is obvious that no question of continuing work during treatment will arise in such cases. I am, Sir, yours faithfully, ERADICATION. April 21st, 1927. "
P. T. HERRING. The St. Andrews, University, Department. Physiology April 27th. 1927.
W. CRAMER.
To the Editor
"
faithfully.
is of value from both these points of view." All the available evidence goes to show that fats, apart from their high caloric value, have no specific food value, such as carbohydrates, for instance, possess by virtue of their so-called " protein-sparing action," and that no advantage is derived from a high intake of fat. On the contrary, the experimental work of Colonel R. McCarrisonindicates that a high intake of fat may have an unfavourable effect on the function of the thyroid gland, unless it is corrected by a corresponding increased intake of iodine. I am, Sir, yours faithfully,
PENALISATION OF THE TUBERCULOUS.
,
of THE LANCET. SIR,-Dr. Rosenthal’s surprise at my results was no greater than my own disappointment. He himself THE TITLE OF DOCTOR.—By a judgment of Mr. explains the reason that great difficulties existed in Justice Middleton, osteopaths and manipulative surgeons the manufacture of the dye, and Mr. W. Martindale- in the province of Ontario are debarred from using the " local chemist "-prepared a substance differing prefix " doctor " as an occupational designation. Under the m very slight degree from the original prepared by the Ontario Medical Act the use of the term doctor " is forbidden to all "
Dr. E. C. White. As there
are, however, grave doubts as to whether this substance behaves in a similar way to White’s preparation I am reinvestigating the whole matter with bromsulphalein kindly supplied to me gratuitously by Dr. White and by Messrs. Bynson, W’estcott, and Dunning, of Baltimore. If I have been led into erroneous conclusions I shall take the first opportunity of contradicting them, but at the present time I am keeping an open mind upon the subject. In conclusion, I may add that I have been in tominunication with Dr. White about the chemistry of these dyes, and his letter threw the first doubts Upon the dye which I had used. T
am
Sir.
yours
faithfnHv
ERNEST BULMER, Birmingham, April 15th,
M.D., M.R.C.P.
1927.
1 Brit. Med. Jour., 1924, i., 989.
except registered physicians.
On HOSPITAL. last NOTTINGHAM Saturday Princess Mary opened the new out-patients’ department of lot,tingham (ieneral Hospital and an extension of the Children’s Hospital. The ground floor of the out-patients’ wing of the General Hospital includes four blocks of consulting rooms, dressing rooms, and examination rooms. The upper floor consists of a complete nose, ear, and throat hospital with 40 beds, an operating theatre and other adjuncts ; the basement contains a fully-equipped department for radiography, ultra-violet ray and therapeutic treatment, and a complete orthopedic department, with a gymnasium. The extension has cost close upon £100,000, of which Mr. W. Gr. Player has given £50,000. The Children’s Hospital has been so much enlarged and improved that it is virtually a new building, connected by a corridor with the original, which is eventually to become a nurses’ home. There are 78beds in six wards, ample provision is made for open-air treatment, and there are playgrounds on the roof. Mr. John Player has given £40,000 towards the cost. -