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CSF HVA concentrations in schizotypal and other personality disorders
Affective Personality Disorders
BIOL PSYCHIATRY | 99 | ;29:43A- | 85A
137A
AFFECTIVE PERSONALITY DISORDERS F r i d a y , M a y 10, 1 : 0 0 - 6 : 0 0 I'M
Ponchartrain A
202 EVENT RELATED POTENTIALS IN SCHIZOTYPAL PERSONALITY DISORDER AND SCHIZOPHRENIA Oren Kalus, M.D., Thomas B. Horvath, M.D.. Ann Peterson, M.A., Emil F. Coccaro, M.D., Vivian Mitropou!ou, M.A., Michael Davidson, M.D., Kenneth L. Davis, M.D., Larry J. Siever, M.D. Mount Sinai School of Mea~cine and Veterans Affairs Medical Center, New York, NY I0029. Auditory event related cortical potentials (ERP) were compared in patients with sch~zop~nia ~SZ; in = 20), schizoid, a! ~r.r~oaality disorder (SPD~ (n = !9), and norma~ controls (NC) (n = 20) to determine (1) if the diminished P300 amplitude (AMP) reported ir~ SZ may extend to SPD, and (21 whether the association between N200 AMP and anhedonia reported in subjects at risk for psychosis might be replicated in SPD patients with negative symptoms. Subjects were healthy, medication free for 2 weeks, and diagnosed on SADS (SZ) and SIDP (PD). An "'Oddball Paradigm" with fr~..quent and rare tones was ~ d and recorded on a Nicolet Pathfinder !I with a CZ ¢o~ieal electrode (linked to mastoids). P300 AMP was significantly differe,,,,t across the three g r o u p ~ F : = 4.12, p < 0.01, ANOVA) and sigaificarttty d ~ s h e d in ~ e SZ patients compared to normals (p < 0.05, Scheffe). The P300 AMP of SPD patients was intermediate between the SZ and NC groups, sho,a,ing no significant difference with either. N 2 0 O A ~ was significantly correlated with the sum of pegative schizotypal symptoms (r = + 0.49, p < 0.02). The results suggest a possible overlap of re.duced P300 AMP _h-z~.~veenSFD and SZ as well as ERP correlates for some schizoq/pat symptoms.
203
CSF HVA CONCENTRATIONS IN SCHIZOTYPAL AND OTHER PERSONALITY DISORDERS F° Amin, M . D . E . F, . Coccm"o, ~~,.D. ~ , R - L . Trestman, P h . D .,M . D . , P. Knott, Ph.D., T. Mahon, BOA., M. Davidson, M.D., K.L. Davis, M.D., L.J. Siever, ~M_ . D. Mount Sinai Schoai oJ Medicine/Brorvc VAMC, New York, NY 10029. Cerebrospinai fluid (CSF) concentrations of the dopamine metabohte homovaniiiie acid (i-Vv'A) were measured in a group (n = 10) of schizotypal personality disorder (SPD) patients and a coe:/o| group (n = 14) of other personality disorder (OPD) patients. The personality disorder diagno~s were assessed- by DSMIII criteria using the SIDP. DSM-II! diagnoses of schizophrenia, schizoaffecave, and bipolar disorders were ruled out by the SADS interview. All patients were free of sigr~ficant medical illnesses, free of psychotropic medications for 3 weeks, used low monoamine diet for 3 days and were hospitalized ~,t least 2 days prior to the lumbar puncture (LP). The LP was -performed between 9 and i0 A~, after at least 9 hr of strict bed rest. The LP was done through the vertebral space between L3 and 1,4. CSF samples representing 12th15th ml aliquot were stored at - 80°C and assayed for HVA usieg HFLC. Mean CSF kaVA concentrations in SPD patients were found to be. significantly higher t h ~ OPD controls (t = 2.74, p = 0.0!). The sum of DSM-III SPD characteristics in each patient in the total sample correlated si~,ificantly with CSF HVA concentrations (r = 0.43, p < 0.04). This correlation appeared to be due to the psychotic-like SPD characteristics (i.e., magical thinking, ideas of reference, recurrent illusions, and guspiciousness) and not due to the other SPD characteristics (i.e., social isolation, odd speech, inadequate rapport, and undue social anxiety) as CSF HVA concentrations correlated very strongly with the former SPD character/sties (r = 0.59, p < .002) but not with the latter (r = O. 11, p = NS). These findings raise the possibility of a central dopaminergic dysfunction in SPD that may modulate the psychotic-like symptoms of this disorder.
BIOL PSYCHIATRY | 99 | ;29:43A- | 85A
137A
AFFECTIVE PERSONALITY DISORDERS F r i d a y , M a y 10, 1 : 0 0 - 6 : 0 0 I'M
Ponchartrain A
202 EVENT RELATED POTENTIALS IN SCHIZOTYPAL PERSONALITY DISORDER AND SCHIZOPHRENIA Oren Kalus, M.D., Thomas B. Horvath, M.D.. Ann Peterson, M.A., Emil F. Coccaro, M.D., Vivian Mitropou!ou, M.A., Michael Davidson, M.D., Kenneth L. Davis, M.D., Larry J. Siever, M.D. Mount Sinai School of Mea~cine and Veterans Affairs Medical Center, New York, NY I0029. Auditory event related cortical potentials (ERP) were compared in patients with sch~zop~nia ~SZ; in = 20), schizoid, a! ~r.r~oaality disorder (SPD~ (n = !9), and norma~ controls (NC) (n = 20) to determine (1) if the diminished P300 amplitude (AMP) reported ir~ SZ may extend to SPD, and (21 whether the association between N200 AMP and anhedonia reported in subjects at risk for psychosis might be replicated in SPD patients with negative symptoms. Subjects were healthy, medication free for 2 weeks, and diagnosed on SADS (SZ) and SIDP (PD). An "'Oddball Paradigm" with fr~..quent and rare tones was ~ d and recorded on a Nicolet Pathfinder !I with a CZ ¢o~ieal electrode (linked to mastoids). P300 AMP was significantly differe,,,,t across the three g r o u p ~ F : = 4.12, p < 0.01, ANOVA) and sigaificarttty d ~ s h e d in ~ e SZ patients compared to normals (p < 0.05, Scheffe). The P300 AMP of SPD patients was intermediate between the SZ and NC groups, sho,a,ing no significant difference with either. N 2 0 O A ~ was significantly correlated with the sum of pegative schizotypal symptoms (r = + 0.49, p < 0.02). The results suggest a possible overlap of re.duced P300 AMP _h-z~.~veenSFD and SZ as well as ERP correlates for some schizoq/pat symptoms.
203
CSF HVA CONCENTRATIONS IN SCHIZOTYPAL AND OTHER PERSONALITY DISORDERS F° Amin, M . D . E . F, . Coccm"o, ~~,.D. ~ , R - L . Trestman, P h . D .,M . D . , P. Knott, Ph.D., T. Mahon, BOA., M. Davidson, M.D., K.L. Davis, M.D., L.J. Siever, ~M_ . D. Mount Sinai Schoai oJ Medicine/Brorvc VAMC, New York, NY 10029. Cerebrospinai fluid (CSF) concentrations of the dopamine metabohte homovaniiiie acid (i-Vv'A) were measured in a group (n = 10) of schizotypal personality disorder (SPD) patients and a coe:/o| group (n = 14) of other personality disorder (OPD) patients. The personality disorder diagno~s were assessed- by DSMIII criteria using the SIDP. DSM-II! diagnoses of schizophrenia, schizoaffecave, and bipolar disorders were ruled out by the SADS interview. All patients were free of sigr~ficant medical illnesses, free of psychotropic medications for 3 weeks, used low monoamine diet for 3 days and were hospitalized ~,t least 2 days prior to the lumbar puncture (LP). The LP was -performed between 9 and i0 A~, after at least 9 hr of strict bed rest. The LP was done through the vertebral space between L3 and 1,4. CSF samples representing 12th15th ml aliquot were stored at - 80°C and assayed for HVA usieg HFLC. Mean CSF kaVA concentrations in SPD patients were found to be. significantly higher t h ~ OPD controls (t = 2.74, p = 0.0!). The sum of DSM-III SPD characteristics in each patient in the total sample correlated si~,ificantly with CSF HVA concentrations (r = 0.43, p < 0.04). This correlation appeared to be due to the psychotic-like SPD characteristics (i.e., magical thinking, ideas of reference, recurrent illusions, and guspiciousness) and not due to the other SPD characteristics (i.e., social isolation, odd speech, inadequate rapport, and undue social anxiety) as CSF HVA concentrations correlated very strongly with the former SPD character/sties (r = 0.59, p < .002) but not with the latter (r = O. 11, p = NS). These findings raise the possibility of a central dopaminergic dysfunction in SPD that may modulate the psychotic-like symptoms of this disorder.