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Cytopathology of parasitic disease
368
Molecular and BiochemicalParasitology, 11 (1984) 368 Elsevier
BOOK REVIEW Cytopathology of Parasitic Disease Ciba Foundation Symposium 99, Pitman Books Ltd., London, pp. viii & 273. The title of this symposium is somewhat misleading, for the volume contains a series of articles on mechanisms of invasion and pathogenesis investigated predominantly by techniques Of cell biology and immunology. There is not a great deal here for the morphologist. The contributions differ in quality and style, varying between those in which the authors' own data are presented and more general surveys. There is also uneven representation of the diseases themselves: four articles on Trypanosoma cruzi, four on leishmaniasis and one each on amoebiasis, toxoplasmosis.and schistosomiasis (plus a useful short survey by S.J. Kiebanoff et al. on the oxidative response of phagocytes to invasion by parasites). The volume overall is extremely well edited, highly readable and provocative to the inquiring mind. D. Mirelman describes fascinating mechanisms of interaction between bacteria, Entamoeba histolytica and cells of the intestinal lumen which lead to profound modifications in amoebic virulence. Z.A. Andrade and L. Hudson respectively discuss the still controversial issues of Trypanosoma cruzi induced damage to the myocardium and autonomic nervous system. A. Sher describes important studies by his group concerning the immunoregulatory mechanisms which determine the differing outcomes of leishmanial infection in inbred mice. These genetically based syndromes are highly relevant to our growing understanding of pathogenic mechanisms in clinical ieishmaniasis. It is indicative of the accelerating rate of progress that further studies from this laboratory have already advanced appreciably beyond the stage described at this meeting two years ago. A notable feature of-this volume is the highly informative and well transcribed discussion which occupies 30 per cent of the total pages. In many respects it makes the most valuable contribution of all highlighting current thinking and possible approaches to controversial issues. Numerous problems are delineated for the innovative experimentalist. This symposium will be soon be out of date. Nevertheless, it will be good to return to, like earlier CIBA volumes on parasite diseases, as a valuable milestone against which to measure future progress. James G. Howard
Molecular and BiochemicalParasitology, 11 (1984) 368 Elsevier
BOOK REVIEW Cytopathology of Parasitic Disease Ciba Foundation Symposium 99, Pitman Books Ltd., London, pp. viii & 273. The title of this symposium is somewhat misleading, for the volume contains a series of articles on mechanisms of invasion and pathogenesis investigated predominantly by techniques Of cell biology and immunology. There is not a great deal here for the morphologist. The contributions differ in quality and style, varying between those in which the authors' own data are presented and more general surveys. There is also uneven representation of the diseases themselves: four articles on Trypanosoma cruzi, four on leishmaniasis and one each on amoebiasis, toxoplasmosis.and schistosomiasis (plus a useful short survey by S.J. Kiebanoff et al. on the oxidative response of phagocytes to invasion by parasites). The volume overall is extremely well edited, highly readable and provocative to the inquiring mind. D. Mirelman describes fascinating mechanisms of interaction between bacteria, Entamoeba histolytica and cells of the intestinal lumen which lead to profound modifications in amoebic virulence. Z.A. Andrade and L. Hudson respectively discuss the still controversial issues of Trypanosoma cruzi induced damage to the myocardium and autonomic nervous system. A. Sher describes important studies by his group concerning the immunoregulatory mechanisms which determine the differing outcomes of leishmanial infection in inbred mice. These genetically based syndromes are highly relevant to our growing understanding of pathogenic mechanisms in clinical ieishmaniasis. It is indicative of the accelerating rate of progress that further studies from this laboratory have already advanced appreciably beyond the stage described at this meeting two years ago. A notable feature of-this volume is the highly informative and well transcribed discussion which occupies 30 per cent of the total pages. In many respects it makes the most valuable contribution of all highlighting current thinking and possible approaches to controversial issues. Numerous problems are delineated for the innovative experimentalist. This symposium will be soon be out of date. Nevertheless, it will be good to return to, like earlier CIBA volumes on parasite diseases, as a valuable milestone against which to measure future progress. James G. Howard