- Email: [email protected]
December, 2009
In Context
Ten most wanted December, 2009 1
Epigenetic mechanisms (Review, November) Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol 2009; 8: 1056–72.
2
Duchenne muscular dystrophy (Review, January) Bushby K, Finkel R, Birnkrant DJ, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol 2010; 9: 77–93.
3
Initial features of PD (Review, December) Rodriguez-Oroz MC, Jahanshahi M, Krack P, et al. Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms. Lancet Neurol 2009; 8: 1128–39.
4
Multiple system atrophy (Review, December) Stefanova N, Bücke P, Duerr S, Wenning GK. Multiple system atrophy: an update. Lancet Neurol 2009; 8: 1172–78.
5
Complications after stroke (Review, January) Kumar S, Selim MH, Caplan LR. Medical complications after stroke. Lancet Neurol 2010; 9: 105–18.
6
Sporadic ataxia (Review, January) Klockgether T. Sporadic ataxia with adult onset: classification and diagnostic criteria. Lancet Neurol 2010; 9: 94–104.
7
Neuropathology of PD (Review, December) Dickson DW, Braak H, Duda JE, et al. Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol 2009; 8: 1150–57.
8
ECASS III: extra outcomes (Articles, December) Bluhmki E, Chamorro A, Dávalos A, et al. Stroke treatment with alteplase given 3·0–4·5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol 2009; 8: 1095–102.
9
Progression of PD (Review, December) Maetzler W, Liepelt I, Berg D. Progression of Parkinson’s disease in the clinical phase: potential markers. Lancet Neurol 2009; 8: 1158–71.
10 Antibodies in limbic encephalitis (Articles, January) Lancaster E, Lai M, Peng X, et al. Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 2010; 9: 67–76. The top ten Lancet Neurology articles downloaded from ScienceDirect in December, 2009.
www.thelancet.com/neurology Vol 9 March 2010
Lifeline Renaud Du Pasquier obtained his MD from the University of Geneva, Switzerland. After a Swiss Board certification in neurology and internal medicine, he did a research fellowship in neurovirology and neuroimmunology at the Beth Israel Deaconess Medical Center, Boston, MA, USA. Back in Switzerland, he established his laboratory at the Centre Hospitalo-Universitaire Vaudois, Lausanne. His group studies the physiopathogenesis of multiple sclerosis and the link between viruses and demyelination. What has been the greatest achievement of your career? Obtaining professorship from the Swiss National Foundation. This programme gives protected time and funds for research. It really was an asset in establishing my lab.
See Articles page 264
What inspired you? I love both the clinic and research. They are very different but enrich each other. To be able to combine both was my strongest motivation after my medical studies. If you had not entered your current profession, what would you have liked to do? Been a bush pilot; flying solo was one of the most exhilarating experiences in my life. Who was your most influential teacher, and why? Francis Waldvogel, former Head of the Department of Internal Medicine, Geneva, and currently executive director of the World Knowledge Dialogue Foundation, Geneva, Switzerland. Beyond the fact that he is a fascinating teacher, he played a decisive part in my decision to pursue an academic career. What would be your advice to a newly qualified doctor? When it’s time to choose your research domain or medical specialty, follow your gut feeling: think “What is the domain or specialty you really feel attracted to?” and forget for a little while about strategic considerations. What are you currently reading? A novel in French entitled Le village de l’Allemand ou le journal des Frères Schiller by Boualem Sansal, which is about the painful discovery by a son that his father is not the hero he thought he was, but a former war criminal. What was your first experiment as a child? To find out how strong a firecracker had to be to blow up a rusted iron pipe. I was caught before I could conduct the experiment to its end. What is the most memorable comment from your school reports? “Renaud should keep playing tennis and quit high school.” Fortunately, my parents did not follow this advice. If you knew you had a week to live, how would you live those days? Under pressure! As a scientist, I am accustomed to deadlines, but this would be the ultimate one.
241
Ten most wanted December, 2009 1
Epigenetic mechanisms (Review, November) Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol 2009; 8: 1056–72.
2
Duchenne muscular dystrophy (Review, January) Bushby K, Finkel R, Birnkrant DJ, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol 2010; 9: 77–93.
3
Initial features of PD (Review, December) Rodriguez-Oroz MC, Jahanshahi M, Krack P, et al. Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms. Lancet Neurol 2009; 8: 1128–39.
4
Multiple system atrophy (Review, December) Stefanova N, Bücke P, Duerr S, Wenning GK. Multiple system atrophy: an update. Lancet Neurol 2009; 8: 1172–78.
5
Complications after stroke (Review, January) Kumar S, Selim MH, Caplan LR. Medical complications after stroke. Lancet Neurol 2010; 9: 105–18.
6
Sporadic ataxia (Review, January) Klockgether T. Sporadic ataxia with adult onset: classification and diagnostic criteria. Lancet Neurol 2010; 9: 94–104.
7
Neuropathology of PD (Review, December) Dickson DW, Braak H, Duda JE, et al. Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria. Lancet Neurol 2009; 8: 1150–57.
8
ECASS III: extra outcomes (Articles, December) Bluhmki E, Chamorro A, Dávalos A, et al. Stroke treatment with alteplase given 3·0–4·5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol 2009; 8: 1095–102.
9
Progression of PD (Review, December) Maetzler W, Liepelt I, Berg D. Progression of Parkinson’s disease in the clinical phase: potential markers. Lancet Neurol 2009; 8: 1158–71.
10 Antibodies in limbic encephalitis (Articles, January) Lancaster E, Lai M, Peng X, et al. Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 2010; 9: 67–76. The top ten Lancet Neurology articles downloaded from ScienceDirect in December, 2009.
www.thelancet.com/neurology Vol 9 March 2010
Lifeline Renaud Du Pasquier obtained his MD from the University of Geneva, Switzerland. After a Swiss Board certification in neurology and internal medicine, he did a research fellowship in neurovirology and neuroimmunology at the Beth Israel Deaconess Medical Center, Boston, MA, USA. Back in Switzerland, he established his laboratory at the Centre Hospitalo-Universitaire Vaudois, Lausanne. His group studies the physiopathogenesis of multiple sclerosis and the link between viruses and demyelination. What has been the greatest achievement of your career? Obtaining professorship from the Swiss National Foundation. This programme gives protected time and funds for research. It really was an asset in establishing my lab.
See Articles page 264
What inspired you? I love both the clinic and research. They are very different but enrich each other. To be able to combine both was my strongest motivation after my medical studies. If you had not entered your current profession, what would you have liked to do? Been a bush pilot; flying solo was one of the most exhilarating experiences in my life. Who was your most influential teacher, and why? Francis Waldvogel, former Head of the Department of Internal Medicine, Geneva, and currently executive director of the World Knowledge Dialogue Foundation, Geneva, Switzerland. Beyond the fact that he is a fascinating teacher, he played a decisive part in my decision to pursue an academic career. What would be your advice to a newly qualified doctor? When it’s time to choose your research domain or medical specialty, follow your gut feeling: think “What is the domain or specialty you really feel attracted to?” and forget for a little while about strategic considerations. What are you currently reading? A novel in French entitled Le village de l’Allemand ou le journal des Frères Schiller by Boualem Sansal, which is about the painful discovery by a son that his father is not the hero he thought he was, but a former war criminal. What was your first experiment as a child? To find out how strong a firecracker had to be to blow up a rusted iron pipe. I was caught before I could conduct the experiment to its end. What is the most memorable comment from your school reports? “Renaud should keep playing tennis and quit high school.” Fortunately, my parents did not follow this advice. If you knew you had a week to live, how would you live those days? Under pressure! As a scientist, I am accustomed to deadlines, but this would be the ultimate one.
241