- Email: [email protected]
Deficit subtype of schizophrenia and frontal impairments
1925
Poster session
BIOL. PSYCHIATRY 1997;42:15-2975
Results: Among the 18 deficit patients, 14 had a pathological NES score (78%), whereas only 1 of the 14 non deficit patients had such a pathological score (7%). A strong relationship was found between pathological NES score and deficit score (p < 0.001). No differences regarding equivalent CPZ doses were observed between both groups. Conclusion: These preliminary results might be in favor of a neurodevel• opmental factor in deficit schizophrenic patients.
165-1571 Depressive symptoms In deficit and nondeficlt schizophrenic patients S. Langlois-Thery, I. Nkam. S. Germain-Robin. A. Van Der Elst. P. Brazo, F. Thibaut. S. Dollfus, M. Petit. Groupe de recherche et Programme Hospltalier de Recherche Clinique (P.H.R.C.). S. Dol/tus, CHU Cl'te de Nacre. caen, Frence. Groupe de recherche et Programme Hosp/talier de Recherche Clinique (P.H.R.C.). M. Petit UniveTSitli de Rouen. France The 11m of this study was to compare depressive symptomatology In deficit and nondeficlt schizophrenic stabilized treated patients. Methods: Twenty eight schizophrenic patients (DSM IV) were assessed by several evaluations for depression (CDS. Calgary Depression Scale: BDI, Beck Depression Inventory) and diagnostic criteria for depression In schizophrenia (ROC. ICD 10, DSM IV). Patients were categorized into deficit (n • 13) and nondeflclt (n • 15) groups using the Schedule for the Deficit Syndrome (SDS: Klrkpatrick et aI. 1989). Antecedents of depressive eplsodes or suicidal attemps, were also notified. Results: Five nondeficlt patients met criteria of post-psychotic depression (33%) against two In deficit group (15%). There was no statistical differences for antecedents of depressive episodes or suicidal 8ttemps between the two groups. Scores of BDI and CDS were superior in nondeficlt patients but this difference did not reach statistical significance. Conclusion: These preliminary findings showed fewer depressive symp• toms in deficit patients. These resuhs require further analyses using larger samples of patients to characterize clinical particularities In deficit schizophre• nia.
165-1581 saccadic eye movements In deficit and nondeficlt schizophrenia I. Nkam, F. Thibaut. P. Denise, O. Levillaln, S. langlois-Thery, A. Van Oer Elst. P. Brazo. P. Delamillieure. T. Vasse, O. Etard, S. Dollfus, M. Petit. Groupe de recherche et Programme Hospital/er de Recherche Clin/que. S. DoIffus. CHU- ~te de nacre 14033 caen. France. Groupe de recherche et Programme Hospltal/er de Recherche CI/n/que, M. Petit, Un/veTS/tli de Rouen, FflJlIC6 The 11m of this study was to compare saccadic and smooth pursuit eye movement tasks in deficit and nondeficlt schizophrenic patients. Method: Thirty patients, meeting DSM IV criteria for schizophrenia, were assessed by the PANSS (Kay et ai, 1987) and were categorized Into a deficit (n • 9) and a nondeficlt (n .21) group using the SChedule for the Deficit Syndrome (Klrpatrick et ai, 1989). We have used two oculomotor tasks: An anti-saccade paradigm and a study of smooth pursuit of a sinusoidal target. Smooth pursuit gain (ratio of eye velocity to target velocity) and rate 01 successful antisaccades were measured. Results: Deficit patients (mean %standard deviation. 17.52 %6,41) have perfonned worse as compared with nondeficlt patients (mean % standard devation • 9.56 % 4.85) as regard to the rate of successful antisaccades (p < 0.05). Their gain was inferior (0.75) to that of nondeflclt patients (0.84) but this difference did not reach statistical significance. Conclusion: This preliminary findings suggest more cerebral Impairments In deficit group and requlra further analyses using larger samples of patients.
165-1591 Association study between schizophrenia and apollpoproteln E alleles B. Coron, F. Thibaut, O. CampIon. S. Dollfus, Th. Frebourg, M. Petit. Groupe de recherche et Programme HospItal/er de Recherche Clinique, S. DoI/fus. CH~te de nacre 14033 caen, FflJlIC6, Groupe de recherche et Programme Hospital/er de Recherche CI/n/que. M. Petit Un/versltli de Rouen. FflJlIC6 Several studies suggest that the apoIipoproteln E4 allele is an Important risk factor for the development of Alzheimer's disease (AD) and lewy bodies type dementia. A high frequency 01 the ApoE E4 allele has also been as-
m
sociated with cognitive decline in elder1y non demented subjects. CognitiYe deficits and brain structural abnormalities have consistently been repor1ecI in schizophrenia. Furthermore. some studies suggest an increased prevalence of Alzheimer neupathological findings in the brain of schizophrenia patients. We therefore determined Apo E allele frequencies in 102 schizophrenic pa• tients according to DSMIII-R criteria (26 females. 76 males) and 87 control subjects (47 females. 40 females). No significant difference in Apo E2. Ape) E3. Apo E4 frequencies has been observed between schizophrenic patients (0.08; 0.78; 0.12 respectively) and controls (0.07; 0.76; 0.17 nespectiyeIy). Furthermora a progression In thought disorder has been observed in patients with primary enduring negative symptoms or deficit symptoms as ~ with nondeficit schizophrenia In that purpose. we have used categorization into deficit (n = 17) and nondefleit (n = 26) subgroups which was available lor 43 schizophrenic patients belonging to the Initial sample. The allelic distribu• tions did not significantly differ between deficit and nondeficlt patients (deficit: 0.09; 0.76; 0.15 respectively; nondeficit: 0.08; 0.80; 0.12 respectively). Our preliminary results do not support the hypothesis that Ape E4 allele may be involved In a genetic predisposition for deficit schlzophnenla.
I
165-160 Deficit subtype of schizophrenia and frontal Impairments
P. Brazo, I. Halbecq, P. Delamlllieure. L Segard. F. Thlbaut, S. Langlols-Thery, A. Van Der Elst. T. Vasse, M. Petit, S. Dollfus. GttXJpe de recherche et Programme Hosp/talier de Recherche Clinique (P.H.R.C.), S. Dolltus. CHU Cl'te de Nacre. 14033 caen. France, Groupe de rechet'che et Programme Hosp/talierde Recherche Clinique (P.H.R.C.), M. Petit, Un/veTSitli de Rouen, France The aim of the study was to test that deficit schizophnenic patients (Carpenter et al.• 1988) had more cognitive Impairments than non defICit schizoptvwlic patients. in particular regarding frontal functions. Methods: The Schedule for the Deficit Syndrome (Klr1cpatrick et aL. 1989) was used to categorize 25 DSMIV schizophrenic patients into deficit (N - 5) and non deficit groups (N =20). They were assessed with neuropsychological measures of frontal lobe [Trail Making test B (TMB). WISCOnSin card Sorting Test categories (WCST). Stroop Color-Word interference (Stroop), IormaI verbal fluency. the Brown-Peterson test. Porteus] and of temporal lobe performances (intrusion errors from the California Verbal Leamlng Test (CVLT». Results: Deficit patients were more impaired than non deficit patients tor TMB [m % SO 224 ± 72 vs 139 % 65 seconds; p < 0.05]. WCST (2.4 % 1 vs 4.9 ± 1; P < 0.01]: Stroop [-5.9 % 7.5 vs -1.18 % 6.3; NSI. lluenoe [12.4 % 3.4 vs 16.1 % 5.4; NS]. However. they did not differ with the OCher frontal tests and with the CVLT. Conclusion: These results suggest that deficit patients might be more impaired In frontallunctions than non deficit patients, whereas their ~ performances might be similar.
=
165-1631 Attentional disorders In schizophrenia: Inftuence of neuroleptic treatment and correlation between cognitive performances and clinical features J.G. Rohmer. B. Kastler. F. Biringer. M. Patris. Department d Psychiatry Unit 2. C.H.R.U, 67091 Strasbourg, France It's generally admitted that patients with schizophrenia present various degree of attention disorders. With computerized tests. elaborated in our U'lIt and aimed to evaluate quantitatively various attention modalities (attentiOn centered of one sensorial modality, divided attention. selective attention and attention disturbance induced by various perturbers). we tried to determine the attention disorders In patients (30 cases) fulfilling the OSM IV Criteria for schizophrenia compared to normal subjects matched for age. sex, study level and marital status. In one group. the subjects were clinically stabilized under neuroleptic treatment for a least 15 days and In the other. the subjects were withoI.t psychotropic treatment for a least one month. Our data showed a global drop of the scores obtained by schizophrenics in all the tests regarding the mean reaction time and the error ratio. llle schizophrenics are disturbed by aleatory stimuli and by orders referring to a category. They have difficulties to extract pertinent infonnalion from context. NL seem to have liWe influence: the rasults show a slight bIA significative tendency for I cognitive improvement under NL trealJnent. ~ tests, however, showed graat differences in attentionaJ processes between patients which were correlated with negative and positive symptoms ISC:Clred
Poster session
BIOL. PSYCHIATRY 1997;42:15-2975
Results: Among the 18 deficit patients, 14 had a pathological NES score (78%), whereas only 1 of the 14 non deficit patients had such a pathological score (7%). A strong relationship was found between pathological NES score and deficit score (p < 0.001). No differences regarding equivalent CPZ doses were observed between both groups. Conclusion: These preliminary results might be in favor of a neurodevel• opmental factor in deficit schizophrenic patients.
165-1571 Depressive symptoms In deficit and nondeficlt schizophrenic patients S. Langlois-Thery, I. Nkam. S. Germain-Robin. A. Van Der Elst. P. Brazo, F. Thibaut. S. Dollfus, M. Petit. Groupe de recherche et Programme Hospltalier de Recherche Clinique (P.H.R.C.). S. Dol/tus, CHU Cl'te de Nacre. caen, Frence. Groupe de recherche et Programme Hosp/talier de Recherche Clinique (P.H.R.C.). M. Petit UniveTSitli de Rouen. France The 11m of this study was to compare depressive symptomatology In deficit and nondeficlt schizophrenic stabilized treated patients. Methods: Twenty eight schizophrenic patients (DSM IV) were assessed by several evaluations for depression (CDS. Calgary Depression Scale: BDI, Beck Depression Inventory) and diagnostic criteria for depression In schizophrenia (ROC. ICD 10, DSM IV). Patients were categorized into deficit (n • 13) and nondeflclt (n • 15) groups using the Schedule for the Deficit Syndrome (SDS: Klrkpatrick et aI. 1989). Antecedents of depressive eplsodes or suicidal attemps, were also notified. Results: Five nondeficlt patients met criteria of post-psychotic depression (33%) against two In deficit group (15%). There was no statistical differences for antecedents of depressive episodes or suicidal 8ttemps between the two groups. Scores of BDI and CDS were superior in nondeficlt patients but this difference did not reach statistical significance. Conclusion: These preliminary findings showed fewer depressive symp• toms in deficit patients. These resuhs require further analyses using larger samples of patients to characterize clinical particularities In deficit schizophre• nia.
165-1581 saccadic eye movements In deficit and nondeficlt schizophrenia I. Nkam, F. Thibaut. P. Denise, O. Levillaln, S. langlois-Thery, A. Van Oer Elst. P. Brazo. P. Delamillieure. T. Vasse, O. Etard, S. Dollfus, M. Petit. Groupe de recherche et Programme Hospital/er de Recherche Clin/que. S. DoIffus. CHU- ~te de nacre 14033 caen. France. Groupe de recherche et Programme Hospltal/er de Recherche CI/n/que, M. Petit, Un/veTS/tli de Rouen, FflJlIC6 The 11m of this study was to compare saccadic and smooth pursuit eye movement tasks in deficit and nondeficlt schizophrenic patients. Method: Thirty patients, meeting DSM IV criteria for schizophrenia, were assessed by the PANSS (Kay et ai, 1987) and were categorized Into a deficit (n • 9) and a nondeficlt (n .21) group using the SChedule for the Deficit Syndrome (Klrpatrick et ai, 1989). We have used two oculomotor tasks: An anti-saccade paradigm and a study of smooth pursuit of a sinusoidal target. Smooth pursuit gain (ratio of eye velocity to target velocity) and rate 01 successful antisaccades were measured. Results: Deficit patients (mean %standard deviation. 17.52 %6,41) have perfonned worse as compared with nondeficlt patients (mean % standard devation • 9.56 % 4.85) as regard to the rate of successful antisaccades (p < 0.05). Their gain was inferior (0.75) to that of nondeflclt patients (0.84) but this difference did not reach statistical significance. Conclusion: This preliminary findings suggest more cerebral Impairments In deficit group and requlra further analyses using larger samples of patients.
165-1591 Association study between schizophrenia and apollpoproteln E alleles B. Coron, F. Thibaut, O. CampIon. S. Dollfus, Th. Frebourg, M. Petit. Groupe de recherche et Programme HospItal/er de Recherche Clinique, S. DoI/fus. CH~te de nacre 14033 caen, FflJlIC6, Groupe de recherche et Programme Hospital/er de Recherche CI/n/que. M. Petit Un/versltli de Rouen. FflJlIC6 Several studies suggest that the apoIipoproteln E4 allele is an Important risk factor for the development of Alzheimer's disease (AD) and lewy bodies type dementia. A high frequency 01 the ApoE E4 allele has also been as-
m
sociated with cognitive decline in elder1y non demented subjects. CognitiYe deficits and brain structural abnormalities have consistently been repor1ecI in schizophrenia. Furthermore. some studies suggest an increased prevalence of Alzheimer neupathological findings in the brain of schizophrenia patients. We therefore determined Apo E allele frequencies in 102 schizophrenic pa• tients according to DSMIII-R criteria (26 females. 76 males) and 87 control subjects (47 females. 40 females). No significant difference in Apo E2. Ape) E3. Apo E4 frequencies has been observed between schizophrenic patients (0.08; 0.78; 0.12 respectively) and controls (0.07; 0.76; 0.17 nespectiyeIy). Furthermora a progression In thought disorder has been observed in patients with primary enduring negative symptoms or deficit symptoms as ~ with nondeficit schizophrenia In that purpose. we have used categorization into deficit (n = 17) and nondefleit (n = 26) subgroups which was available lor 43 schizophrenic patients belonging to the Initial sample. The allelic distribu• tions did not significantly differ between deficit and nondeficlt patients (deficit: 0.09; 0.76; 0.15 respectively; nondeficit: 0.08; 0.80; 0.12 respectively). Our preliminary results do not support the hypothesis that Ape E4 allele may be involved In a genetic predisposition for deficit schlzophnenla.
I
165-160 Deficit subtype of schizophrenia and frontal Impairments
P. Brazo, I. Halbecq, P. Delamlllieure. L Segard. F. Thlbaut, S. Langlols-Thery, A. Van Der Elst. T. Vasse, M. Petit, S. Dollfus. GttXJpe de recherche et Programme Hosp/talier de Recherche Clinique (P.H.R.C.), S. Dolltus. CHU Cl'te de Nacre. 14033 caen. France, Groupe de rechet'che et Programme Hosp/talierde Recherche Clinique (P.H.R.C.), M. Petit, Un/veTSitli de Rouen, France The aim of the study was to test that deficit schizophnenic patients (Carpenter et al.• 1988) had more cognitive Impairments than non defICit schizoptvwlic patients. in particular regarding frontal functions. Methods: The Schedule for the Deficit Syndrome (Klr1cpatrick et aL. 1989) was used to categorize 25 DSMIV schizophrenic patients into deficit (N - 5) and non deficit groups (N =20). They were assessed with neuropsychological measures of frontal lobe [Trail Making test B (TMB). WISCOnSin card Sorting Test categories (WCST). Stroop Color-Word interference (Stroop), IormaI verbal fluency. the Brown-Peterson test. Porteus] and of temporal lobe performances (intrusion errors from the California Verbal Leamlng Test (CVLT». Results: Deficit patients were more impaired than non deficit patients tor TMB [m % SO 224 ± 72 vs 139 % 65 seconds; p < 0.05]. WCST (2.4 % 1 vs 4.9 ± 1; P < 0.01]: Stroop [-5.9 % 7.5 vs -1.18 % 6.3; NSI. lluenoe [12.4 % 3.4 vs 16.1 % 5.4; NS]. However. they did not differ with the OCher frontal tests and with the CVLT. Conclusion: These results suggest that deficit patients might be more impaired In frontallunctions than non deficit patients, whereas their ~ performances might be similar.
=
165-1631 Attentional disorders In schizophrenia: Inftuence of neuroleptic treatment and correlation between cognitive performances and clinical features J.G. Rohmer. B. Kastler. F. Biringer. M. Patris. Department d Psychiatry Unit 2. C.H.R.U, 67091 Strasbourg, France It's generally admitted that patients with schizophrenia present various degree of attention disorders. With computerized tests. elaborated in our U'lIt and aimed to evaluate quantitatively various attention modalities (attentiOn centered of one sensorial modality, divided attention. selective attention and attention disturbance induced by various perturbers). we tried to determine the attention disorders In patients (30 cases) fulfilling the OSM IV Criteria for schizophrenia compared to normal subjects matched for age. sex, study level and marital status. In one group. the subjects were clinically stabilized under neuroleptic treatment for a least 15 days and In the other. the subjects were withoI.t psychotropic treatment for a least one month. Our data showed a global drop of the scores obtained by schizophrenics in all the tests regarding the mean reaction time and the error ratio. llle schizophrenics are disturbed by aleatory stimuli and by orders referring to a category. They have difficulties to extract pertinent infonnalion from context. NL seem to have liWe influence: the rasults show a slight bIA significative tendency for I cognitive improvement under NL trealJnent. ~ tests, however, showed graat differences in attentionaJ processes between patients which were correlated with negative and positive symptoms ISC:Clred