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Design statistics in pharmacochemistry
572 Calcium Channel Modulators in Heart and Smooth Muscle. Basic Mechanisms and Pharmacological Aspects. Edited by S Abraham and G Amitai. VCH, Verlagsgesellschaft, Weiheim, 1990,396 p, DM 164.00 In these proceedings of the 33rd Oholo Biological Conference, many authors pool their knowledge on the basic mechanisms and pharmacological aspects of calcium channel modulators in heart and smooth muscle. Particular emphasis is paid to the biochemical and molecular biological facets of the subject. The scientific data compiled in this book are divided into five parts concerning: - receptor-operated and voltage-dependent mechanisms - excitation-contraction coupling in smooth muscles - pharmacodynamic effects of calcium channel modulators - model systems for myocardial ischemia and calcium channels - drug design and new approaches. Guide to Flow Cytometry Methods. By W McLean Grogan and JM Collins. Marcel Dekker, Inc, New York, 1990, 240 p, US & Canada $ 99.75, $ 119.50 (all other countries) This book highlights the versatility of flow cytometry as an analytical tool in numerous areas of investigation. Guide to Flow Cytometry Methods details the methodology and procedure used in studies of the cell cycle, cell development and differentiation, ageing, immunology, membrane fluidity, aneuploidy analysis of the 15 most common forms of cancer, discusses numerous techniques including preparation of singlecell suspensions, DNA analysis, viability assays, immunofluorescence assays and mitochondrial staining. Biodegradable Polymers as Drug Delivery Systems. Edited by M Chasin and R Langer. Marcel Dekker, Inc, New York, 1990, 368 p, US & Canada $ 99.75, $ 119.50 (all other countries) This book (45th of Drugs in the Pharmaceutical Sciences Series) reviews the properties, synthesis and formulations of a variety of polymers. Offering practical details abouth both standard and recently developed polymers, Biodegradable Polymers as Drug Delivery Systems presents the following topics for each polymer-introduction and background, chemistry and synthesis, formulation information concerning microcapsules, solvent casting, injection molding, compression molding and unique problems and opportunities, kinetics of drug release, toxicology and regulatory affair questions, preclinical studies, clinical studies and future directions. Biodegradable Polymers as Drug Delivery Systems contains over 850 references. L’Homme Sensoriel. By A Goudot-Perrot. Slatkine, Genbve, 1990, 124 p. This book contains 10 chapters (in French) Pharmacologic Paris, 1989,302
Fondamentale. p
Edited by C Jacquot. Ellipses,
This book contains 8 chapters (in French) main mechanisms of action of drugs.
dealing
with
the
HPLC in Clinical Chemistry. By IN Papadoyannis. Chromatographic Science Series. Volume 54. Marcel Dekker, New York, 1990, 504 p, US$ 115.00 (US & Canada), US$ 138.00 (all other countries)
This book focuses on time-saving specialized clinical use and provides over 1500 references.
techniques
for
Membrane fusion. Edited by J Wilschut and D Hoekstra. Marcel Dekker, Inc, New York, 1991, 930 p, US$ 195.00 (US & Canada), US$234.00 (all other countries) This volume provides a broad overview of recent progress in membrane -fusion research-highlighting an interdisciplinary treatment of the subject from the fields of biophysics, biochemistry, cell biology, virology, and biotechnology-in a single volume. Featuring easy-access sections on the general properties of membranes and applications of membrane fusion techniques, this sourcebook outlines membrane structure, lipid polymorphism, and intermembrane forces, covers membrane fusion in model systems, presents the fusogenic properties of enveloped viruses, discusses the fusion and flow of intracellular membranes and cell-cell fusion occurring during fertilization and myogenesis, offers applications of membrane fusion techniques in cell-biological research and biotechnology. Biological Mass Spectrometry. Proceedings of the Second International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, USA, August 27-31, 1989, by AL Burlingame, Department of Pharmaceutical Chemistrv, University of California, San Francisco, CA, USA and JA -McCloskey; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA, Elsevier Science Publishers, Amsterdam, 1990,700 p, US$230.75/Dfl450.00 Design Statistics in Pharmacochemistry. By PP Mager. Research Studies Press Ltd, Taunton and John Wiley & Sons, New York, 1990,661 p, & 85.00 This book is title No 16 in RSP’s Chemometrics Series (Series Editor: Dr David Bawden) The goal of the book is to give the intuitive abilities of researchersmore play by applying the principles of statistical design and analvsis to real exneriments. The author works with real data from medicinal, oiganic, and agricultural chemistry, and examines multidimensional design and analysis to illustrate the capabilities of the methods, so that an experimenter can adapt the guidelines to suit his needs. In summary, the approaches the author uses start from a design constructed according to the rules of decision theory, collect the experimental data to get summary statistics, test the hypotheses using global and simultaneous statistical inference techniques, and use the predictive model power of the results in further procedures. In this volume, the authors explore new methods of tandem mass spectrometry with array detection systems which provide high accuracy in identification, are far more rapid than the automated Edman sequencing devices, and have comparable sensitivity. Such tandem instruments have the extra major advantage of inherent ability to deal with virtuallv any kind of structural diversity - particularly powerful for- studies of covalently modified biouolvmers. The remarkable new instruments using electrospray ‘and matrix-assisted laser ionization method< which are able to desorb and measure the molecular weights of large proteins and nucleic acids intact, are described. GABA, Receptors in Mammalian Function. By NG Bowery, The School of Pharmacy, London, UK, H Bittiger and HR Olpe, Ciba-Geigy AG, Switzerland, John Wiley & Sons Ltd, Chichester, England, 1990,442 p, & 55.00
Fondamentale. p
Edited by C Jacquot. Ellipses,
This book contains 8 chapters (in French) main mechanisms of action of drugs.
dealing
with
the
HPLC in Clinical Chemistry. By IN Papadoyannis. Chromatographic Science Series. Volume 54. Marcel Dekker, New York, 1990, 504 p, US$ 115.00 (US & Canada), US$ 138.00 (all other countries)
This book focuses on time-saving specialized clinical use and provides over 1500 references.
techniques
for
Membrane fusion. Edited by J Wilschut and D Hoekstra. Marcel Dekker, Inc, New York, 1991, 930 p, US$ 195.00 (US & Canada), US$234.00 (all other countries) This volume provides a broad overview of recent progress in membrane -fusion research-highlighting an interdisciplinary treatment of the subject from the fields of biophysics, biochemistry, cell biology, virology, and biotechnology-in a single volume. Featuring easy-access sections on the general properties of membranes and applications of membrane fusion techniques, this sourcebook outlines membrane structure, lipid polymorphism, and intermembrane forces, covers membrane fusion in model systems, presents the fusogenic properties of enveloped viruses, discusses the fusion and flow of intracellular membranes and cell-cell fusion occurring during fertilization and myogenesis, offers applications of membrane fusion techniques in cell-biological research and biotechnology. Biological Mass Spectrometry. Proceedings of the Second International Symposium on Mass Spectrometry in the Health and Life Sciences, San Francisco, CA, USA, August 27-31, 1989, by AL Burlingame, Department of Pharmaceutical Chemistrv, University of California, San Francisco, CA, USA and JA -McCloskey; Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA, Elsevier Science Publishers, Amsterdam, 1990,700 p, US$230.75/Dfl450.00 Design Statistics in Pharmacochemistry. By PP Mager. Research Studies Press Ltd, Taunton and John Wiley & Sons, New York, 1990,661 p, & 85.00 This book is title No 16 in RSP’s Chemometrics Series (Series Editor: Dr David Bawden) The goal of the book is to give the intuitive abilities of researchersmore play by applying the principles of statistical design and analvsis to real exneriments. The author works with real data from medicinal, oiganic, and agricultural chemistry, and examines multidimensional design and analysis to illustrate the capabilities of the methods, so that an experimenter can adapt the guidelines to suit his needs. In summary, the approaches the author uses start from a design constructed according to the rules of decision theory, collect the experimental data to get summary statistics, test the hypotheses using global and simultaneous statistical inference techniques, and use the predictive model power of the results in further procedures. In this volume, the authors explore new methods of tandem mass spectrometry with array detection systems which provide high accuracy in identification, are far more rapid than the automated Edman sequencing devices, and have comparable sensitivity. Such tandem instruments have the extra major advantage of inherent ability to deal with virtuallv any kind of structural diversity - particularly powerful for- studies of covalently modified biouolvmers. The remarkable new instruments using electrospray ‘and matrix-assisted laser ionization method< which are able to desorb and measure the molecular weights of large proteins and nucleic acids intact, are described. GABA, Receptors in Mammalian Function. By NG Bowery, The School of Pharmacy, London, UK, H Bittiger and HR Olpe, Ciba-Geigy AG, Switzerland, John Wiley & Sons Ltd, Chichester, England, 1990,442 p, & 55.00