Development of oligodendrocyte and myelination in mouse optic nerve

s143

8. Myelin

241 Hiromi Lab

Development

.Akita. Hiroko

of \eural

The miyation. development

of Oligodendrocyte

Baba. Anna

Information. differention

National

sub\ entricular

techniques

NGZ-positive

and increase in the nutnber

during

for Physiological

development

from chiasm at P7. and reached close to retina at PI0

incr-ease up to ilweeks nilgate

after birth

B!, %eeks

and thickness

of ape. morphology

\\ithin

toward

the neKe

continued

in optic nerve but

PDGFctR

oc! tc.s in mouse optic nerve

eye ball.

started

of optic neme became

sheaths. ho\\ever,

are not produced

cells.

in the

chiasm in El 8 By

showed that myelination

of myetin

pi-ogenitors

stage. and differentiate

appeared

have been shown to migrate

and PLP staining

seem to be the main source of the oligodend!

progenitors.

into optic nerve through

progenitors

Thus. oligodendrocyte

from brain in late embryonic

progenitors

The numbers

PDGFctreceptor(PDGFaR)-positive

as olisodendrocyte

and migrated

MBP

\en,e

ha\ e been studied in lnouse optic nerve during

By in situ h\,bridization.

in El6.

Optic

Sciences

of olipodendl-oqtes

otipodendrocyte

almost the same as that in the adult

in Mouse

Ikenaka

cells. both of which are considered

zone at the third Lentricle

immunohistochemistry,

Kazuhiro

Institute

and myelination

using histochemical

but not PLP-positike

I\,anova.

and M>,elination

-oliyodendrocvte

to