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DIAGNOSIS, TREATMENT AND COMPLICATIONS OF THORACIC AORTIC PATHOLOGY
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DIAGNOSIS, TREATMENT AND COMPLICATIONS OF THORACIC AORTIC PATHOLOGY
M. Bustamante 1 , J. Jorda 1 , J. Izquierdo 1 , I. Garcia 2 , A. Ponton 2 , A. Gonzalez-Tutor 1 . 1 Radiology, Marques Valdecilla Hospital, Santander, Spain; 2 Cardiovascular Surgery, Marques Valdecilla Hospital, Santander, Spain Background: Diseases of the descending thoracic aorta have an important morbidity and mortality, mainly in pathologies like acute dissection. We report the experience of our center in its treatment by means of endoprosthesis. Methods: Between July 2001 and October 2007 27 patients received thoracic aorta endoprosthesis. All procedures were performed under general anesthesia and could be completed in all cases without conversion to open surgery. Results: All patients but 3 were males, with an average age of 63.5 years (42-81 years). The cause of interventions were aneurysm in 13 patients (48.1%), pseudoaneurysm in 3 cases (11.1%), in 7 patients (25.9%) a classic type B dissection was present, penetrating ulcer in 3 patient (11.1%) and in 1 case (3.7%) intramural haematoma was the indication for the procedure. The left subclavian artery was covered in 7 patients. Type 2 endoleak was present in two patients after the intervention but disappeared during follow-up. In 1 patient a module of the thoracic aorta endoprosthesis migrated to the aortic bifurcation and in another patient the iliac artery was injured. Peri-operative mortality was of 3 patients (1 case with type B dissection, another with a ruptured aneurysm and another without known cause). During follow-up 2 patients died of events non-related to the procedure. Conclusions: Endovascular techniques are effective in the treatment of the diseases of the descending thoracic aorta and present an acceptable risk even during the learning period. 211
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265 COMPARISON OF ANTROPOMETRIC MEASUREMENTS IN TURKISH CHILDREN FROM ISTANBUL, TURKEY VERSUS NURNBERG, GERMANY
P. Schwandt 1 , G. Haas 1 , A. Baykan 2 , D. Agirbasli 3 , E. Liepold 1 , M. Agirbasli 2 . 1 Arteriosklerose Praventions Institut, München, Germany; 2 Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey; 3 Department of Genetics, Marmara University Medical Center, Istanbul, Turkey Background: Understanding anthropometric measures may help us to determine the contributors of mortality from CAD. Methods: We used data collected in two different surveys from two different countries; Istanbul-Turkey and Nürnberg-Germany. Results: We compared Turkish children living in 2 different countries for anthropometric measures. Children from Istanbul had lower BMI and other anthropometric indices (Table 1, 2).
INFECTION WITH CHLAMYDIA PNEUMONIAE INDUCES A PRONOUNCED PRO-INFLAMMATORY PHENOTYPE IN HUVEC VIA INDUCTION OF EGR-1 AND NFAT
A. Csordas 1 , G. Wick 1 , M. Maass 2 , S. Lach 2 . 1 Laboratory of Autoimmunity, Biocenter Innsbruck, Innsbruck Medical University, Austria; 2 2Institute of Medical Microbiology, Hygiene and Infectious Diseases, University Clinic Salzburg, Austria
PUBLICATION ONLY
Background: Atherosclerosis is a complex multifactorial disease with multiple aetiologies that act in concert to promote plaque formation in the vascular wall. Recently, infectious pathogens like C. pneumoniae have emerged as novel components involved the process of endothelial cell injury. The present work aims at investigating whether infection with C. pneumoniae modulates the endothelial cell in a way that shifts its immunologically inert physiological properties towards a pro-inflammatory phenotype. Methods: Infection with C. pneumoniae was carried out in collaboration with the Institute of Microbiology, University Clinic of Salzburg. Quantitative real time PCR was performed using the Lightcycler Faststart DNA master kit according to the manufacturer’s recommendations. Results: We found that a transcriptional response to infection with C. pneumoniae was visible as early as at 1 h. At this time point, we found massive upregulation of the pro-inflammatory transcription factors early growth response factor 1 (EGR-1) and nuclear factor of activated T-cells (NFAT). At the same time, pro-inflammatory cytokines like IL-6 and IL-8 were found to be increased. We also found a pro-coagulative state in HUVEC infected with C. pneumoniae as reflected by upregulation of tissue factor. At later time points, we found upregulation of the eicosanoid-producing enzymes COX2 and ALOX5. Conclusion: Our work revealed pronounced upregulation of substances that act as strong chemoattractant agents for neutrophils such as IL-8 and leukotriene B4 as produced by ALOX5. This finding indicates that the innate immune system might have a prominent role to play in the case of Chlamydia-induced atherosclerosis.
Conclusions: Socio-economic, dietary, physical activity status may account for significant differences in anthropometric indices. 213
ANTIOXIDATIVE STRESS SYSTEMS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
R. Abellan 1 , S. Martinez-Hervas 1,2 , T. Pedro 2 , J. Real 2 , A. Garcia-Garcia 1 , F. Chaves 1 , G. Saez-Merino 3 , R. Carmena 2 , J. Ascaso 2 . 1 Fundacion para la Investigacion. Hospital Clinico Universitario de Valencia; 2 Service of Endocrinology and Nutrition. Hospital Clinico Universitario de Valencia. University of Valencia. Valencia. Spain; 3 Department of Biochemistry. University of Valencia. Valencia. Spain Objective: To study antioxidative stress systems related to endothelial oxidative damage in subjects with heterozygous familial hypercholesterolemia (hFH). Study design: We have studied 31 normolipidemic, non-diabetic sub-
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey
DIAGNOSIS, TREATMENT AND COMPLICATIONS OF THORACIC AORTIC PATHOLOGY
M. Bustamante 1 , J. Jorda 1 , J. Izquierdo 1 , I. Garcia 2 , A. Ponton 2 , A. Gonzalez-Tutor 1 . 1 Radiology, Marques Valdecilla Hospital, Santander, Spain; 2 Cardiovascular Surgery, Marques Valdecilla Hospital, Santander, Spain Background: Diseases of the descending thoracic aorta have an important morbidity and mortality, mainly in pathologies like acute dissection. We report the experience of our center in its treatment by means of endoprosthesis. Methods: Between July 2001 and October 2007 27 patients received thoracic aorta endoprosthesis. All procedures were performed under general anesthesia and could be completed in all cases without conversion to open surgery. Results: All patients but 3 were males, with an average age of 63.5 years (42-81 years). The cause of interventions were aneurysm in 13 patients (48.1%), pseudoaneurysm in 3 cases (11.1%), in 7 patients (25.9%) a classic type B dissection was present, penetrating ulcer in 3 patient (11.1%) and in 1 case (3.7%) intramural haematoma was the indication for the procedure. The left subclavian artery was covered in 7 patients. Type 2 endoleak was present in two patients after the intervention but disappeared during follow-up. In 1 patient a module of the thoracic aorta endoprosthesis migrated to the aortic bifurcation and in another patient the iliac artery was injured. Peri-operative mortality was of 3 patients (1 case with type B dissection, another with a ruptured aneurysm and another without known cause). During follow-up 2 patients died of events non-related to the procedure. Conclusions: Endovascular techniques are effective in the treatment of the diseases of the descending thoracic aorta and present an acceptable risk even during the learning period. 211
212
265 COMPARISON OF ANTROPOMETRIC MEASUREMENTS IN TURKISH CHILDREN FROM ISTANBUL, TURKEY VERSUS NURNBERG, GERMANY
P. Schwandt 1 , G. Haas 1 , A. Baykan 2 , D. Agirbasli 3 , E. Liepold 1 , M. Agirbasli 2 . 1 Arteriosklerose Praventions Institut, München, Germany; 2 Department of Cardiology, Marmara University Medical Center, Istanbul, Turkey; 3 Department of Genetics, Marmara University Medical Center, Istanbul, Turkey Background: Understanding anthropometric measures may help us to determine the contributors of mortality from CAD. Methods: We used data collected in two different surveys from two different countries; Istanbul-Turkey and Nürnberg-Germany. Results: We compared Turkish children living in 2 different countries for anthropometric measures. Children from Istanbul had lower BMI and other anthropometric indices (Table 1, 2).
INFECTION WITH CHLAMYDIA PNEUMONIAE INDUCES A PRONOUNCED PRO-INFLAMMATORY PHENOTYPE IN HUVEC VIA INDUCTION OF EGR-1 AND NFAT
A. Csordas 1 , G. Wick 1 , M. Maass 2 , S. Lach 2 . 1 Laboratory of Autoimmunity, Biocenter Innsbruck, Innsbruck Medical University, Austria; 2 2Institute of Medical Microbiology, Hygiene and Infectious Diseases, University Clinic Salzburg, Austria
PUBLICATION ONLY
Background: Atherosclerosis is a complex multifactorial disease with multiple aetiologies that act in concert to promote plaque formation in the vascular wall. Recently, infectious pathogens like C. pneumoniae have emerged as novel components involved the process of endothelial cell injury. The present work aims at investigating whether infection with C. pneumoniae modulates the endothelial cell in a way that shifts its immunologically inert physiological properties towards a pro-inflammatory phenotype. Methods: Infection with C. pneumoniae was carried out in collaboration with the Institute of Microbiology, University Clinic of Salzburg. Quantitative real time PCR was performed using the Lightcycler Faststart DNA master kit according to the manufacturer’s recommendations. Results: We found that a transcriptional response to infection with C. pneumoniae was visible as early as at 1 h. At this time point, we found massive upregulation of the pro-inflammatory transcription factors early growth response factor 1 (EGR-1) and nuclear factor of activated T-cells (NFAT). At the same time, pro-inflammatory cytokines like IL-6 and IL-8 were found to be increased. We also found a pro-coagulative state in HUVEC infected with C. pneumoniae as reflected by upregulation of tissue factor. At later time points, we found upregulation of the eicosanoid-producing enzymes COX2 and ALOX5. Conclusion: Our work revealed pronounced upregulation of substances that act as strong chemoattractant agents for neutrophils such as IL-8 and leukotriene B4 as produced by ALOX5. This finding indicates that the innate immune system might have a prominent role to play in the case of Chlamydia-induced atherosclerosis.
Conclusions: Socio-economic, dietary, physical activity status may account for significant differences in anthropometric indices. 213
ANTIOXIDATIVE STRESS SYSTEMS IN SUBJECTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
R. Abellan 1 , S. Martinez-Hervas 1,2 , T. Pedro 2 , J. Real 2 , A. Garcia-Garcia 1 , F. Chaves 1 , G. Saez-Merino 3 , R. Carmena 2 , J. Ascaso 2 . 1 Fundacion para la Investigacion. Hospital Clinico Universitario de Valencia; 2 Service of Endocrinology and Nutrition. Hospital Clinico Universitario de Valencia. University of Valencia. Valencia. Spain; 3 Department of Biochemistry. University of Valencia. Valencia. Spain Objective: To study antioxidative stress systems related to endothelial oxidative damage in subjects with heterozygous familial hypercholesterolemia (hFH). Study design: We have studied 31 normolipidemic, non-diabetic sub-
77th Congress of the European Atherosclerosis Society, April 26–29, 2008, Istanbul, Turkey