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Diagnostic Value of Preoperative CEA Serum Levels for Esophageal Cancer Lymph Node Metastasis
Cardiothoracic Surgery SESSION TITLE: Cardiothoracic SESSION TYPE: Original Investigation Poster PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
Diagnostic Value of Preoperative CEA Serum Levels for Esophageal Cancer Lymph Node Metastasis Yan Zhao MD* Bin You PhD; and Hui Li PhD Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China PURPOSE: To investigate the relationships between tumor marker CEA and biological characteristics of esophageal cancer, and it’s value of predicting lymph node metastasis for esophageal cancer METHODS: Consecutive 111 patients with esophageal cancer who underwent esophagectomy in Beijing Chaoyang Hospital were retrospectively evaluated between December 2010 and January 2014. The Single and multiple factors regression analysis were used to identify the risk factors for Abnormal level of CEA and lymph node metastasis, ROC curves analysis were performed to confirm the diagnostic value of preoperative CEA serum levels for esophageal cancer lymph node metastasis.
CARDIOTHORACIC SURGERY
RESULTS: There were 67 (60.36%) patients with lymph node metastasis.univariate and multivariate analysis indicated that Tumor N status were single risk factors for Abnormal level of CEA (P<0.01, OR¼2.206, 95% CI:1.370w3.552); Increased abnormal CEA and Tumor T status were risk factors of lymph node metastasis of esophageal cancer (P<0.01, OR¼3.936, 95%CI:1.480w10.469; P<0.01, OR¼3.558,95%CI:1.798w7.041), ROC analysis indicated that the AUC of CEA and CT for lymph node metastasis is 0.687 and 0.689. Combine with the two methods above in the diagnosis of lymph node metastasis, the AUC is 0.785 (P<0.05). CONCLUSIONS: Serum CEA has certain prediction value for lymph node metastasis of esophageal cancer, and the value could be more credible when combined with chest enhancement CT. The number of lymph nodes dissection can be reduced in patients with shallow tumor invasion and normal CEA level, For patients with deep invasion, and CEA is significantly elevated, due to the risk of lymph node metastasis, the range of lymph node dissection should be expanded. CLINICAL IMPLICATIONS: Confirm the value of predicting lymph node metastasis for esophageal cancer DISCLOSURE: The following authors have nothing to disclose: Yan Zhao, Bin You, Hui Li No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.057
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
54A
[
149#4S CHEST APRIL 2016
]
Diagnostic Value of Preoperative CEA Serum Levels for Esophageal Cancer Lymph Node Metastasis Yan Zhao MD* Bin You PhD; and Hui Li PhD Department of Thoracic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China PURPOSE: To investigate the relationships between tumor marker CEA and biological characteristics of esophageal cancer, and it’s value of predicting lymph node metastasis for esophageal cancer METHODS: Consecutive 111 patients with esophageal cancer who underwent esophagectomy in Beijing Chaoyang Hospital were retrospectively evaluated between December 2010 and January 2014. The Single and multiple factors regression analysis were used to identify the risk factors for Abnormal level of CEA and lymph node metastasis, ROC curves analysis were performed to confirm the diagnostic value of preoperative CEA serum levels for esophageal cancer lymph node metastasis.
CARDIOTHORACIC SURGERY
RESULTS: There were 67 (60.36%) patients with lymph node metastasis.univariate and multivariate analysis indicated that Tumor N status were single risk factors for Abnormal level of CEA (P<0.01, OR¼2.206, 95% CI:1.370w3.552); Increased abnormal CEA and Tumor T status were risk factors of lymph node metastasis of esophageal cancer (P<0.01, OR¼3.936, 95%CI:1.480w10.469; P<0.01, OR¼3.558,95%CI:1.798w7.041), ROC analysis indicated that the AUC of CEA and CT for lymph node metastasis is 0.687 and 0.689. Combine with the two methods above in the diagnosis of lymph node metastasis, the AUC is 0.785 (P<0.05). CONCLUSIONS: Serum CEA has certain prediction value for lymph node metastasis of esophageal cancer, and the value could be more credible when combined with chest enhancement CT. The number of lymph nodes dissection can be reduced in patients with shallow tumor invasion and normal CEA level, For patients with deep invasion, and CEA is significantly elevated, due to the risk of lymph node metastasis, the range of lymph node dissection should be expanded. CLINICAL IMPLICATIONS: Confirm the value of predicting lymph node metastasis for esophageal cancer DISCLOSURE: The following authors have nothing to disclose: Yan Zhao, Bin You, Hui Li No Product/Research Disclosure Information DOI:
http://dx.doi.org/10.1016/j.chest.2016.02.057
Copyright ª 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
54A
[
149#4S CHEST APRIL 2016
]