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Dibenzanthracenes and Environmental Carcinogenesis
88
Whereas the chapters just described may appeal more to clinically interested toxicologists, other chapters will be studied in greater detail by toxicologists 'proper' who might be interested in aliphatic halogenated hydrocarbons and possibly the activation of these toxicants and the unfavourable action of the enzyme beta-lyase, which represents a principally interesting toxic mechanism. The nephrotoxicity of bromobenzene is also dealt with and of couse the actions of metals on the kidney - - these in the form of a short review from which one will obtain the basic knowledge and literature to proceed to more detailed studies. An important field of recent interest is the action of fungal toxins like ochratoxin A, an example of food-derived nephropathy, is also described. The concluding chapters deal with renal carcinogenesis with - 3 0 0 citations and finally with a particular and specific syndrome, namely the light hydrocarbon nephropathy which occurs exclusively in adult male rats. All chapters are carefully composed and written and will fulfil the intention of the editors as stated in the preface, namely, to serve as an introduction for some, a review for others, and a textbook for many. In this regard success can be predicted which will be supported by the high quality of printing and binding (but not by the high price). The book offers wide access by citing the original literature in each chapter, though sometimes deleting the last authors in multi-authored citations. A Subject Index of 20 pages concludes this volume, which will surely find place not only in the target organ toxicology series but more importantly on the book shelves of active toxicologists. K.J. Netter
Dibenzanthracenes and Environmental Carcinogenesis, by W.F. Karcher, Cambridge University Press, Cambridge, UK, 1992, pp. 271, £75.00. The chemistry of dibenzanthracenes and their importance for environmental carcinogenesis is discussed in detail. Dibenzanthracenes are an important group of pentacyclic PAH, including dibenz[a,c]- ,dibenz[a,h]-, dibenz[a,j]-, and dibenz[a,/]anthracene. The chemistry of dibenzanthracenes described in this monograph indudes physical and chemical properties, analytical methods, synthesis and metabolites and radiolabeled analogues. The occurrence of dibenzanthracenes in the environment and in food products is summarized and compared to that of some other important PAHs, e.g. pentacene, benzo[a]pyrene and benz[a]anthracene. In the biological part, the metabolism and cellular interactions, toxicity, mutagenicity and carcinogenicity including epidemiological results of dibenzanthracenes are discussed. The last chapter is devoted to structure-activity relationships. The reference list with nearly 900 citations includes the important publications and reports. The monograph represents an extensive documentation of chemistry and biological activities of dibenzanthracenes and a useful reference book. Prof. Dr. G. Eisenbrand
Whereas the chapters just described may appeal more to clinically interested toxicologists, other chapters will be studied in greater detail by toxicologists 'proper' who might be interested in aliphatic halogenated hydrocarbons and possibly the activation of these toxicants and the unfavourable action of the enzyme beta-lyase, which represents a principally interesting toxic mechanism. The nephrotoxicity of bromobenzene is also dealt with and of couse the actions of metals on the kidney - - these in the form of a short review from which one will obtain the basic knowledge and literature to proceed to more detailed studies. An important field of recent interest is the action of fungal toxins like ochratoxin A, an example of food-derived nephropathy, is also described. The concluding chapters deal with renal carcinogenesis with - 3 0 0 citations and finally with a particular and specific syndrome, namely the light hydrocarbon nephropathy which occurs exclusively in adult male rats. All chapters are carefully composed and written and will fulfil the intention of the editors as stated in the preface, namely, to serve as an introduction for some, a review for others, and a textbook for many. In this regard success can be predicted which will be supported by the high quality of printing and binding (but not by the high price). The book offers wide access by citing the original literature in each chapter, though sometimes deleting the last authors in multi-authored citations. A Subject Index of 20 pages concludes this volume, which will surely find place not only in the target organ toxicology series but more importantly on the book shelves of active toxicologists. K.J. Netter
Dibenzanthracenes and Environmental Carcinogenesis, by W.F. Karcher, Cambridge University Press, Cambridge, UK, 1992, pp. 271, £75.00. The chemistry of dibenzanthracenes and their importance for environmental carcinogenesis is discussed in detail. Dibenzanthracenes are an important group of pentacyclic PAH, including dibenz[a,c]- ,dibenz[a,h]-, dibenz[a,j]-, and dibenz[a,/]anthracene. The chemistry of dibenzanthracenes described in this monograph indudes physical and chemical properties, analytical methods, synthesis and metabolites and radiolabeled analogues. The occurrence of dibenzanthracenes in the environment and in food products is summarized and compared to that of some other important PAHs, e.g. pentacene, benzo[a]pyrene and benz[a]anthracene. In the biological part, the metabolism and cellular interactions, toxicity, mutagenicity and carcinogenicity including epidemiological results of dibenzanthracenes are discussed. The last chapter is devoted to structure-activity relationships. The reference list with nearly 900 citations includes the important publications and reports. The monograph represents an extensive documentation of chemistry and biological activities of dibenzanthracenes and a useful reference book. Prof. Dr. G. Eisenbrand