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Die ultraschalldiagnostik in der schwangerschaft
Book reviews
84
dose or potency of the medication. The dysfunction was not transient but showed up as strongly after one month of life as it did during the neonatal period. Juchan (Wachington, D.C., USA) describes the central role of cytochrome P-450 in oxidation reactions in the feto-placental unit. Placental transfer of drugs and effects on the fetus and newborn is discussed for gentamycin. Michael1 Heymann, Kari Teramo and Abraham Rudolph (San Francisco, Calif., USA) described the effects of local anesthetic agents on fetal circulation. In chronic sheep experiments they found dose-dependent effects of local anesthetics and fetal myocardial depression as well as direct central nervous system effects. When administered as a paracervical block, the rate and concentration of delivery of the drug to the fetus was variable and not predictable. Else Ackermann and Klaus Richter (GDR) showed that the rate of conversion of diazepam is lower in fetal than in adult human liver tissue so that one may expect an accumulation of diazepam metabolites on the fetal side. Neonatal studies are presented on salicylate pharmacokinetics, phenobarbital, phenytoin, carbamazepine, digoxin, cefalotin, drug protein binding and diurnal variation of drug kinetics. The Symposium ends with ethical and methodological challenge in research in perinatal pharmacology. This book is strongly recommended to all those interested in and concerned about medication during pregnancy, labor and the neonatal period. T.K.A.B. Eskes, Nijmegen
Die Ultraschalldiagnostik in der Schwangerschaft
H.J. Hollander (ed.) Urban und Schwarzenberg, Miinchen-BerlinWien, 1975 (xi + 188 pp., 1 I2 Figs., 7 Tables) DM 58.-
Indeed, the growing use of diagnostic ultrasound techniques, also in smaller hospitals, creates the need for good documentation. This book contains much personal research, as a result of which the novice especially obtains a clear view of the diagnostic possibilities in obstetrics. In the first chapters the authors deal at great length with the basic principles of the ultrasound employed, with a description of the various techniques in use. Fortunately they do not confine themselves to the apparatus they used (Vidoson, Siemens); also describe other commercially available equipment. The biological effect of ultrasound and the possible harmful side-effects are described in detail, with references to other publications, including recent ones. The whole field of diagnostic ultrasound as applied in obstetrics is discussed; the book has been brought very up-to-date by adding references to recent publications. A great deal of attention is devoted to fetal biometry: determination of the fetal biparieta1 diameter, measurement of fetal abdomen and trunk circumference and placental thickness. In connection with this the authors invariably present their own growth curves and normal values. These values must be used with the greatest caution, because on the one hand each local population may be biologically different, and on the other hand the individual growth of normally developing fetuses may vary widely. A striking recurrent feature in the discussion of clinical applications is the amount of attention paid to obstetric background and the way in which diagnostic ultrasound techniques should be included in clinical examination. It is this very feature which makes this handbook very valuable as a reference work. The Vidoson technique employed entails the drawback that the illustrations are frequently not very sharp and that hardly any space has been reserved for the modern, very fine grey-scale technique. For all those who employ diagnostic ultrasound this book is greatly recommended. T.M. Hameeteman,
Three years after the publication of the first edition of this handbook for diagnostic ultrasound in obstetrics, a second edition has already been produced. From the outset this well-documented work has attracted much attention.
Gerinnungsanalysen Interpretation, Schnellorientierung, len
Vleuten
Therapiekontrol-
84
dose or potency of the medication. The dysfunction was not transient but showed up as strongly after one month of life as it did during the neonatal period. Juchan (Wachington, D.C., USA) describes the central role of cytochrome P-450 in oxidation reactions in the feto-placental unit. Placental transfer of drugs and effects on the fetus and newborn is discussed for gentamycin. Michael1 Heymann, Kari Teramo and Abraham Rudolph (San Francisco, Calif., USA) described the effects of local anesthetic agents on fetal circulation. In chronic sheep experiments they found dose-dependent effects of local anesthetics and fetal myocardial depression as well as direct central nervous system effects. When administered as a paracervical block, the rate and concentration of delivery of the drug to the fetus was variable and not predictable. Else Ackermann and Klaus Richter (GDR) showed that the rate of conversion of diazepam is lower in fetal than in adult human liver tissue so that one may expect an accumulation of diazepam metabolites on the fetal side. Neonatal studies are presented on salicylate pharmacokinetics, phenobarbital, phenytoin, carbamazepine, digoxin, cefalotin, drug protein binding and diurnal variation of drug kinetics. The Symposium ends with ethical and methodological challenge in research in perinatal pharmacology. This book is strongly recommended to all those interested in and concerned about medication during pregnancy, labor and the neonatal period. T.K.A.B. Eskes, Nijmegen
Die Ultraschalldiagnostik in der Schwangerschaft
H.J. Hollander (ed.) Urban und Schwarzenberg, Miinchen-BerlinWien, 1975 (xi + 188 pp., 1 I2 Figs., 7 Tables) DM 58.-
Indeed, the growing use of diagnostic ultrasound techniques, also in smaller hospitals, creates the need for good documentation. This book contains much personal research, as a result of which the novice especially obtains a clear view of the diagnostic possibilities in obstetrics. In the first chapters the authors deal at great length with the basic principles of the ultrasound employed, with a description of the various techniques in use. Fortunately they do not confine themselves to the apparatus they used (Vidoson, Siemens); also describe other commercially available equipment. The biological effect of ultrasound and the possible harmful side-effects are described in detail, with references to other publications, including recent ones. The whole field of diagnostic ultrasound as applied in obstetrics is discussed; the book has been brought very up-to-date by adding references to recent publications. A great deal of attention is devoted to fetal biometry: determination of the fetal biparieta1 diameter, measurement of fetal abdomen and trunk circumference and placental thickness. In connection with this the authors invariably present their own growth curves and normal values. These values must be used with the greatest caution, because on the one hand each local population may be biologically different, and on the other hand the individual growth of normally developing fetuses may vary widely. A striking recurrent feature in the discussion of clinical applications is the amount of attention paid to obstetric background and the way in which diagnostic ultrasound techniques should be included in clinical examination. It is this very feature which makes this handbook very valuable as a reference work. The Vidoson technique employed entails the drawback that the illustrations are frequently not very sharp and that hardly any space has been reserved for the modern, very fine grey-scale technique. For all those who employ diagnostic ultrasound this book is greatly recommended. T.M. Hameeteman,
Three years after the publication of the first edition of this handbook for diagnostic ultrasound in obstetrics, a second edition has already been produced. From the outset this well-documented work has attracted much attention.
Gerinnungsanalysen Interpretation, Schnellorientierung, len
Vleuten
Therapiekontrol-