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DIGITALIS.
36 are then to be dissolved, each in a of cold water, and the insoluble residua are to be triturated in water until the fluid remains colourless. The whole of the liquids are now to be collected together and submitted to evaporation, until they mark 10° by the areometer ; in this state they are to be precipitated by ammonia, and allowed to become cool. When the fluid is completely cold, the precipitate is placed on a filter, and washed with cold water, until the latter passes ofl’colourless. The precipitate is then again washed with alcohol, at 18°, which removes the colouring matter. The solid product is now dried and treated with boiling alcohol, at 360, a small quantity of animal charcoal being added ; the dissolved matter is now filtered ; one half is separated by distillation, and the remainder placed in a glass vessel, and allowed to crystallise. The crystals of morphine are then separated. As some of the crystals of morphine contain a resinous matter they must be washed with strong, cold alcohol, to separate the latter substance; they are then thrown upon a filter, allowed to dry, and weighed. The alcohol, which has been employed for the purpose of washing, also contains some morphine; to obtain this the alcohol is submitted to distillation ; the extractive residue is treated with water, acidulated with hydrochloric acid, a small quantity of animal charcoal being added ; the matter is then filtered, and precipitated by ammonia; the precipitate is now treated in the same manner as that obtained by evaporation. The ammoniated waters also contain To obtain the latter they some morphine. are submitted to a slow evaporation, until the extractive matter remains as dry as possible ; this extract is then mixed with some animal black, and treated with boiling alcohol ; the alcoholic solution is filtered, and the morphine obtained by evaporation. The presence of narcotine may be detected by a weak solution of potass, which takes up the morphine, and leaves the narcotine undissolved. A number of experiments made with various samples of Smyrna opium, show that the average quantity of morphine obtained from a pound of that opium, is eight and a half to nine drachms.—Jour. de Chimie., September, 1838.
the latter
pound
SPONTANEOUS EVOLUTION OF THE FŒTUS.
before the attendant physician was called in. On arriving he found the left arm projecting beyond the external organs of gene. ration. The mouth of the uterus was hard and thick, and closely embraced the shoulder of the foetus. The patient was immediately bled, after which it was possible to pass up two fingers between the arm and os uteri, but any further dilatation was found to be impracticable. The woman was allowed to repose for some time, and the attempts at dilatation again renewed, but without success. doses of an opiate medicine were now Large administered internally, and the extract of belladonna rubbed on the os uteri. After the lapse of several hours, and during the absence of the accoucheur, the woman was seized with violent pains ; the shoulder ascended, the breech presented itself at the os uteri, and the woman was delivered by the midwife in attendance.—Siebold’s Journal.
PREPARATION OF JALAP. THE powder of jalap may be easily deprived of the nauseous taste which renders it so disagreeable, by the following process: R Pou’dered jalap, one part ; Rectified sulphuric ether, three parts. Alacerate for twenty-four hours, and then fluid, which has accarefullya decant the colour. Add a fresh deep yellow quired proportion of ether to the powder ; macerate again for twenty-four hours and decant. The powder must now be allowed to dry on a sheet of paper, and when perfectly dry is to be triturated in a mortar; by this means may be obtained a powder which is completely deprived of odour, and still retains all its purgative qualities.
DIGITALIS. M. LABELONGE having made numerous experiments on digitalis, is of opinion that the medicinal principle of this plant has not yet been obtained in a separate state ; that water takes up only a few of the principles, while alcohol takes up only certain other ones ; hence digitalis should be treated with water and alcohol together, or with alcohol at 22°, in order to produce an hydro-alcoholic extract, containing the volatile oil, resins, salts, bitter extractive principle, &c., of the plant. —Journal de Chimie, July, 1838.
SALICINE IN INTERMITTENT FEVER.
THE following example of spontaneous Dr. A. FioRto has employed salicine in evolution of the foetus, which we extract 108 cases of intermittent fever with the from a late number of Siebold’ Journal, may greatest success. The highest dose admibe added to those already recorded :nistered was twenty-four grains, and in The patient in this case was a woman, every case, except two, the disease was imthirty years of age, who had already mediately moderated by the remedy, and given birth to several children. The eventually curad.-Medic. Yahrbücher, Vol, membranes had given way eighteen hours 24, No. 1, p. 171.
the latter
pound
SPONTANEOUS EVOLUTION OF THE FŒTUS.
before the attendant physician was called in. On arriving he found the left arm projecting beyond the external organs of gene. ration. The mouth of the uterus was hard and thick, and closely embraced the shoulder of the foetus. The patient was immediately bled, after which it was possible to pass up two fingers between the arm and os uteri, but any further dilatation was found to be impracticable. The woman was allowed to repose for some time, and the attempts at dilatation again renewed, but without success. doses of an opiate medicine were now Large administered internally, and the extract of belladonna rubbed on the os uteri. After the lapse of several hours, and during the absence of the accoucheur, the woman was seized with violent pains ; the shoulder ascended, the breech presented itself at the os uteri, and the woman was delivered by the midwife in attendance.—Siebold’s Journal.
PREPARATION OF JALAP. THE powder of jalap may be easily deprived of the nauseous taste which renders it so disagreeable, by the following process: R Pou’dered jalap, one part ; Rectified sulphuric ether, three parts. Alacerate for twenty-four hours, and then fluid, which has accarefullya decant the colour. Add a fresh deep yellow quired proportion of ether to the powder ; macerate again for twenty-four hours and decant. The powder must now be allowed to dry on a sheet of paper, and when perfectly dry is to be triturated in a mortar; by this means may be obtained a powder which is completely deprived of odour, and still retains all its purgative qualities.
DIGITALIS. M. LABELONGE having made numerous experiments on digitalis, is of opinion that the medicinal principle of this plant has not yet been obtained in a separate state ; that water takes up only a few of the principles, while alcohol takes up only certain other ones ; hence digitalis should be treated with water and alcohol together, or with alcohol at 22°, in order to produce an hydro-alcoholic extract, containing the volatile oil, resins, salts, bitter extractive principle, &c., of the plant. —Journal de Chimie, July, 1838.
SALICINE IN INTERMITTENT FEVER.
THE following example of spontaneous Dr. A. FioRto has employed salicine in evolution of the foetus, which we extract 108 cases of intermittent fever with the from a late number of Siebold’ Journal, may greatest success. The highest dose admibe added to those already recorded :nistered was twenty-four grains, and in The patient in this case was a woman, every case, except two, the disease was imthirty years of age, who had already mediately moderated by the remedy, and given birth to several children. The eventually curad.-Medic. Yahrbücher, Vol, membranes had given way eighteen hours 24, No. 1, p. 171.