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DIRECT CAROTID WALL SHEAR STRESS IN ACUTE CORONARY SYNDROME PATIENTS DECREASED AFTER ONE MONTH MEDICAL MANAGEMENT
A1771 JACC March 17, 2015 Volume 65, Issue 10S
TCT@ACC-i2: Interventional Cardiology Direct Carotid Wall Shear Stress in Acute Coronary Syndrome Patients Decreased after One Month Medical Management Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Coronary II Abstract Category: 36. TCT@ACC-i2: IVUS and Intravascular Physiology Presentation Number: 2101-284 Authors: Sang-Rok Lee, Lae-Young Jung, Soo Kyoung Song, Ji-Young Yoon, Yi-Shik Kim, Sun Hwa Lee, Kyoung-Suk Rhee, Jei-Keon Chae, Won-Ho Kim, Jae-Ki Ko, Chonbuk National University Hospital, Jeonju, South Korea, University of California San Diego, San Diego, CA, USA Background: Although wall shear stress (WSS) is determined by the products of blood viscosity (BV), velocity and lumen diameter, there has been few studies for the direct measurement of WSS by imaging modalities. The aim of our study was to investigate the carotid WSS directly by doppler and BV parameters in acute coronary syndrome (ACS) patients.
Methods: Consecutive 143 patients who were diagnosed as ACS were enrolled (65.48±10.94 years, 110 males). Low-shear BV (diastolic BV) and high-shear BV (systolic BV) were measured at shear rates of 1 and 300 s-1, by a scanning capillary tube viscometer (Bio-Visco Inc., South Korea) at both admission and one month later. Doppler parameters for lumen diameter andc velocity of common carotid arteries (CCA) were measured and WSS were calculated by formula. Results: The mean maximal-CCA [Right CCA: left CCA (mm) = 6.95±0.95: 6.59±1.09] and mean minimal-CCA diameter [Right CCA: left CCA (mm) = 6.57±0.93: 6.21±1.03] were measured. The whole BV decreased significantly at one month later (systolic BV; 44.34±7.60 vs 42.03±5.75 mP, p=0.007, diastolic BV; 296.20±75.48 vs 277.13±65.21 mP, p=0.028). The WSS were also significantly decreased during one month clinical follow up in both CCA at systole (table). Conclusion: We could directly measure the carotid WSS. The carotid WSS was decreased significantly after one month medical treatment. Future larger studies are needed to clarify our results. Wall shear stress
baseline
one month
p-value
Right CCA-systole (dyn/cm2)
20.28±7.54
18.45±5.89
0.002
Left CCA-systole (dyn/cm )
23.82±21.61
21.61±6.16
0.003
Right CCA-diastole (dyn/cm )
48.62±20.13
40.53±14.24
0.001
Left CCA-diastole (dyn/cm )
56.90±22.54
47.33±15.27
0.001
2
2
2
TCT@ACC-i2: Interventional Cardiology Direct Carotid Wall Shear Stress in Acute Coronary Syndrome Patients Decreased after One Month Medical Management Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 3:45 p.m.-4:30 p.m. Session Title: Coronary II Abstract Category: 36. TCT@ACC-i2: IVUS and Intravascular Physiology Presentation Number: 2101-284 Authors: Sang-Rok Lee, Lae-Young Jung, Soo Kyoung Song, Ji-Young Yoon, Yi-Shik Kim, Sun Hwa Lee, Kyoung-Suk Rhee, Jei-Keon Chae, Won-Ho Kim, Jae-Ki Ko, Chonbuk National University Hospital, Jeonju, South Korea, University of California San Diego, San Diego, CA, USA Background: Although wall shear stress (WSS) is determined by the products of blood viscosity (BV), velocity and lumen diameter, there has been few studies for the direct measurement of WSS by imaging modalities. The aim of our study was to investigate the carotid WSS directly by doppler and BV parameters in acute coronary syndrome (ACS) patients.
Methods: Consecutive 143 patients who were diagnosed as ACS were enrolled (65.48±10.94 years, 110 males). Low-shear BV (diastolic BV) and high-shear BV (systolic BV) were measured at shear rates of 1 and 300 s-1, by a scanning capillary tube viscometer (Bio-Visco Inc., South Korea) at both admission and one month later. Doppler parameters for lumen diameter andc velocity of common carotid arteries (CCA) were measured and WSS were calculated by formula. Results: The mean maximal-CCA [Right CCA: left CCA (mm) = 6.95±0.95: 6.59±1.09] and mean minimal-CCA diameter [Right CCA: left CCA (mm) = 6.57±0.93: 6.21±1.03] were measured. The whole BV decreased significantly at one month later (systolic BV; 44.34±7.60 vs 42.03±5.75 mP, p=0.007, diastolic BV; 296.20±75.48 vs 277.13±65.21 mP, p=0.028). The WSS were also significantly decreased during one month clinical follow up in both CCA at systole (table). Conclusion: We could directly measure the carotid WSS. The carotid WSS was decreased significantly after one month medical treatment. Future larger studies are needed to clarify our results. Wall shear stress
baseline
one month
p-value
Right CCA-systole (dyn/cm2)
20.28±7.54
18.45±5.89
0.002
Left CCA-systole (dyn/cm )
23.82±21.61
21.61±6.16
0.003
Right CCA-diastole (dyn/cm )
48.62±20.13
40.53±14.24
0.001
Left CCA-diastole (dyn/cm )
56.90±22.54
47.33±15.27
0.001
2
2
2