- Email: [email protected]
Discoloration of deciduous teeth induced by administration of tetracycline antepartum
COMMUNICATIONS IN BRIEF
to pursue this aspect of the over-all problem in a srries of similar but consecutive and prosprctiv" mother-child cast• findings. By searching the records of the Department of Obstetrics of the Vanderbilt Clinic of the Colmnbia ··· Presbyt rrian M(•dical C:cntt'r, motlwr-c hi lei case histories wrn· obtained which fulfill<·d all of the following criteria: (I) thl' moth<·r suffered premature rupturt' of the fetal nwmbrarlt's; ( 2) sht• rrceived tetracycline during the courst' of managing such an episode; and ( 3) a li\·in,!!; otTspring was dclivt•red. From this g-mup of po· tential ''experimental" mother-child casf' histories, all those wt-re eliminated from furtht•r study wherein th<• record of the infant rt'\·ealt•d that he or sht• had received a tctracydirw antibiotic following birth. Hence, only thost• 7 patirnts were ultimately included in this studv whose exposure to tetracycline had hePn 1 .~ strict I'd, as far as could b-.. clt'lcrmincd, to t lw antepartum period. Thus, in addition to the case prcviomly rf'portecl by us, 1 7 consecutive additional childr••n, all tf:'rm births, ·l to 5 yrars of age ( 4 mal•·s and :\ fcmah's) were found to fulfill tht' above 1 ritcria and, hcncr, s•·rvrd as tht• basis of this studv. It was found that all 7 motht•rs had r<'Cf'i\·,:d a similar dosage of tetracycline ( 1 Gm. pn dav 't from tht• time of rupture nf the mcmbr:uws lllltil the time of birth. Each child was suhjt'cted to thorough t011th discoloration determination studies employing an S. S. White Filling Porcelain Color :Matching Guide under daylight conditions utilizing a tPchnique and standards which haw previously bt·t•n ciP:;crilwd. Tlw pertinent data taken fmm the moth•·rchilcl case histories an~ included in Table I. The findings regarding thr discoloration of t h<' tPl'th found in thr 7 children at the time of clinical examination an· smnmariz<'cl in Tablr II. From th(' tabulatl'd data. it will be notl'd th:lt all 7 children l'xarnin<'d (lOCI p('r c<'nt.l ,,,.n• found to have deciduous teeth some or all of which \\l'rl' considered to ht• definitivelv dis• ol. ort'd according to our stand:1rds.
Discoloration of deciduous teeth induced by administration of tetracycline antepartum AUSTIN H. KUTSCHER, D.D.S. EDWARD V. ZEGARELLI, D.D.S., M.S. HAROLD M. M. TOVELL, M.D. BURTON HOCHBERG, D.D.S.* JOEL HA UPTMA~. D.D.S.* School of Dental and Oral Surgery, Columbia University, New J'ork, New York, and Woman's Hospital, New York, New York
I :-.. A prc\·iom report, 1 the discoloration of the teeth observed in a boy 3 years, 10 months whose mother had received a total of 20.75 Grn. of tetracycline antepartum was described. While this report was !wing- prepared for publication, t1NO papers were published which also deq·ribed discoloration of the deciduous dentition of children following tetracycline therapy to the mother during the period of gestation. In a hrid note, Harcourt, Johnson, and Storey" reporu•d upon a 2-year-old patient with bright ycllow staining of the deciduous dentition who had !wen Pxpos('d to tetracycline therapy during fl'lal lift•. Rendle-Shorta described a similar discoloration of the deciduous teeth in a child born to a mother who recollected having received a tt·tracycline during tht• last 6 wcrks of grstation. S1wrific details w<·n· not included in either in~tanr<'.
Since the above individual case rrports and suhst•quNlt rdrospective studies have all contribut•·cl in a positive fa.,hion to an understanding: of tht' discoloration-inducing effects of tt'tranclint' of th•: human dt•ntitio~, it was decided Thi:-- ~tudy wa~ supported in pa1 t hy an institutional · .1-n·ant from the National Institutes o( H<-·alth. '""{}nitNi Stat!'-, Pub1ir Health S('n·ire Rt·~PaJch F1·llow
1%~.
.
291
292
:'-wj.Jlt"lflfw!
Communications in brief
\1o
I ( )!,,.,r .
1.-,
.._,, (
jtjt,IJ •\II<';
Table I. Pertinent data taken from mother-child ca;.,• hi.,tori•··'
')
5
~
Time at which a tetracycline was gin·n (days prior to delivPry) Dosage of tetracycline ( Gm./ day' Duration of tetraeydine therapy
H
( davs) Duration .,f pregnancy 'Jormal delivery? Was child breast fed?
Term
TPrm
Yes
TPnlt Yes
Tt•rm
Yes
I\o
,\;o
:\o
'\'o
Table II. Findings regarding the discoloration of dw teeth found in 7 rhildr('n at th•· time of
1--+ 5- i
:!
:l l
5 H-19
ti
7
Tenlt
:\o
'J"
y,.,
Our lin dings provide additional t'\·idelH ,. ,,J t<'lracvclirw\ role in the distoloration ol ttTth
ing dw latt<·r da\s of the ,\(!'.stational 1wriod.
I nten1ity of dircoloration
discolured deciduous teeth
2+
3~
0 !:! 0
n
()
()
()
()
[I)
6
:.:o
:_>(I
()
II
()
12
I)
0
H
ll
~ ()
6 4 5
6 6
1:! 16
.!
I.
REFERENCES Kutscher. A. H .. Zegarelli, E. \. "I uHll. H. H., and Hochbl"r!!. B.: .J. .\. M .. \. 184: -Jilfi.
.!
Harcourt. ], K .. Johnson. ~- V\'.
4+
()
2
0-2
y,.,
'hildrcn wh
Nu. of Case No.
Tt·nn
Tllis smdy part kularly <'tHpha>i:t<'' t.·t racy• Iinc ' rok in tht• di"·nloration of fl.-cidnons t•·•·th ol
clinical examination Details of tetracycliliP therapy to mothl'r (Gm.)
Tt·nH Yes 'Jo
y,.,
()
All of the deciduous teeth of each of the 7 children W\'1'<' suhj•·cted tu fluure.-r·•·m..- studie:under ultraviolet light. The results indicated that: (a) not all of thl' discolored te<'ih fiuoresced; ! IJ) thos•• that did fluon'sc•· did not appear to have an intensity of fluon•sr<'IKt' rwn·ssarily in kreping- with the intensi1y of di:
196:i.
E.: Arch. Oral Bioi. 7: .J.31. 'l
R<'ndlt'-Short. T.
J.:
and Ston'\
196~.
LancPt 1: lli'H. l'ltic
6,'10 West !68th Street .lliet<' J'ork. :Veu: }',nk lOO'il
Argentaffin cells in mucinous cystadenocarcinoma of the ovary E. H. Rl.FFOLO, M.D R.
·w.
V>ITHERS. M.D
Department., of Pathology and Ubctet1ic.' and Gynecolnj.!y. Tampa Generallllllpital. Tampa. Florida
B H E ;>; :-; E H Utmors are fn·qrwlltl~ ass"ciatcd ,,·ith mucinous cvstad,.nomas, hmYt'\'
c: -.tadt'noc~tt·ci
noma. The following report d,•,nilws such
:111
\Vithin th•· cystad<'wxarcinotlf:< 11.-r•· found arl!;<'lltatlin '•·lk Tlwir si_;.(ltiJi,·:nH ,. in tl~t· in.'!ann·.
hi,togt•m•,is nf !lws!'
\
'i9-ye:~r-old
tllllHH''
whit•·
j, di,cu"•·d.
multip;~r.t.
II
ye:~rs
post·
nwnopausal. complain~d onlv of urinary frPqlleJH'\ Pelvic examination revealed a !at ge. firm. mu1 ,., ahle. apparently o1·ari~n mass. Lahor8tory n'port; were entirely noncontributory. l_'pon <'Xploration. .1 large. partially solid. and cystit right o1arian tumor was found. :\ total hysterectonty :wd l.i
to pursue this aspect of the over-all problem in a srries of similar but consecutive and prosprctiv" mother-child cast• findings. By searching the records of the Department of Obstetrics of the Vanderbilt Clinic of the Colmnbia ··· Presbyt rrian M(•dical C:cntt'r, motlwr-c hi lei case histories wrn· obtained which fulfill<·d all of the following criteria: (I) thl' moth<·r suffered premature rupturt' of the fetal nwmbrarlt's; ( 2) sht• rrceived tetracycline during the courst' of managing such an episode; and ( 3) a li\·in,!!; otTspring was dclivt•red. From this g-mup of po· tential ''experimental" mother-child casf' histories, all those wt-re eliminated from furtht•r study wherein th<• record of the infant rt'\·ealt•d that he or sht• had received a tctracydirw antibiotic following birth. Hence, only thost• 7 patirnts were ultimately included in this studv whose exposure to tetracycline had hePn 1 .~ strict I'd, as far as could b-.. clt'lcrmincd, to t lw antepartum period. Thus, in addition to the case prcviomly rf'portecl by us, 1 7 consecutive additional childr••n, all tf:'rm births, ·l to 5 yrars of age ( 4 mal•·s and :\ fcmah's) were found to fulfill tht' above 1 ritcria and, hcncr, s•·rvrd as tht• basis of this studv. It was found that all 7 motht•rs had r<'Cf'i\·,:d a similar dosage of tetracycline ( 1 Gm. pn dav 't from tht• time of rupture nf the mcmbr:uws lllltil the time of birth. Each child was suhjt'cted to thorough t011th discoloration determination studies employing an S. S. White Filling Porcelain Color :Matching Guide under daylight conditions utilizing a tPchnique and standards which haw previously bt·t•n ciP:;crilwd. Tlw pertinent data taken fmm the moth•·rchilcl case histories an~ included in Table I. The findings regarding thr discoloration of t h<' tPl'th found in thr 7 children at the time of clinical examination an· smnmariz<'cl in Tablr II. From th(' tabulatl'd data. it will be notl'd th:lt all 7 children l'xarnin<'d (lOCI p('r c<'nt.l ,,,.n• found to have deciduous teeth some or all of which \\l'rl' considered to ht• definitivelv dis• ol. ort'd according to our stand:1rds.
Discoloration of deciduous teeth induced by administration of tetracycline antepartum AUSTIN H. KUTSCHER, D.D.S. EDWARD V. ZEGARELLI, D.D.S., M.S. HAROLD M. M. TOVELL, M.D. BURTON HOCHBERG, D.D.S.* JOEL HA UPTMA~. D.D.S.* School of Dental and Oral Surgery, Columbia University, New J'ork, New York, and Woman's Hospital, New York, New York
I :-.. A prc\·iom report, 1 the discoloration of the teeth observed in a boy 3 years, 10 months whose mother had received a total of 20.75 Grn. of tetracycline antepartum was described. While this report was !wing- prepared for publication, t1NO papers were published which also deq·ribed discoloration of the deciduous dentition of children following tetracycline therapy to the mother during the period of gestation. In a hrid note, Harcourt, Johnson, and Storey" reporu•d upon a 2-year-old patient with bright ycllow staining of the deciduous dentition who had !wen Pxpos('d to tetracycline therapy during fl'lal lift•. Rendle-Shorta described a similar discoloration of the deciduous teeth in a child born to a mother who recollected having received a tt·tracycline during tht• last 6 wcrks of grstation. S1wrific details w<·n· not included in either in~tanr<'.
Since the above individual case rrports and suhst•quNlt rdrospective studies have all contribut•·cl in a positive fa.,hion to an understanding: of tht' discoloration-inducing effects of tt'tranclint' of th•: human dt•ntitio~, it was decided Thi:-- ~tudy wa~ supported in pa1 t hy an institutional · .1-n·ant from the National Institutes o( H<-·alth. '""{}nitNi Stat!'-, Pub1ir Health S('n·ire Rt·~PaJch F1·llow
1%~.
.
291
292
:'-wj.Jlt"lflfw!
Communications in brief
\1o
I ( )!,,.,r .
1.-,
.._,, (
jtjt,IJ •\II<';
Table I. Pertinent data taken from mother-child ca;.,• hi.,tori•··'
')
5
~
Time at which a tetracycline was gin·n (days prior to delivPry) Dosage of tetracycline ( Gm./ day' Duration of tetraeydine therapy
H
( davs) Duration .,f pregnancy 'Jormal delivery? Was child breast fed?
Term
TPrm
Yes
TPnlt Yes
Tt•rm
Yes
I\o
,\;o
:\o
'\'o
Table II. Findings regarding the discoloration of dw teeth found in 7 rhildr('n at th•· time of
1--+ 5- i
:!
:l l
5 H-19
ti
7
Tenlt
:\o
'J"
y,.,
Our lin dings provide additional t'\·idelH ,. ,,J t<'lracvclirw\ role in the distoloration ol ttTth
ing dw latt<·r da\s of the ,\(!'.stational 1wriod.
I nten1ity of dircoloration
discolured deciduous teeth
2+
3~
0 !:! 0
n
()
()
()
()
[I)
6
:.:o
:_>(I
()
II
()
12
I)
0
H
ll
~ ()
6 4 5
6 6
1:! 16
.!
I.
REFERENCES Kutscher. A. H .. Zegarelli, E. \. "I uHll. H. H., and Hochbl"r!!. B.: .J. .\. M .. \. 184: -Jilfi.
.!
Harcourt. ], K .. Johnson. ~- V\'.
4+
()
2
0-2
y,.,
'hildrcn wh
Nu. of Case No.
Tt·nn
Tllis smdy part kularly <'tHpha>i:t<'' t.·t racy• Iinc ' rok in tht• di"·nloration of fl.-cidnons t•·•·th ol
clinical examination Details of tetracycliliP therapy to mothl'r (Gm.)
Tt·nH Yes 'Jo
y,.,
()
All of the deciduous teeth of each of the 7 children W\'1'<' suhj•·cted tu fluure.-r·•·m..- studie:under ultraviolet light. The results indicated that: (a) not all of thl' discolored te<'ih fiuoresced; ! IJ) thos•• that did fluon'sc•· did not appear to have an intensity of fluon•sr<'IKt' rwn·ssarily in kreping- with the intensi1y of di:
196:i.
E.: Arch. Oral Bioi. 7: .J.31. 'l
R<'ndlt'-Short. T.
J.:
and Ston'\
196~.
LancPt 1: lli'H. l'ltic
6,'10 West !68th Street .lliet<' J'ork. :Veu: }',nk lOO'il
Argentaffin cells in mucinous cystadenocarcinoma of the ovary E. H. Rl.FFOLO, M.D R.
·w.
V>ITHERS. M.D
Department., of Pathology and Ubctet1ic.' and Gynecolnj.!y. Tampa Generallllllpital. Tampa. Florida
B H E ;>; :-; E H Utmors are fn·qrwlltl~ ass"ciatcd ,,·ith mucinous cvstad,.nomas, hmYt'\'
c: -.tadt'noc~tt·ci
noma. The following report d,•,nilws such
:111
\Vithin th•· cystad<'wxarcinotlf:< 11.-r•· found arl!;<'lltatlin '•·lk Tlwir si_;.(ltiJi,·:nH ,. in tl~t· in.'!ann·.
hi,togt•m•,is nf !lws!'
\
'i9-ye:~r-old
tllllHH''
whit•·
j, di,cu"•·d.
multip;~r.t.
II
ye:~rs
post·
nwnopausal. complain~d onlv of urinary frPqlleJH'\ Pelvic examination revealed a !at ge. firm. mu1 ,., ahle. apparently o1·ari~n mass. Lahor8tory n'port; were entirely noncontributory. l_'pon <'Xploration. .1 large. partially solid. and cystit right o1arian tumor was found. :\ total hysterectonty :wd l.i