- Email: [email protected]
Discoveries in pharmacology, vol 3
TIPS -June
1987 iVol.81
235
their co-operation is only partly understood. The functional role of NPY in the peripheral circulation is probably not related exclusively to sympathetic neuratransmission.
stein, M. (1982) Adn Physiol. Scan& 116, 477-480 10 EkbIad, E., Edvinsson, L., Wahlestedt, C., Uddman, R., HQkanson, R. and Sundler, F. (1984) Regal. Pepf. 8,225-235 11 Uddman, R., Ekblad, E., Edvinsson, L., Hakanson, R. and Sundler, F. (1985) Regal. Pepf. 10,243-257 12 Everitt, B. J., H&felt, T., Terenius, L., Tatemoto, K.. Mutt. V. and Goldstein. M. (1984) Ne&&ce 11, 44-62 . 13 Allen, J. M., Adrian, T. E., Tatemoto, K., Polak, J. M., Hughes, J. and Bloom. S. R. (1982) Neumpepfidcs 3,71-77 14 Fried, G., Terenius, L., HoMeIt, T. and Goldstein, M. (1985) I. Ncurosci. 5, 450458 15 Lundberg, J. M., Rudehill, A., Sollevi, A., Theodorsson-Norheim, E. and Hamberger, A. (1986) Neurosci. Left. 63, 96-100 16 Dahllif, C., Dahkif, I’. and Lundberg, J. M. (1985) Eur. I. Pkarmasol. 109,289292 17 Zukowska-Grojec, Z., Haass, M. and Bayorh, M. A. (1986) Regul. Fept. 15, 99-110 18 Edvinsson, L., Emson, I’., McCulIoch, I.. Tatemoto. K. and Uddman. R. (1984) ‘Acta Pkysioi &and. 122, 155-163 _ 19 Fcxe, K., Aenati, L. F., Harkstrand, A., Zini, I., Tagmoto, K., Mm10 rich, E., H&felt, T., Mutt, V. and Terenius, L. 11983) Acta Phvsiai. Stand. 118, 189-192 20 Carter, D. A., Vallejo, M. and Lightman. S. L. (1985) Peptides C~421-425 21 Tuor,~U. I., KeIIy, P. A. T., Edvinsson, L., Tatemoto, K. and McCuIIoch, J. Am-.1. Physiol. (in press) 22 Allen, J. M., Bircham, P. M. M., Edwards,
Acknowledgements Supported by grants from the Swedish Medical Research Cauncil. References 1 Tatemoto, K. (1982) Proc. Nufl Acad. Sci. WA 79,5485-5489 2 Minth, C. D., Bloom, 5 R., Polak, J. M. and Dixon, J. E. (1984) pmt. NufI Acad. Sci. USA 81,4577-4581 3 Allen. J. M., PoIak, J. A?. and Bloom, S. R. (1985) Nempeptides 6, 95-100 4 Auer, L. M., Edvinsson. L. and Johansson, 8. B. (1983) Arta Pkysiol. Scan& 119. 213-217 5 Lundberg, J. M., Fried, G., Pemow, J.. Theodoason-Narheim, E. and jinggard, A. (1986) Ada Physiof. Stand. 126, 151-152 6 Hellstrom. P. M., Olerup. 0. and Tatemote. K. (1985) Ada Physiol. Stand. 124. 6w24 7 Lundberg, J. M., dnggard, A., Theodorsson-Norheim, E. and Pemow, J. (1984) Neurosci. Left. 52, 175-180 8 Lundberg, J. M. and Tatemoto, K. (1982) Acfa Plzysiol. Stand. 116, 393-402 9 Lundberg, J. M., Terenius, L., Hiikfelt, T., Martling, C. R., Tatemoto, K., Mutt, V.. PoIak, J. M., Bloom, S. R. and Gold-
.
A Is& back in time Discoveries in Pharmacology, Vols l-3 edited by M. 1. Parnham and J. Bruiuels, Elsevier Science Pub2983, Vol. 1, Df/.352, lishers, US$IX?.25 (xiv + 508), ISBN 0 444 804935; 2984, Vol. 2, Df1.367, US$136.00 (xviii + 708L ISBN 0 444 80578 8; 1986, Vol. 3, Df1.350 (xviii + 4c4), !SBX a 44G 8!??52 7. This is an impressive three about 1500 volume-edition pages derived from 55 contributions an discoveries in pharmacology. Volume 1 deals with psychaand neuro-pharmacology, volume 2 with haemodynamics, hormones and inflammation, and volume 3 with pharmacological methods, chemotherapy. and receptors Thus an appreciable area of pharmacology is covered. Most chapters are reviews with an introduction giving the historical
23
24
25
26 27
28
29
A. V., Tatemoto, K. and Bloom, S. R. (1983) Regul. Per& 6,247-253 Lundbera, 1. M.. Hua. X. and FrancoCereced; A. (19&Q)A& Physioi. Scand. 121, 325332 Allen. J- M., GjBrstrup, P., Bjijrkman, J.-A.,Ek,L..Abrahamsson,T.andBloom, S. R. (1986) Acta Physiol. Scond. 126, 405-411 Wahlestedt, C., Wahlfart, 8. and Hakanson, IL (1987) Acta. physioi. Scund. 129, 459-463 Kilbom, M. J., Potter, E. K. and McCIoskey, D. I. (1985) Kc& Pest. I2.155-161 Edvinsson, L., EkbJad, I3.i Wkanson, R. and Wahlestedt, C. (1984) Br. \. Pknnnnccl. 83,591-525 Edvinsson, L., Emson, P., McCuIIoch, J., Tatemoto, K. and Uddman, R. (1983) Neurosci. Letf. 43, 79-84 Edvinsson, L. (1985) Actn Pkysiol. Scud. 125,33-41
30 Pernow, J., Saria, A. and Lundberg, J. %h (1986) Acts Pkysiol. Stand. 126, 239-249 31 WahIestedt. C.. Edvinsson, L., Ekblad, E. and H&anson. R. (1985) J. Pkarmacol. Exp. ‘Illet. 234,735-741 32 Wahlestedt, C., Yanaihara, N. and H%anson, R. (1986) Regul. pepf. 13, 307318 33 Fredholm, B., Jansen, I. and Edvinsson, L. (1985) Acfa PhysioI. Scnnd. 124, 467469 34 WahIestedt,C.,Edvinsson,L., Ekblad,E. and H&nson, R. In: NenronaZ Mcssengers in Vascrrlur Function, (AmehIo, B., Nobin, A. and Owman, c., reds), Femstkim Symp. no 10, Elswier, Amsterdam, in press
cology has not only developed rapidly over the i t decennia but more and more ma!ecular, physiaiogical and biochemical insight
’
background to the topic; in same instances the physiological and biochemical aspects are cansidered too. The organization of the volumes as a whole, the choice of the various chapters as well as the selection of authors far the various contributions is well done. Taking into account the wide spread of topics, the presentations are quite homogeneous in level and depth. There is a good baiance in the iayout and figures as a rule are welt chosen. Whet is most important, the material presented is on the whole of goad to high quality. To your reviewer, an old-timer in the field, a good deal of the reading gave a not unpleasant d&&-vu, sometimes flash-back sensation. For the youngsters and newtamers it probably will be a more ‘Ah-ha’ or ‘Did it happen that way?’ reaction. What becomes clear, if it was not evident already, pharma-
has been perspectives
gained thus opening to a still mare ration-
al approach in drug development and application. These volumes will find few readers but many users. They are a valuable and trustworthy source of information, in particular to those involved in teaching and instruction in pharmacology, and possibly even physiology and biochemistry. Whilst I suggest that only a few individuals will buy these books far personal Use, libraries of teaching and research institutes for pharmacology, therapeutics and toxicology as well as industrial laboratories involved in drug development will find them indispensable. E. J. ARIENS Insfifufe of Pharmacology and Toxicology. Uniaersity of Nijmegcn, Gecrt GrootepIeiu N21, PO Bar 9101, 6500 IfB Nijnregeh, The Netherlands.
1987 iVol.81
235
their co-operation is only partly understood. The functional role of NPY in the peripheral circulation is probably not related exclusively to sympathetic neuratransmission.
stein, M. (1982) Adn Physiol. Scan& 116, 477-480 10 EkbIad, E., Edvinsson, L., Wahlestedt, C., Uddman, R., HQkanson, R. and Sundler, F. (1984) Regal. Pepf. 8,225-235 11 Uddman, R., Ekblad, E., Edvinsson, L., Hakanson, R. and Sundler, F. (1985) Regal. Pepf. 10,243-257 12 Everitt, B. J., H&felt, T., Terenius, L., Tatemoto, K.. Mutt. V. and Goldstein. M. (1984) Ne&&ce 11, 44-62 . 13 Allen, J. M., Adrian, T. E., Tatemoto, K., Polak, J. M., Hughes, J. and Bloom. S. R. (1982) Neumpepfidcs 3,71-77 14 Fried, G., Terenius, L., HoMeIt, T. and Goldstein, M. (1985) I. Ncurosci. 5, 450458 15 Lundberg, J. M., Rudehill, A., Sollevi, A., Theodorsson-Norheim, E. and Hamberger, A. (1986) Neurosci. Left. 63, 96-100 16 Dahllif, C., Dahkif, I’. and Lundberg, J. M. (1985) Eur. I. Pkarmasol. 109,289292 17 Zukowska-Grojec, Z., Haass, M. and Bayorh, M. A. (1986) Regul. Fept. 15, 99-110 18 Edvinsson, L., Emson, I’., McCulIoch, I.. Tatemoto. K. and Uddman. R. (1984) ‘Acta Pkysioi &and. 122, 155-163 _ 19 Fcxe, K., Aenati, L. F., Harkstrand, A., Zini, I., Tagmoto, K., Mm10 rich, E., H&felt, T., Mutt, V. and Terenius, L. 11983) Acta Phvsiai. Stand. 118, 189-192 20 Carter, D. A., Vallejo, M. and Lightman. S. L. (1985) Peptides C~421-425 21 Tuor,~U. I., KeIIy, P. A. T., Edvinsson, L., Tatemoto, K. and McCuIIoch, J. Am-.1. Physiol. (in press) 22 Allen, J. M., Bircham, P. M. M., Edwards,
Acknowledgements Supported by grants from the Swedish Medical Research Cauncil. References 1 Tatemoto, K. (1982) Proc. Nufl Acad. Sci. WA 79,5485-5489 2 Minth, C. D., Bloom, 5 R., Polak, J. M. and Dixon, J. E. (1984) pmt. NufI Acad. Sci. USA 81,4577-4581 3 Allen. J. M., PoIak, J. A?. and Bloom, S. R. (1985) Nempeptides 6, 95-100 4 Auer, L. M., Edvinsson. L. and Johansson, 8. B. (1983) Arta Pkysiol. Scan& 119. 213-217 5 Lundberg, J. M., Fried, G., Pemow, J.. Theodoason-Narheim, E. and jinggard, A. (1986) Ada Physiof. Stand. 126, 151-152 6 Hellstrom. P. M., Olerup. 0. and Tatemote. K. (1985) Ada Physiol. Stand. 124. 6w24 7 Lundberg, J. M., dnggard, A., Theodorsson-Norheim, E. and Pemow, J. (1984) Neurosci. Left. 52, 175-180 8 Lundberg, J. M. and Tatemoto, K. (1982) Acfa Plzysiol. Stand. 116, 393-402 9 Lundberg, J. M., Terenius, L., Hiikfelt, T., Martling, C. R., Tatemoto, K., Mutt, V.. PoIak, J. M., Bloom, S. R. and Gold-
.
A Is& back in time Discoveries in Pharmacology, Vols l-3 edited by M. 1. Parnham and J. Bruiuels, Elsevier Science Pub2983, Vol. 1, Df/.352, lishers, US$IX?.25 (xiv + 508), ISBN 0 444 804935; 2984, Vol. 2, Df1.367, US$136.00 (xviii + 708L ISBN 0 444 80578 8; 1986, Vol. 3, Df1.350 (xviii + 4c4), !SBX a 44G 8!??52 7. This is an impressive three about 1500 volume-edition pages derived from 55 contributions an discoveries in pharmacology. Volume 1 deals with psychaand neuro-pharmacology, volume 2 with haemodynamics, hormones and inflammation, and volume 3 with pharmacological methods, chemotherapy. and receptors Thus an appreciable area of pharmacology is covered. Most chapters are reviews with an introduction giving the historical
23
24
25
26 27
28
29
A. V., Tatemoto, K. and Bloom, S. R. (1983) Regul. Per& 6,247-253 Lundbera, 1. M.. Hua. X. and FrancoCereced; A. (19&Q)A& Physioi. Scand. 121, 325332 Allen. J- M., GjBrstrup, P., Bjijrkman, J.-A.,Ek,L..Abrahamsson,T.andBloom, S. R. (1986) Acta Physiol. Scond. 126, 405-411 Wahlestedt, C., Wahlfart, 8. and Hakanson, IL (1987) Acta. physioi. Scund. 129, 459-463 Kilbom, M. J., Potter, E. K. and McCIoskey, D. I. (1985) Kc& Pest. I2.155-161 Edvinsson, L., EkbJad, I3.i Wkanson, R. and Wahlestedt, C. (1984) Br. \. Pknnnnccl. 83,591-525 Edvinsson, L., Emson, P., McCuIIoch, J., Tatemoto, K. and Uddman, R. (1983) Neurosci. Letf. 43, 79-84 Edvinsson, L. (1985) Actn Pkysiol. Scud. 125,33-41
30 Pernow, J., Saria, A. and Lundberg, J. %h (1986) Acts Pkysiol. Stand. 126, 239-249 31 WahIestedt. C.. Edvinsson, L., Ekblad, E. and H&anson. R. (1985) J. Pkarmacol. Exp. ‘Illet. 234,735-741 32 Wahlestedt, C., Yanaihara, N. and H%anson, R. (1986) Regul. pepf. 13, 307318 33 Fredholm, B., Jansen, I. and Edvinsson, L. (1985) Acfa PhysioI. Scnnd. 124, 467469 34 WahIestedt,C.,Edvinsson,L., Ekblad,E. and H&nson, R. In: NenronaZ Mcssengers in Vascrrlur Function, (AmehIo, B., Nobin, A. and Owman, c., reds), Femstkim Symp. no 10, Elswier, Amsterdam, in press
cology has not only developed rapidly over the i t decennia but more and more ma!ecular, physiaiogical and biochemical insight
’
background to the topic; in same instances the physiological and biochemical aspects are cansidered too. The organization of the volumes as a whole, the choice of the various chapters as well as the selection of authors far the various contributions is well done. Taking into account the wide spread of topics, the presentations are quite homogeneous in level and depth. There is a good baiance in the iayout and figures as a rule are welt chosen. Whet is most important, the material presented is on the whole of goad to high quality. To your reviewer, an old-timer in the field, a good deal of the reading gave a not unpleasant d&&-vu, sometimes flash-back sensation. For the youngsters and newtamers it probably will be a more ‘Ah-ha’ or ‘Did it happen that way?’ reaction. What becomes clear, if it was not evident already, pharma-
has been perspectives
gained thus opening to a still mare ration-
al approach in drug development and application. These volumes will find few readers but many users. They are a valuable and trustworthy source of information, in particular to those involved in teaching and instruction in pharmacology, and possibly even physiology and biochemistry. Whilst I suggest that only a few individuals will buy these books far personal Use, libraries of teaching and research institutes for pharmacology, therapeutics and toxicology as well as industrial laboratories involved in drug development will find them indispensable. E. J. ARIENS Insfifufe of Pharmacology and Toxicology. Uniaersity of Nijmegcn, Gecrt GrootepIeiu N21, PO Bar 9101, 6500 IfB Nijnregeh, The Netherlands.