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Diseases of the Adrenals
520
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
various electronic and nuclear forces, these are studied in connection with their linkage or dis· rupture. Then one ascends at the level of the greater aggreg:;ctions, the giant molecules, organic chemistry, and further going-up to the colloidal, threadlike and leaflike units which form the fibrils and fibers, the films. membranes, and septa throughout living cells. The structure of protoplasm, the plasma membrane which is the between living and non· living material; the submicroscopic architecture, changes in permeability. One of the main phases of the discussion is the myosin in muscles. In addition to the senior author, Haber, variou~ sections are taken up by Hitchcock, Bateman, Goddard, and Fenn. R. ~'. FRANK. Diseases of the Adrenals by Sofferll is a very compact but complete and thorough monograph on all phases of the adrenal gland. There is a short but detailed description of the chemical tests used in connection with adrenal diagnosis, particularly the determination of the sodium and chlorides in the serum and urine; likewise that of potassium and the assay for the male sex hormone and the 17-ketosteroids. The tests are completed by a description of the salt tolerance test, the salt deprivation test, and finally, perirenal insufflation. A short but adequate chapter deals with the physiology of the gland, including the effect on electrolytes, carbohydrate metabolism, and the secretion of the cortical hormone. The author takes up the relationship of the adrenals to all the other glands of internal secretion, a very complicated situation; likewise the effect of shock upon the adrenals. The pathologic symptomatology and laboratory findings in Addison's disease are described in great detail, the author having a large clinical material with which to illustrate. A separate cha.pter deals with the treatment of Addison's a very delicate situation which requires experience, laboratory control and minute attention to detail. Personally, I predict that the treatment of Addison's disease will beeome a specialty much like the treatment of diabetes has become. A chapter is devoted to the adreno·genital syndrome, both where it is purely functional, and where it is due to hyperplasia and malignant tumors. The very varied clinical manifestations are gone into in detail, including the effect on carbohydrate metabolism. The blood electrolyte changes in connection with hormonal studies are dealt with carefully. '!'he final two chapters cover the subject of disturbances of the medulla. This is a very well-balanced monograph written by a man who has a long personal ex· perience with laboratory investigations and likewise a large clinical material which he has handled over a number of years. This monograph is to be highly recommended. R. T. FRANK. Biological Actions of Sex Hormones by Burrows12 goes far beyond a mere compilation of the literature, although it covers the entire subject in a most detailed and masterly fashion. The author has a long experience in expE;rimental work on the sex hormones, which has en· abled him to present a huge bibliography in a most compact but yet accurate, full and well understandable form. It is quite impossible in the compass of the review to give even a faint impression of the immense amount of documentation, its excellent arrangement, and ease of finding. Naturally there are many omissions because the literature today is too great to permit of complete presentation, except in the form of an index medicus. The hormones taken up are the gonadotropic ones, the gonadal hormones, both androgens and estrogens, the progestins, and finally the sex hormones of the adrenal cortex. This book should prove a •tandard source book for many years to come. R. T. FRANK. llD!seases of the A
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
various electronic and nuclear forces, these are studied in connection with their linkage or dis· rupture. Then one ascends at the level of the greater aggreg:;ctions, the giant molecules, organic chemistry, and further going-up to the colloidal, threadlike and leaflike units which form the fibrils and fibers, the films. membranes, and septa throughout living cells. The structure of protoplasm, the plasma membrane which is the between living and non· living material; the submicroscopic architecture, changes in permeability. One of the main phases of the discussion is the myosin in muscles. In addition to the senior author, Haber, variou~ sections are taken up by Hitchcock, Bateman, Goddard, and Fenn. R. ~'. FRANK. Diseases of the Adrenals by Sofferll is a very compact but complete and thorough monograph on all phases of the adrenal gland. There is a short but detailed description of the chemical tests used in connection with adrenal diagnosis, particularly the determination of the sodium and chlorides in the serum and urine; likewise that of potassium and the assay for the male sex hormone and the 17-ketosteroids. The tests are completed by a description of the salt tolerance test, the salt deprivation test, and finally, perirenal insufflation. A short but adequate chapter deals with the physiology of the gland, including the effect on electrolytes, carbohydrate metabolism, and the secretion of the cortical hormone. The author takes up the relationship of the adrenals to all the other glands of internal secretion, a very complicated situation; likewise the effect of shock upon the adrenals. The pathologic symptomatology and laboratory findings in Addison's disease are described in great detail, the author having a large clinical material with which to illustrate. A separate cha.pter deals with the treatment of Addison's a very delicate situation which requires experience, laboratory control and minute attention to detail. Personally, I predict that the treatment of Addison's disease will beeome a specialty much like the treatment of diabetes has become. A chapter is devoted to the adreno·genital syndrome, both where it is purely functional, and where it is due to hyperplasia and malignant tumors. The very varied clinical manifestations are gone into in detail, including the effect on carbohydrate metabolism. The blood electrolyte changes in connection with hormonal studies are dealt with carefully. '!'he final two chapters cover the subject of disturbances of the medulla. This is a very well-balanced monograph written by a man who has a long personal ex· perience with laboratory investigations and likewise a large clinical material which he has handled over a number of years. This monograph is to be highly recommended. R. T. FRANK. Biological Actions of Sex Hormones by Burrows12 goes far beyond a mere compilation of the literature, although it covers the entire subject in a most detailed and masterly fashion. The author has a long experience in expE;rimental work on the sex hormones, which has en· abled him to present a huge bibliography in a most compact but yet accurate, full and well understandable form. It is quite impossible in the compass of the review to give even a faint impression of the immense amount of documentation, its excellent arrangement, and ease of finding. Naturally there are many omissions because the literature today is too great to permit of complete presentation, except in the form of an index medicus. The hormones taken up are the gonadotropic ones, the gonadal hormones, both androgens and estrogens, the progestins, and finally the sex hormones of the adrenal cortex. This book should prove a •tandard source book for many years to come. R. T. FRANK. llD!seases of the A