Dissecting aneurysms of the aorta

AMERICAN

479

SOCIETY FOR THE STUDY OF.4RTERIOSCI~EROSIS

lipid. Furthermore, the amount of glomerular lipid in intercapillary glomerulosclerosis was directly proportional to the severity of the renal lesion. This was not found to be the case in the control groups. Finally, distinctive features in the amount, form, and location of glomerular lipid deposits were noted in the group with intercapillary glomerulosclerosis. These observarions and the inferences drawn from them suggest that the deposition of fat in glomeruli is of primary importance in the development of the lesions of intercapillary glomerulosclerosis, THE

PREVENTION

M. MORRISON

LESTER Hunferian

OF EXPERIMENTAL ATHEROSCLEROSIS CHOLINE FEEDINGS

Laboratory,

Depariment

AND AMERIGO

ROSSI, Los ANGELES, and Internal

of Erperimental Medicine Medical Eva.ngelists

BY

CALIF.

Medicine,

College of

The oral feeding of 0.5 mg. choline chloride dajly together with 0.5 Gm. chclesterol to twenty-nine three-month-old rabbits prevented atherosclerosis in 5.5 per cent of the animals at the expiration of the ninety-two day experimental period. The oral feeding of 1.0 Gm. choline chloride daily together with 0.5 Gm. cholesterol to thirty-two three-month-old rabbits prevented atherosclerosis in 78 per cent at the expiration of the ninety-two day experimental period. ABSORPTION

M. MORRISON

LESTER Hunferian

OF AORTIC

Laboratory,

ATHEROSCLEROSIS FEEDING

AND AMERIGO

Department of Experimental Medical

BY CHOLINE

ROSSI, Los ANGELES, Medicine

and Internal

CALIF.

Medicine,

College oj

Ezangelibts

Choline caused reabsorption of aortic atherosclerosis in the majority rabbits whose lesions had been produced by cholesterol feeding. DISSECTING JAKUBG.SCHLICHTER,GEORGE The

ANEURYSMS D. AMROMIN,AND

Pathology and Cardiovascular Departments,

Medical

of

OF THE AORTA A.J.L. Research

SOLWAY,

Institute,

Michael

CHICAGO,~LL. Reese Hospital

Fourteen cases of dissecting aneurysm of the aorta were reviewed from the morphologic and clinical aspect; two of these were on the basis of arteriosclerosis &nd twelve were secondary to medionecrosis of the aorta. Alterations were encountered in the vasa vasorum of nine aortas. Ischemia of the media of the aorta is implicated as the underlying primary factor in the production of medionecrosis. The various experimental, physiologic, anatomic, and congenital factors which ma’y singly or in combination bring about medionecrosis and dissecting aneurysm are stressed. The vasa vasorum of the aorta in an instance of dissecting aneurysm were injected with radiopaque dye. The abnormal distribution of the vasa vasorum, as compared with the noI ma1human aorta, is demonstrated.