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DISTANCE TO MAJOR ROADS AND TIME RESIDING IN URBAN ENVIRONMENT ARE INDEPENDENT PREDICTORS OF ENDOTHELIAL DYSFUNCTION
A2073 JACC March 17, 2015 Volume 65, Issue 10S
Vascular Medicine Distance to Major Roads and Time Residing in Urban Environment Are Independent Predictors of Endothelial Dysfunction Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 10:00 a.m.-10:45 a.m. Session Title: New Findings in Vascular Inflammation and Endothelial Function Abstract Category: 45. Vascular Medicine: Non Coronary Arterial Disease Presentation Number: 1120-336 Authors: Kevin James Lane, Jahnavi Sunderarajan, Kenneth K. Chui, Hari Vanzan, Sadagopan Thanikachalam, Mohan Thanikachalam, Yale School of Forestry and Environmental Studies, New Haven, CT, USA, Tufts University School of Medicine, Boston, MA, USA
Background: Increasing prevalence of cardiovascular diseases and air pollution in urban populations in Southeast Asia has not been widely examined. We use MODIS satellite based land cover (LC) at different time points as a measure of increasing urbanization and distance to major roadway (MJR) as a proxy for air pollution, to assess the effect on brachial artery flow mediated dilatation (FMD), a measure of endothelial function as percent value.
Methods: We assessed FMD in 8,080 participants, whose residences were geolocated and distance to MJR was calculated and joined with LC data for the years 2000 and 2010. LC was classified into urban and rural. All generalized linear regression models controlled for age, sex, blood pressure, BMI, blood sugar, anxiety, stress, LDL, socioeconomic, sedentary and smoking status.
Results: After multivariable adjustments, residents living in urban areas had significantly lower FMD (24.7%) compared to residents in rural areas (34.1%). In further analysis, residents in the urban areas prior to 2000 had significantly lower mean FMD (21.3%) compared to residential areas classified as urban after 2000 (23.5%; p<0.01) [Fig]. Amongst urban participants a 10 m increase in distance from MJR was significantly associated with a 0.05% point increase in FMD.
Conclusion: Time in an urban area and proximity to MJR were significant predictors of reduced endothelial function. Ongoing research will elucidate risk factors in the urban environment contributing to endothelial dysfunction.
Vascular Medicine Distance to Major Roads and Time Residing in Urban Environment Are Independent Predictors of Endothelial Dysfunction Poster Contributions Poster Hall B1 Saturday, March 14, 2015, 10:00 a.m.-10:45 a.m. Session Title: New Findings in Vascular Inflammation and Endothelial Function Abstract Category: 45. Vascular Medicine: Non Coronary Arterial Disease Presentation Number: 1120-336 Authors: Kevin James Lane, Jahnavi Sunderarajan, Kenneth K. Chui, Hari Vanzan, Sadagopan Thanikachalam, Mohan Thanikachalam, Yale School of Forestry and Environmental Studies, New Haven, CT, USA, Tufts University School of Medicine, Boston, MA, USA
Background: Increasing prevalence of cardiovascular diseases and air pollution in urban populations in Southeast Asia has not been widely examined. We use MODIS satellite based land cover (LC) at different time points as a measure of increasing urbanization and distance to major roadway (MJR) as a proxy for air pollution, to assess the effect on brachial artery flow mediated dilatation (FMD), a measure of endothelial function as percent value.
Methods: We assessed FMD in 8,080 participants, whose residences were geolocated and distance to MJR was calculated and joined with LC data for the years 2000 and 2010. LC was classified into urban and rural. All generalized linear regression models controlled for age, sex, blood pressure, BMI, blood sugar, anxiety, stress, LDL, socioeconomic, sedentary and smoking status.
Results: After multivariable adjustments, residents living in urban areas had significantly lower FMD (24.7%) compared to residents in rural areas (34.1%). In further analysis, residents in the urban areas prior to 2000 had significantly lower mean FMD (21.3%) compared to residential areas classified as urban after 2000 (23.5%; p<0.01) [Fig]. Amongst urban participants a 10 m increase in distance from MJR was significantly associated with a 0.05% point increase in FMD.
Conclusion: Time in an urban area and proximity to MJR were significant predictors of reduced endothelial function. Ongoing research will elucidate risk factors in the urban environment contributing to endothelial dysfunction.