Diverticular disease of the colon

SEMINAR

Seminar

Diverticular disease of the colon

Neil Stollman, Jeffrey B Raskin Colonic diverticulosis refers to small outpouchings from the colonic lumen due to mucosal herniation through the colonic wall at sites of vascular perforation. Abnormal colonic motility and inadequate intake of dietary fibre have been implicated in its pathogenesis. This acquired abnormality is typically found in developed countries, and its prevalence rises with age. Most patients affected will remain entirely asymptomatic; however, 10–20% of those affected can manifest clinical syndromes, mainly diverticulitis and diverticular haemorrhage. As our elderly population grows, we can anticipate a concomitant rise in the number of patients with diverticular disease. Here, we review the incidence, pathophysiology, clinical presentation, and management of diverticular disease of the colon and its complications. Diverticulosis of the colon is quite frequent in developed countries and prevalence rises with age. Although up to twothirds of people older than age 80 years are affected, most remain asymptomatic. The causes of colonic diverticula include alterations in colonic wall resistance, disordered colonic motility, and dietary deficiencies, especially fibre. Clinical manifestations of this disorder range from nonspecific intermittent abdominal pain to potentially lifethreatening complications such as diverticulitis or haemorrhage. CT scanning and colonoscopy are important in diagnosis and management. Here, we review epidemiology, causes, clinical presentation, and management of diverticular disease of the colon.

Epidemiology Prevalence of colonic diverticulosis is difficult to measure because most patients are asymptomatic. In early (1920–1940) autopsy and barium enema series, rates of 2–10% were reported.1 Data show a substantial rise in colonic diverticula within the past few decades. Prevalence of diverticular disease increases with age, from less than 10% in people younger than age 40 years to 50–66% in patients older than age 80 years.1–3 No sex differences seem to exist. Diverticulosis has been labelled a disease of western civilisation because of its striking geographic variability. The disorder is rare in rural Africa and Asia, with the highest prevalence seen in the USA, Europe, and Australia.1 Within a given country, the incidence of colonic diverticula can vary in ethnic groups—eg, in Chinese inhabitants of Singapore, incidence was reported to be 0·14 cases per million population per year versus 5·41 cases in Europeans.4 Urbanisation within a country over time can also lead to a rise in prevalence of diverticulosis. Follow-up in Singapore has indicated colonic diverticulosis in 19%, an increase Lancet 2004; 363: 631–39 See Personal account page 640 Division of Gastroenterology, San Francisco General Hospital, and University of California San Francisco, San Francisco, CA, USA (N Stollman MD); and Division of Gastroenterology, University of Miami School of Medicine, Jackson Memorial Medical Center, Miami, FL, USA (Prof J B Raskin MD) Correspondence to: Dr Neil Stollman, Division of Gastroenterology, San Francisco General Hospital, 1001 Potrero Avenue, Suite 3-D, San Francisco, CA 94110, USA (e-mail: [email protected])

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

attributed mainly to dietary changes.5 Results of series of symptomatic diverticular disease in Africa have shown a rising incidence in increasingly urbanised communities.6,7 Cases of complicated diverticulitis have risen 50% in Finland in the past two decades, an increase attributed to an ageing population and reduced fibre consumption.8 Although much of the epidemiological research mentioned is simply descriptive, understanding and assessing these noted trends could yield insight into pathogenesis of the disorder and help to predict disease course and complications.

Pathological anatomy Colonic diverticula typically form in parallel rows between the taeniae coli because of weakness of the muscle wall at sites of penetration of the vasa recta supplying the mucosa. In European and US populations, diverticula arise mainly in the distal colon, with 90% of patients having sigmoid colon involvement and only 15% having right-sided diverticula.3,9–11 This finding is in contrast to that seen in Asian populations, in which right-sided involvement is more prominent.5,12 Diverticula vary from solitary findings to many hundreds. They are typically 5–10 mm in diameter but can exceed 2 cm. An entity of giant colonic diverticula has been described with sizes up to 25 cm. Most are single, located in the sigmoid colon, and asymptomatic, but can present with infection, obstruction, or perforation.13

Search strategy and selection criteria Sources of information included: authors’ published work and research; and original research, reviews, and practice guidelines identified by computer database search—eg, MEDLINE, LexisNexis, The Cochrane Library, and Science Citation Index. Most recent publications were prioritised. Search terms included: “diverticulosis”, “diverticulitis”, “diverticular disease”, “diverticular hemorrhage”, “gastrointestinal bleeding”, “diverticular abscess”, “diverticular fistula”, “colonoscopy”, “endoscopy”, “epidemiology”, “pathogenesis”, “motility”, “fiber”, “computerized tomography”, “CT-scanning”, “surgery”, “laparoscopic”, “ultrasound”, “ultrasonography”, “barium enema”, “contrast enema”, “NSAID”, and “non-steroidal anti-inflammatory”, with Boolean operators AND and OR. Human and animal studies in the English language were reviewed and manually crossreferenced.

631

SEMINAR

Mesentery Artery

Diverticulum

Contraction

Contraction

Pressure tracing Figure 1: Segmentation of colon by contractions producing little bladders Modified from reference 24 with permission of the Royal College of Surgeons of England, 1964.

Although diverticulosis is an acquired disorder, findings of observational studies suggest that the disease pattern— eg, right-sided, pancolonic—might be established early on and then remain constant, rather than increasing over time in number and extent. In sequential studies with barium enema, no progression of disease has generally been noted in most patients.14 In fact, two distinct forms of diverticulosis might exist: one discernible by muscle thickening, mainly in the left colon, and associated with perforation and diverticulitis; the other due to a diffuse connective tissue abnormality, resulting in pancolonic diverticulosis and a propensity for bleeding.15 This possibility could, in part, account for anatomic differences described between European and US patients and those from Asia.

Cause and pathogenesis Colonic wall resistance Early gross descriptions of diverticular colons typically noted thickening of muscle wall and shortening of the taeniae coli, with resultant concertina-like bunching of haustral folds. Although muscle contraction is noted, routine histology has not generally indicated muscle hypertrophy. Findings of electron microscopic studies have shown that diverticular colonic walls consist of structurally normal muscle cells but elastin deposition is amplified by more than 200% in muscle cells in the taenia coli compared with those without diverticula.16 Elastin is laid down in a contracted form, resulting in shortening of the taenia coli and bunching of circular muscle. Age-related changes in collagen composition could have a causal role in weakening of wall resistance. An increase in type III collagen synthesis has been described.17,18 Further, changes in collagen crosslinking have been shown in animal and human models.19,20 The importance of gut wall connective tissue is underscored by early development of diverticula in patients with connective tissue disorders such as Marfan’s and Ehlers-Danlos syndromes.21 Disordered motility In the 1960s, Arfwidsson22 did manometry on patients with or without sigmoid diverticula and showed higher resting, postprandial, and neostigmine-stimulated luminal pressures in diverticular patients than in controls. Painter and colleagues23,24 confirmed these findings in response to neostigmine or morphine in individuals with sigmoid diverticula (intraluminal hypertension) and did simultaneous cineradiography. Painter suggested a theory of segmentation in which contraction of the colon causes a

632

series of discrete “little bladders” (figure 1). He proposed that this segmentation had a physiological role in delaying of transport and augmentation of water reabsorption but could also generate excessively high pressures within every bladder, favouring herniation. This effect might be amplified by dietary fibre deficiency.25 Subsequently, patients with symptomatic diverticulosis have been shown to have higher motility indices than either asymptomatic patients or healthy controls.26 High right-sided pressures have also been recorded in patients with right-colon diverticulosis, suggesting that abnormal motility could also have a role in pathogenesis of proximal diverticula.27 A preponderance of excitatory cholinergic nerves and a diminution of action of non-adrenergic, non-cholinergic inhibitory nerves by nitric oxide have been noted in diverticular colons compared with controls.28 These findings suggest that an imbalance in usual excitatory and inhibitory influences could favour enhanced tonicity. Whether altered motility and intraluminal hypertension are a cause of disease or symptoms, or an effect of same, is uncertain. Dietary fibre The geographic variability of diverticular disease and correlation with a western diet have long suggested a dietary factor as fundamental in pathogenesis of the disorder. Burkitt and Painter1 were the most eloquent proponents of this theory, labelling diverticulosis a deficiency disease that, like scurvy, could be avoided with dietary changes. They recorded transit times and stool weights from more than 1200 individuals in the UK and rural Uganda.29 The UK patients, eating a low fibre diet, had transit times of about 80 h and mean stool weights of 110 g/day. By contrast, rural Ugandans, eating very high fibre diets, had times of 34 h and weights of more than 450 g/day. The longer transit time and smaller stool volumes were thought to increase intraluminal pressure, predisposing to diverticular herniation. As reasonable as this hypothesis seems, results of studies in western populations comparing transit times and stool volumes in patients with and without diverticular disease have failed to show significant differences. Nonetheless, corroborative data in animals do exist, most notably in rats fed diets of various fibre content throughout their lifespan.30 45% of rats on the lowest fibre diet developed diverticula compared with only 9% of those fed the highest fibre diet. Furthermore, in another animal model, high fibre diets protected against collagen crosslinking and were associated with reduced frequency of diverticulosis.19

Uncomplicated diverticulosis Most patients, perhaps 75–80%, with anatomical diverticulosis will remain asymptomatic throughout their lifetime. Of the few who develop complications, diverticulitis—and its difficulties such as abscesses, fistulas, or obstruction—is the most usual manifestation, followed by diverticular haemorrhage, both of which are addressed below. The asymptomatic patient Asymptomatic diverticular disease is frequently an incidental finding during assessment of a patient for another reason, such as routine screening for colon cancer. No treatment or follow-up needs to be offered to this large population, most of whom will remain asymptomatic, although findings of one study suggested a possible prophylactic benefit of a high-fibre diet. In a

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

SEMINAR

prospective study of 51 529 US male health professionals followed up for more than 4 years, 385 new cases of symptomatic diverticular disease were identified.31 A significant inverse association was recorded between dietary fibre intake and risk of development of clinically evident diverticular disease. Insoluble fibre from fruits and vegetables was noted to be more protective than cereal fibres.32 These results provide support for a recommendation that patients with asymptomatic diverticular disease might benefit from increasing their fruit and vegetable fibre intake, a stance endorsed by the American Dietetic Association.33 The symptomatic patient Patients can present with non-specific abdominal complaints—eg, lower abdominal pain, usually leftsided—and subsequently be shown to have diverticulosis coli; a causal relation is sometimes difficult to establish. Such patients do not usually manifest signs of inflammation, such as pyrexia or neutrophilia, which could indicate diverticulitis. Pain is generally exacerbated by eating and diminished with defecation or flatus, which suggests colonic wall tension due to raised intraluminal pressure. Patients might also report other symptoms such as bloating or constipation. Assessment can indicate fullness or mild tenderness in the left lower quadrant, but frank rebound or guarding should be absent. A guaiac-positive stool in this setting should never be attributed to diverticulosis without complete colonic assessment. Findings of laboratory studies should be normal. Diagnostic modalities For years, barium enema was the standard investigation in diverticulosis patients, and although it provides information on number and location of colonic diverticula, it cannot discern clinical relevance. However, inaccurate findings have been reported in nearly a third of patients with diverticulosis.34 This disorder has, in the past, been regarded as a contraindication to colonoscopy for fear of causing a perforation.35,36 Further data and extensive clinical experience, however, have shown that colonoscopy is safe in this population, although the diverticular colon can be difficult to examine because of spasm, luminal narrowing, and fixation.37 Treatment Brodribb38 did a randomised double-blind trial of a highfibre diet in 18 patients with symptomatic diverticular disease. A significant placebo effect was noted at 1 month; however, by 3 months, a significant reduction in bowel symptoms was seen in patients on the high-fibre diet. These findings suggest that patients should gradually increase their dietary fibre over weeks, and be aware that their symptoms might initially worsen before they improve, which could take months. In a subsequent study,39 no improvement in symptom endpoints was reported despite a decline in transit times and increases in stool weight and frequency. Despite these conflicting data, some amelioration of symptoms in patients with uncomplicated disease can be reasonably expected with a high-fibre diet. Hypermotility of the diverticular colon suggests that anticholinergic or antispasmodic drugs might improve symptoms by diminishing muscular contraction. Nonetheless, no adequately controlled therapeutic trials have shown a benefit. No rationale exists for use of antibiotics or narcotic analgesics in uncomplicated diverticular disease.

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

Complicated diverticular disease Diverticulitis Diverticulitis is the most usual clinical complication of diverticular disease, affecting 10–25% of patients with diverticula.3 The process by which diverticulitis arises has been likened to that of appendicitis, with a diverticulum becoming obstructed by inspissated stool in its neck.40 This faecalith abrades the mucosa of the sac, causing inflammation and expansion of usual bacterial flora, with diminished venous outflow and localised ischaemia. Bacteria may breach the mucosa and extend the process through the full wall thickness, ultimately leading to perforation.41 Extent and localisation of the perforation will establish its clinical behaviour. Microperforations can remain contained by pericolic fat and mesentery and cause small pericolic abscesses. Large perforations can result in an extensive abscess, which could continue around the bowel wall and form a large inflammatory mass or extend to other organs. Free perforation into the peritoneum causing frank peritonitis can be life-threatening but is rare. Clinical features People with diverticulitis generally present with left lower quadrant pain, indicating the propensity for this disorder to arise in the sigmoid colon in western countries, although individuals with redundant sigmoid colons can manifest suprapubic or right-sided pain. Asian patients have predominantly right-sided diverticula and will usually present with right lower quadrant pain.42 Pain may be intermittent or constant and is sometimes associated with a change in bowel habits.43 Haematochezia is rare, although anorexia, nausea, and vomiting can arise. Physical examination usually discloses localised tenderness and, occasionally, a palpable mass. Bowel sounds are typically depressed but can be normal in mild cases or enhanced in the presence of obstruction. Rectal examination may reveal tenderness or a mass, especially with a low-lying pelvic abscess. Fever is present in most patients, although hypotension and shock are unusual. White blood cell count is sometimes raised.43 The differential diagnosis of this presentation includes acute appendicitis, especially in Asian patients or those with redundant sigmoid colons.42 Aphthous ulcers, anorectal involvement, and chronic diarrhoea suggest a possible diagnosis of Crohn’s colitis. Colon carcinoma, like diverticulosis, affects colons of ageing westerners, and a causal relation has been postulated. Most probably, colon cancer and diverticulosis are both results of the same environmental effects, mainly dietary. Chronic symptoms of weight loss or bleeding should raise suspicion for carcinoma. Surgical investigation and resection could be necessary to make a precise diagnosis. In uncomplicated cases, elective colonoscopy after acute inflammation has resolved will allow for exclusion of malignant disease. Elderly people with diverticulosis are also at risk for ischaemic colitis. Features helpful to differentiate between these disorders include presence of thumbprinting on abdominal radiographs and haematochezia, both suggesting ischaemia. Gynaecological disorders, such as ruptured ovarian cysts, ovarian torsion, ectopic pregnancy, or pelvic inflammatory disease, can resemble acute diverticulitis in female patients. Pelvic ultrasound can be helpful in obtaining an accurate diagnosis. Other forms of colitis, such as pseudomembranous or amoebic, can also mimic diverticulitis. Diagnostic modalities Most patients with diverticulitis present with signs and symptoms sufficient to justify clinical diagnosis and

633

SEMINAR

Figure 2: Barium enemas of manifestations of diverticulitis (A) Acute diverticulitis with oedema (arrow) of the bowel wall. (B) Intramural sinus tract (arrow) in acute diverticulitis. (C) Confined perforation or abscess (arrow) in acute diverticulitis. All figures courtesy of Javier Casillas.

institute empiric treatment, although a thorough physical examination and basic laboratory studies, such as white blood cell count, should be done in patients coming to clinical attention. Further studies should be reserved for individuals in whom diagnosis remains uncertain, response to empiric treatment is suboptimal, or a complication is suspected. Chest and abdominal radiographs should generally be done in patients with clinically significant abdominal pain. A chest radiograph taken while the patient is upright can aid detection of pneumoperitoneum and help to assess cardiopulmonary status. Abdominal radiographs can show abnormal findings in 30–50% of patients,44,45 which include small or large bowel dilation or ileus, pneumoperitoneum, bowel obstruction, or soft-tissue densities suggesting abscesses. Contrast enemas—once the diagnostic standard—are limited by the fact that diverticulitis is mainly an extraluminal process. If they are to be undertaken, watersoluble contrast material should be used and a lowpressure single-contrast study done. Findings deemed highly suggestive of diverticulitis include extravasated contrast material outlining an abscess cavity, intramural sinus tract, or fistula (figure 2).9,46 Absence of any diverticula should provoke reconsideration of the diagnosis. In retrospective analyses, contrast enema has been shown to have a sensitivity of 62–94%, with falsenegative results in 2–15%.47,48 CT scanning has an increasing role in diagnosis, and should be regarded as the diagnostic procedure of choice. Abdominal and pelvic scanning is done with intravenous, oral, and rectal contrast. Criteria suggestive

of diverticulitis include pericolic infiltration of fatty tissue, colonic wall thickening, and abscess formation (figure 3). In many trials comparing CT with barium enema in suspected diverticulitis, sensitivities for CT of 93–98% and specificities of 75–100% have been consistently reported, significantly more accurate than contrast enemas.46,49–51 Because of risk of perforation from either the device or air insufflation, endoscopy is generally avoided in initial assessment of the patient with acute diverticulitis. Its use should be restricted to situations in which diagnosis of diverticulitis is unclear. In such cases, limited sigmoidoscopy with minimum insufflation can be helpful to exclude other diagnoses, such as inflammatory, infectious, or ischaemic colitis. Treatment Need for admission is the initial decision to be made in uncomplicated diverticulitis, which is based on patient’s presentation, their ability to tolerate oral intake, severity of illness, comorbid disease, and adequate outpatient support. Outpatients should be treated with a clear liquid diet and a broad-spectrum oral antibiotic with activity against anaerobes and gram-negative rods (in particular, Escherichia coli and Bacteroides fragilis).52 Symptomatic improvement should generally be evident within 2–3 days, at which time diet can be slowly advanced. Antibiotic treatment should be continued for 7–10 days. Patients needing admission should have clear liquids or nothing by mouth and intravenous fluids. Intravenous antibiotics should be started, aimed mainly at colonic anaerobic and gram-negative flora.52 Improvement of symptoms should

Figure 3: CT scans of manifestations of diverticulitis (A) Contained abscess (arrow) in severe sigmoid diverticulitis. (B) Large air-containing abscess (arrow) in subacute diverticulitis. (C) Large diverticular abscess (arrow) with penetration into retroperitoneal structures and extending through abdominal wall into subcutaneous tissue. All figures courtesy of Javier Casillas.

634

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

SEMINAR

be expected within 2–4 days, at which point diet can be advanced. If improvement continues, patients may be discharged to complete a 7–10 day oral antibiotic course. Failure of conservative medical treatment warrants a diligent search for complications, consideration of alternative diagnoses, and surgical consultation. Most patients admitted with acute diverticulitis will respond to conservative treatment, but 15–30% will need surgery during that time.9,48,53 Free perforation with generalised peritonitis, although uncommon, carries a high mortality rate (up to 35%) and needs urgent surgical intervention.9,48 For most patients who respond well to conservative treatment, an important clinical question subsequently revolves around likelihood of recurrence and role of prophylactic surgical resection. Risk of recurrent symptoms after an attack of acute diverticulitis has been reported between 7% and 45%; a third is a reasonable approximation.9,48,53 Recurrent attacks are less likely to respond to medical treatment and have a high mortality rate;48,53 thus, most authorities agree that elective resection is indicated after two attacks of uncomplicated diverticulitis.54–56 The risk-benefit analysis of such an approach must be tailored with consideration of severity and responsiveness of the episode, general health of the patient, and risk of subsequent occurrence. Risk of resection is an evolving factor, with reports of increasingly favourable experiences with laparoscopic resections for diverticular disease.57–62 This approach might reduce the threshold for resection in some patients by lowering operative morbidity. However, some patients will still have symptoms after surgical resection. Diverticulitis in special situations Diverticulitis is seen in about 2–5% of people younger than 40 years old,9,53 mainly in males.9,63,64 Disease is more virulent in young patients, with 66–88% needing urgent surgery during their initial attack, with a high risk of recurrences or complications.9,63,65,66 Obesity can also be an important risk factor in young people.67 For these reasons, and because of the low operative risk of an elective procedure in an otherwise healthy young patient, resection is generally indicated after one well-documented episode of uncomplicated diverticulitis.48,54 Others, however, have questioned this assertion.56,68,69 Immunocompromised patients with diverticulitis may present with more subtle signs and symptoms than those who are immunocompetent and represent a difficult diagnostic challenge. They are less likely to benefit from medical treatment and have a higher rate of free perforation, need for surgery, and postoperative mortality than non-compromised patients.70,71 Because of this high risk, some authorities have advocated elective resection after one episode in an immunosuppressed individual.54 Complicated diverticulitis Abscess When perforation of a diverticulum takes place, a localised phlegmon initially develops; further spread can lead to formation of large local or distant abscesses. Clinical signs suggesting abscess formation include a tender mass on investigation or persistent fever despite an adequate trial of antibiotics. When an abscess is suspected, CT scanning is the best modality for making the diagnosis and following its course. Small pericolic abscesses can generally be treated conservatively with continued antibiotics and bowel rest.56,72 In patients in whom surgery is needed, a singlestage resection and anastomosis can generally be done. For those with distant or unresolving abscesses, drainage

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

is indicated. Surgery was previously the main option, but CT-guided percutaneous drainage of abdominal abscesses is now used in preference when feasible. The advantage of percutaneous catheter drainage is rapid control of sepsis and patient stabilisation. Further, drainage might eliminate need for a two-stage procedure with interval colostomy, instead allowing temporary palliative drainage and subsequent single-stage resection.73,74 Fistulas When a diverticular phlegmon or abscess extends or ruptures into an adjacent organ, fistulas can arise, the most typical being colovesicular.75 Such fistulas have a two to one male predominance, attributable to protection of the bladder by the uterus and 50% rate of hysterectomy in female patients with colovesical fistulas. Pneumaturia and faecaluria are suggestive signs.76 Cystoscopy, cystography, and contrast radiographs or methylene blue studies can show fistula tracts. Single-stage operative resection with fistula closure can be undertaken in most patients.75,76 Colovaginal fistulas are the next most frequent, representing about 25% of all cases.75 Passage of stool or flatus via the vagina is pathognomonic. Frequent vaginal infections or copious discharge should prompt consideration of a colovaginal fistula. Treatment is surgical resection of the diseased colon with repair of the contiguous organ.56 Coloenteric, colouterine, coloureteral, and colocutaneous fistulas arise much less typically. Obstruction During an episode of acute diverticulitis, partial colonic obstruction can happen because of relative lumenal narrowing from pericolic inflammation or compression from abscess formation. Colonic pseudo-obstruction can also take place. Acute diverticulitis might cause small bowel obstruction or ileus if a loop of small intestine becomes incorporated into the inflammatory mass. These presentations usually improve as inflammation subsides with effective treatment; failure to do so should prompt surgical consultation. Recurrent episodes of diverticulitis, sometimes subclinical, can initiate progressive fibrosis and stricturing of the colonic wall without persisting inflammation. Ultimately, high-grade or complete obstruction can happen, needing surgery. An insidious presentation with non-specific symptoms is typical. Generally, a stricture with uncertain cause is identified on barium enema. The important issue is to distinguish between a diverticular stricture and a stenosing neoplasm. Doctors should attempt to make this differentiation by colonoscopy with biopsy, but this procedure is not always possible.77 Strictures in which malignant disease cannot be excluded should undergo surgical en bloc resection. A trial of endoscopic treatment with balloon dilation can be attempted in patients in whom neoplasm is judged sufficiently excluded.78–80 Early work with colonic metal stents has suggested that they might have a role in colonic obstruction due to diverticular disease. Stenting can provide temporary decompression, allowing for bowel preparation and subsequent single-stage resection without diversion.81,82

Haemorrhage Important lower gastrointestinal bleeding can be caused by diverticula, vascular ectasias, colitis, or neoplasms.10,83–85 Diverticular sources have been reported to be the most typically identified cause, accounting for greater than 40% of lower gastrointestinal bleeding episodes.86,87 Severe haemorrhage can arise in 3–5% of patients with diverticulosis.10,88,89 Despite the fact that most diverticula

635

SEMINAR

Figure 4: Endoscopic pictures of diverticulum (A) Diverticulum with visible vessel. (B) Oozing during epinephrine injection. (C) Diverticulum post injection. All photos courtesy of Francisco C Ramirez.

are in the left colon in western individuals, the site of bleeding may more often be located in the proximal colon.10,88,90–93 Pathophysiology Microangiography on resected specimens from patients with bleeding diverticula shows intimal thickening and medial thinning of the vasa recta as it courses over the dome of the diverticulum.90 These changes arise asymetrically towards the lumen and lead to segmental weakening of the artery, predisposing to rupture. Factors that initiate this arterial change are unknown, although inflammation does not seem to be a contributing factor. This finding accords with the clinical impression that bleeding rarely complicates diverticulitis. The association of use of non-steroidal antiinflammatories (NSAIDs) with ulcer disease and upper gastrointestinal bleeding is well documented, but data have also implicated these drugs in diverticular bleeding. In a large prospective series of patients with lower gastrointestinal bleeding (in whom 50% were diverticular), a bleeding risk with NSAIDs was reported that was equal to that of duodenal ulcer.94 In the Health Professionals Follow-up Study,95 regular NSAID use was associated with raised risk of diverticular bleeding. Whether patients with diverticulosis should be counselled to avoid NSAIDs—as is done for ulcer patients—or use COX2 selective agents—is still conjecture. Clinical features Clinical presentation of diverticular haemorrhage is usually one of an abrupt painless onset. The patient can have mild lower abdominal cramps or the urge to defecate, followed by passage of voluminous red or maroon blood or clots. While melaena can sometimes happen with a slowly bleeding right colon lesion, the arterial nature of diverticular bleeding makes this presentation uncommon. Presence of colonic diverticula should not be judged an adequate explanation for a positive faecal occult blood test or as a cause of iron deficiency anaemia. Haemorrhage ceases spontaneously in 70–80% of patients, and rebleeding rates range from 22% to 38%.88,89,92 The chance of a third bleeding episode can be as high as 50%, leading many doctors to recommend surgical resection after a second bleeding episode, similar to recommendations made for recurrent divericulitis.54,88 Diagnosis and management Overall management of lower gastrointestinal bleeding is beyond the scope of this review, but is described in other

636

articles.89,96 Fluid and blood product resuscitation needs immediate attention. Exclusion of an upper gastrointestinal source by endoscopy is warranted, because 10–15% of patients with haematochezia will have an upper gastrointestinal tract cause. Flexible sigmoidoscopy is an appropriate initial approach to rule out an obvious rectosigmoid lesion, and can be done either unprepared or after enema administration. If no cause is identified, further assessment with non-invasive (nuclear scintigraphy) or invasive (angiography, colonoscopy) techniques can be undertaken in an attempt to localise and treat the bleeding source. Scintigraphy has several theoretical advantages in assessment of lower gastrointestinal bleeding. It is noninvasive and sensitive to bleeding rates as low as 0·1 mL/min. Furthermore, once labelled, red cells remain active for up to 24 h, permitting repeat imaging in the patient with intermittent bleeding.97 At best, however, nuclear scans provide information only about the anatomic site of bleeding, not its cause, and have no therapeutic potential. Further, accuracy of predicting the bleeding site has been questioned.98 In view of the high sensitivity and relative simplicity of scintigraphy, however, many centres use this method as a screening test before angiography, to keep the number of negative angiograms to a minimum and allow for selection of a specific artery for injection.97 Angiography has a sensitivity for lower gastrointestinal bleeding at a rate of 0·5 mL/min, although this value is from animal work.83 An important use of diagnostic angiography is to identify the site of bleeding with enough accuracy to allow selective hemicolectomy, rather than empirical subtotal colectomy, although accuracy has been questioned.99 An additional role for angiography rests in its therapeutic potential. Intra-arterial vasopressin can control haemorrhage in more than 90% of patients.100 This treatment is usually only temporary, however, because up to half of treated people will rebleed with discontinuation of infusion. Nonetheless, even temporary control of bleeding can allow semielective surgical procedure in a well-prepared patient, rather than emergency resection, with concomitant reduction in surgical morbidity.100 Angiographic embolisation of very distal bleeding branches (subselective) is also effective and safe.101 For most patients, diverticular bleeding is self-limited. Subsequent colonoscopy should be done to elucidate the bleeding source and to exclude neoplasia.9,102–104 The role of colonoscopy during episodes of lower gastrointestinal bleeding is being defined.105,106 A rapid oral purge with

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

SEMINAR

electrolyte solution to prepare the colon for emergent colonoscopy has been shown to be safe and effective.107–109 In small series, endoscopy has been used to control acute bleeding (figure 4).110–118 In a cohort of 48 patients with lower gastrointestinal bleeding,118 ten had definite signs of diverticular haemorrhage and were treated endoscopically, and none had recurrent bleeding. In a historical control group of 17 patients not treated with colonoscopy,119 nine had additional bleeding. Although such treatment may be applicable to only a few patients with lower intestinal bleeding, colonoscopic haemostasis will probably have an increasing role in the future. Surgery in lower gastrointestinal bleeding is usually reserved until endoscopic or angiographic treatments fail. Segmental resection is most usually done if the bleeding site is clearly identified from a therapeutically unsuccessful angiographic or endoscopic procedure. Rebleeding is seen in about 6% of patients.100 In people with persistent bleeding and no angiographic or endoscopic identification of a definite bleeding site, subtotal colectomy could be needed. Conflict of interest statement None declared.

Acknowledgments No funding was received for this Seminar.

References 1

2 3 4 5 6

7 8 9 10

11 12

13

14 15 16 17

18

19

Painter NS, Burkitt DP. Diverticular disease of the colon: a deficiency disease of Western civilization. BMJ 1971; 2: 450–54. Painter NS, Burkitt DP. Diverticular disease of the colon, a 20th century problem. Clin Gastroenterol 1975; 4: 3–21. Parks TG. Natural history of diverticular disease of the colon. Clin Gastroenterol 1975; 4: 53–69. Kyle J, Adesola A, Tinckler L, deBeaux J. Incidence of diverticulitis. Scand J Gastroenterol 1967; 2: 77–80. Lee YS. Diverticular disease of the large bowel in Singapore: an autopsy survey. Dis Colon Rectum 1986; 29: 330–35. Walker AR, Segal I. Epidemiology of noninfective intestinal diseases in various ethnic groups in South Africa. Isr J Med Sci 1979; 15: 309–13. Ogunbiyi OA. Diverticular disease of the colon in Ibadan, Nigeria. Afr J Med Med Sci 1989; 18: 241–44. Makela J, Kiviniemi H, Laitinen S. Prevalence of perforated sigmoid diverticulitis is increasing. Dis Colon Rectum 2002; 45: 955–61. Roberts PL, Veidenheimer MC. Current management of diverticulitis. Adv Surg 1994; 27: 189–208. Reinus JF, Brandt LJ. Vascular ectasias and diverticulosis: common causes of lower intestinal bleeding. Gastroenterol Clin North Am 1994; 23: 1–20. Slack W. The anatomy, pathology and some clinical features of diverticulitis of the colon. Br J Surg 1962; 50: 185–90. Chia JG, Wilde CC, Ngoi SS, Goh PM, Ong CL. Trends of diverticular disease of the large bowel in a newly developed country. Dis Colon Rectum 1991; 34: 498–501. Levi DM, Levi JU, Rogers AI, Bergau DK, Wenger J. Giant colonic diverticulum: an unusual manifestation of a common disease. Am J Gastroenterol 1993; 88: 139–42. Horner J. Natural history of the diverticulosis of the colon. Am J Dig Dis 1958; 3: 343–50. Ryan P. Changing concepts in diverticular disease. Dis Colon Rectum 1983; 26: 12–18. Whiteway J, Morson BC. Elastosis in diverticular disease of the sigmoid colon. Gut 1985; 26: 258–66. Bode MK, Karttunen TJ, Makela J, Risteli L, Risteli J. Type I and III collagens in human colon cancer and diverticulosis. Scand J Gastroenterol 2000; 35: 747–52. Stumpf M, Cao W, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V. Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. Int J Colorectal Dis 2001; 16: 271–75. Wess L, Eastwood MA, Edwards CA, Busuttil A, Miller A. Collagen alteration in an animal model of colonic diverticulosis. Gut 1996; 38: 701–06.

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

20 Wess L, Eastwood MA, Wess TJ, Busuttil A, Miller A. Cross linking of collagen is increased in colonic diverticulosis. Gut 1995; 37: 91–94. 21 Simpson J, Scholefield JH, Spiller RC. Pathogenesis of colonic diverticula. Br J Surg 2002; 89: 546–54. 22 Arfwidsson S, Kock N, Lehmann L, Winberg T. Pathogenesis of multiple diverticula of the sigmoid colon in diverticular diseases. Acta Chir Scan Suppl 1964; 342: 1–68. 23 Painter NS, Truelove SC, Ardran GM, Tuckey M. Segmentation and the localization of intraluminal pressure in the human colon, with special reference to the pathogenesis of colonic diverticula. Gastroenterology 1968; 54 (suppl): 778–80. 24 Painter NS. The aetiology of diverticulosis of the colon with special reference to the action of certain drugs on the behavior of the colon. Ann R Coll Surg Engl 1964; 34: 98–119. 25 Hodgson J. Effect of methylcellulose on rectal and colonic pressures in treatment of diverticular disease. BMJ 1972; 3: 729–31. 26 Cortesini C, Pantalone D. Usefulness of colonic motility study in identifying patients at risk for complicated diverticular disease. Dis Colon Rectum 1991; 34: 339–42. 27 Sugihara K, Muto T, Morioka Y. Motility study in right sided diverticular disease of the colon. Gut 1983; 24: 1130–34. 28 Tomita R, Fujisaki S, Tanjoh K, Fukuzawa M. Role of nitric oxide in the left-sided colon of patients with diverticular disease. Hepatogastroenterology 2000; 47: 692–96. 29 Burkitt DP, Walker AR, Painter NS. Effect of dietary fibre on stools and the transit-times, and its role in the causation of disease. Lancet 1972; 2: 1408–12. 30 Fisher N, Berry CS, Fearn T, Gregory JA, Hardy J. Cereal dietary fiber consumption and diverticular disease: a lifespan study in rats. Am J Clin Nutr 1985; 42: 788–804. 31 Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC. A prospective study of diet and the risk of symptomatic diverticular disease in men. Am J Clin Nutr 1994; 60: 757–64. 32 Aldoori WH, Giovannucci EL, Rockett HR, Sampson L, Rimm EB, Willett WC. A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr 1998; 128: 714–19. 33 Marlett J, McBurney M, Slavin J. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc 2002; 102: 993–1000. 34 Boulos PB, Karamanolis DG, Salmon PR, Clark CG. Is colonoscopy necessary in diverticular disease? Lancet 1984; 1: 95–96. 35 Wolff W, Shinya H. Colonoscopy. N Engl J Med 1973; 288: 974–75. 36 Williams CB, Lane RH, Sakai Y. Colonoscopy: an air-pressure hazard. Lancet 1973; 2: 729. 37 Anderson JC, Messina CR, Cohn W, et al. Factors predictive of difficult colonoscopy. Gastrointest Endosc 2001; 54: 558–62. 38 Brodribb AJ. Treatment of symptomatic diverticular disease with a high-fibre diet. Lancet 1977; 1: 664–66. 39 Ornstein M. Are fibre supplements really necessary in diverticular disease of the colon? A controlled clinical trial. BMJ 1981; 282: 1353–56. 40 Berman LG, Burdick D, Heitzman ER, Prior JT. A critical reappraisal of sigmoid peridiverticulitis. Surg Gynecol Obstet 1968; 127: 481–91. 41 Williams R, Davis I. Diverticular disease of the colon, 5th edn. Philadelphia: Saunders, 1995. 42 Markham NI, Li AK. Diverticulitis of the right colon: experience from Hong Kong. Gut 1992; 33: 547–49. 43 Ambrosetti P, Robert JH, Witzig JA, et al. Acute left colonic diverticulitis: a prospective analysis of 226 consecutive cases. Surgery 1994; 115: 546–50. 44 Kourtesis GJ, Williams RA, Wilson SE. Surgical options in acute diverticulitis: value of sigmoid resection in dealing with the septic focus. Aust N Z J Surg 1988; 58: 955–59. 45 Morris J, Stellato TA, Lieberman J, Haaga JR. The utility of computed tomography in colonic diverticulitis. Ann Surg 1986; 204: 128–32. 46 Doringer E. Computerized tomography of colonic diverticulitis. Crit Rev Diagn Imaging 1992; 33: 421–35. 47 Shrier D, Skucas J, Weiss S. Diverticulitis: an evaluation by computed tomography and contrast enema. Am J Gastroenterol 1991; 86: 1466–71. 48 The standards task force of the American Society of Colon and Rectal Surgeons. Practice parameters for sigmoid diverticulitis: supporting documentation. Dis Colon Rectum 1995; 38: 126–32. 49 Hulnick DH, Megibow AJ, Balthazar EJ, Naidich DP, Bosniak MA. Computed tomography in the evaluation of diverticulitis. Radiology 1984; 152: 491–95. 50 Cho KC, Morehouse HT, Alterman DD, Thornhill BA. Sigmoid diverticulitis: diagnostic role of CT—comparison with barium enema studies. Radiology 1990; 176: 111–15.

637

SEMINAR

51 Ambrosetti P, Jenny A, Becker C, Terrier TF, Morel P. Acute left colonic diverticulitis: compared performance of computed tomography and water-soluble contrast enema: prospective evaluation of 420 patients. Dis Colon Rectum 2000; 43: 1363–67. 52 Chow A. Appendicitis and diverticulitis. Philadelphia: Lippincott, 1994. 53 Parks TG. Natural history of diverticular disease of the colon: a review of 521 cases. BMJ 1969; 4: 639–42. 54 Stollman NH, Raskin JB. Diagnosis and management of diverticular disease of the colon in adults: ad hoc practice parameters committee of the American College of Gastroenterology. Am J Gastroenterol 1999; 94: 3110–21. 55 Kohler L, Sauerland S, Neugebauer E. Diagnosis and treatment of diverticular disease: results of a consensus development conference. Surg Endosc 1999; 13: 430–36. 56 Wong WD, Wexner SD, Lowry A, et al. Practice parameters for the treatment of sigmoid diverticulitis: supporting documentation. Dis Colon Rectum 2000; 43: 290–97. 57 Franklin ME Jr, Dorman JP, Jacobs M, Plasencia G. Is laparoscopic surgery applicable to complicated colonic diverticular disease? Surg Endosc 1997; 11: 1021–25. 58 Smadja C, Sbai Idrissi M, Tahrat M, et al. Elective laparoscopic sigmoid colectomy for diverticulitis: results of a prospective study. Surg Endosc 1999; 13: 645–48. 59 Kockerling F, Schneider C, Reymond MA, et al. Laparoscopic resection of sigmoid diverticulitis: results of a multicenter study. Surg Endosc 1999; 13: 567–71. 60 Berthou JC, Charbonneau P. Elective laparoscopic management of sigmoid diverticulitis: results in a series of 110 patients. Surg Endosc 1999; 13: 457–60. 61 Stevenson A, Stitz R, Lumley J, Fielding G. Laparoscopically assisted anterior resection for diverticular disease: follow-up of 100 consecutive patients. Ann Surg 1998; 227: 335–42. 62 Lauro A, Alonso Poza A, Cirocchi R, et al. Laparoscopic surgery for colon diverticulitis. Minerva Chir 2002; 57: 1–5. 63 Konvolinka CW. Acute diverticulitis under age forty. Am J Surg 1994; 167: 562–65. 64 Acosta JA, Grebenc ML, Doberneck RC, McCarthy JD, Fry DE. Colonic diverticular disease in patients 40 years old or younger. Am Surg 1992; 58: 605–07. 65 Freischlag J, Bennion RS, Thompson JE Jr. Complications of diverticular disease of the colon in young people. Dis Colon Rectum 1986; 29: 639–43. 66 Chautems RC, Ambrosetti P, Ludwig A, Mermillod B, Morel P, Soravia C. Long-term follow-up after first acute episode of sigmoid diverticulitis: is surgery mandatory? A prospective study of 118 patients. Dis Colon Rectum 2002; 45: 962–66. 67 Schauer PR, Ramos R, Ghiatas AA, Sirinek KR. Virulent diverticular disease in young obese men. Am J Surg 1992; 164: 443–46. 68 Reisman Y, Ziv Y, Kravrovitc D, Negri M, Wolloch Y, Halevy A. Diverticulitis: the effect of age and location on the course of disease. Int J Colorectal Dis 1999; 14: 250–54. 69 Spivak H, Weinrauch S, Harvey JC, Surick B, Ferstenberg H, Friedman I. Acute colonic diverticulitis in the young. Dis Colon Rectum 1997; 40: 570–74. 70 Perkins JD, Shield CF 3rd, Chang FC, Farha GJ. Acute diverticulitis: comparison of treatment in immunocompromised and nonimmunocompromised patients. Am J Surg 1984; 148: 745–48. 71 Tyau ES, Prystowsky JB, Joehl RJ, Nahrwold DL. Acute diverticulitis: a complicated problem in the immunocompromised patient. Arch Surg 1991; 126: 855–58. 72 Ambrosetti P, Robert J, Witzig JA, et al. Incidence, outcome, and proposed management of isolated abscesses complicating acute left-sided colonic diverticulitis: a prospective study of 140 patients. Dis Colon Rectum 1992; 35: 1072–76. 73 Schechter S, Eisenstat TE, Oliver GC, Rubin RJ, Salvati EP. Computerized tomographic scan-guided drainage of intra-abdominal abscesses: preoperative and postoperative modalities in colon and rectal surgery. Dis Colon Rectum 1994; 37: 984–88. 74 Stabile BE, Puccio E, van Sonnenberg E, Neff CC. Preoperative percutaneous drainage of diverticular abscesses. Am J Surg 1990; 159: 99–104. 75 Woods RJ, Lavery IC, Fazio VW, Jagelman DG, Weakley FL. Internal fistulas in diverticular disease. Dis Colon Rectum 1988; 31: 591–96. 76 McBeath RB, Schiff M Jr, Allen V, Bottaccini MR, Miller JI, Ehreth JT. A 12-year experience with enterovesical fistulas. Urology 1994; 44: 661–65. 77 Forde KA, Treat MR. Colonoscopy in the evaluation of strictures. Dis Colon Rectum 1985; 28: 699–701. 78 Kozarek RA. Hydrostatic balloon dilation of gastrointestinal stenoses: a national survey. Gastrointest Endosc 1986; 32: 15–19.

638

79 Manten H, Zara J, Rakin J. Balloon dilation of rectosigmoid strictures: transendoscopic approach. Gastrointest Endosc 1986; 32: 164. 80 Oz MC, Forde KA. Endoscopic alternatives in the management of colonic strictures. Surgery 1990; 108: 513–19. 81 Tamim WZ, Ghellai A, Counihan TC, Swanson RS, Colby JM, Sweeney WB. Experience with endoluminal colonic wall stents for the management of large bowel obstruction for benign and malignant disease. Arch Surg 2000; 135: 434–38. 82 Paul L, Pinto I, Gomez H, Fernandez-Lobato R, Moyano E. Metallic stents in the treatment of benign diseases of the colon: preliminary experience in 10 cases. Radiology 2002; 223: 715–22. 83 Potter GD, Sellin JH. Lower gastrointestinal bleeding. Gastroenterol Clin North Am 1988; 17: 341–56. 84 Boley SJ, DiBiase A, Brandt LJ, Sammartano RJ. Lower intestinal bleeding in the elderly. Am J Surg 1979; 137: 57–64. 85 Gostout CJ, Wang KK, Ahlquist DA, et al. Acute gastrointestinal bleeding: experience of a specialized management team. J Clin Gastroenterol 1992; 14: 260–67. 86 Peura DA, Lanza FL, Gostout CJ, Foutch PG. The American College of Gastroenterology bleeding registry: preliminary findings. Am J Gastroenterol 1997; 92: 924–28. 87 Longstreth GF. Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 1997; 92: 419–24. 88 McGuire HH Jr, Haynes BW Jr. Massive hemorrhage for diverticulosis of the colon: guidelines for therapy based on bleeding patterns observed in fifty cases. Ann Surg 1972; 175: 847–55. 89 Zuckerman GR, Prakash C. Acute lower intestinal bleeding: part II— etiology, therapy, and outcomes. Gastrointest Endosc 1999; 49: 228–38. 90 Meyers MA, Alonso DR, Gray GF, Baer JW. Pathogenesis of bleeding colonic diverticulosis. Gastroenterology 1976; 71: 577–83. 91 Casarella WJ, Kanter IE, Seaman WB. Right-sided colonic diverticula as a cause of acute rectal hemorrhage. N Engl J Med 1972; 286: 450–53. 92 McGuire HH Jr. Bleeding colonic diverticula: a reappraisal of natural history and management. Ann Surg 1994; 220: 653–56. 93 Wong SK, Ho YH, Leong AP, Seow-Choen F. Clinical behavior of complicated right-sided and left-sided diverticulosis. Dis Colon Rectum 1997; 40: 344–48. 94 Wilcox CM, Alexander LN, Cotsonis GA, Clark WS. Nonsteroidal antiinflammatory drugs are associated with both upper and lower gastrointestinal bleeding. Dig Dis Sci 1997; 42: 990–97. 95 Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Willett WC. Use of acetaminophen and nonsteroidal anti-inflammatory drugs: a prospective study and the risk of symptomatic diverticular disease in men. Arch Fam Med 1998; 7: 255–60. 96 Zuccaro G Jr. Management of the adult patient with acute lower gastrointestinal bleeding. Am J Gastroenterol 1998; 93: 1202–08. 97 Alavi A, Ring EJ. Localization of gastrointestinal bleeding: superiority of 99mTc sulfur colloid compared with angiography. AJR Am J Roentgenol 1981; 137: 741–48. 98 Hunter JM, Pezim ME. Limited value of technetium 99m-labeled red cell scintigraphy in localization of lower gastrointestinal bleeding. Am J Surg 1990; 159: 504–06. 99 Cohn SM, Moller BA, Zieg PM, Milner KA, Angood PB. Angiography for preoperative evaluation in patients with lower gastrointestinal bleeding: are the benefits worth the risks? Arch Surg 1998; 133: 50–55. 100 Browder W, Cerise EJ, Litwin MS. Impact of emergency angiography in massive lower gastrointestinal bleeding. Ann Surg 1986; 204: 530–36. 101 Gordon RL, Ahl KL, Kerlan RK, et al. Selective arterial embolization for the control of lower gastrointestinal bleeding. Am J Surg 1997; 174: 24–28. 102 Shinya H, Cwern M, Wolf G. Colonoscopic diagnosis and management of rectal bleeding. Surg Clin North Am 1982; 62: 897–903. 103 Tedesco FJ, Waye JD, Raskin JB, Morris SJ, Greenwald RA. Colonoscopic evaluation of rectal bleeding: a study of 304 patients. Ann Intern Med 1978; 89: 907–09. 104 Irvine EJ, O’Connor J, Frost RA, et al. Prospective comparison of double contrast barium enema plus flexible sigmoidoscopy v colonoscopy in rectal bleeding: barium enema v colonoscopy in rectal bleeding. Gut 1988; 29: 1188–93. 105 Forde KA. Colonoscopy in acute rectal bleeding. Gastrointest Endosc 1981; 27: 219–20. 106 Deyhle P, Blum A, Nuesch H. Emergency coloscopy (sic) in the management of acute perianal hemorrhage. Endoscopy 1974; 6: 229–32.

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

SEMINAR

107 Jensen DM, Machicado GA. Diagnosis and treatment of severe hematochezia: the role of urgent colonoscopy after purge. Gastroenterology 1988; 95: 1569–74. 108 Jensen D, Machicado G, Tapia J. Emergent colonoscopy in patients with severe hematochezia. Gastrointest Endosc 1983; 29: 177. 109 Caos A, Benner KG, Manier J, et al. Colonoscopy after Golytely preparation in acute rectal bleeding. J Clin Gastroenterol 1986; 8: 46–49. 110 Mauldin JL. Therapeutic use of colonoscopy in active diverticular bleeding. Gastrointest Endosc 1985; 31: 290–91. 111 Johnston J, Sones J. Endoscopic heater probe coagulation of the bleeding colonic diverticulum. Gastrointest Endosc 1986; 32: 160. 112 Savides TJ, Jensen DM. Colonoscopic hemostasis for recurrent diverticular hemorrhage associated with a visible vessel: a report of three cases. Gastrointest Endosc 1994; 40: 70–73. 113 Foutch PG, Zimmerman K. Diverticular bleeding and the pigmented protuberance (sentinel clot): clinical implications, histopathological

THE LANCET • Vol 363 • February 21, 2004 • www.thelancet.com

correlation, and results of endoscopic intervention. Am J Gastroenterol 1996; 91: 2589–93. 114 Bertoni G, Conigliaro R, Ricci E, Mortilla MG, Bedogni G, Fornaciari G. Endoscopic injection hemostasis of colonic diverticular bleeding: a case report. Endoscopy 1990; 22: 154–55. 115 Kim YI, Marcon NE. Injection therapy for colonic diverticular bleeding: a case study. J Clin Gastroenterol 1993; 17: 46–48. 116 Andress HJ, Mewes A, Lange V. Endoscopic hemostasis of a bleeding diverticulum of the sigma with fibrin sealant. Endoscopy 1993; 25: 193. 117 Witte JT. Band ligation for colonic bleeding: modification of multiband ligating devices for use with a colonoscope. Gastrointest Endosc 2000; 52: 762–65. 118 Hokama A, Uehara T, Nakayoshi T, et al. Utility of endoscopic hemoclipping for colonic diverticular bleeding. Am J Gastroenterol 1997; 92: 543–46. 119 Jensen DM, Machicado GA, Jutabha R, Kovacs TO. Urgent colonoscopy for the diagnosis and treatment of severe diverticular hemorrhage. N Engl J Med 2000; 342: 78–82.

639