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DNA replication in eukaryotic cells
t
is not easy to fin
useful addition?
essential companion to Kornberg and Baker’s DNAReplication. With the current
problems that eukaryotes have in duplicating their chromosomes. For a start, rather than just dealing with a sing(e replication origin typical of bacteria, eukaryotic chromosomes have thousands. In the replication programme of S phase, some origins fire early and others late, but all are constrained to function once and only once to ensure that the genome undergoes a single round of replication. To understand this S-phase regulation, we have to view it in the larger context of the cell cyclle, because the normal alternation of S phase and mitosis reflects the interlocked control of both processes by cyclin-dependent kinases. Advances over the last few years have provided at least a rudimentary picture of replication regulation, but the story is far from complete. Even with this basic grasp, we have also to appreciate how
more specialized. Chapters in the second section deal with the detailed enzymology and stucture of replication proteins. A final group of chapters describes what is known of the replication of particular genomes, including a range of viruses and extra-chromosomal DNAs.One theme that comes across is how the replication field has beer. stimulated by the convergence of biochemical work on replication factors and viral systems with a range of other approaches that are, for instance, more cell biological in outloo these different traditions can described as fully integrated, but they are at lead moving in the right direction. Future developments, such as an in vitro system for yeast DNAreplication, should help to continue this trend.
intended for teachers and those outside the field and here the value of particular contributions is more uneven, but overall this is a highly significant addition to the replication literature.
Department of Zoology,Universityof Oxford, South Parks Road, Oxford,UK OX13PS.
Did you know that you are et-Ned to a 50% discount on a subscription to TiBS?
is not easy to fin
useful addition?
essential companion to Kornberg and Baker’s DNAReplication. With the current
problems that eukaryotes have in duplicating their chromosomes. For a start, rather than just dealing with a sing(e replication origin typical of bacteria, eukaryotic chromosomes have thousands. In the replication programme of S phase, some origins fire early and others late, but all are constrained to function once and only once to ensure that the genome undergoes a single round of replication. To understand this S-phase regulation, we have to view it in the larger context of the cell cyclle, because the normal alternation of S phase and mitosis reflects the interlocked control of both processes by cyclin-dependent kinases. Advances over the last few years have provided at least a rudimentary picture of replication regulation, but the story is far from complete. Even with this basic grasp, we have also to appreciate how
more specialized. Chapters in the second section deal with the detailed enzymology and stucture of replication proteins. A final group of chapters describes what is known of the replication of particular genomes, including a range of viruses and extra-chromosomal DNAs.One theme that comes across is how the replication field has beer. stimulated by the convergence of biochemical work on replication factors and viral systems with a range of other approaches that are, for instance, more cell biological in outloo these different traditions can described as fully integrated, but they are at lead moving in the right direction. Future developments, such as an in vitro system for yeast DNAreplication, should help to continue this trend.
intended for teachers and those outside the field and here the value of particular contributions is more uneven, but overall this is a highly significant addition to the replication literature.
Department of Zoology,Universityof Oxford, South Parks Road, Oxford,UK OX13PS.
Did you know that you are et-Ned to a 50% discount on a subscription to TiBS?