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Does comorbid OCD influence the severity of the eating disorder in patients with anorexia and bulimia nervosa?
140S
Cognitive neuropsychiatry
BIOL. PSYCHIATRY 1997:42: IS--297S
release, and platelet ketanserln binding. There was a marked significant decrease in Bmax lor imipramine binding In the OCD group, although there was no difference In Kd between groups. There was no correlation between clinical assessment 01 severity and psychopathology between the two groups, when serotonin markers were studied. The study implicates the serotonin transporter in Obsessive Compulsive Disorder. This study was supported by a grant Irom the Department 01 Science & Technology.
150-71 A comparison of hydroxyzine, busplrone and placebo In patients with generalised anxiety
M.H. Lader lor the FrencMJK Hydroxyzine Study Group. Institute of Psychiatry. University of London, UK The efficacy of hydroxyzine and busplrone, controlled by placebo, was In• vestigated in a double-blind. Parallel group, multicentre study conducted In France and the U.K. A total 01246 patients with Generalised Anxiety Disorder in primary care was allocated randomly to treatments with hydroxyzine (12.5 mg, moming and mld-
I50-a I serotonin Relation between ImpUlsivity, anxiety and peripheral Indices In anorexia nervosa F. Askenazy. M. Candito. H. Cad. M. Myquel. G. Darcourt, A. Puech. Service de PlkIopsychiatrie. Fondation Lenval. Nice, France This study was devised with two subgroups defined as (1) anorexia nervosa without binge eating, and (2) anorexia nervosa with binge eating. Our hypothesis was that these sUbgroups would differ on impulsivity and central serotonin function - high impulsivity being correlated with reduced serotonin function. Method: For all patients Impulsivity rating scales, Hamilton anxiely rat• ing scale. and questionnaire detailing severity 01 eating disorders were assessed. Whole blood serotonin concentrations, Iree and total tryptophan concentrations. and large neutral amino acids were assayed. Results: Nineteen patients with anorexia nervosa were studied and twelve healthy matched controls. Data suggest that lree and total tryptophan concentrations, and the ratio tryptophan concentrations to large neutral amino acids may distinguish healthy and patients. Contrary to the hypothesis, these biological Indices can not differentiate subgroups 01 anorexic subjects although separated by Impulsivity scores or bulimic behavior. Then anxiety scores were significantly higher In the impulsive group and could be a discriminatory Indlce 01 different subgroups. Finally. a positive correlation was lound between anxiety and whole blood serotonin concentration In the impulsive group.
150-91 Does comorbld OCD Influence the severity of the
eaUng disorder In patients with anorexia and bulimia nervosa?
M. de Zwaan. A. Strnad. C. Lennkh. Department of General Psychiatry. University of Vienna, Austria The prevalence 01 obsessive-compulslve disorder (OCD) among 66 lemale Inpatients with eating disorders (ED) was determined using a structured clinical Interview. Twelve (18.2%) mel the OSM III-R criteria lor a lifetime diagnosls 01 OCD and 7 (10.6%) met criteria for a current diagnosis. Eighteen 01 the patients met criteria lor anorexia nervosa. 35 lor bulimia nervosa. and 13 lor both diagnoses. The prevalence rates 01 OCD were not significantly different between the three groups. Patients with and without OCD did not differ with regard to age and weight. However, patients with an ED and OCD scored significantly higher than patients without OCD on eating related and general psychopathological measures. They had higher total scores on the
gO-item Symptom Checklist (SCL·90-R) with significantly higher scores in the subscales Anxiety, Somatization, Psychotlcism. and OCD and they had higher total scores on the Eating Disorder Inventory (EDI) with significanuy higher scores In the subscales Ineffectiveness. Interpersonal Distrust" and Interoceptive Awareness. In addition. patients with a lifetime diagnosis d OCD exhibited a higher prevalence 01 cornorbld psychiatric disorders SUCh as major depression, anxiety disorders. and sornatoforrn disorders. In line with others, our data demonstrate that patients with an ED and dIsplay a significantly higher degree of eating related and general psychopathology than do those patients without OCD. Further research Is warranted 10 determine if obsessive-compulsive symptoms indicate a worse prognosis fer the treatment of the ED and if patients with ED and concomitant might specifically benefit from treatment with SSRls which have been shown to be effective In OCD as well as ED.
ceo
ceo
51. Cognitive neuropsychiatry
151-1 I adUlts A functional MRI study of cognlUve performance In with infantile-onset auUsm H. Ring, S. Baron-Cohen, S. Wheelrlght. S. Williams. St BarthoIomew's & the Royal London School of Medicine. London. UK Alms: To investigate the hypothesis that autistic subjects display a pattern of task-related cerebral activation distinct lrom that observed in non-autistic: controls during the performance of a cognitive task which autistic subjects perform better than controls. Methods: Using functional magnetic resonance Imaging techniques we studied seven adults with Inlantile-onset autism and norma/IQ together Wi1tI 10 normal controls during performance 01 an embedded ligures task. This task requires the Identification of a simple two-
151-21 for "Soft-signs assessment In a psychometric hlgh-risk schizophrenia adolescent sample" J.E. Oblols, N. Barrantes. B. Caparr6s. F. Serrano. Departament de Psicologfa dela Salut I Social. Universitat Aut6nomB de Barcelona Bel/aterra (Barcelona). Spain Methods: From a sample 011500 normal adolescents, CPT-Ilnked atten• tional deficit was used to select an Index group (N .. 150) 01 VUlnerable lor schizophrenia spectrum disorders boys and girts (Age .. 13 ± 1). The Index (N .. 150) and a matched Control group (N ., 150) were then 8SSeSSed With a battery to test anhedonia (Chapman scales). intelligence (Raven + WlSC). lrontal lobe performance (WCST) and Soft Neurological Signs (SNS). SNS assessment included foot coordinations, rythm. linger opposition, svn<:inesia and agraphestesia In a (0-4) range scale. Results: In the group that included the worse SNS scorers (n • 27) from the pooled sample (n .. 300) we lound a higher proportion 01 Index cases (2017; Chi-square (p) .. 0.02) and twice males as lemales (1819). We then compared Index subjects with SNS to Index subjects without SNS; the first group showed higher physical and social anhedonia. lower Intelligence aM impaired frontal lobe performance when compared to the second group.
151-31 ContextuallnformaUon processes In patients with schizophrenia
N. Bazin. P. Perruchet, M.C. Hardy-Bayle, A. Feline. CHG Lagny-Mame fa Val/ee, Lagny sur Marne, France The aim of this study Is to evaluate schizophrenic patients ability to use c0n• text information In implicit and explicit cognitive tasks. We report here three
Cognitive neuropsychiatry
BIOL. PSYCHIATRY 1997:42: IS--297S
release, and platelet ketanserln binding. There was a marked significant decrease in Bmax lor imipramine binding In the OCD group, although there was no difference In Kd between groups. There was no correlation between clinical assessment 01 severity and psychopathology between the two groups, when serotonin markers were studied. The study implicates the serotonin transporter in Obsessive Compulsive Disorder. This study was supported by a grant Irom the Department 01 Science & Technology.
150-71 A comparison of hydroxyzine, busplrone and placebo In patients with generalised anxiety
M.H. Lader lor the FrencMJK Hydroxyzine Study Group. Institute of Psychiatry. University of London, UK The efficacy of hydroxyzine and busplrone, controlled by placebo, was In• vestigated in a double-blind. Parallel group, multicentre study conducted In France and the U.K. A total 01246 patients with Generalised Anxiety Disorder in primary care was allocated randomly to treatments with hydroxyzine (12.5 mg, moming and mld-
I50-a I serotonin Relation between ImpUlsivity, anxiety and peripheral Indices In anorexia nervosa F. Askenazy. M. Candito. H. Cad. M. Myquel. G. Darcourt, A. Puech. Service de PlkIopsychiatrie. Fondation Lenval. Nice, France This study was devised with two subgroups defined as (1) anorexia nervosa without binge eating, and (2) anorexia nervosa with binge eating. Our hypothesis was that these sUbgroups would differ on impulsivity and central serotonin function - high impulsivity being correlated with reduced serotonin function. Method: For all patients Impulsivity rating scales, Hamilton anxiely rat• ing scale. and questionnaire detailing severity 01 eating disorders were assessed. Whole blood serotonin concentrations, Iree and total tryptophan concentrations. and large neutral amino acids were assayed. Results: Nineteen patients with anorexia nervosa were studied and twelve healthy matched controls. Data suggest that lree and total tryptophan concentrations, and the ratio tryptophan concentrations to large neutral amino acids may distinguish healthy and patients. Contrary to the hypothesis, these biological Indices can not differentiate subgroups 01 anorexic subjects although separated by Impulsivity scores or bulimic behavior. Then anxiety scores were significantly higher In the impulsive group and could be a discriminatory Indlce 01 different subgroups. Finally. a positive correlation was lound between anxiety and whole blood serotonin concentration In the impulsive group.
150-91 Does comorbld OCD Influence the severity of the
eaUng disorder In patients with anorexia and bulimia nervosa?
M. de Zwaan. A. Strnad. C. Lennkh. Department of General Psychiatry. University of Vienna, Austria The prevalence 01 obsessive-compulslve disorder (OCD) among 66 lemale Inpatients with eating disorders (ED) was determined using a structured clinical Interview. Twelve (18.2%) mel the OSM III-R criteria lor a lifetime diagnosls 01 OCD and 7 (10.6%) met criteria for a current diagnosis. Eighteen 01 the patients met criteria lor anorexia nervosa. 35 lor bulimia nervosa. and 13 lor both diagnoses. The prevalence rates 01 OCD were not significantly different between the three groups. Patients with and without OCD did not differ with regard to age and weight. However, patients with an ED and OCD scored significantly higher than patients without OCD on eating related and general psychopathological measures. They had higher total scores on the
gO-item Symptom Checklist (SCL·90-R) with significantly higher scores in the subscales Anxiety, Somatization, Psychotlcism. and OCD and they had higher total scores on the Eating Disorder Inventory (EDI) with significanuy higher scores In the subscales Ineffectiveness. Interpersonal Distrust" and Interoceptive Awareness. In addition. patients with a lifetime diagnosis d OCD exhibited a higher prevalence 01 cornorbld psychiatric disorders SUCh as major depression, anxiety disorders. and sornatoforrn disorders. In line with others, our data demonstrate that patients with an ED and dIsplay a significantly higher degree of eating related and general psychopathology than do those patients without OCD. Further research Is warranted 10 determine if obsessive-compulsive symptoms indicate a worse prognosis fer the treatment of the ED and if patients with ED and concomitant might specifically benefit from treatment with SSRls which have been shown to be effective In OCD as well as ED.
ceo
ceo
51. Cognitive neuropsychiatry
151-1 I adUlts A functional MRI study of cognlUve performance In with infantile-onset auUsm H. Ring, S. Baron-Cohen, S. Wheelrlght. S. Williams. St BarthoIomew's & the Royal London School of Medicine. London. UK Alms: To investigate the hypothesis that autistic subjects display a pattern of task-related cerebral activation distinct lrom that observed in non-autistic: controls during the performance of a cognitive task which autistic subjects perform better than controls. Methods: Using functional magnetic resonance Imaging techniques we studied seven adults with Inlantile-onset autism and norma/IQ together Wi1tI 10 normal controls during performance 01 an embedded ligures task. This task requires the Identification of a simple two-
151-21 for "Soft-signs assessment In a psychometric hlgh-risk schizophrenia adolescent sample" J.E. Oblols, N. Barrantes. B. Caparr6s. F. Serrano. Departament de Psicologfa dela Salut I Social. Universitat Aut6nomB de Barcelona Bel/aterra (Barcelona). Spain Methods: From a sample 011500 normal adolescents, CPT-Ilnked atten• tional deficit was used to select an Index group (N .. 150) 01 VUlnerable lor schizophrenia spectrum disorders boys and girts (Age .. 13 ± 1). The Index (N .. 150) and a matched Control group (N ., 150) were then 8SSeSSed With a battery to test anhedonia (Chapman scales). intelligence (Raven + WlSC). lrontal lobe performance (WCST) and Soft Neurological Signs (SNS). SNS assessment included foot coordinations, rythm. linger opposition, svn<:inesia and agraphestesia In a (0-4) range scale. Results: In the group that included the worse SNS scorers (n • 27) from the pooled sample (n .. 300) we lound a higher proportion 01 Index cases (2017; Chi-square (p) .. 0.02) and twice males as lemales (1819). We then compared Index subjects with SNS to Index subjects without SNS; the first group showed higher physical and social anhedonia. lower Intelligence aM impaired frontal lobe performance when compared to the second group.
151-31 ContextuallnformaUon processes In patients with schizophrenia
N. Bazin. P. Perruchet, M.C. Hardy-Bayle, A. Feline. CHG Lagny-Mame fa Val/ee, Lagny sur Marne, France The aim of this study Is to evaluate schizophrenic patients ability to use c0n• text information In implicit and explicit cognitive tasks. We report here three