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Dorzolamide Hydrochloride
DORZOLAMIDE HYDROCHLORIDE
Marie-Paule Quint', Jeffrey Grove', and Scott M. Thomas
2
(1) Laboratoires Merck Sharp & Dohme-Chibret Centre de Recherche Riom, France
(2) Merck Research Laboratories Rahway, NJ USA
ANALYTICAL PROFILES OF DRUG SUBSTANCES AND EXClPlENTS VOLUME 21
311
Copyright 0 2001 by Academic Press. All rights of rcprcduction in any form reserved. 1075-6280/01 $30.00
378
M.-P. QUINT, J. GROVE, AND S.M. THOMAS
The analytical profile on Dorzolamide Hydrochloride originally appeared in Volume 26 of the Analytical ProJiles of Drug Substances and Excipients. Due to events beyond the authors’ control, the following typographical errors were not corrected before printing: 1.
The title and page headers (pages 283-3 17) should read Dorzolamide Hydrochloride (and not Dorsolamide Hydrochloride).
2. Page 287, paragraph 2, line 12 read ethoxzolamide (not ethoxzolaniide). 3. Page 296, Figure 4, the units for the ordinate should read solubility (mg/mL, as base). 4.
Page 299, section 3.7.2, read Table 3 (not Table 1).
5.
Page 304, read Table 4 (not Table 5).
6. Page 3 12, the figures showing the structures of the two degradation products should be at the end of section 5.2 and not 5.1. Dorzolamide is stable in the solid state (5.1), degradation occurs in the liquid state (5.2). 7. Page 3 15 read [ 171 at paragraph end (not [ 161).
Marie-Paule Quint', Jeffrey Grove', and Scott M. Thomas
2
(1) Laboratoires Merck Sharp & Dohme-Chibret Centre de Recherche Riom, France
(2) Merck Research Laboratories Rahway, NJ USA
ANALYTICAL PROFILES OF DRUG SUBSTANCES AND EXClPlENTS VOLUME 21
311
Copyright 0 2001 by Academic Press. All rights of rcprcduction in any form reserved. 1075-6280/01 $30.00
378
M.-P. QUINT, J. GROVE, AND S.M. THOMAS
The analytical profile on Dorzolamide Hydrochloride originally appeared in Volume 26 of the Analytical ProJiles of Drug Substances and Excipients. Due to events beyond the authors’ control, the following typographical errors were not corrected before printing: 1.
The title and page headers (pages 283-3 17) should read Dorzolamide Hydrochloride (and not Dorsolamide Hydrochloride).
2. Page 287, paragraph 2, line 12 read ethoxzolamide (not ethoxzolaniide). 3. Page 296, Figure 4, the units for the ordinate should read solubility (mg/mL, as base). 4.
Page 299, section 3.7.2, read Table 3 (not Table 1).
5.
Page 304, read Table 4 (not Table 5).
6. Page 3 12, the figures showing the structures of the two degradation products should be at the end of section 5.2 and not 5.1. Dorzolamide is stable in the solid state (5.1), degradation occurs in the liquid state (5.2). 7. Page 3 15 read [ 171 at paragraph end (not [ 161).