DOUBLE KIDNEY TRANSPLANTATION: A MULTICENTRIC STUDY

DOUBLE KIDNEY TRANSPLANTATION: A MULTICENTRIC STUDY

497 IMPACT OF DOUBLE-J STENT ON UROLOGICAL COMPLICATIONS IN RENAL TRANSPLANT RECIPIENTS: RESULTS OF A PROSPECTIVE, PARALLEL CLINICAL TRIAL 498 DOUBLE...

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497 IMPACT OF DOUBLE-J STENT ON UROLOGICAL COMPLICATIONS IN RENAL TRANSPLANT RECIPIENTS: RESULTS OF A PROSPECTIVE, PARALLEL CLINICAL TRIAL

498 DOUBLE KIDNEY TRANSPLANTATION: A MULTICENTRIC STUDY Bertelli R.1, Tsivian M.1, Nardo B.1, Gilioli C2, Benozzi L.2, Capocasale E., Dalla Valle R., Neri F.1, Cavallari G.1, Faenza A.1

Gimeno V., Bonillo M.A.$ORQVR02OLYHU)%URVHWD(-LP«QH]&UX]-) La Fe University Hospital, Dept. of Urology, Valencia, Spain Introduction & Objectives: We performed a prospective trial with two parallel groups to compare the incidence of early urological complications in renal transplant recipients with or without ureteral stenting Material & Methods: $WRWDORISDWLHQWVUHFHLYLQJDUHQDOWUDQVSODQWDWDVLQJOHFHQWUH ZHUHDOORFDWHGSUHRSHUDWLYHO\WRXQGHUJR'RXEOH-VWHQWRUQRVWHQWLQWZRGLᚎHUHQWW\SHVRI ureterovesical anastomosis (Paquin and Lich-Gregoir) from January 2005 and December 2006. Mean time of stent removal was 25.9 days. Eight patients had a graft loss (4 renal artery thrombosis, 2 massive bleeding, 2 perioperative deaths) and were excluded from the VWXG\7KHVWHQWJURXSLQFOXGHGSDWLHQWV PHQDQGZRPHQ ZLWKDPHDQDJHRI \HDUV  7KHQRVWHQWJURXSLQFOXGHGSDWLHQWV PHQDQGZRPHQ ZLWKDPHDQ age of 49.9 years (21-74). Early urological complications were recorded, including urinary leakage or obstruction, and urinary tract infections (UTI) after 1 month of transplantation though we do not consider positive urine culture as a true urological complication exclusively related to stenting. The Fisher exact test was used as statistical analysis. Results: In the stent group there was 1 case of urinary leakage (1.7%) that was solved with DSURWUDFWHGSHULRGRIVWHQWLQJDQGWZRXUHWHURYHVLFDOREVWUXFWLRQV  GHPRQVWUDWHG DIWHUVWHQWUHPRYDODQGWUHDWHGZLWKSQHXPDWLFGLODWLRQDQG'RXEOH-LQVHUWLRQ,QWKHᚏUVW month after transplantation a total of 22 positive urine cultures in 17 patients were detected EHLQJ ( FROL   WKH PRVW IUHTXHQW PLFURRUJDQLVP LQYROYHG 7KHUH ZHUH QR FOLQLFDO LPSOLFDWLRQVUHODWHGWRSRVLWLYHFXOWXUHᚏQGLQJV,QWKHQRVWHQWJURXSSDWLHQWVKDGXULQDU\ leakage (4.8%) and 5 uretero-vesical obstructions (8%) treated with an endourological DSSURDFK SQHXPDWLFGLODWLRQDQG'RXEOH-LQVHUWLRQ ,QWKHᚏUVWPRQWKDIWHUWUDQVSODQWDWLRQ a total of 9 positive urine cultures in 9 patients were detected being E. coli (44.4%) the most frequent micro-organism involved. There were no clinical implications related to positive FXOWXUHᚏQGLQJV:HGLGQRWᚏQGDQ\VLJQLᚏFDQWGLᚎHUHQFHVEHWZHHQERWKJURXSVDFFRUGLQJ to urinary leakage and ureteral obstruction (p> 0,05) though a tendency was observed for a better outcome when Double-J was used. Conclusions: Using a ureteral stent at renal transplantation decreases the early urinary FRPSOLFDWLRQV RI XULQH OHDNDJH DQG REVWUXFWLRQ +RZHYHU WKHUH LV D VLJQLᚏFDQW LQFUHDVH LQSRVLWLYHXULQHFXOWXUHVLQWKHᚏUVWGD\VDIWHUWUDQVSODQWDWLRQLQWKHVWHQWJURXSWKRXJK ZLWKRXWDQ\FOLQLFDOHᚎHFW6WHQWUHPRYDOZLWKLQZHHNVRILQVHUWLRQVHHPVDGYLVDEOH

1 University of Bologna, Transplantation Centre, Bologna, Italy, 2University of Modena, Transplantation Centre, Modena, Italy, University of Parma, Transplantation Centre, Parma, Italy

Introduction & Objectives: 0DUJLQDO RUJDQV GHᚏQHG ELRSWLFDOO\ DV QRW suitable for single kidney transplantation may be considered for double kidney transplantation (DKT). The aim of this study is to assess long term results of DKT in a multicentric experience. Material & Methods: From 2001 to 2007, 80 DKT were performed in the transplant centres of Bologna, Parma and Modena, using organs with mean ELRSWLF VFRUH RI  UDQJH   5HFLSLHQWVಬ PHDQ DJH ZDV s \HDUV 7KH PDLQ LQGLFDWLRQV IRU WUDQVSODQW ZHUH JORPHUXODU QHSKURSDWK\   DQG hypertensive nephroangiosclerosis(14). Mean HLA A,B,DR mismatches: 'RQRUVಬPHDQDJHZDVsPHDQFUHDWLQLQHFOHDUDQFHsP/PLQ Nearly all grafts were perfused with Celsior solution (mean cold ischemia WLPHsK ,PPXQRVXSSUHVVLRQUHJLPHQVZHUHEDVHGRQWDFUROLPXV  RU cyclosporine(25). Results: )LIW\SDWLHQWVKDGDJRRGSRVWRSHUDWLYHUHQDOIXQFWLRQ  KDG DFXWH WXEXODU QHFURVLV UHTXLULQJ GLDO\VLV    DFXWH UHMHFWLRQV RFFXUUHG 8ULQDU\FRPSOLFDWLRQVUDWHZDVᚏVWXODVDQGVWHQRVHV QHHGHG VXUJLFDO UHYLVLRQ  WKHUH ZHUH    VXUJLFDO UHYLVLRQV IRU ERZHO LQMXU\   EOHHGLQJ   DQG O\PSKRFHOH   7ZR SDWLHQWV XQGHUZHQW LPPHGLDWH ELODWHUDO transplantectomy due to massive thrombosis. Four patients underwent transplantectomy of single graft due to bleeding(1), vascular(2) and infective complications(1). Graft and patient survival was 95% and 100%, 95% and 96% DWDQGPRQWKVUHVSHFWLYHO\ Conclusions: DKT allows to use organs of marginal donors that otherwise would not be accepted for transplantation. In our experience this solution is an HᚎHFWLYHVWUDWHJ\WRIDFHRUJDQVKRUWDJHZLWKJRRGRXWFRPHV

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RETROPERITONEOSCOPIC LIVE DONOR NEPHRECTOMY: REPORT OF 151 CASES AND A COMPARISON BETWEEN THE OPERATIONS ON THE RIGHT HAND AND THE LEFT HAND SIDE

COMPARISON OF RENAL FUNCTION RECOVERY IN DONOR AND RECIPIENT AFTER LIVING DONOR NEPHRECTOMY: HANDASSISTED LAPAROSCOPIC VS. OPEN PROCEDURES

Ebinger N.1, Ruszat R.1, Wyler S.1, Gürke L.2, Steiger J., Gasser T.4, Bachmann A.1

Kwon T.G.1, Oh W.S.1, Yoo E.S.1, Chung S.K.1, Kim B.W.1, Park Y.K.1, Seo J.H.2, Kim H.T.

1 University Hospital Basel, Dept. of Urology, Basel, Switzerland, 2University Hospital Basel, Dept. of Vascular Surgery and Transplantation, Basel, Switzerland, University Hospital Basel, Dept. of Immunology and Transplantation Medicine, Basel, Switzerland, 4University Hospital Basel, Liestal, Dept. of Urology, Basel, Switzerland

Introduction & Objectives: Retroperitoneoscopic live donor nephrectomy has become the standard surgical procedure in our hospital since 2001. We present our data of 151 cases and compare the perioperative data between the operations on the right and the left side. Material & Methods:  OLYH GRQRUV I  P  OHIW  ULJKW   ZHUH RSHUDWHG IURP 1RYHPEHUWR$XJXVW7KHDYHUDJHDJHZDV  \HDUVDQGWKHDYHUDJH%0, ZDV  NJP7KHRSHUDWLRQWHFKQLTXHZDVWKHFRPPRQUHWURSHULWRQHRVFRSLF method in the hyperextended lateral position. One operation was hand assisted because there ZHUHDUWHULHV Results: $YHUDJHRSHUDWLQJWLPHZDV  PLQXWHV ULJKW>@OHIW>@ PLQXWHV  7KH DYHUDJH ZDUP LVFKHPLD WLPH ZDV    VHFRQGV ULJKW  >@ OHIW >@VHFRQGV ,QRIWKHFDVHV Q  DFRQYHUVLRQWRRSHQVXUJHU\ZDVQHFHVVDU\ Q  EHFDXVH RI LQMXU\ WR WKH DRUWD GXULQJ D OHIW VLGH RSHUDWLRQ Q  EHFDXVH RI  YHLQV DQG  supplementary artery on the right side which necessitated a change to the left side). The average EORRG ORVV ZDV    PO ULJKW  >@ OHIW  >@ PO  1RERG\ KDG QHHGHG DQ intraoperative transfusion. The average hospitalization time was 11 (4-29) days, (after the operation on the right 10 (4-14) days, on the left 11 (5-29) days). Minor intraoperative complications occurred LQ  RI WKH FDVHV Q   ULJKW  >Q @ OHIW  >Q @  3RVWRSHUDWLYH FRPSOLFDWLRQV RFFXUUHGLQRIWKHFDVHV Q   ULJKW>Q @OHIW>Q @ ,QRIWKHFDVHV Q  DVHFRQGRSHUDWLRQZDVQHFHVVDU\ Q EHFDXVHRIDUWHULDOLOLDFDOEOHHGLQJQ EHFDXVH of a chyloretroperitoneum with laparoscopic fenestration, both left side operations). From those SDWLHQWVRSHUDWHGRQWKHULJKWVLGHWKHUHZHUHDEQRUPDOYDVFXODUFRQGLWLRQVLQ Q  EXW only in 2.9% (n=1, the patient with 2 veins and 1 supplementary artery) was there a problem. This necessitated conversion to open surgery and to change to the left side. Vascular abnormalities on the left side occurred in 6.9% of the cases (n=8), only 0.8% (n=1) with minor intraoperative stapler problems and 0.8% (n=1) with minor postoperative bleeding in the suture area and fever. Only one (9.1%) of the 11 patients with abnormal vascular conditions, had a major complication requiring conversion to open surgery and change to the other side. Conclusions: Perioperative results prove retroperitoneoscopic live donor nephrectomy to be a safe operation technique for the donor. Perioperative data of operations performed on the right side are not worse than those on the left side. Even if there is an indication to remove the right kidney or if there are vascular abnormalities, this should not be a reason to choose open surgery.

1

Kyungpook National University Hospital, Dept. of Urology, Daegu, South Korea, 2Kumi Cha Medical Centre, Dept. of Urology, Kumi, South Korea,  Youngnam University Hospital, Dept. of Urology, Daegu, South Korea Introduction & Objectives: Pneumoperitoneum, as used in laparoscopic GRQRU QHSKUHFWRP\ PD\ UHVXOW LQ QHJDWLYH HᚎHFW RQ UHQDO IXQFWLRQ LQ GRQRU and recipient. We compared renal function in donor and recipient after hand assisted laparoscopic (HALDN) and open donor nephrectomy (ODN). Material & Methods: Between January 1999 and September 2006, a total of 166 live donor nephrectomies were performed either HALDN (88) or ODN (78). We followed the variation of donor and recipient serum creatinine preoperatively DQGRQGD\VDQGPRQWKVSRVWRSHUDWLYHO\ Results: Preoperative patients’ characteristics of donors and recipients, such DV DJH VH[ ERG\ PDVV LQGH[ ZHUH QRW GLᚎHUHQW EHWZHHQ WZR JURXSV 7KH mean operative time of HALDN and ODN was 221 and 210 min, and mean ischemic time was 4.9 and 4.5 min, respectively. Mean serum creatinine of the UHFLSLHQWRQWKHᚏUVWGD\DIWHUWUDQVSODQWDWLRQZDVVLJQLᚏFDQWO\KLJKHULQ+$/'1 WKDQ2'1JURXSV YVPJG/ +RZHYHUIURPSRVWRSHUDWLYHGD\V WR  \HDU WKHUH ZDV QR GLᚎHUHQFH EHWZHHQ WZR JURXSV 6HUXP FUHDWLQLQH LQ GRQRUZDVQRWVLJQLᚏFDQWO\GLᚎHUHQWEHWZHHQWZRJURXSVWKURXJKRXWWKHVWXG\ SHULRGV )URP  PRQWKV SRVWRSHUDWLYHO\ GRQRU VHUXP FUHDWLQLQH RI +$/'1 DQG 2'1 JURXSV UHPDLQHG  DQG  KLJKHU WR SUHRSHUDWLYH OHYHOV respectively. Overall acute rejection rates of HALDN and ODN groups were 6.8% (6/88) and 5.1% (4/78), respectively. Conclusions: The renal function recovery of donor was similar in both HALDN and ODN. In terms of graft renal function recovery, HALDN was comparable to that of ODN except immediate graft function (postoperative day 1).

Eur Urol Suppl 2008;7(3):195