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Drinking water and health
112
Reviews
Amino acid analysis revealed a high content of both aspartic and glutamic acids (or the corresponding amides). The LD~o(24 h) is 12 mg/kg mouse body weight. Monguine inhibits protein synthesis in hepatoma tissue culture cells and globin synthesis in a rabbit reticulocyte lysate. (Author's abstract)
Kocsls, J. J., JOLLO, D. J., W1TMER, C. M., NELSON, J. O. and SNYDER, R. (Eds) Advances in Experimental Medicine and Biology, Vol. 197, Biological Reactive Intermediates III. Mechanism o f Action in Animal Models and Human Disease. New York: Plenum Press (1986). A GREATvariety of chemicals are known to give rise to strongly reactive electrophilic intermediates in biological systems. The biological consequences of cell interactions with such reactive chemicals include mutation, carcinogenesis, teratogenesis, immunological responses and cell death. The book covers the proceedings of the 3rd International Symposium on Biological Reactive Intermediates (6 - 8 June 1985, University of Maryland). Its content, more than 1000 pages, reflects the nearly explosive growth of this research area during the last two decades. J. MEIER
THOMAS, R. D. (Ed.) Drinking Water and Health, Vol. 6. Washington, DC: National Academy Press (1986). THE TITLE of this book is misleading, since, although published by the U.S. Safe Drinking Water Committee, it is dedicated to the examination of current practices in risk assessment. Thus, many principles discussed are by no means limited to the exposure of humans to toxicants in drinking water. With chapters on developmental and reproductive toxicity, carcinogenesis, neurotoxicity, d o s e - route extrapolations and the use of epidemiological studies, an excellent review on the state of the art in risk assessment is provided. Thus, although the link to drinking water is always found, this book can be helpful as a general introduction to risk assessment. J. MEIER
FOA, V., EMMETT, E. A., MARONI, M. and COLOMBI, A. (Eds) Occupational and Environmental Chemical Hazards. Chichester: Ellis Horwood Ltd (1987). THE MAXNproblem occupational medicine is faced with concerns the etiology of work-related diseases. This is certainly multifactorial and, at least in part, influenced by lifestyle. The book, which contains the proceedings of the International Symposium on Biochemical and Cellular Indices of Human Toxicity in Occupational and Environmental Medicine (Milan, Italy, 1 6 - 22 June 1986), deals with the tools applicable to the investigation of chemical toxicity in a variety of organs. Divided into six parts, it covers, besides general aspects, liver toxicity induced by exogenous chemicals. In each section a senior scientist has summarized the state of the art in the light of the contributed papers. J. MEIER
CAmNS, J. JR (Ed.) Ecoaccidents. Nato Conference Series, Series 1: Ecology, Vol. II. New York: Plenum Press
(1985). IN 1983, a NATO Advanced Research Workshop on Ecoaccidents was hold in Noordwijkerkout, the Netherlands. The book covers some case histories (the best known being the Seveso Case, where in 1976 TCDD contamination originating from a chemical plant took place), as well as some chapters on possible scenarios and regulatory aspects. It is of course evident that advanced technological societies will occasionally have ecoaccidents. Recent dramatic ecoaccidents (Bhopal, India; Basle, Switzerland) show the increasing need for ecotoxicological research work to be done. The papers presented in this book give some insight into what has
Reviews
Amino acid analysis revealed a high content of both aspartic and glutamic acids (or the corresponding amides). The LD~o(24 h) is 12 mg/kg mouse body weight. Monguine inhibits protein synthesis in hepatoma tissue culture cells and globin synthesis in a rabbit reticulocyte lysate. (Author's abstract)
Kocsls, J. J., JOLLO, D. J., W1TMER, C. M., NELSON, J. O. and SNYDER, R. (Eds) Advances in Experimental Medicine and Biology, Vol. 197, Biological Reactive Intermediates III. Mechanism o f Action in Animal Models and Human Disease. New York: Plenum Press (1986). A GREATvariety of chemicals are known to give rise to strongly reactive electrophilic intermediates in biological systems. The biological consequences of cell interactions with such reactive chemicals include mutation, carcinogenesis, teratogenesis, immunological responses and cell death. The book covers the proceedings of the 3rd International Symposium on Biological Reactive Intermediates (6 - 8 June 1985, University of Maryland). Its content, more than 1000 pages, reflects the nearly explosive growth of this research area during the last two decades. J. MEIER
THOMAS, R. D. (Ed.) Drinking Water and Health, Vol. 6. Washington, DC: National Academy Press (1986). THE TITLE of this book is misleading, since, although published by the U.S. Safe Drinking Water Committee, it is dedicated to the examination of current practices in risk assessment. Thus, many principles discussed are by no means limited to the exposure of humans to toxicants in drinking water. With chapters on developmental and reproductive toxicity, carcinogenesis, neurotoxicity, d o s e - route extrapolations and the use of epidemiological studies, an excellent review on the state of the art in risk assessment is provided. Thus, although the link to drinking water is always found, this book can be helpful as a general introduction to risk assessment. J. MEIER
FOA, V., EMMETT, E. A., MARONI, M. and COLOMBI, A. (Eds) Occupational and Environmental Chemical Hazards. Chichester: Ellis Horwood Ltd (1987). THE MAXNproblem occupational medicine is faced with concerns the etiology of work-related diseases. This is certainly multifactorial and, at least in part, influenced by lifestyle. The book, which contains the proceedings of the International Symposium on Biochemical and Cellular Indices of Human Toxicity in Occupational and Environmental Medicine (Milan, Italy, 1 6 - 22 June 1986), deals with the tools applicable to the investigation of chemical toxicity in a variety of organs. Divided into six parts, it covers, besides general aspects, liver toxicity induced by exogenous chemicals. In each section a senior scientist has summarized the state of the art in the light of the contributed papers. J. MEIER
CAmNS, J. JR (Ed.) Ecoaccidents. Nato Conference Series, Series 1: Ecology, Vol. II. New York: Plenum Press
(1985). IN 1983, a NATO Advanced Research Workshop on Ecoaccidents was hold in Noordwijkerkout, the Netherlands. The book covers some case histories (the best known being the Seveso Case, where in 1976 TCDD contamination originating from a chemical plant took place), as well as some chapters on possible scenarios and regulatory aspects. It is of course evident that advanced technological societies will occasionally have ecoaccidents. Recent dramatic ecoaccidents (Bhopal, India; Basle, Switzerland) show the increasing need for ecotoxicological research work to be done. The papers presented in this book give some insight into what has