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Drugs affecting lipid metabolism
Volume 64 h’umbeu
Book reviews
4
which is probably a reflection of a lack of knowledge and data. Most of the presentations seem to accept the idea that anatomic changes with age is consonant with the aging process. This may be true to some extent, but surely is not entirely true nor always possible to know when it is or is not true. For example, the chapter on aging changes in blood vessels is particularly representative of this failure. Section F on page 55 on the vasa vasorum states: “As part of the aging changes, vasa vasorum grow into the media of the aorta from the adventitia. These capillaries are found mostly in the outer third of the muscular layer, although they may extend to the middle third.” That is the entire presentation of a subject that has aroused the interest of many investigators concerned with the development of arteriosclerosis. Furthermore, no references are given to document the paragraph nor are quantitative data given. As written, the concepts are presented to suggest that the vasa vasorum are capillaries only. Such a paragraph is useless to the reader and would have been better if it had not been written. If the reader is interested in anatomic changes in man associated with chronologic age, this book can serve as a beginning of his review of the subject. Some chapters are better than others, however. Unfortunately, this book contains many such loose statements which have been made by some authors who are not experts in the field. Because of a lack of a good source of collected data on the anatomic and pathologic changes associated with the aging process, one may wish to use this book for information on the aging process, but he is warned to do so cautiously and to know more about the source of the data and the qualifications of the author. The chapters vary in quality and value to a reader. Maybe in the next edition the Editor will have scholars and students of the aging process to write al! chapters. Such a book is needed, but it must be of high quality.
and training and is followed by a dozen subdivisions, each concisely stating the contributions, recent advances, and current problems in the various areas of both basic and clinical fields of study. Not only are these excellent summarizations, but each is documented with an extensive bibliography which furnishes especially citations of recent publications. Among the specific recommendations made are: the setting up of a permanent committee to program and implement a continuing research effort in the cerebral vascular area; provisions for up-to-date source books on current literature; cerebral vascular conferences-workshops to provide for exchange of information; training programs for specialized scientific personnel; expansion of research in areas of basic science as well as in all clinical phases, and an integrated basic and clinical endeavor. This is a very instructive concise survev.
DRUGS AFFECTING LIPID METABOLISM. Edited by S. Garattini and R. Paoletti. Proceedings of the Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1960. Amsterdam, 1961, Elsevier Publishing Company, 604 pages. U. S. distributor, D. Van Nostrand Company, Inc., Princeton, N. J. Price $19.50. The
SURVEY REPORT of the Cerebral Vascular Study Group, Institute of Neurological Diseases and Blindness, National Institutes of Health. St. Louis, 1961, Bargett Printing and Publishing Company, 139 pages. This report was prepared by a committee of seven members, with Dr. James L. O’Leary as Chairman, 13 consultants, and 4 representatives of the National Institutes of Health, a group eminently qualified to do this work. Its purpose is to advise and aid the Institute of Neurological Diseases and Blindness in planning a continuing program in the cerebral vascular field. The report is assembled in three sections: I. Introductory Statement for the Lay Reader. II. Present Knowledge of Cerebral Vascular Disease. III. Desiderata and Recommendations. The main body of the survey is found in Section II, which begins with a brief statement concerning the general problems in research
57.5
talks given at the Lipid Congress in 1960, at Milan, Italy, are published in this book and are very informative. .% wide range of material is presented, from the basic synthesis and metabolism of fatty acids to drugs that affect serum lipids both in animals and human beings. Therefore, this book could be prontably studied by basic science workers as well as physicians treating patients. This is one of the few books that contain information about results with the many hypolipemic agents now available, such as the hormones and their analogues, heparin and heparin-like substances, unsaturated fatty- acids, special phospholipids, psychotropic drugs, nicotinic acid and its derivatives, and several agents that may be new to the reader. ‘l’he information is complex because of the many different animals used, the wide variety of methods used to measure the lipids, the complex designs, and the variety of problems that were investigated. One is left with a large number of isolated facts about lipids and the awareness of the great potential of synthesizing them into concepts that will explain problems in both health and disease of human beings and animals.
SMOKIKG AND HEALTH (Summary and Report of the Royal College of Physicians of London on Smoking in Relation to Cancer of the Lung and Other Diseases). New York, 1962, Pitman Publishing Corporation, 70 pages. Price $1. In
1959, the committee in relation
Royal College of Physicians set up a to report on the question of smoking to carcinoma and other diseases.
Book reviews
4
which is probably a reflection of a lack of knowledge and data. Most of the presentations seem to accept the idea that anatomic changes with age is consonant with the aging process. This may be true to some extent, but surely is not entirely true nor always possible to know when it is or is not true. For example, the chapter on aging changes in blood vessels is particularly representative of this failure. Section F on page 55 on the vasa vasorum states: “As part of the aging changes, vasa vasorum grow into the media of the aorta from the adventitia. These capillaries are found mostly in the outer third of the muscular layer, although they may extend to the middle third.” That is the entire presentation of a subject that has aroused the interest of many investigators concerned with the development of arteriosclerosis. Furthermore, no references are given to document the paragraph nor are quantitative data given. As written, the concepts are presented to suggest that the vasa vasorum are capillaries only. Such a paragraph is useless to the reader and would have been better if it had not been written. If the reader is interested in anatomic changes in man associated with chronologic age, this book can serve as a beginning of his review of the subject. Some chapters are better than others, however. Unfortunately, this book contains many such loose statements which have been made by some authors who are not experts in the field. Because of a lack of a good source of collected data on the anatomic and pathologic changes associated with the aging process, one may wish to use this book for information on the aging process, but he is warned to do so cautiously and to know more about the source of the data and the qualifications of the author. The chapters vary in quality and value to a reader. Maybe in the next edition the Editor will have scholars and students of the aging process to write al! chapters. Such a book is needed, but it must be of high quality.
and training and is followed by a dozen subdivisions, each concisely stating the contributions, recent advances, and current problems in the various areas of both basic and clinical fields of study. Not only are these excellent summarizations, but each is documented with an extensive bibliography which furnishes especially citations of recent publications. Among the specific recommendations made are: the setting up of a permanent committee to program and implement a continuing research effort in the cerebral vascular area; provisions for up-to-date source books on current literature; cerebral vascular conferences-workshops to provide for exchange of information; training programs for specialized scientific personnel; expansion of research in areas of basic science as well as in all clinical phases, and an integrated basic and clinical endeavor. This is a very instructive concise survev.
DRUGS AFFECTING LIPID METABOLISM. Edited by S. Garattini and R. Paoletti. Proceedings of the Symposium on Drugs Affecting Lipid Metabolism, Milan, Italy, 1960. Amsterdam, 1961, Elsevier Publishing Company, 604 pages. U. S. distributor, D. Van Nostrand Company, Inc., Princeton, N. J. Price $19.50. The
SURVEY REPORT of the Cerebral Vascular Study Group, Institute of Neurological Diseases and Blindness, National Institutes of Health. St. Louis, 1961, Bargett Printing and Publishing Company, 139 pages. This report was prepared by a committee of seven members, with Dr. James L. O’Leary as Chairman, 13 consultants, and 4 representatives of the National Institutes of Health, a group eminently qualified to do this work. Its purpose is to advise and aid the Institute of Neurological Diseases and Blindness in planning a continuing program in the cerebral vascular field. The report is assembled in three sections: I. Introductory Statement for the Lay Reader. II. Present Knowledge of Cerebral Vascular Disease. III. Desiderata and Recommendations. The main body of the survey is found in Section II, which begins with a brief statement concerning the general problems in research
57.5
talks given at the Lipid Congress in 1960, at Milan, Italy, are published in this book and are very informative. .% wide range of material is presented, from the basic synthesis and metabolism of fatty acids to drugs that affect serum lipids both in animals and human beings. Therefore, this book could be prontably studied by basic science workers as well as physicians treating patients. This is one of the few books that contain information about results with the many hypolipemic agents now available, such as the hormones and their analogues, heparin and heparin-like substances, unsaturated fatty- acids, special phospholipids, psychotropic drugs, nicotinic acid and its derivatives, and several agents that may be new to the reader. ‘l’he information is complex because of the many different animals used, the wide variety of methods used to measure the lipids, the complex designs, and the variety of problems that were investigated. One is left with a large number of isolated facts about lipids and the awareness of the great potential of synthesizing them into concepts that will explain problems in both health and disease of human beings and animals.
SMOKIKG AND HEALTH (Summary and Report of the Royal College of Physicians of London on Smoking in Relation to Cancer of the Lung and Other Diseases). New York, 1962, Pitman Publishing Corporation, 70 pages. Price $1. In
1959, the committee in relation
Royal College of Physicians set up a to report on the question of smoking to carcinoma and other diseases.