Dynamic Science: Biochemistry in Cambridge, 1898-1949

Dynamic Science: Biochemistry in Cambridge, 1898-1949

TIBS 1 7 - J U N E 1 9 9 2 21 Gonzalez, F. A., Raden, D. L. and Davis, R. J. (1991) J. Biol. Chem. 266, 22159-22163 22 Mukhopadhyay, N. K. et al. (19...

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TIBS 1 7 - J U N E 1 9 9 2

21 Gonzalez, F. A., Raden, D. L. and Davis, R. J. (1991) J. Biol. Chem. 266, 22159-22163 22 Mukhopadhyay, N. K. et al. (1992) J. Biol. Chem. 267, 3325-3335 23 Payne, D. M. et al. (1991) EMBOJ. 10, 885-892 24 Posada, J. and Cooper, J. A. (1992) Science 255, 212-215 25 Ettehadieh, E. et al. (1992) Science 255, 853-855 26 Seger, R. et al. (1991) Proc. Natl Acad. Sci. USA 88, 6142-6146 27 Lundgren, K. et al. (1991) Cell 64, 1111-1122 28 Crews, C. M., Alessandrini, A. and Erikson, R. L. (1991) Proc. Natl Acad. Sci. USA 88, 8845-8849 29 Wu, J. et al. (1991) Proc. Natl Acad. Sci. USA 88, 9508-9512

30 Ahn, N. G. et al. (1991) J. Biol. Chem. 266, 4220-4227 31 Gomez, N. and Cohen, P. (1991) Nature 353, 170-173 32 Matsuda, S. et al. (1992) EMBO J. 11, 973-982 33 Seger, R. et al. J. Biol. Chem. (in press) 34 Teague, M. A., Chaleff, D. T. and Errede, B. (1986) Proc. Natl Acad. Sci. USA 83, 7371-7375 35 Elion, E. A., Brill, J. A. and Fink, G. R. (1991) Proc. Natl Acad. Sci. USA 88, 9392-9396 36 Ballard, M. J. et a/. (1991) EMBO J. 10, 3753-3758 37 Pelech, S. L., Tombes, R. M., Meijer, L. and Krebs, E. G. (1988) Dev. Biol. 130, 28-36 38 Draetta, G. (1990) Trends Biochem. Sci. 15,

378-383 39 Freeman, R. S. and Donoghue, D. J. (1991) Biochemistry 30, 2293-2302 40 Gotoh, Y. et al. (1991) Nature 349, 251-254 41 Cheng, H-C., Litwin, C. M. E., Hwang, D. M. and Wang, J. H. (1991) J. Biol. Chem. 266, 17919-17925 42 Gould, K. L. et al. (1991) EMBO J. 10, 3297-3309 43 Krek, W. and Nigg, E. A. (1991) EMBO J. 10, 305-316 44 Solomon, M. J., Lee, T. and Kirschner, M. W. (1992) Mol. Biol. Cell 3, 13-27 45 Peter, M., Sanghera, J. S., Pelech, S. L. and Nigg, E. Eur. J. Biochem. (in press) 46 Hein, J. (1990) Methods Enzymol. 183, 626-645

BOOKSinBRIEF Understanding the Biochemistry of Respiration e d i t e d by D. C. J a m e s a n d G. S. M a t t h e w s , Cambridge University Press, 1 9 9 1 . £ 5 . 7 5 , $ 1 1 . 9 5 (v + 9 0 pages) ISBN 0 5 2 1 3 9 9 9 3 9

The aim of this text is to provide a companion text in Biology/Biochemistry classes for A-level and first-year college students. The book is written to be independent of other texts in that there is a short chapter of basic chemistry before it launches into respiration and oxidative phosphorylation. The various chapters are concise, well written and use schematics, highlighted concepts and summary statements to great effect. My only criticism of the presentation of information is that the emphasis is on the biochemistry of respiration in animal mitochondria. It would have been useful to establish in the minds of students that oxidative phosphorylation occurs in the plasma membrane of bacteria and that there are important parallels between oxidative phosphorylation and photophosphorylation. In deciding whether to use this short book in conjunction with general texts of biology or biochemistry, teachers will need to weigh what emphasis they should put on cellular respiration, in the USA this subject matter is usually covered in one or two lectures in high school courses and in two or three lectures at most in lower division courses in college. It will be a 'hard sell' to persuade students to buy a special book for such a small part of the course, regardless of how well written the book is. R.C.

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Dynamic Science: Biochemistry in Cambridge, 1898-1949 Mark Weatherall and Harmke Kamminga, Cambridge Wellcome Unit

by

Publications, 1 9 9 2 . £ 4 . 0 0 UK, £ 4 . 5 0 Europe, £ 6 . 0 0 elsewhere ( 8 5 pages) ISBN 0 9 5 1 6 6 9 3 2 X

This illustrated booklet is issued on the occasion of an exhil:lition of the same name in the Cambridge University School of Clinical Medicine. The primary focus is on the school of Frederick Gowland Hopkins, with the text drawing on a variety of published and unpublished sources. The booklet brings together information about laboratories, institutes, teaching, research activities and individual biochemists. Copies may be ordered from: The Wellcome Unit for the History of Medicine, Free School Lane, Cambridge, UK CB2 3RH. Please enclose payment in US$ or £sterling with orders.

Figure 1 Hopkins and Cole with the first sample of tryptophan.

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