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E007 Insulin attenuates angiotensin II-induced venoconstriction in man
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Y A IT PN R D A E T NE RNI RI R S T SCO A NE C H S S A YA I PH S U R E RL NIE A OI EM T N A A NR E IG O A O E C U I M R IF S D E P DE O C S L N W T EN A- IR E TL P O ANN L U LSR Y R UT LM IE O AV UR K Y R ( P B A E A S RB ~ A TC EO EH jC PE T ~ a RK R o ES K s Oih J nC Lid R F r eai J uM z t r. -v RC s V sd Y ch V AS A, C T I‘ w TR S n C H o Ca S M lr C eI D y a i t s S h aS o a tS rhn t . i aap en m M afr aG a ht S e Snlr iNephfofogy A U a a rev n a o M a 2 S ec U P d n 1I ev d c nea ia r ta D i eth l ho i ti Unit, E/ieeharResearch oLa/wetoryarrdOepertmerrtof on s e l t f I r i a re n f f c a h d a i ao sHematology, it u rWestern et c Galiiea s Hospital, a o lNahariya, o r e t a na ir a ea o n keel. T p o y rw f C o e i S ot o o e O v h hr r c u m o a e t n i r n o n e o a e uh d r et al m a c o b nte p n h d n sI y stm r w m e W ah n d ei i om p u n pop a e d c sr ue eakdh hl ( i ot e u rsu vPr p p t t e H n r i m a S u os g i aoa s k c i a n xi l n o a i r sh s m ae nrt i t o s afe r na d l t trl t oo ( I a a t O e t Ot tG t m x st h sI i t we T vd e sm e )t d i p sn o. l e h a ( y D p a e o P e g e E r r a n t n a f a t a e t i o m mg s w em a n s n l po s h pea a a a s u d c , setK s e o l Ye l t aotW8q w t sdm W rs al u o p H ri n oaarb r - r 2 w o f St a W ( el ur b s Ii s d oxygen aPeCiSS e orreMes w i i r d o r i e o v ( aa W r S a si K ah H ca tY m I o - n mO o % ni p z V e eV r d X c a( a e m E omv- [ [ h f al M l C m C ae) c t QM ( a W S A u K ~H n tN Y iR i ce nS W a aW w l o p m r ae O ea p e ds r u s e b e d rG s i s i v a e n n c a miau a ai uvr ee o l ~r erti i u a n r ber - s F s ho wa w l A cw em r il r i Par hT riya i o e c Mt e n t et f p g l dH c t o i ia gE b n aifwE S w i a h e c yi t W pt o g as rHm r ah Rs f m l n a C h a a M e u r ieaY [ t ni K P p t eei E a t w t m h w a l O e v a a w a h a adl n r h ea i c ai rgnt cea t m tev at ri m iv i aa hr l z sr i e t rd I os o r a h w r f b w em we l D’ i i ir n o a g g e a o a h gch r td t t r ha d ett i r a me n a b ap rs i r t els u a a s a m P we a h ( i ia e < g r r ro O sd N af ai . wi S e 0D a= e nc [Ca~iwas m b f c e i y a t ( M A g r o u p ) :f s P a PO to A M w I Bf I Ha Mi N RN u Iia H E O W ( S YW Si I T E Tss g /w GF Ll S T R A s X f b e o 1 u n a l a ar t r t r B ( H W ( mI Ep p O e o i v0 d 1 f aV dX h 3W 6 S 1 5. H R. 8 2 0 y 4w O +o 6. M 2 9ti 3 a t rO ”4 . #1 Q .2 o ah f n A naog / w m i 4W < 4k . a I s 7 o S 2 H 1 R .b Ml 9 m. fe 1 0 8a .g 7d 4vW u Y4. c h 3 3 2 o i 7 b a1 I n e. t Hn i ae l w 3 .1 i ieM t a I w 3 K 0 y 6 s. w a 7s c r w 0 ae b 3m O o o+ i 2 , t s nh a . 2 ‘ o c W m < g + r o o 0ge o r s< h .i sp t g ro a o 0i K0 f no i ah 7e g udhn o0o. m u ln ar p1 r 0 a s t a r et a . g l aE p l o tm E i p i o ea u a n r g ch d d ne a dm i i gG oi ao g n if n l r s f i a e tn i u T fe > tr s s O w ~ 2 i asra n c i e c t ei s u e us oT n fa b ts f g Fe a a u t r n w hn u Fe sm r p t e e s i n s u o oo l id u h p n 7e g r o A l r aS oa h co K A i f t g ou rt Kg n r e l a eh pVoe) c ( w g i b F g u o Sr t WF r vw o f H b P [ a e M ( p C t f < M = O w a S W te H H t t e Rh R S h Cuc s I l h U uh a M a l i S l t ho on a g N [ f e a eui e n C a Mg sc f n wta insulin r c e ho y sSs i b r io s a abl d Pu r ar n Hi ntn i ia I h-#ec < t Ea a P p oFo O =mh m f i r a d F re d l r sa l t( m re P e g o .n ul0s e n aM0 d d g. e tw i rc e c p ee ne C n a dh e T a l e o o pe o t v a f h vp a a aI r rf ho n[ n ce w o r s o . i r o vd e rd w u a d nf t a e u ti xsi bh a pn e aw n i a dr r r w a g s l d ie n wt e sv t s sarM ie i o a K W o r d s y : K We o r h en y cs p s e a ei a l p s nn d ns st ei rMc ir i t r i t t s r yP i Es r u h h m y e w n r o t p m a p u h s y c i r a a n l s s i e s uk
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GT EH NY TE E L D E TNN RU I S A T A G I O I TNI TI BT R N O PE ITI N n S T M U u L RI L I M O N A C B SO N lS S A(uT A RN & C N Og I NN B J D a u O B e E tuKl a a rh o i n KMalireddi,M Gollsmudi,MFWilson*.StateU n iA B o r Cv 6 E 5 F d a Ns0 * B a ~ r n o N Y a B N u ot e 6l Yla r f wa 0 P hL F 9rr d y m ao xn A gf s o i a t R e s H ( mI s i e na w Ay i e n t n s .r i s d e h nu mo a p l y oe v o a o C a a cs a r i cr d t y i e L ir o c i n vt t s n e oa t o o(s nc mrcttar b ew h tson a eeur l idg mc i i B c nA i o r v l h b e nn o t e o h t s lh ai ya x w r pi ss vuo ro c ltie n l a r na is I ot r r ids n t a w hs yi s bp n oA e I ti erc p e l t a i i r te wsutt ca n l ai a e t pi oe w L r f m h t ~s X > t pe u y i a tr n unknown. W e w x hd v a insulinis currently s ahn ta d i t e dem t wi a a t t ti e e u nh m w i n i 1 n t n oh r e i i s s ner r n e n u o aa t s t t s ci l e l A I i I sn t u i sgtt s ( a = uy b m i =b m f B j rn o ae@e g 2 c d 2 a m. d t s es w L a L m e r w e G o 2 a 5 r o = 1 A u1 m 3 l w / 7 Mt 6a m c ea irw a sn as h vq H c ro . h H g e i uau )e tt ei . n tk u7 r T w l t w ur f m i a o ed h n na on aI nrurnc ms s ben dn etr an r u s s spo cdaue a t u eeae c oo v d A Ii ( n aa a c eg m 1 t nm n n for2 themeasurement i e r n o na. ao he l b w drawn iob li ofnplasma mi . s s o l i f t u gwv w i ( 1 3 6 un w i ia U0s ncholesterol / au t 8e 6f A2r ta m i. i lf r e s y h nnn sa e h tu a oni um a e g nnt t be l l rsauei u ne r f 5 m Vn d i w m li e n stot a leo im t r u r t m r eol t tga an lit ao t uah alb m s hu e vh c c n t u4 m a ef t i e f u ir bt me n l i t ia H w ap t c o t i r T i une s se n s h nr p f l 2m o i C i ni v d at h n i cle o w a cmua r no t t 2 fp l i e gt ao ce oa t ihr a t r.an asm ur ntea a w A r w r m ue N e i Ade b p i y a O e z s t a t V e u w r e eg dr a p c a ht l woor g li a t f a ge h ct B m d a w 3 + im A s I m a e e se m (i l h d g i La e t. n.i aL m ir n a i t n @ ei c n. f n t 5 n troi i n rot n eo s i s v i e ( g n 0/0, p < o 0 n Ve io i tnw a rni02ccL r ni o e Iacc f .t r t r ori i i d d A Hi a i i u w a 3t n m d. sr a c i e 1e dn e o n insw t ,a teie b s ss 3 of dc nei i r a L r n s di a f Lg ca nt i i n fs s . s a in p . g t e ( s *5t 3c ta 6 d*t u4 e w if 5 a 2nl: v4i 3 3 m r eI e cu i l a a , y 2n ~ 4 A I m c e( o < 0 a nt dw a s . i a e rats 0t a e i g o 1f L c at n LN a ti 4 n t 1 h r wa0 ei s t c rt a c r o A o I e v I m e v b- n p or m e e e el c s rn m d p e s iat t c ei s greater 1 uU/tnin.Conclusion: i a d n than s o se I wu c t do l t n pe i h l c h s aln e l v nAsn n I a A 1 ti n ta e o i c ndbu no r Lus nr duaslun d a t l aa t r i i ctei i e r e e datnt enn igv o A I a i i i pn n w i t e s er n n T r e nf r u sd i a s et i schi tl m y t s h nodo , i i t t nfp g b t nwa n af a a e a hr enn l a ni rn o I ce l ec te i r m ae v sa ne s o iA o I c hf s i o t pc ep o ew ai rs ri c tl a s e ln e ee no s T m p a r i p o h r h ay el opn v a ae n i n ss ic ss y a t i i h r pe ner o o sp s s c t i l ud e s ra lto t s ai i i s o n K W H yr i o p ne rr s eta A N
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Y A IT PN R D A E T NE RNI RI R S T SCO A NE C H S S A YA I PH S U R E RL NIE A OI EM T N A A NR E IG O A O E C U I M R IF S D E P DE O C S L N W T EN A- IR E TL P O ANN L U LSR Y R UT LM IE O AV UR K Y R ( P B A E A S RB ~ A TC EO EH jC PE T ~ a RK R o ES K s Oih J nC Lid R F r eai J uM z t r. -v RC s V sd Y ch V AS A, C T I‘ w TR S n C H o Ca S M lr C eI D y a i t s S h aS o a tS rhn t . i aap en m M afr aG a ht S e Snlr iNephfofogy A U a a rev n a o M a 2 S ec U P d n 1I ev d c nea ia r ta D i eth l ho i ti Unit, E/ieeharResearch oLa/wetoryarrdOepertmerrtof on s e l t f I r i a re n f f c a h d a i ao sHematology, it u rWestern et c Galiiea s Hospital, a o lNahariya, o r e t a na ir a ea o n keel. T p o y rw f C o e i S ot o o e O v h hr r c u m o a e t n i r n o n e o a e uh d r et al m a c o b nte p n h d n sI y stm r w m e W ah n d ei i om p u n pop a e d c sr ue eakdh hl ( i ot e u rsu vPr p p t t e H n r i m a S u os g i aoa s k c i a n xi l n o a i r sh s m ae nrt i t o s afe r na d l t trl t oo ( I a a t O e t Ot tG t m x st h sI i t we T vd e sm e )t d i p sn o. l e h a ( y D p a e o P e g e E r r a n t n a f a t a e t i o m mg s w em a n s n l po s h pea a a a s u d c , setK s e o l Ye l t aotW8q w t sdm W rs al u o p H ri n oaarb r - r 2 w o f St a W ( el ur b s Ii s d oxygen aPeCiSS e orreMes w i i r d o r i e o v ( aa W r S a si K ah H ca tY m I o - n mO o % ni p z V e eV r d X c a( a e m E omv- [ [ h f al M l C m C ae) c t QM ( a W S A u K ~H n tN Y iR i ce nS W a aW w l o p m r ae O ea p e ds r u s e b e d rG s i s i v a e n n c a miau a ai uvr ee o l ~r erti i u a n r ber - s F s ho wa w l A cw em r il r i Par hT riya i o e c Mt e n t et f p g l dH c t o i ia gE b n aifwE S w i a h e c yi t W pt o g as rHm r ah Rs f m l n a C h a a M e u r ieaY [ t ni K P p t eei E a t w t m h w a l O e v a a w a h a adl n r h ea i c ai rgnt cea t m tev at ri m iv i aa hr l z sr i e t rd I os o r a h w r f b w em we l D’ i i ir n o a g g e a o a h gch r td t t r ha d ett i r a me n a b ap rs i r t els u a a s a m P we a h ( i ia e < g r r ro O sd N af ai . wi S e 0D a= e nc [Ca~iwas m b f c e i y a t ( M A g r o u p ) :f s P a PO to A M w I Bf I Ha Mi N RN u Iia H E O W ( S YW Si I T E Tss g /w GF Ll S T R A s X f b e o 1 u n a l a ar t r t r B ( H W ( mI Ep p O e o i v0 d 1 f aV dX h 3W 6 S 1 5. H R. 8 2 0 y 4w O +o 6. M 2 9ti 3 a t rO ”4 . #1 Q .2 o ah f n A naog / w m i 4W < 4k . a I s 7 o S 2 H 1 R .b Ml 9 m. fe 1 0 8a .g 7d 4vW u Y4. c h 3 3 2 o i 7 b a1 I n e. t Hn i ae l w 3 .1 i ieM t a I w 3 K 0 y 6 s. w a 7s c r w 0 ae b 3m O o o+ i 2 , t s nh a . 2 ‘ o c W m < g + r o o 0ge o r s< h .i sp t g ro a o 0i K0 f no i ah 7e g udhn o0o. m u ln ar p1 r 0 a s t a r et a . g l aE p l o tm E i p i o ea u a n r g ch d d ne a dm i i gG oi ao g n if n l r s f i a e tn i u T fe > tr s s O w ~ 2 i asra n c i e c t ei s u e us oT n fa b ts f g Fe a a u t r n w hn u Fe sm r p t e e s i n s u o oo l id u h p n 7e g r o A l r aS oa h co K A i f t g ou rt Kg n r e l a eh pVoe) c ( w g i b F g u o Sr t WF r vw o f H b P [ a e M ( p C t f < M = O w a S W te H H t t e Rh R S h Cuc s I l h U uh a M a l i S l t ho on a g N [ f e a eui e n C a Mg sc f n wta insulin r c e ho y sSs i b r io s a abl d Pu r ar n Hi ntn i ia I h-#ec < t Ea a P p oFo O =mh m f i r a d F re d l r sa l t( m re P e g o .n ul0s e n aM0 d d g. e tw i rc e c p ee ne C n a dh e T a l e o o pe o t v a f h vp a a aI r rf ho n[ n ce w o r s o . i r o vd e rd w u a d nf t a e u ti xsi bh a pn e aw n i a dr r r w a g s l d ie n wt e sv t s sarM ie i o a K W o r d s y : K We o r h en y cs p s e a ei a l p s nn d ns st ei rMc ir i t r i t t s r yP i Es r u h h m y e w n r o t p m a p u h s y c i r a a n l s s i e s uk
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GT EH NY TE E L D E TNN RU I S A T A G I O I TNI TI BT R N O PE ITI N n S T M U u L RI L I M O N A C B SO N lS S A(uT A RN & C N Og I NN B J D a u O B e E tuKl a a rh o i n KMalireddi,M Gollsmudi,MFWilson*.StateU n iA B o r Cv 6 E 5 F d a Ns0 * B a ~ r n o N Y a B N u ot e 6l Yla r f wa 0 P hL F 9rr d y m ao xn A gf s o i a t R e s H ( mI s i e na w Ay i e n t n s .r i s d e h nu mo a p l y oe v o a o C a a cs a r i cr d t y i e L ir o c i n vt t s n e oa t o o(s nc mrcttar b ew h tson a eeur l idg mc i i B c nA i o r v l h b e nn o t e o h t s lh ai ya x w r pi ss vuo ro c ltie n l a r na is I ot r r ids n t a w hs yi s bp n oA e I ti erc p e l t a i i r te wsutt ca n l ai a e t pi oe w L r f m h t ~s X > t pe u y i a tr n unknown. W e w x hd v a insulinis currently s ahn ta d i t e dem t wi a a t t ti e e u nh m w i n i 1 n t n oh r e i i s s ner r n e n u o aa t s t t s ci l e l A I i I sn t u i sgtt s ( a = uy b m i =b m f B j rn o ae@e g 2 c d 2 a m. d t s es w L a L m e r w e G o 2 a 5 r o = 1 A u1 m 3 l w / 7 Mt 6a m c ea irw a sn as h vq H c ro . h H g e i uau )e tt ei . n tk u7 r T w l t w ur f m i a o ed h n na on aI nrurnc ms s ben dn etr an r u s s spo cdaue a t u eeae c oo v d A Ii ( n aa a c eg m 1 t nm n n for2 themeasurement i e r n o na. ao he l b w drawn iob li ofnplasma mi . s s o l i f t u gwv w i ( 1 3 6 un w i ia U0s ncholesterol / au t 8e 6f A2r ta m i. i lf r e s y h nnn sa e h tu a oni um a e g nnt t be l l rsauei u ne r f 5 m Vn d i w m li e n stot a leo im t r u r t m r eol t tga an lit ao t uah alb m s hu e vh c c n t u4 m a ef t i e f u ir bt me n l i t ia H w ap t c o t i r T i une s se n s h nr p f l 2m o i C i ni v d at h n i cle o w a cmua r no t t 2 fp l i e gt ao ce oa t ihr a t r.an asm ur ntea a w A r w r m ue N e i Ade b p i y a O e z s t a t V e u w r e eg dr a p c a ht l woor g li a t f a ge h ct B m d a w 3 + im A s I m a e e se m (i l h d g i La e t. n.i aL m ir n a i t n @ ei c n. f n t 5 n troi i n rot n eo s i s v i e ( g n 0/0, p < o 0 n Ve io i tnw a rni02ccL r ni o e Iacc f .t r t r ori i i d d A Hi a i i u w a 3t n m d. sr a c i e 1e dn e o n insw t ,a teie b s ss 3 of dc nei i r a L r n s di a f Lg ca nt i i n fs s . s a in p . g t e ( s *5t 3c ta 6 d*t u4 e w if 5 a 2nl: v4i 3 3 m r eI e cu i l a a , y 2n ~ 4 A I m c e( o < 0 a nt dw a s . i a e rats 0t a e i g o 1f L c at n LN a ti 4 n t 1 h r wa0 ei s t c rt a c r o A o I e v I m e v b- n p or m e e e el c s rn m d p e s iat t c ei s greater 1 uU/tnin.Conclusion: i a d n than s o se I wu c t do l t n pe i h l c h s aln e l v nAsn n I a A 1 ti n ta e o i c ndbu no r Lus nr duaslun d a t l aa t r i i ctei i e r e e datnt enn igv o A I a i i i pn n w i t e s er n n T r e nf r u sd i a s et i schi tl m y t s h nodo , i i t t nfp g b t nwa n af a a e a hr enn l a ni rn o I ce l ec te i r m ae v sa ne s o iA o I c hf s i o t pc ep o ew ai rs ri c tl a s e ln e ee no s T m p a r i p o h r h ay el opn v a ae n i n ss ic ss y a t i i h r pe ner o o sp s s c t i l ud e s ra lto t s ai i i s o n K W H yr i o p ne rr s eta A N
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