- Email: [email protected]
Early Diagnosis and Treatment of Cancer: Ovarian Cancer
Journal of Surgical Research 166, 205 (2011)
BOOK REVIEW Early Diagnosis and Treatment of Cancer: Ovarian Cancer Philadelphia, PA: Saunders Elsevier. ISBN-13: 978-1-41604685-1. 234 pages. 2010. In the preface to the series of textbooks ‘‘Early Diagnosis and Treatment of Cancer,’’ editor Stephen C. Yang states that the series was designed to gather state of the art research and recommendations into compact, easy to use volumes. With that goal in mind, I believe that the editors of the Ovarian Cancer volume, Robert Bristow and Deborah Armstrong, have done just that. The key points section which headlines each chapter is excellent as a quick review or a way to skim each chapter. The use of multiple figures and well designed tables makes it a pleasure to read and easy to retain the information. The first six chapters are devoted to aspects of ovarian cancer that occur prior to the diagnosis. The first chapter discusses epidemiology and clinical presentation, and the second chapter discusses the biology and pathology of ovarian cancer. Chapter 3 gives a clear overview of familial syndromes and genetic testing and does a great job incorporating clear diagrams and figures to help drive the important points home. Chapter 4 is a robust discussion of ovarian cancer prevention, including chemoprevention and prophylactic surgery. This chapter benefits from a thorough discussion of the literature as well as tables highlighting the odds ratios for the most important studies on chemoprevention and prophylactic oophorectomy. Chapter 5, written by two radiologists, provides the best overview of diagnostic imaging in ovarian cancer that I have encountered. Not only is screening for ovarian cancer discussed, but the role of FDG-PET in ovarian cancer is reviewed, as well as specific tumor characterization by imaging, and the limitations of imaging in recurrent ovarian cancer. Chapter 6 provides a comprehensive review of ovarian cancer screening. Not only are the major screening studies using CA 125 and transvaginal ultrasound covered, but multiple markers as well as biomarker discovery is reviewed as well. In addition, the concepts of 2D-PAGE, DIGE, SELDI-TOF, and protein arrays are compared and contrasted for a better understanding of the current
biomarker research. While not as complete as a surgical procedural atlas, chapter 7 does cover a variety of surgical techniques related to ovarian cancer, including en bloc pelvic resection, diaphragm resection, liver resection, and splenectomy. In addition, the major studies supporting cytoreduction are reviewed as well as the rationale and evidence for fertility sparing surgery where indicated. Chapter 8 is a review of the current standard of care chemotherapy for ovarian cancer. To write this with clarity is no small feat, but is accomplished quite well here, though not as thoroughly as other texts. Chapters 9 and 10 truly make this book stand out. Chapter 9 is totally devoted to the chemotherapeutic management of recurrent ovarian cancer. This is an excellent overview of the current evidence and issues in treatment of women with recurrent ovarian cancer. Chapter 10 is completely devoted to secondary cytoreduction in recurrent ovarian cancer, an issue that does not typically get as much attention in general gynecologic oncology textbooks. The devotion of a whole chapter on this subject adds to the value of this text greatly. As thorough and easy to read as this book is, there is some room for improvement. It would benefit from a chapter devoted to the management of symptoms in recurrent ovarian cancer, as well as the role of end of life care in this population where cure is rare. In addition, some topics are covered twice in different chapters, creating some redundancy. For instance, the surgical management of LMP tumors as well as non-epithelial tumors is covered both in chapter 7 and chapter 11; and secondary cytoreduction has its own chapter but is also covered in less detail in chapter 7. However, these are minor issues in what I believe to be a valuable reference for clinicians, fellows, residents, and students who care for women with ovarian cancer.
205
Stephen Lee Rose, M.D. Department of Obstetrics and Gynecology University of Wisconsin 600 Highland Ave. H4/636 Clinical Science Center Madison, WI 53792 E-mail: [email protected] doi:10.1016/j.jss.2010.11.896
0022-4804/$36.00 Ó 2011 Elsevier Inc. All rights reserved.
BOOK REVIEW Early Diagnosis and Treatment of Cancer: Ovarian Cancer Philadelphia, PA: Saunders Elsevier. ISBN-13: 978-1-41604685-1. 234 pages. 2010. In the preface to the series of textbooks ‘‘Early Diagnosis and Treatment of Cancer,’’ editor Stephen C. Yang states that the series was designed to gather state of the art research and recommendations into compact, easy to use volumes. With that goal in mind, I believe that the editors of the Ovarian Cancer volume, Robert Bristow and Deborah Armstrong, have done just that. The key points section which headlines each chapter is excellent as a quick review or a way to skim each chapter. The use of multiple figures and well designed tables makes it a pleasure to read and easy to retain the information. The first six chapters are devoted to aspects of ovarian cancer that occur prior to the diagnosis. The first chapter discusses epidemiology and clinical presentation, and the second chapter discusses the biology and pathology of ovarian cancer. Chapter 3 gives a clear overview of familial syndromes and genetic testing and does a great job incorporating clear diagrams and figures to help drive the important points home. Chapter 4 is a robust discussion of ovarian cancer prevention, including chemoprevention and prophylactic surgery. This chapter benefits from a thorough discussion of the literature as well as tables highlighting the odds ratios for the most important studies on chemoprevention and prophylactic oophorectomy. Chapter 5, written by two radiologists, provides the best overview of diagnostic imaging in ovarian cancer that I have encountered. Not only is screening for ovarian cancer discussed, but the role of FDG-PET in ovarian cancer is reviewed, as well as specific tumor characterization by imaging, and the limitations of imaging in recurrent ovarian cancer. Chapter 6 provides a comprehensive review of ovarian cancer screening. Not only are the major screening studies using CA 125 and transvaginal ultrasound covered, but multiple markers as well as biomarker discovery is reviewed as well. In addition, the concepts of 2D-PAGE, DIGE, SELDI-TOF, and protein arrays are compared and contrasted for a better understanding of the current
biomarker research. While not as complete as a surgical procedural atlas, chapter 7 does cover a variety of surgical techniques related to ovarian cancer, including en bloc pelvic resection, diaphragm resection, liver resection, and splenectomy. In addition, the major studies supporting cytoreduction are reviewed as well as the rationale and evidence for fertility sparing surgery where indicated. Chapter 8 is a review of the current standard of care chemotherapy for ovarian cancer. To write this with clarity is no small feat, but is accomplished quite well here, though not as thoroughly as other texts. Chapters 9 and 10 truly make this book stand out. Chapter 9 is totally devoted to the chemotherapeutic management of recurrent ovarian cancer. This is an excellent overview of the current evidence and issues in treatment of women with recurrent ovarian cancer. Chapter 10 is completely devoted to secondary cytoreduction in recurrent ovarian cancer, an issue that does not typically get as much attention in general gynecologic oncology textbooks. The devotion of a whole chapter on this subject adds to the value of this text greatly. As thorough and easy to read as this book is, there is some room for improvement. It would benefit from a chapter devoted to the management of symptoms in recurrent ovarian cancer, as well as the role of end of life care in this population where cure is rare. In addition, some topics are covered twice in different chapters, creating some redundancy. For instance, the surgical management of LMP tumors as well as non-epithelial tumors is covered both in chapter 7 and chapter 11; and secondary cytoreduction has its own chapter but is also covered in less detail in chapter 7. However, these are minor issues in what I believe to be a valuable reference for clinicians, fellows, residents, and students who care for women with ovarian cancer.
205
Stephen Lee Rose, M.D. Department of Obstetrics and Gynecology University of Wisconsin 600 Highland Ave. H4/636 Clinical Science Center Madison, WI 53792 E-mail: [email protected] doi:10.1016/j.jss.2010.11.896
0022-4804/$36.00 Ó 2011 Elsevier Inc. All rights reserved.