Early intracellular events in the myocardium during hypoxia

109

Abstracts Four

identically

wedges

were

constructed

filled

iothalamate,

with

66.8%

trations:

1:4,

irradiated

on a tine

x-ray

tube,

The

iodine)

1:8,

following

and

three

camera

x-ray

(MA),

isodensity

eter traces and isodensity introduced

duration

(ED).

relation

(Jarrel-

axis of individual

images

The com-

was used to prepare The microdensitom-

plots were not corrected by

analysis

near linear

the

of the

between

tine

x-ray

results

path length

MA

and

ED.

some

background

able

to the tine

minimized

Although error

there

(“noise”),

x-ray

system

and corrected

for

system.

reveals

that

through

dye and film density does exist in an optimal KV,

varied (KV),

characteristics.

flying spot scanner

distortion

were

kilovoltage

at the same time under

plots for each image.

Nonetheless,

locations.

Microdensitometer

Ash) traces along the central puter-linked

at fixed

parameters

for density

J. HILDNER, M.D., S. SERGE BAROLD, M.D. and PHILIP

wedge was

the

range of

appears

in part

distortion,

a

to be

attributit can

for by an appropriate

be

com-

puter program. This

near linear

film density volume

relation

between

can be utilized

path length

to determine

by two-dimensional

numerical

and

ventricular

integration.

D. A. PIATNEK-LEUNISSEN, PH.D., Philadelphia,

lactate

hypoxia

and decreased

as

expressed

creatine

phosphate

was shown in this laboratory decreased the

coronary

metabolic

adequate tissue

perfusion

metabolism

oxygen

respired

of events

of certain

chest

6.5 to 8%

dogs

endocardial

samples

were analyzed

tate.

remaining

isolation

of endocardial

which

were

assessed

tonic

buffer)

and

Intramitochondrial because chondrial

ventricular

functionally fatty

of its implication swelling

and

arti-

mixtures

for and

for CP and lac-

ventricle

structurally

arterial

epicardial was

and epicardial

free

in-

were

oxygen

Left

left

obviate

at decreased

45 to 60 minutes. The

to

explore

tissue beds, myocardial

Open

with

To

and

levels

related

pressure.

was studied

saturation.

ficially

(CP)

used

for

mitochondria

(swelling

in hypo-

(polarographically). acid

was

determined

as a causal

agent

uncoupling

of

in mitooxidative

phosphorylation. With

moderate

tive metabolism tional or structural

14 F)

(mean

46).

relating

the

graded tive

LV

no impairment

was reflected changes.

VOLUME 21, JANUARY 1968

of oxida-

as mitochondrial

func-

Beach,

Fla.

function

was evaluated

in 42 patients

ranging

in age from

18 to 65 years

Function

curves

response

and

of the infusions

coronary

were

constructed

left ventricle

(LV)

of angiotensin.

cineangiograms

to

Selecwere

also

obtained. Hemodynamic

and

angiographic

data

vided for 19 patients

with occlusive

disease

normal

(CAD),

idiopathic

18

myocardial

response

subjects

[LVEDP])

in all

abnormal

in all 5 with

occlusive

CAD.

20

without

of 23

Control

function

however, by

was

and

study.

In

was abnormal

the response

6 of 11 with CAD and normal

LV

LV

Since

patients

an

cineangiogram, a normal

of stress is required

and

elevated or both

LVEDP

and

correlate

with

of LV

func-

the evaluation

in the preoperative (revascularization,

of angiotensin

LVEDP

responses.

do not necessarily

function.

(10 of (8 of 8),

and LV cineangio-

although

function,

is important

CAD

CAD,

or abnormal

cineangiogram

normal tion

LVEDP

angiotensin

with LV

LV with

to stress was also abnormal.

both normal

poor

were

in 9 of 19

was elevated

or both,

indicate

in

IMH)

patients

However,

LVEDP,

normal with

4 of these 9 had abnormal

the LVEDP

patients

and

LV cineangiograms

angiotensin

grams had abnormal

The

(increase

subjects

and

no CAD

CAD whose LV cineangiogram

2 of 7 with

with

and in 14 of 19 with

(normal

in 19 of 23 with

with CAD;

5

of LV end-diastolic

LVEDP

CAD

and in 11 of 19 with CAD. normal

and

18 normal

IMH

proartery

(IMH).

stress was normal

in LV stroke work with elevation pressure

were

coronary

hypertrophy

to angiotensin

assessment

etc.),

and that provided

some

of

form

by an infusion

has proved to be safe and reliable.

An Experimental Analysis of the Earliest Effects of Internal Thoracic Artery Implantation on the EMIL L. MANTINI, M.D., SUSUMU Ischemic Ventricle. TANAKA, F .A.c.c., Forty near

experiments

artery

were

LILLEHEI,

performed

coronary

in dogs.

zone

of cyanosis, An internal

motion.

was then implanted were analyzed initial

The

was ligated

zone using the technic the

M.D.,

artery

a distal

paradoxical

of animals

following

WALTON

Minn.

producing

and

of the ischemic Groups

C.

descending

its origin

asynergism

vals

and

M.D.

Minneapolis,

left anterior

mammary hypoxia

Miami

intravenous

In

Pa.

increased

to be linearly

perfusion

sequence

by

Myocardial (28 M,

10) or in whom

Early Intracellular Events in the Myocardium During Hypoxia. R. L. A. LEUNISSEN, M.D. and Myocardial

SAMET, M.D., F.A.c.c.,

system with the

exposure

conditions.

were analyzed

Each

a wide range:

Myocardial Function in Patients with Coronary Artery Disease. JOSEPH W. LINHART, M.D., FRANK

45’

(sodium

to four concen-

1: 32.

The tine films were developed identical

lucite dye

image intensifier

through

milliamperage

diluted

1: 16,

wedge

separately

hollow

a radiopaque

into the center of Vineberg. at regular

procedure.

inter-

Epicardial