- Email: [email protected]
Echocardiographic findings in patients with obstructive sleep apnea
e106
Abstracts / Sleep Medicine 14S (2013) e93–e164
more reliable dreams diary method and explore additional features in the dreams of adolescent Canadians. Materials and methods: Fifty males and 50 females, ages 12–17, kept a diary of day’s events and dreams for 10 days. One dream per participant was scored by two independent judges, with interrater reliability, using the Hall and Van de Castle method of content analysis. All variables were controlled for dream report length by dividing by word count. DreamSAT was used for statistical comparisons and a control was used for family-wise multiple comparisons. Results: Independent samples t-tests revealed that females had significantly more words in their dreams (t (78) = 3.543, p = .001), and more female (t (98) = 2.785, p = .006) and family characters (t (98) = 2.683, p = .009.), whereas males had significantly more strangers (t (61) = 3.578, p = .001). Males had both more total aggression (t (74) = 2.452, p = .017), and more recreation implement objects (t (60) = 2.572, p = .013). In addition, a variable in DreamSAT measuring negative tone revealed that males had more negatively toned dreams than females (t (87) = 2.653, p = .009). Conclusion: These results support previous research on gender differences in the dreams of adolescents and stress the early appearance of aggression in male dreams compared to female dreams. It will be interesting to examine the evolution of these differences in older groups. Acknowledgement: Supported by a grant from the Social Sciences and Humanities Research Council of Canada. http://dx.doi.org/10.1016/j.sleep.2013.11.229
Influence of arterial hypertension on renal function in patients with obstructive sleep apnea hypopnea syndrome L. Dheryan 1, G. Podosyan 2, A. Matevosyan 3, P. Zelveian 2 1 Yerevan State Medical University, Yerevan, Armenia 2 Center of Preventive Cardiology, National Institute of Health, Yerevan, Armenia 3 Sleep Research Laboratory at the Center of Preventive Cardiology, Armenia
Introduction: Aim of the study has been an investigation of possible relationship between glomerular filtration rate (GFR) and arterial hypertension (AH) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Materials and methods: Forty patients (35 male, 5 female, mean age 43.3 ± 12.5 year) with OSAHS (apnea–hypopnea index (AHI) >5 episodes/h) have been included in the study. Investigated 40 patients have been divided into the two groups: patients having only OSAHS (group I) and patients having OSAHS and AH (group II). GFR has been estimated using the Cockcroft–Gault formula. Normal rates for GFR have been estimated as 100–130 ml/m/1.73 m2. For statistical analysis of GFR classified groups median values have been used as a ‘‘dividing point’’. Relationship between GFR and AH has been estimated according to Pearson v2 and Fisher exact test. Results: Increased values for GFR have been revealed in both groups. However, relatively lower rates from median values of GFR have been detected in 11 patients from group I (55%; CI 34.2– 74.2%) and in 12 patients from group II (60%; CI 38.7–78.1%). Statistically significant differences have not been observed between two groups of patients; while tendency of higher GFR values from median ones have been revealed in the group I (169.0 ± 52.5 vs. 157.5 ± 36.8 ml/m/1.73 m2, p = 0.427). Conclusion: Hyperfiltration is common for patients with OSAHS. In the same time a presence of arterial hypertension is accompanied only by tendency for decrease of absolute values of glomerular filtration rate.
Acknowledgement: Anna Petrosyan laboratory technician. http://dx.doi.org/10.1016/j.sleep.2013.11.230
Echocardiographic findings in patients with obstructive sleep apnea M. Dias 1, R. Reis 2, A. Antunes 1 1 Pneumonology Department, Centro Hospitalar Vila Nova de Gaia/ Espinho, Armenia 2 Pneumonology Department, Centro Hospitalar Trás-os-Montes e Alto Douro, Armenia
Introduction: Obstructive sleep apnea (OSA) is associated with several adverse cardiovascular effects. This study aims to compare the echocardiographic findings of patients with and without OSA. Materials and methods: We performed a retrospective study which included patients referred to a pneumonology outpatient department for suspected OSA between January 2012 and June 2013. Demographic and anthropometric data, cardiovascular risk factors, echocardiographic findings and polysomnographic data were collected. Comparisons were made between subjects with and without OSA. Results: We included 127 patients with a mean age of 56 ± 12 years, 85 (67%) were male. 89 (70%) patients had OSA (34% mild, 17% moderate, 18% severe) and this group was older (58 vs. 50, p = 0.001), had higher body mass index (31.7 vs. 27.2, p < 0.001) and a higher prevalence of hypertension (83% vs. 58%, p = 0.003) and diabetes (88% vs. 66%, p = 0.048). We found that OSA was significantly associated with left atrial enlargement (41.6 mm vs. 36.6 mm, p < 0.001). In those patients with moderate and severe OSA, pulmonary hypertension was more prevalent (62% vs. 39%, p = 0.047) and the left ventricular ejection fraction (LVEF) was inferior. Moreover, there was a negative correlation between the apnea–hypopnea index (AHI) and the LVEF (rho = 0.287, p = 0.007) and an even stronger negative correlation between oxygen desaturation index (ODI) and LVEF (r = 0.327, p = 0.012). However, no correlation was found between LVEF and minimal oxygen saturation. There was no significant difference between the prevalence of ventricular hypertrophy and diastolic dysfunction in different groups. Conclusion: OSA can affect atrial diameter, pulmonary pressure and systolic function, which can be associated to a poorer prognosis. ODI was the best predictor of LVEF which seems to indicate that this index is the polysomnographic parameter more determinant in the deterioration of systolic function. The next step will be to investigate if these alterations can improve with PAP therapy. http://dx.doi.org/10.1016/j.sleep.2013.11.231
Metabolic syndrome influences the severity of sleep apnea syndrome: from the cordioprev study A. Leon Acuna 1, I. Ordonez Dios 2, P. Perez Martinez 1, A. Jimenez Romero 2, B. Jurado Gamez 2, J. Lopez Miranda 3 1 Andalucia Health Service, Lipid and Atherosclerosis Unit, IMIBIC, Spain 2 Andalucia Health Service, Department of Respiratory Medicine, Spain 3 Andalucia Health Service, Lipid and Atherosclerosis Unit, Spain
Introduction: Sleep Apnea Syndrome (SAHS) represents a significant risk factor for the development of cardiovascular disease and evidence suggests a relation with Metabolic Syndrome (MetS). However, it is not clear whether SAHS exacerbates the metabolic
Abstracts / Sleep Medicine 14S (2013) e93–e164
more reliable dreams diary method and explore additional features in the dreams of adolescent Canadians. Materials and methods: Fifty males and 50 females, ages 12–17, kept a diary of day’s events and dreams for 10 days. One dream per participant was scored by two independent judges, with interrater reliability, using the Hall and Van de Castle method of content analysis. All variables were controlled for dream report length by dividing by word count. DreamSAT was used for statistical comparisons and a control was used for family-wise multiple comparisons. Results: Independent samples t-tests revealed that females had significantly more words in their dreams (t (78) = 3.543, p = .001), and more female (t (98) = 2.785, p = .006) and family characters (t (98) = 2.683, p = .009.), whereas males had significantly more strangers (t (61) = 3.578, p = .001). Males had both more total aggression (t (74) = 2.452, p = .017), and more recreation implement objects (t (60) = 2.572, p = .013). In addition, a variable in DreamSAT measuring negative tone revealed that males had more negatively toned dreams than females (t (87) = 2.653, p = .009). Conclusion: These results support previous research on gender differences in the dreams of adolescents and stress the early appearance of aggression in male dreams compared to female dreams. It will be interesting to examine the evolution of these differences in older groups. Acknowledgement: Supported by a grant from the Social Sciences and Humanities Research Council of Canada. http://dx.doi.org/10.1016/j.sleep.2013.11.229
Influence of arterial hypertension on renal function in patients with obstructive sleep apnea hypopnea syndrome L. Dheryan 1, G. Podosyan 2, A. Matevosyan 3, P. Zelveian 2 1 Yerevan State Medical University, Yerevan, Armenia 2 Center of Preventive Cardiology, National Institute of Health, Yerevan, Armenia 3 Sleep Research Laboratory at the Center of Preventive Cardiology, Armenia
Introduction: Aim of the study has been an investigation of possible relationship between glomerular filtration rate (GFR) and arterial hypertension (AH) in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Materials and methods: Forty patients (35 male, 5 female, mean age 43.3 ± 12.5 year) with OSAHS (apnea–hypopnea index (AHI) >5 episodes/h) have been included in the study. Investigated 40 patients have been divided into the two groups: patients having only OSAHS (group I) and patients having OSAHS and AH (group II). GFR has been estimated using the Cockcroft–Gault formula. Normal rates for GFR have been estimated as 100–130 ml/m/1.73 m2. For statistical analysis of GFR classified groups median values have been used as a ‘‘dividing point’’. Relationship between GFR and AH has been estimated according to Pearson v2 and Fisher exact test. Results: Increased values for GFR have been revealed in both groups. However, relatively lower rates from median values of GFR have been detected in 11 patients from group I (55%; CI 34.2– 74.2%) and in 12 patients from group II (60%; CI 38.7–78.1%). Statistically significant differences have not been observed between two groups of patients; while tendency of higher GFR values from median ones have been revealed in the group I (169.0 ± 52.5 vs. 157.5 ± 36.8 ml/m/1.73 m2, p = 0.427). Conclusion: Hyperfiltration is common for patients with OSAHS. In the same time a presence of arterial hypertension is accompanied only by tendency for decrease of absolute values of glomerular filtration rate.
Acknowledgement: Anna Petrosyan laboratory technician. http://dx.doi.org/10.1016/j.sleep.2013.11.230
Echocardiographic findings in patients with obstructive sleep apnea M. Dias 1, R. Reis 2, A. Antunes 1 1 Pneumonology Department, Centro Hospitalar Vila Nova de Gaia/ Espinho, Armenia 2 Pneumonology Department, Centro Hospitalar Trás-os-Montes e Alto Douro, Armenia
Introduction: Obstructive sleep apnea (OSA) is associated with several adverse cardiovascular effects. This study aims to compare the echocardiographic findings of patients with and without OSA. Materials and methods: We performed a retrospective study which included patients referred to a pneumonology outpatient department for suspected OSA between January 2012 and June 2013. Demographic and anthropometric data, cardiovascular risk factors, echocardiographic findings and polysomnographic data were collected. Comparisons were made between subjects with and without OSA. Results: We included 127 patients with a mean age of 56 ± 12 years, 85 (67%) were male. 89 (70%) patients had OSA (34% mild, 17% moderate, 18% severe) and this group was older (58 vs. 50, p = 0.001), had higher body mass index (31.7 vs. 27.2, p < 0.001) and a higher prevalence of hypertension (83% vs. 58%, p = 0.003) and diabetes (88% vs. 66%, p = 0.048). We found that OSA was significantly associated with left atrial enlargement (41.6 mm vs. 36.6 mm, p < 0.001). In those patients with moderate and severe OSA, pulmonary hypertension was more prevalent (62% vs. 39%, p = 0.047) and the left ventricular ejection fraction (LVEF) was inferior. Moreover, there was a negative correlation between the apnea–hypopnea index (AHI) and the LVEF (rho = 0.287, p = 0.007) and an even stronger negative correlation between oxygen desaturation index (ODI) and LVEF (r = 0.327, p = 0.012). However, no correlation was found between LVEF and minimal oxygen saturation. There was no significant difference between the prevalence of ventricular hypertrophy and diastolic dysfunction in different groups. Conclusion: OSA can affect atrial diameter, pulmonary pressure and systolic function, which can be associated to a poorer prognosis. ODI was the best predictor of LVEF which seems to indicate that this index is the polysomnographic parameter more determinant in the deterioration of systolic function. The next step will be to investigate if these alterations can improve with PAP therapy. http://dx.doi.org/10.1016/j.sleep.2013.11.231
Metabolic syndrome influences the severity of sleep apnea syndrome: from the cordioprev study A. Leon Acuna 1, I. Ordonez Dios 2, P. Perez Martinez 1, A. Jimenez Romero 2, B. Jurado Gamez 2, J. Lopez Miranda 3 1 Andalucia Health Service, Lipid and Atherosclerosis Unit, IMIBIC, Spain 2 Andalucia Health Service, Department of Respiratory Medicine, Spain 3 Andalucia Health Service, Lipid and Atherosclerosis Unit, Spain
Introduction: Sleep Apnea Syndrome (SAHS) represents a significant risk factor for the development of cardiovascular disease and evidence suggests a relation with Metabolic Syndrome (MetS). However, it is not clear whether SAHS exacerbates the metabolic