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EEG and clinical outcome in children with idiopathic epilepsies
S182 P31.13 E N D O G E N O U S C O M P O N E N T S IN EVENT RELATED POTENTIALS OF BRAIN'S SUBCORTICAL STRUCTURES.
Canan Basar-Eroglu and E. Basar (Lubeck, W. Germany) In our earlier studies, we developed a working hypothesis describing the sensory evoked potential as a superposition of stimulus-locked and enhanced EEG with the shape of damped oscillatory wave-forms in frequency channels of 1 3.5 Hz, 3,5.-8 Hz, 8-15 Hz, 15 25 Hz and 40 Hz (E. Basar: EEG-Brain Dynamics, Elsevier 1980). The endogenous components of ERPs in 8 chronically implanted and moving cats have been analysed by acoustical stimulation of 1550 Hz (rare) tones presented randomly amongst 1500Hz (frequent) tones. The comparison of ERPs in cortical and subcortical structures of the brain to rare stinmli with the ERPs to frequent stimulation showed that the duration of the enhanced EEG responses in the 1-3.5 Hz, 3.5-8 Hz and 8-13 Hz are different. The damped enhanced oscillations in the acoustical cortex, hippocampus and reticular formation are more prolonged in the ERPs to rare stimulation, the damping time is elapsed in all three frequency ranges. These findings are in accordance with our observation in studies on the endogenous components of h u m a n ERPs. We tentatively conclude that during matching and decision-making processes the reactions of the delta, theta and alpha enhancements have longer durations in comparison to the EEG-enhancement phenomenon elicited with simple sensory stimulation. The question concerning the originating site of endogenous potentials is discussed.
EPILEPSY ii: EEG STUDIES. P32.01 EEG AND CLINICAL O U T C O M E IN C H I L D R E N W I T H I D I O P A T H I C EPILEPSIES,
V. Farkm, C. Benninger, P. Matthis and D. Scheffner
during treatment, multifocal abnormalities disappeared m most of these cases. Generalized paroxysms (mainly slow wave activity) disappeared in all patients with generalized epilepsies if they became seizure-free. Focal and generalized epileptic discharges occuring before the beginning of treatment did not seem to have a reliable prognostic value concerning the clinical outcome.
P32.02 P E R S I S T E N C E T H E T A IN S L E E P EEG.
OF
NOCICEPTIVE
EVOKED
J.R. Santoni (Santo Domingo, Dominican Republic) A repeat Diphenhydramine sleep EEG prospective study at 1 4 year intervals was carried out to test persistence of frontal theta paroxysms evoked by distal limb pricking with a woodstick (light pinprick) (Santoni Mendoza, Electroenceph. Clin, Neurophysiol., 1969, 27: 682). A sample of forty children suffering T / C epilepsy or febrile convulsions (FC) who presented with this sign (x 2.3 yr), Three responses without awakening qualified. The responses persisted in 7 / 1 0 at one year, 6 / 9 at two years 8/11 at 3 years and 7 / 1 0 after 4 years (70%, 66%, 72%, 70% respectively). Mean ages were: 4.6 for positives, 5.1 years for negatives. G a m m a , t and x 2 analysis showed no correlation between responses and the 1 - 4 year intervals without significant differences between age, sex and medication. Thus, responses represent lasting abnormal phenomena unrelated to early maturation, EEG normal variables or declining age incidence in FC. A retrospective paper with Abreu, Lopez, Ramos (1983) showed it in 76-78% of 349 T / C of FC (x 2.63). A forthcoming study confirmed it in 16% of 30 normals ( ~ = 2.88 yrs), against 54 60% of 173 FC and 118 T / C epileptics (x 3.42 yrs). Its rarity in normal children and the occurrence in convulsives plus the demonstration of persistence suggest the semiological importance of this sign.
(Heidelberg, W. Germany) The aim of this study was to examine the influence of idiopathic epilepsy and its therapy on the EEG in children. Patients consisted of 40 primary generalized and 40 partial epileptic children (4-15 years old) who were 2 - 5 years on anti-epileptic therapy. EEGs recorded before the beginning of treatment were compared with those after at least 2 years of anti-epileptic treatment and correlated with the clinical outcome. The EEGs were evaluated visually and by frequency analysis. The background activity before treatment showed moderate slowing in about 1 / 3 r d of the patients, especially in those who did not become seizure-free later on. During treatment, only slight changes of background activity occurred without significant correlation within the two groups. Although focal abnormalities were not significantly reduced
P32.03 C O M P U T E D T O M O G R A P H Y IN C H I L D R E N W I T H AN E L E C T R O E N C E P H A L O G R A P H I C PA'ITERN OF H Y P S A R R H Y T H M I A .
Eleni Bazigou-Fotopulu, V. Kiriakidou
A.
Gouliamos,
C.
Skiadas
and
(Athens, Greece) CT-scans of 70 children with mean age 7 months (range 1 to 32 months) and a seizure disorder consisting of flexor or extensor spasms and an electroencephalographic pattern of hypsarrhythmia were studied. Before starting A C T t t therapy, 36 (51.4%) patients had normal and 34 (48.6%) had abnormal CT-scans. In the abnormal group, only one (3%) corresponded
Canan Basar-Eroglu and E. Basar (Lubeck, W. Germany) In our earlier studies, we developed a working hypothesis describing the sensory evoked potential as a superposition of stimulus-locked and enhanced EEG with the shape of damped oscillatory wave-forms in frequency channels of 1 3.5 Hz, 3,5.-8 Hz, 8-15 Hz, 15 25 Hz and 40 Hz (E. Basar: EEG-Brain Dynamics, Elsevier 1980). The endogenous components of ERPs in 8 chronically implanted and moving cats have been analysed by acoustical stimulation of 1550 Hz (rare) tones presented randomly amongst 1500Hz (frequent) tones. The comparison of ERPs in cortical and subcortical structures of the brain to rare stinmli with the ERPs to frequent stimulation showed that the duration of the enhanced EEG responses in the 1-3.5 Hz, 3.5-8 Hz and 8-13 Hz are different. The damped enhanced oscillations in the acoustical cortex, hippocampus and reticular formation are more prolonged in the ERPs to rare stimulation, the damping time is elapsed in all three frequency ranges. These findings are in accordance with our observation in studies on the endogenous components of h u m a n ERPs. We tentatively conclude that during matching and decision-making processes the reactions of the delta, theta and alpha enhancements have longer durations in comparison to the EEG-enhancement phenomenon elicited with simple sensory stimulation. The question concerning the originating site of endogenous potentials is discussed.
EPILEPSY ii: EEG STUDIES. P32.01 EEG AND CLINICAL O U T C O M E IN C H I L D R E N W I T H I D I O P A T H I C EPILEPSIES,
V. Farkm, C. Benninger, P. Matthis and D. Scheffner
during treatment, multifocal abnormalities disappeared m most of these cases. Generalized paroxysms (mainly slow wave activity) disappeared in all patients with generalized epilepsies if they became seizure-free. Focal and generalized epileptic discharges occuring before the beginning of treatment did not seem to have a reliable prognostic value concerning the clinical outcome.
P32.02 P E R S I S T E N C E T H E T A IN S L E E P EEG.
OF
NOCICEPTIVE
EVOKED
J.R. Santoni (Santo Domingo, Dominican Republic) A repeat Diphenhydramine sleep EEG prospective study at 1 4 year intervals was carried out to test persistence of frontal theta paroxysms evoked by distal limb pricking with a woodstick (light pinprick) (Santoni Mendoza, Electroenceph. Clin, Neurophysiol., 1969, 27: 682). A sample of forty children suffering T / C epilepsy or febrile convulsions (FC) who presented with this sign (x 2.3 yr), Three responses without awakening qualified. The responses persisted in 7 / 1 0 at one year, 6 / 9 at two years 8/11 at 3 years and 7 / 1 0 after 4 years (70%, 66%, 72%, 70% respectively). Mean ages were: 4.6 for positives, 5.1 years for negatives. G a m m a , t and x 2 analysis showed no correlation between responses and the 1 - 4 year intervals without significant differences between age, sex and medication. Thus, responses represent lasting abnormal phenomena unrelated to early maturation, EEG normal variables or declining age incidence in FC. A retrospective paper with Abreu, Lopez, Ramos (1983) showed it in 76-78% of 349 T / C of FC (x 2.63). A forthcoming study confirmed it in 16% of 30 normals ( ~ = 2.88 yrs), against 54 60% of 173 FC and 118 T / C epileptics (x 3.42 yrs). Its rarity in normal children and the occurrence in convulsives plus the demonstration of persistence suggest the semiological importance of this sign.
(Heidelberg, W. Germany) The aim of this study was to examine the influence of idiopathic epilepsy and its therapy on the EEG in children. Patients consisted of 40 primary generalized and 40 partial epileptic children (4-15 years old) who were 2 - 5 years on anti-epileptic therapy. EEGs recorded before the beginning of treatment were compared with those after at least 2 years of anti-epileptic treatment and correlated with the clinical outcome. The EEGs were evaluated visually and by frequency analysis. The background activity before treatment showed moderate slowing in about 1 / 3 r d of the patients, especially in those who did not become seizure-free later on. During treatment, only slight changes of background activity occurred without significant correlation within the two groups. Although focal abnormalities were not significantly reduced
P32.03 C O M P U T E D T O M O G R A P H Y IN C H I L D R E N W I T H AN E L E C T R O E N C E P H A L O G R A P H I C PA'ITERN OF H Y P S A R R H Y T H M I A .
Eleni Bazigou-Fotopulu, V. Kiriakidou
A.
Gouliamos,
C.
Skiadas
and
(Athens, Greece) CT-scans of 70 children with mean age 7 months (range 1 to 32 months) and a seizure disorder consisting of flexor or extensor spasms and an electroencephalographic pattern of hypsarrhythmia were studied. Before starting A C T t t therapy, 36 (51.4%) patients had normal and 34 (48.6%) had abnormal CT-scans. In the abnormal group, only one (3%) corresponded